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Cited by 211Diabetes and associated disordersPancreatic function and diabetesCharacterization and Applications of Magnetic Nanoparticles

The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.

Noninvasive imaging of pancreatic islet inflammation in type 1A diabetes patients

Open access
Gaglia, Jason L., Guimaraes, Alexander R., Harisinghani, Mukesh, Turvey, Stuart E., Jackson, Richard, Benoist, Christophe, Mathis, Diane, Weissleder, Ralph·2011·Journal of Clinical Investigation
DOI 10.1172/jci44339PMC PMC3007157
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Abstract

Type 1A diabetes (T1D) is an autoimmune disease characterized by leukocyte infiltration of the pancreatic islets of Langerhans. A major impediment to advances in understanding, preventing, and curing T1D has been the inability to "see" the disease initiate, progress, or regress, especially during the occult phase. Here, we report the development of a noninvasive method to visualize T1D at the target organ level in patients with active insulitis. Specifically, we visualized islet inflammation, manifest by microvascular changes and monocyte/macrophage recruitment and activation, using magnetic resonance imaging of magnetic nanoparticles (MNPs). As a proof of principle for this approach, imaging of infused ferumoxtran-10 nanoparticles permitted effective visualization of the pancreas and distinction of recent-onset diabetes patients from nondiabetic controls. The observation that MNPs accumulate in the pancreas of T1D patients opens the door to exploiting this noninvasive imaging method to follow T1D progression and monitoring the ability of immunomodulatory agents to clear insulitis.

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Crossref · 10.1172/jci44339

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Research works printed but not linked: 2

  1. Papaccio, 1993, Histol Histopathol., 8, 751
  2. Signore, 1996, Clin Exp Rheumatol., 14 suppl 15, S41

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Metadata

Authors
Gaglia, J. L., Guimaraes, A. R., Harisinghani, M., Turvey, S. E., Jackson, R., Benoist, C., Mathis, D., & Weissleder, R.
Affiliations
  • Harvard University (US)
  • Broad Institute (US)
ORCID
Venue
Journal of Clinical Investigation
Publisher
American Society for Clinical Investigation
Published
2011-01-04
Volume
121
Issue
1
Pages
442-445
ISSN
0021-9738 (ISSN-L)
DOI
10.1172/jci44339
PMC
PMC3007157
OpenAlex
W2067753785
Cited by
209
References
21
Citations by year
2026: 2 · 2025: 3 · 2024: 6 · 2023: 11 · 2022: 5 · 2021: 16 · 2020: 9 · 2019: 13 · 2018: 14 · 2017: 15 · 2016: 19 · 2015: 26 · 2014: 17 · 2013: 20 · 2012: 22
FWCI
9.54
Type
journal article
Language
en
Open access
Locations
  • Journal of Clinical Investigation (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion, cc-by)
Funders
  • Cancer Research Institute
  • Pfizer
  • RSNA Research and Education Foundation
  • Radiological Society of North America
  • Harvard University
  • Harvard Catalyst (UL1-RR025758, RR025758)
  • Covis Pharma
  • National Institutes of Health (5u54ca119349-05, P50-CA86355, U54-CA119349, CA119349, CA86355)
  • U.S. Public Health Service (P01-A1-054904)
  • National Heart, Lung, and Blood Institute (U01HL080731)
  • National Cancer Institute (P50-CA-86355, U24CA092782, P50CA086355, U54 CA-119349)
  • National Center for Research Resources (UL1RR025758)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
  • Physical Sciences › Engineering › Biomedical Engineering › Characterization and Applications of Magnetic Nanoparticles
Keywords
type 1A diabetes, insulitis, pancreatic islet inflammation, non-invasive imaging, magnetic nanoparticles, ferumoxtran-10, magnetic resonance imaging, monocyte/macrophage recruitment, microvascular changes, autoimmune disease
MeSH terms
Adolescent, Adult, Dextrans, Diabetes Mellitus, Type 1, Female, Humans, Inflammation, Islets of Langerhans, Macrophages, Magnetic Resonance Imaging, Male, Microcirculation, Monocytes, Case-Control Studies, Young Adult, Magnetite Nanoparticles

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