The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
The therapeutic promise of the cancer stem cell concept
Open accessAbstract
Cancer stem cells (CSCs) are a subpopulation of tumor cells that selectively possess tumor initiation and self-renewal capacity and the ability to give rise to bulk populations of nontumorigenic cancer cell progeny through differentiation. As we discuss here, they have been prospectively identified in several human malignancies, and their relative abundance in clinical cancer specimens has been correlated with malignant disease progression in human patients. Furthermore, recent findings suggest that clinical cancer progression driven by CSCs may contribute to the failure of existing therapies to consistently eradicate malignant tumors. Therefore, CSC-directed therapeutic approaches might represent translationally relevant strategies to improve clinical cancer therapy, in particular for those malignancies that are currently refractory to conventional anticancer agents directed predominantly at tumor bulk populations.
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Cited by
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Metadata
- Authors
- Frank, N. Y., Schatton, T., & Frank, M. H.
- Venue
- Journal of Clinical Investigation
- Published
- 2010-01-04
- Volume
- 120
- Issue
- 1
- Pages
- 41-50
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2026379260
- Cited by
- 636
- References
- 10
- FWCI
- 26.93
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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