The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Blunted feedback suppression of SREBP processing by dietary cholesterol in transgenic mice expressing sterol-resistant SCAP(D443N)
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Over-accumulation of dietary cholesterol in the liver inhibits SREBP-mediated LDLR gene transcription, leading to reduced hepatic LDLR mRNA levels in hypercholesterolemic animals.
“It is well-established that over-accumulation of dietary cholesterol in the liver inhibits sterol-regulatory element binding protein (SREBP)-mediated LDL receptor (LDLR) gene transcription leading to a reduced hepatic LDLR mRNA level in hypercholesterolemic animals.”
From A novel posttranscriptional mechanism for dietary cholesterol-mediated suppression of liver LDL receptor expression (2014) · cites this paper as [15]
The Results report that a cholesterol/cholic acid diet increased liver cholesterol in wild-type mice and reduced hepatic LDL receptor mRNA by 20%. The Discussion links cholesterol feeding to reduced nuclear SREBP-2, but describes the connection to LDL receptor transcription as a suggestion rather than establishing the claimed causal chain across hypercholesterolemic animals generally. Page numbers are unavailable in our copy. (LLM, conf=0.84)
Experimental — accuracy not yet measuredOver-accumulation of dietary cholesterol in the liver prevents proteolytic activation of SREBPs and leads to a decline in expression of SREBP target genes, including LDLR and SREBP2 itself.
“Over-accumulation of dietary cholesterol in the liver prevents the proteolytic activation of SREBPs and leads to a decline in the expression of SREBP target genes, including LDLR and SREBP2 itself.”
From A novel posttranscriptional mechanism for dietary cholesterol-mediated suppression of liver LDL receptor expression (2014) · cites this paper as [15]
The Results (page not specified) show that a cholesterol/cholic acid diet sharply reduced nuclear SREBP-2 in wild-type mouse liver and reduced LDL receptor mRNA by 20%. The paper does not report that dietary cholesterol reduced SREBP-2 gene expression itself; the Discussion describes SREBP-2 self-regulation as a possibility. Suppression was also blunted, rather than complete, in the SCAP(D443N) transgenic mice. (LLM, conf=0.87)
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Citations
Cites
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Diet-induced hypercholesterolemia in mice: prevention by overexpression of LDL receptors
Yokode, M., Hammer, R. E., Ishibashi, S., Brown, M. S., & Goldstein, J. L. (1990) · Science · doi:10.1126/science.2244210 · Cited by 175
Self-citationHofmann, S. L., Russell, D. W., Brown, M. S., Goldstein, J. L., & Hammer, R. E. (1988) · Science · doi:10.1126/science.3344433 · Cited by 117
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Research works printed but not linked: 6
- Hua, X., C. Yokoyama, J. Wu, M.R. Briggs, M.S. Brown, J.L. Goldstein, and X. Wang. 1993. SREBP-2, a second basic-helix-loop-helix-leucine zipper protein that stimulates transcription by binding to a sterol regulatory element. Proc. Natl. Acad. Sci. USA. 90:11603-11607.
- Lopez, J.M., M.K. Bennett, H.B. Sanchez, J.M. Rosenfeld, and T.F. Os- borne. 1996. Sterol regulation of acetyl CoA carboxylase: a mechanism for co- ordinate control of cellular lipid. Proc. Natl. Acad. Sci. USA. 93:1049-1053.
- Nohturfft, A., M.S. Brown, and J.L. Goldstein. 1998. Sterols regulate processing of carbohydrate chains of wild-type SREBP cleavage-activating pro- tein (SCAP), but not sterol-resistant mutants Y298C or D443N. Proc. Natl. Acad. Sci. USA. 95:12848-12853.
- Palmiter, R.D., E.P. Sandgren, M.R. Avarbock, D.D. Allen, and R.L. Brinster. 1991. Heterologous introns can enhance expression of transgenes in mice. Proc. Natl. Acad. Sci. USA. 88:478-482.
- Sheng, Z., H. Otani, M.S. Brown, and J.L. Goldstein. 1995. Independent regulation of sterol regulatory element binding proteins 1 and 2 in hamster liver. Proc. Natl. Acad. Sci. USA. 92:935-938.
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Cited by
Sorted by citations
SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver
Horton, J. D., Goldstein, J. L., & Brown, M. S. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0215593 · Cited by 4,092
Self-citationRegulation of Sterol Synthesis in Eukaryotes
Espenshade, P. J., & Hughes, A. L. (2007) · Annual Review of Genetics · doi:10.1146/annurev.genet.41.110306.130315 · Cited by 593
Wouters, K., van Bilsen, M., van Gorp, P. J., Bieghs, V., Lütjohann, D., Kerksiek, A., Staels, B., Hofker, M. H., & Shiri-Sverdlov, R. (2010) · FEBS Letters · doi:10.1016/j.febslet.2010.01.046 · Cited by 109
Azzu, V., Vacca, M., Kamzolas, I., Hall, Z., Leslie, J., Carobbio, S., Virtue, S., Davies, S. E., Lukasik, A., Dale, M., et al. (2021) · Molecular Metabolism · doi:10.1016/j.molmet.2021.101210 · Cited by 52
Insulin Regulation of Hepatic Lipid Homeostasis
Uehara, K., Santoleri, D., Whitlock, A. E. G., & Titchenell, P. M. (2023) · Comprehensive Physiology · doi:10.1002/cphy.c220015 · Cited by 49
Singh, A. B., Kan, C. F. K., Shende, V., Dong, B., & Liu, J. (2014) · Journal of Lipid Research · doi:10.1194/jlr.m049429 · Cited by 35
Zhang, Z.-H., Liu, X.-Q., Zhang, C., He, W., Wang, H., Chen, Y.-H., Liu, X.-J., Chen, X., & Xu, D.-X. (2016) · Scientific Reports · doi:10.1038/srep33513 · Cited by 18
Metadata
- Authors
- Korn, B. S., Shimomura, I., Bashmakov, Y., Hammer, R. E., Horton, J. D., Goldstein, J. L., & Brown, M. S.
- Venue
- Journal of Clinical Investigation
- Published
- 1998-12-15
- Volume
- 102
- Issue
- 12
- Pages
- 2050-2060
- ISSN
- 0021-9738
- Cited by
- 56
- References
- 3
- Language
- en
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