The DOI matches its Crossref record; 55 of the 56 references it cites were found in a registry or an index.
Characterization of selective resistance to insulin signaling in the vasculature of obese Zucker (fa/fa) rats
Open accessAbstract
Both insulin resistance and hyperinsulinemia have been reported to be independent risk factors for cardiovascular diseases. However, little is known regarding insulin signaling in the vascular tissues in insulin-resistant states. In this report, insulin signaling on the phosphatidylinositol 3-kinase (PI 3-kinase) and mitogen-activated protein (MAP) kinase pathways were compared in vascular tissues of lean and obese Zucker (fa/fa) rats in both ex vivo and in vivo studies. Ex vivo, insulin-stimulated tyrosine phosphorylation of insulin receptor beta subunits (IRbeta) in the aorta and microvessels of obese rats was significantly decreased compared with lean rats, although the protein levels of IRbeta in the 2 groups were not different. Insulin-induced tyrosine phosphorylation of insulin receptor substrates 1 and 2 (IRS-1 and IRS-2) and their protein levels were decreased in the aorta of obese rats compared with lean rats. The association of p85 subunit to the IRS proteins and the IRS-associated PI 3-kinase activities stimulated by insulin in the aorta of obese rats were significantly decreased compared with the lean rats. In addition, insulin-stimulated serine phosphorylation of Akt, a downstream kinase of PI 3-kinase pathway, was also reduced significantly in isolated microvessels from obese rats compared with the lean rats. In euglycemic clamp studies, insulin infusion greatly increased tyrosine phosphorylation of IRbeta- and IRS-2-associated PI 3-kinase activity in the aorta of lean rats, but only slight increases were observed in obese rats. In contrast, insulin stimulated tyrosine phosphorylation of MAP kinase (ERK-1/2) equally in isolated microvessels of lean and obese rats, although basal tyrosine phosphorylation of ERK-1/2 was higher in the obese rats. To our knowledge, these data provided the first direct measurements of insulin signaling in the vascular tissues, and documented a selective resistance to PI 3-kinase (but not to MAP kinase pathway) in the vascular tissues of obese Zucker rats.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“This observation is of important clinical significance, since diacylglycerol, long-chain fatty acyl CoAs, and ceramides all have been shown to cause serine phosphorylation of insulin resistance and IRS-1 and lead to the development of insulin resistance in skeletal muscle ( 59 , 60 ).”
From Skeletal Muscle Insulin Resistance Is the Primary Defect in Type 2 Diabetes (2009) · cites this paper as [60]
Experimental — accuracy not yet measuredIn the citing paper
“Vascular insulin resistance leads to downregulation of IRS-1 and 2 and decreased phosphorylation of Akt and eNOS, whereas the ET-1 pathway remains unaffected.”
From The Vasculature in Prediabetes (2018) · cites this paper as [48]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Nitric oxide: physiology, pathophysiology, and pharmacology.
Moncada, S., Palmer, R. M., & Higgs, E. A. (1991) · Pharmacological Reviews · doi:10.1016/s0031-6997(25)06663-3 · Cited by 15,525
Mechanisms of fatty acid-induced inhibition of glucose uptake.
Boden, G., Chen, X., Ruiz, J., White, J. V., & Rossetti, L. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117252 · Cited by 3,720
Hyperinsulinemia as an independent risk factor for ischemic heart disease
Després, J.-P., Lamarche, B., Mauriège, P., Cantin, B., Dagenais, G. R., Moorjani, S., & Lupien, P.-J. (1996) · New England Journal of Medicine · doi:10.1056/nejm199604113341504 · Cited by 1,699
Steinberg, H. O., Chaker, H., Leaming, R., Johnson, A., Brechtel, G., & Baron, A. D. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118709 · Cited by 1,687 · cited 2×
“However, physiological studies have documented that endothelial functions as measured by insulin-induced vasodilatation are reduced in insulin-resistant and diabetic patients (12), suggesting that vascular cells are also resistant to insulin for some of its physiological actions.”
BackgroundStructure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein
Sun, X. J., Rothenberg, P., Kahn, C. R., Backer, J. M., Araki, E., Wilden, P. A., Cahill, D. A., Goldstein, B. J., & White, M. F. (1991) · Nature · doi:10.1038/352073a0 · Cited by 1,574
Self-citationMechanism of free fatty acid-induced insulin resistance in humans.
Roden, M., Price, T. B., Perseghin, G., Petersen, K. F., Rothman, D. L., Cline, G. W., & Shulman, G. I. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118742 · Cited by 1,539
Steinberg, H. O., Brechtel, G., Johnson, A., Fineberg, N. S., & Baron, A. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117433 · Cited by 1,216
Insulin Stimulates the Phosphorylation of the 95,000-Dalton Subunit of Its Own Receptor
Kasuga, M., Karlsson, F. A., & Kahn, C. R. (1982) · Science · doi:10.1126/science.7031900 · Cited by 1,132
The effect of insulin on renal handling of sodium, potassium, calcium, and phosphate in man.
DeFronzo, R. A., Cooke, C. R., Andres, R., Faloona, G. R., & Davis, P. J. (1975) · Journal of Clinical Investigation · doi:10.1172/jci107996 · Cited by 1,104
Hyperinsulinemia produces both sympathetic neural activation and vasodilation in normal humans.
Anderson, E. A., Hoffman, R. P., Balon, T. W., Sinkey, C. A., & Mark, A. L. (1991) · Journal of Clinical Investigation · doi:10.1172/jci115260 · Cited by 1,075
Research works printed but not linked: 5
- Kuboki, 1998, Diabetes, 47(Suppl. 1), A24
- Cheatham, 1994, Mol Cell Biol, 14, 4902, 10.1128/MCB.14.7.4902 · DOI
- Myers, 1994, Mol Cell Biol, 14, 357
- Bray, 1977, Fed Proc, 36, 148
- Moncada, 1991, Pharmacol Rev, 43, 109
Cited by
Sorted by citations
Items 401–500 of 604
Ketsawatsomkron, P., Stepp, D. W., Fulton, D. J., & Marrero, M. B. (2010) · Vascular Pharmacology · doi:10.1016/j.vph.2010.06.001 · Cited by 14
Renal Activity of Akt Kinase in Obese Zucker Rats
Ždychová, J., Kazdová, L., Pelikánová, T., Lindsley, J. N., Anderson, S., & Komers, R. (2008) · Experimental Biology and Medicine · doi:10.3181/0801-rm-29 · Cited by 14
Amor, S., Martín-Carro, B., Rubio, C., Carrascosa, J. M., Hu, W., Huang, Y., Garcı́a-Villalón, Á. L., & Granado, M. (2017) · Experimental Gerontology · doi:10.1016/j.exger.2017.10.017 · Cited by 14
Integration of dietary nutrition and TRIB3 action into diabetes mellitus
Lu, G., Li, J., Gao, T., Liu, Q., Chen, O., Zhang, X., Xiao, M., Guo, Y., Wang, J., Tang, Y., et al. (2023) · Nutrition Reviews · doi:10.1093/nutrit/nuad056 · Cited by 14
Orotic Acid Induces Hypertension Associated with Impaired Endothelial Nitric Oxide Synthesis
Choi, Y., Yoon, Y., Lee, K.-Y., Kang, Y.-P., Lim, D. K., Kwon, S. W., Kang, K.-W., Lee, S.-M., & Lee, B. (2015) · Toxicological Sciences · doi:10.1093/toxsci/kfv003 · Cited by 14
Pathogenesis of Type 2 Diabetes Mellitus
DeFronzo, R. A. (2018) · Endocrinology · doi:10.1007/978-3-319-45015-5_8 · Cited by 14
Lee, S. J., Ways, J. A., Barbato, J. C., Essig, D. A., Pettee, K. M., DeRaedt, S. J., Yang, S., Weaver, D. A., Koch, L. G., & Cicila, G. T. (2005) · Physiological Genomics · doi:10.1152/physiolgenomics.00251.2004 · Cited by 14
Pathogenesis of type 2 diabetes mellitus
DeFronzo, R. A. (2015) · Wiley eBooks · doi:10.1002/9781118387658.ch25 · Cited by 17
Pearson, J. T., Thambyah, H. P., Waddingham, M. T., Inagaki, T., Sukumaran, V., Ngo, J. P., Ow, C. P. C., Sonobe, T., Chen, Y. C., Edgley, A. J., et al. (2021) · Clinical Science · doi:10.1042/cs20201441 · Cited by 15
Rathjen, T., Kunkemoeller, B. H., Cederquist, C., Wang, X., Lockhart, S. M., Patti, J. C., Willenbrock, H., Olsen, G. S., Povlsen, G. K., Beck, H. C., et al. (2022) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.122.317476 · Cited by 15
Self-citationInterplay of fatty acids, insulin and exercise in vascular health
Anderson, K. C., Liu, J., & Liu, Z. (2025) · Lipids in Health and Disease · doi:10.1186/s12944-024-02421-5 · Cited by 18
Ike, A., Shirai, K., Nishikawa, H., Iwata, A., Yahiro, E., Sugihara, M., Kawamura, A., Uehara, Y., Zhang, B., Ogawa, M., et al. (2014) · Journal of Cardiology · doi:10.1016/j.jjcc.2014.06.012 · Cited by 13
Molecular Mechanisms of Insulin Resistance
Draznin, B. (2019) · Contemporary Endocrinology · doi:10.1007/978-3-030-25057-7_4 · Cited by 13
Is insulin resistance a disorder of the brain?
Undurti, N. D. (2010) · Frontiers in bioscience · doi:10.2741/3671 · Cited by 13
Kearney, M. T. (2013) · Diabetes · doi:10.2337/db13-0183 · Cited by 13
Kinoshita, J., Tanaka, Y., Niwa, M., Yoshii, H., Takagi, M., & Kawamori, R. (2000) · Diabetes Research and Clinical Practice · doi:10.1016/s0168-8227(99)00115-1 · Cited by 13
Role of PI3K and PKB/Akt in acute natriuretic and NO-mimetic effects of leptin
Bełtowski, J., Wójcicka, G., Jamróz-Wiśniewska, A., & Borkowska, E. (2007) · Regulatory Peptides · doi:10.1016/j.regpep.2006.12.007 · Cited by 13
Roberts, A., Gohil, J., Hudson, L., Connolly, K., Warburton, P., Suman, R., O’Toole, P. J., O'Regan, D. J., Turner, N. A., Riches‐Suman, K., et al. (2015) · Journal of Diabetes Research · doi:10.1155/2015/409432 · Cited by 12
Bronsveld, H. K., Bruin, M. L. D., Wesseling, J., Sanders, J., Hofland, I., Jensen, V., Bazelier, M. T., ter Braak, B., de Boer, A., Vestergaard, P., et al. (2018) · BMC Cancer · doi:10.1186/s12885-018-4072-8 · Cited by 12
Qiao, J.-G. (2005) · World Journal of Gastroenterology · doi:10.3748/wjg.v11.i38.5978 · Cited by 12
Insulin induces monocytic CXCL8 secretion by the mitogenic signalling pathway
Wurm, S., Neumeier, M., Weigert, J., Wanninger, J., Gerl, M., Gindner, A., Schäffler, A., Aslanidis, C., Schölmerich, J., & Buechler, C. (2008) · Cytokine · doi:10.1016/j.cyto.2008.08.003 · Cited by 12
Orally active insulin mimics: where do we stand now?
Balasubramanyam, M., & Mohan, V. (2001) · Journal of Biosciences · doi:10.1007/bf02703748 · Cited by 12
He, H., Weir, R. L., Toutounchian, J. J., Pagadala, J., Steinle, J. J., Baudry, J. Y., Miller, D. D., & Yates, C. R. (2017) · PLoS ONE · doi:10.1371/journal.pone.0180808 · Cited by 12
Toba, H., Gomyo, E., Miki, S., Shimizu, T., Yoshimura, A., Inoue, R., Sawai, N., Tsukamoto, R., Asayama, J., Kobara, M., et al. (2006) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.2006.04385.x · Cited by 12
Effects of insulin and free fatty acids on matrix metalloproteinases
Boden, G. H., & Song, W. (2008) · Current Diabetes Reports · doi:10.1007/s11892-008-0041-y · Cited by 12
Sato, A., Yumita, Y., Kagami, K., Ishinoda, Y., Kimura, T., Osaki, A., Toya, T., Namba, T., Endo, S., Ido, Y., et al. (2022) · Journal of the American Heart Association · doi:10.1161/jaha.122.027538 · Cited by 11
Wu, C., Lin, C.-C., Hsieh, F.-C., Wu, T.-Y., & Fang, A.-H. (2023) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2023/1011591 · Cited by 11
Mima, A., Murakami, A., Lee, R., & Lee, S. (2023) · Metabolism Open · doi:10.1016/j.metop.2023.100240 · Cited by 11
González‐Hedström, D., Guerra-Menéndez, L., Tejera‐Muñoz, A., Amor, S., de la Fuente‐Fernández, M., Martín-Carro, B., Arriazu, R., García-Villalón, Á. L., & Granado, M. (2020) · Nutrients · doi:10.3390/nu12020549 · Cited by 13
Fouillioux, C., Contreras, F., Lares, M., Cano, R., Leal, E., Arráiz, N., Bermúdez, V., & Velasco, M. (2008) · American Journal of Therapeutics · doi:10.1097/mjt.0b013e318169bca8 · Cited by 11
McDonald, M. W., Olver, T. D., Dotzert, M. S., Jurrissen, T. J., Noble, E. G., Padilla, J., & Melling, C. W. J. (2018) · Diabetes and Vascular Disease Research · doi:10.1177/1479164118815279 · Cited by 11
Pathogenesis of Type 2 Diabetes Mellitus
DeFronzo, R. A. (2018) · Endocrinology · doi:10.1007/978-3-319-27317-4_8-1 · Cited by 11
Schwanstecher, C., & Schwanstecher, M. (2011) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-17214-4_1 · Cited by 11
Redox Modulation of Insulin Signaling and Endothelial Function
Christon, R., Drouin, O., & Marette, A. (2005) · Antioxidants and Redox Signaling · doi:10.1089/ars.2005.7.1062 · Cited by 11
Romero‐García, T., Vázquez-Jiménez, J. G., Sánchez-Hernández, R., Olivares-Reyes, J. A., & Rueda, A. (2025) · Frontiers in Physiology · doi:10.3389/fphys.2025.1535153 · Cited by 11
Olmesartan ameliorates peripheral nerve dysfunction in Zucker diabetic fatty rats
Sugimoto, K., Kojima, K., Baba, M., & Yasujima, M. (2011) · Journal of Hypertension · doi:10.1097/hjh.0b013e328347da0f · Cited by 10
Lipotoxicity in Obesity: Benefit of Olive Oil
Saad, E., Sbeit, W., Luai, A., Massad, B., & Assy, N. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-48382-5_26 · Cited by 11
Gaster, M. (2018) · Apmis · doi:10.1111/apm.12908 · Cited by 12
Shaligram, S. S., Akther, F., Razan, M. R., Graham, J. L., Roglans, N., Alegret, M., Parsa, A. G., Stanhope, K. L., Havel, P. J., & Rahimian, R. (2020) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2020.173089 · Cited by 10
Alshahwan, H., Qabazard, B., Mousa, A., Chandrasekhar, B., Santhosh, K., & Yousif, M. H. M. (2022) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2022.175265 · Cited by 10
Johnson, L., Juhlin, T., Engström, G., & Nilsson, P. M. (2014) · BMC Cardiovascular Disorders · doi:10.1186/1471-2261-14-107 · Cited by 10
Yousif, M. H. M. (2008) · Cell Biochemistry and Function · doi:10.1002/cbf.1463 · Cited by 10
Vikram, A., Jena, G., & Ramarao, P. (2010) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2010.09.066 · Cited by 10
Hamlat, N., Forcheron, F., Neggazi, S., del Carmine, P., Feugier, P., Bricca, G., Bouguerra, S. A., & Beylot, M. (2009) · Cardiovascular Diabetology · doi:10.1186/1475-2840-8-64 · Cited by 12
Eleftheriadis, T., Pissas, G., Sounidaki, M., Antoniadi, G., Rountas, C. D., Liakopoulos, V., & Stefanidis, L. (2017) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-016-2915-7 · Cited by 11
Role of protein kinase C in diabetic complications
King, G. L., & Daş-Evcimen, N. (2010) · Expert Review of Endocrinology & Metabolism · doi:10.1586/eem.09.74 · Cited by 9
Self-citationZhang, H., Li, J., Li, R., Zhang, Q., Ma, H., Ji, Q., Guo, W., Wang, H., Lopez, B. L., Christopher, T. A., et al. (2008) · Journal of Hypertension · doi:10.1097/hjh.0b013e3282f343e1 · Cited by 11
Growth factors and cytokines: Emphasis on their role in wound healing and atherosclerosis
Kapoor, M., Nomiyama, T., Bruemmer, D., Kojima, F., & Crofford, L. J. (2006) · Current Anaesthesia and Critical Care · doi:10.1016/j.cacc.2006.02.002 · Cited by 9
Stakos, D., Boudoulas, K. D., Gaillard, T. R., Schuster, D. P., Osei, K., & Boudoulas, H. K. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-2276 · Cited by 9
Tribbles 3: A potential player in diabetic aortic remodelling
Ti, Y., Xie, G.-L., Wang, Z., Ding, W., Zhang, Y., Zhong, M., & Zhang, W. (2015) · Diabetes and Vascular Disease Research · doi:10.1177/1479164115605645 · Cited by 10
Golovchenko, I., Yang, C., Goalstone, M. L., & Draznin, B. (2003) · Metabolism · doi:10.1053/meta.2003.50042 · Cited by 9
Mechanisms of Insulin Signal Transduction
Garvey, W. T. (2004) · Wiley eBooks · doi:10.1002/0470862092.d0301 · Cited by 10
Mechanisms of cardiovascular complications in diabetes and potential new pharmacological therapies
HE, Z. (2003) · European Heart Journal Supplements · doi:10.1016/s1520-765x(03)90041-1 · Cited by 8
Nitric Oxide, Its Role in Diabetes Mellitus and Methods to Improve Endothelial Function
Nikolaeva, M., & Johnstone, M. T. (2023) · Contemporary cardiology · doi:10.1007/978-3-031-13177-6_7 · Cited by 9
Arterial insulin resistance in Yucatan micropigs with diet-induced obesity and metabolic syndrome
Wang, C. C. L., Lu, L., Leitner, J. W., Sarraf, M., Gianani, R., Draznin, B., Greyson, C. R., Reusch, J. E. B., & Schwartz, G. G. (2013) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2013.02.009 · Cited by 8
Young, B. E., Padilla, J., Finsen, S. H., Fadel, P. J., & Mortensen, S. P. (2022) · Endocrinology · doi:10.1210/endocr/bqac008 · Cited by 8
Cavalher-Machado, S. C., Cuman, R. K. N., Sartoretto, J. L., Martins, J. O., Lima, W. T. D., Martins, M. A., Silva, P., & Sannomiya, P. (2008) · Inflammation Research · doi:10.1007/s00011-008-8047-0 · Cited by 8
Mechanisms of insulin signal transduction
Langlais, P. R., Mandarino, L. J., & Garvey, W. T. (2015) · Wiley eBooks · doi:10.1002/9781118387658.ch12 · Cited by 8
Vascular Remodeling in Diabetes Mellitus
Vallurupalli, S., & Mehta, J. L. (2017) · Springer eBooks · doi:10.1007/978-3-319-60324-7_3 · Cited by 7
CDK5 inhibition improves glucose uptake in insulin‐resistant neuronal cells via ERK1/2 pathway
Manglani, K., & Dey, C. S. (2021) · Cell Biology International · doi:10.1002/cbin.11735 · Cited by 7
Phosphorylation of myocardial eNOS is altered in patients suffering from type 2 diabetes
Streit, U., Reuter, H., Bloch, W., Wahlers, T., Schwinger, R. H. G., & Brixius, K. (2012) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00011.2011 · Cited by 7
Qi, Y., Guo, X., & Guo, S. (2016) · Springer eBooks · doi:10.1007/978-3-319-11251-0_28 · Cited by 7
Protein kinase C-mediated insulin receptor phosphorylation in diabetic rat retina
Kida, T., Oku, H., Horie, T., Osuka, S., Fukumoto, M., & Ikeda, T. (2019) · Graefe s Archive for Clinical and Experimental Ophthalmology · doi:10.1007/s00417-019-04324-z · Cited by 6
Taguchi, K., Kaneko, N., Okudaira, K., Matsumoto, T., & Kobayashi, T. (2020) · Acta Physiologica · doi:10.1111/apha.13573 · Cited by 6
Osman, I., Poulose, N., Ganapathy, V., & Segar, L. (2016) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2016.10.007 · Cited by 6
An oxide transport chain essential for balanced insulin action
Wu, X., Chen, K., & Williams, K. J. (2020) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2020.02.006 · Cited by 5
Liu, N., Shukang, G., Shasha, W., & Xiangyun, L. (2021) · Steroids · doi:10.1016/j.steroids.2021.108910 · Cited by 6
Kaneki, M., Shinozaki, S., Chang, K., & Shimizu, N. (2009) · Critical Care Medicine · doi:10.1097/00003246-200910000-00034 · Cited by 6
Effect of obesity on insulin signaling through JAK2 in rat aorta
Zecchin, H. G., de Souza, C. T., Prada, P. O., Carvalheira, J. B. C., Velloso, L. A., & Saad, M. J. A. (2005) · Vascular Pharmacology · doi:10.1016/j.vph.2005.08.019 · Cited by 7
Okazaki, M., Iwasaki, Y., He, J., Nishiyama, M., Taguchi, T., Tsugita, M., Taniguchi, Y., Kambayashi, M., & Hashimoto, K. (2008) · Endocrine Journal · doi:10.1507/endocrj.k08e-078 · Cited by 6
Insulin Resistance and Cardiovascular Disease
Wang, C. C. L. (2009) · Humana Press eBooks · doi:10.1007/978-1-59745-192-5_12 · Cited by 5
Osaki, A., Kagami, K., Ishinoda, Y., Sato, A., Kimura, T., Horii, S., Ito, K., Toya, T., Ido, Y., Namba, T., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24076486 · Cited by 5
Alzheimer’s Disease and Diabetes
Brent, D. A., Gary, L., Aboud, Z., & Gordon, W. (2013) · InTech eBooks · doi:10.5772/54913 · Cited by 6
Lee, S. M., Lee, Y. J., Choi, J. H., Kho, M. C., Yoon, J. J., Shin, S. H., Kang, D. G., & Lee, H. S. (2014) · BMC Complementary and Alternative Medicine · doi:10.1186/1472-6882-14-453 · Cited by 5
MicroRNAs and Endothelial Dysfunction in Relation to Obesity and Type 2 Diabetes
Karolina, D. S. (2014) · Journal of Molecular and Genetic Medicine · doi:10.4172/1747-0862.s1-011 · Cited by 5
[Chronic complications of polycystic ovary syndrome. Review].
Velásquez, E. (2002) · PubMed · Cited by 5
Hamlat, N., Neggazi, S., Forcheron, F., Bricca, G., Beylot, M., & Bouguerra, S. A. (2010) · Diabetes & Metabolism · doi:10.1016/j.diabet.2010.01.003 · Cited by 5
The Role of Insulin Resistance in Cardiorenal Metabolic Syndrome
Xiao, J., Song, W. L., Huang, Y., He, X., Weng, Y., & Yu, H. (2025) · Cardiology in Review · doi:10.1097/crd.0000000000001048 · Cited by 5
Trandafir, M.-F., Savu, O., Păsărică, D., Bleoţu, C., & Gheorghiu, M. (2024) · Medical Sciences · doi:10.3390/medsci12020031 · Cited by 4
Abdelaziz, H. M., Abdelmageed, M. E., & Suddek, G. M. (2025) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2025.177832 · Cited by 5
Management of patients with type 2 diabetes on peritoneal dialysis.
Dasgupta, M. K. (2005) · PubMed · Cited by 4
Spadigam, A. E., Dhupar, A., Syed, S., & Saluja, T. S. (2016) · Indian Journal of Medical and Paediatric Oncology · doi:10.4103/0971-5851.177002 · Cited by 4
Insulin promotes hepatocarcinoma tumorigenesis by up-regulating PKM2 expression
Liu, J., Zhi, Q., Liu, Y., Wang, Y., Chen, L., Ke, Y., Zeng, L., Wu, X., Yang, X., Guleng, B., et al. (2021) · Experimental Cell Research · doi:10.1016/j.yexcr.2021.112872 · Cited by 5
Ola, M. S. (2022) · Current Issues in Molecular Biology · doi:10.3390/cimb44120410 · Cited by 9
Jahn, L. A., Hartline, L. M., Kleiner, A., Horton, W. B., Hasan, F., Tan, A. W. K., Liu, Z., & Barrett, E. J. (2023) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00242.2022 · Cited by 4
Razan, M., Amissi, S., Islam, R. A., Graham, J., Stanhope, K., Havel, P., & Rahimian, R. (2023) · Biomedicines · doi:10.3390/biomedicines11041129 · Cited by 4
CDKN2B-AS1 mediates proliferation and migration of vascular smooth muscle cells induced by insulin
Jin, H., Wu, Z., Zhang, B., Deng, J., Xu, Y.-D., Wang, X.-Y., Song, Z.-Y., Lu, X., Wang, W.-T., & Zheng, X.-T. (2023) · Cell and Tissue Research · doi:10.1007/s00441-023-03836-9 · Cited by 4
Insulin Resistance and Erectile Dysfunction
Kim, S.-C. (2006) · Korean journal of urology · doi:10.4111/kju.2006.47.9.917 · Cited by 4
Molecular Activity of Insulin and Selective Insulin Resistance
Marquezine, G. F., & WAJCHENBERG, B. L. (2007) · The Endocrinologist · doi:10.1097/ten.0b013e31815af5ae · Cited by 4
Insulin-induced epidermal growth factor activation in vascular smooth muscle cells is ADAM-dependent
Roztocil, E., Nicholl, S. M., & Davies, M. G. (2008) · Surgery · doi:10.1016/j.surg.2008.03.023 · Cited by 4
Molecular Mechanisms of Insulin Resistance
Draznin, B. (2009) · Humana Press eBooks · doi:10.1007/978-1-59745-192-5_6 · Cited by 4
Cellular and Functional Effects of Insulin Based Therapies and Exercise on Endothelium
Luse, M. A., Heiston, E. M., Malin, S. K., & Isakson, B. E. (2020) · Current Pharmaceutical Design · doi:10.2174/1381612826666200721002735 · Cited by 4
Potential Mechanisms Linking Insulin to Cancer
Babichev, Y., Khalid, S., & Fantus, I. G. (2011) · Energy balance and cancer · doi:10.1007/978-1-4419-9911-5_7 · Cited by 4
Diabetes mellitus and endothelial dysfunction: a central role for oxidative stress
Schulz, E., & Keaney, J. F. (2003) · Current Opinion in Endocrinology & Diabetes · doi:10.1097/00060793-200308000-00002 · Cited by 4
Cohen, R. A. (2004) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000137187.16206.79 · Cited by 4
Effect of Diabetes on Endothelial Function
Naruse, K., & King, G. L. (2001) · Humana Press eBooks · doi:10.1007/978-1-59259-091-9_3 · Cited by 4
Self-citationSong, Y., Chen, B., Zeng, K., Cai, K., Sun, H., Liu, D., Liu, P., Xu, G., & Jiang, G. (2024) · Magnetic Resonance Imaging · doi:10.1016/j.mri.2024.02.003 · Cited by 3
Gao, H., Zhao, Q., Li, K., Qin, F., Yin, X., Lu, Z., Song, Z., Wu, Y., Shen, Y., Pan, Y., et al. (2021) · Experimental Cell Research · doi:10.1016/j.yexcr.2020.112454 · Cited by 3
The Complex Immunological Alterations in Patients with Type 2 Diabetes Mellitus on Hemodialysis
Trandafir, M.-F., Savu, O., & Gheorghiu, M. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13133687 · Cited by 3
Endothelial versus Metabolic Insulin Resistance, A Descriptive Review
Chen, X., Yao, H., Lai, J., Chen, Y., Li, X., Li, S., Li, L., & He, F. (2024) · Current Diabetes Reviews · doi:10.2174/0115733998288601240327065724 · Cited by 5
Metadata
- Authors
- Jiang, Z. Y., Lin, Y.-W., Clemont, A., Feener, E. P., Hein, K. D., Igarashi, M., Yamauchi, T., White, M. F., & King, G. L.
- Affiliations
- Joslin Diabetes Center (US)
- Corresponding author
- King, George L.
- Venue
- Journal of Clinical Investigation
- Published
- 1999-08-15
- Volume
- 104
- Issue
- 4
- Pages
- 447-457
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC408521
- OpenAlex
- W2051269098
- Cited by
- 604
- References
- 56
- Citations by year
- 2026: 7 · 2025: 14 · 2024: 10 · 2023: 15 · 2022: 15 · 2021: 19 · 2020: 13 · 2019: 13 · 2018: 10 · 2017: 24 · 2016: 28 · 2015: 24 · 2014: 23 · 2013: 27 · 2012: 35
- FWCI
- 12.03
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Joslin Diabetes Center
- National Institutes of Health (DK 36836)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK-53105, DK36836, R01DK053105, P30DK036836)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Keywords
- insulin resistance, MAPK signaling, ERK1/2, insulin receptor beta, IRS-1, insulin receptor substrate 2, p85 regulatory subunit, aorta, microvessels, obesity, Zucker rats, hyperinsulinemia, cardiovascular risk
- MeSH terms
- Animals, Aorta, Insulin, Insulin Resistance, Liver, Male, Microcirculation, Obesity, Phosphoproteins, Phosphorylation, Rats, Zucker, Receptor, Insulin, Recombinant Proteins, Tyrosine, Signal Transduction, Calcium-Calmodulin-Dependent Protein Kinases, Phosphatidylinositol 3-Kinases, Intracellular Signaling Peptides and Proteins, Rats, Insulin Receptor Substrate Proteins, In Vitro Techniques
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review