Cited by 378Dermatology and Skin DiseasesContact Dermatitis and AllergiesAdvancements in Transdermal Drug Delivery

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Epidermal barrier dysfunction and cutaneous sensitization in atopic diseases

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Kubo, Akiharu, Nagao, Keisuke, Amagai, Masayuki·2012·Journal of Clinical Investigation

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Abstract

Classic atopic dermatitis is complicated by asthma, allergic rhinitis, and food allergies, cumulatively referred to as atopic diseases. Recent discoveries of mutations in the filaggrin gene as predisposing factors for atopic diseases have refocused investigators' attention on epidermal barrier dysfunction as a causative mechanism. The skin's barrier function has three elements: the stratum corneum (air-liquid barrier), tight junctions (liquid-liquid barrier), and the Langerhans cell network (immunological barrier). Clarification of the molecular events underpinning epidermal barrier function and dysfunction should lead to a better understanding of the pathophysiological mechanisms of atopic diseases.

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Authors: Kubo, A., Nagao, K., & Amagai, M.
Affiliations: Keio University (JP)
Corresponding author: Amagai, Masayuki
ORCID: Kubo, Akiharu
Nagao, Keisuke
Amagai, Masayuki
Venue: Journal of Clinical Investigation
Publisher: American Society for Clinical Investigation
Published: 2012-02-01
Volume: 122
Issue: 2
Pages: 440-447
ISSN: 0021-9738 (ISSN-L)
DOI: 10.1172/jci57416
PMC: PMC3266780
OpenAlex: W2157038335
Cited by: 378
References: 129
Citations by year: 2026: 13 · 2025: 20 · 2024: 21 · 2023: 21 · 2022: 25 · 2021: 24 · 2020: 28 · 2019: 26 · 2018: 21 · 2017: 32 · 2016: 30 · 2015: 26 · 2014: 41 · 2013: 34 · 2012: 16
FWCI: 7.54
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Journal of Clinical Investigation (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Keio University
Ministry of Education, Culture, Sports, Science and Technology
Japan Society for the Promotion of Science (22249044, 21229014)
Topics: Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
Health Sciences › Medicine › Dermatology › Contact Dermatitis and Allergies
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advancements in Transdermal Drug Delivery
Keywords: skin barrier dysfunction, skin sensitization, atopic dermatitis, atopic diseases, filaggrin mutations, stratum corneum, tight junctions, asthma, allergic rhinitis, food allergy, skin barrier
MeSH terms: Filaggrin Proteins, Animals, Dermatitis, Atopic, Epidermis, Humans, Hypersensitivity, Immediate, Intermediate Filament Proteins, Mutation, Skin

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Epidermal barrier dysfunction and cutaneous sensitization in atopic diseases

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