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Cited by 167

The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.

Pivotal role of the CCL5/CCR5 interaction for recruitment of endothelial progenitor cells in mouse wound healing

Open access
Ishida, Yuko, Kimura, Akihiko, Kuninaka, Yumi, Inui, Masanori, Matsushima, Kouji, Mukaida, Naofumi, Kondo, Toshikazu·2012·Journal of Clinical Investigation
DOI 10.1172/jci43027
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Abstract

BM-derived endothelial progenitor cells (EPCs) are critical and essential for neovascularization in tissue repair and tumorigenesis. EPCs migrate from BM to tissues via the bloodstream, but specific chemotactic cues have not been identified. Here we show in mice that the absence of CCR5 reduced vascular EPC accumulation and neovascularization, but not macrophage recruitment, and eventually delayed healing in wounded skin. When transferred into Ccr5-/- mice, Ccr5+/+ BM cells, but not Ccr5-/- cells, accumulated in the wound site, were incorporated into the vasculature, and restored normal neovascularization. Consistent with these observations, CCL5 induced in vitro EPC migration in a CCR5-dependent manner. Moreover, expression of VEGF and TGF-β was substantially diminished at wound sites in Ccr5-/- mice, which suggests that EPCs are important not only as the progenitors of endothelial cells, but also as the source of growth factors during tissue repair. Taken together, these data identify the CCL5/CCR5 interaction as what we believe to be a novel molecular target for modulation of neovascularization and eventual tissue repair.

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Crossref · 10.1172/jci43027

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Metadata

Authors
Ishida, Y., Kimura, A., Kuninaka, Y., Inui, M., Matsushima, K., Mukaida, N., & Kondo, T.
Venue
Journal of Clinical Investigation
Publisher
American Society for Clinical Investigation
Published
2012-02-01
Volume
122
Issue
2
Pages
711-721
ISSN
0021-9738 (ISSN-L)
DOI
10.1172/jci43027
OpenAlex
W2104782188
Cited by
167
References
10
FWCI
16.28
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Pivotal role of the CCL5/CCR5 interaction for recruitment of endothelial progenitor cells in mouse wound healing. https://app.cochat.ai/papers/10.1172/jci43027
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Ishida, Y., Kimura, A., Kuninaka, Y., Inui, M., Matsushima, K., Mukaida, N., & Kondo, T. (2012). Pivotal role of the CCL5/CCR5 interaction for recruitment of endothelial progenitor cells in mouse wound healing. Journal of Clinical Investigation. https://doi.org/10.1172/jci43027

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.