Cited by 211Diabetes and associated disordersPancreatic function and diabetesCharacterization and Applications of Magnetic Nanoparticles

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Noninvasive imaging of pancreatic islet inflammation in type 1A diabetes patients

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Gaglia, Jason L., Guimaraes, Alexander R., Harisinghani, Mukesh, Turvey, Stuart E., Jackson, Richard, Benoist, Christophe, Mathis, Diane, Weissleder, Ralph·2011·Journal of Clinical Investigation

DOI 10.1172/jci44339PMC PMC3007157

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Abstract

Type 1A diabetes (T1D) is an autoimmune disease characterized by leukocyte infiltration of the pancreatic islets of Langerhans. A major impediment to advances in understanding, preventing, and curing T1D has been the inability to "see" the disease initiate, progress, or regress, especially during the occult phase. Here, we report the development of a noninvasive method to visualize T1D at the target organ level in patients with active insulitis. Specifically, we visualized islet inflammation, manifest by microvascular changes and monocyte/macrophage recruitment and activation, using magnetic resonance imaging of magnetic nanoparticles (MNPs). As a proof of principle for this approach, imaging of infused ferumoxtran-10 nanoparticles permitted effective visualization of the pancreas and distinction of recent-onset diabetes patients from nondiabetic controls. The observation that MNPs accumulate in the pancreas of T1D patients opens the door to exploiting this noninvasive imaging method to follow T1D progression and monitoring the ability of immunomodulatory agents to clear insulitis.

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Authors: Gaglia, J. L., Guimaraes, A. R., Harisinghani, M., Turvey, S. E., Jackson, R., Benoist, C., Mathis, D., & Weissleder, R.
Affiliations: Harvard University (US)
Broad Institute (US)
ORCID: Gaglia, Jason L.
Harisinghani, Mukesh
Turvey, Stuart E.
Benoist, Christophe
Mathis, Diane
Weissleder, Ralph
Venue: Journal of Clinical Investigation
Publisher: American Society for Clinical Investigation
Published: 2011-01-04
Volume: 121
Issue: 1
Pages: 442-445
ISSN: 0021-9738 (ISSN-L)
DOI: 10.1172/jci44339
PMC: PMC3007157
OpenAlex: W2067753785
Cited by: 209
References: 21
Citations by year: 2026: 2 · 2025: 3 · 2024: 6 · 2023: 11 · 2022: 5 · 2021: 16 · 2020: 9 · 2019: 13 · 2018: 14 · 2017: 15 · 2016: 19 · 2015: 26 · 2014: 17 · 2013: 20 · 2012: 22
FWCI: 9.54
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Journal of Clinical Investigation (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion, cc-by)
Funders: Cancer Research Institute
Pfizer
RSNA Research and Education Foundation
Radiological Society of North America
Harvard University
Harvard Catalyst (UL1-RR025758, RR025758)
Covis Pharma
National Institutes of Health (5u54ca119349-05, P50-CA86355, U54-CA119349, CA119349, CA86355)
U.S. Public Health Service (P01-A1-054904)
National Heart, Lung, and Blood Institute (U01HL080731)
National Cancer Institute (P50-CA-86355, U24CA092782, P50CA086355, U54 CA-119349)
National Center for Research Resources (UL1RR025758)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
Physical Sciences › Engineering › Biomedical Engineering › Characterization and Applications of Magnetic Nanoparticles
Keywords: type 1A diabetes, insulitis, pancreatic islet inflammation, non-invasive imaging, magnetic nanoparticles, ferumoxtran-10, magnetic resonance imaging, monocyte/macrophage recruitment, microvascular changes, autoimmune disease
MeSH terms: Adolescent, Adult, Dextrans, Diabetes Mellitus, Type 1, Female, Humans, Inflammation, Islets of Langerhans, Macrophages, Magnetic Resonance Imaging, Male, Microcirculation, Monocytes, Case-Control Studies, Young Adult, Magnetite Nanoparticles

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Noninvasive imaging of pancreatic islet inflammation in type 1A diabetes patients

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