The DOI matches its Crossref record; 55 of the 56 references it cites were found in a registry or an index.
Characterization of selective resistance to insulin signaling in the vasculature of obese Zucker (fa/fa) rats
Open accessAbstract
Both insulin resistance and hyperinsulinemia have been reported to be independent risk factors for cardiovascular diseases. However, little is known regarding insulin signaling in the vascular tissues in insulin-resistant states. In this report, insulin signaling on the phosphatidylinositol 3-kinase (PI 3-kinase) and mitogen-activated protein (MAP) kinase pathways were compared in vascular tissues of lean and obese Zucker (fa/fa) rats in both ex vivo and in vivo studies. Ex vivo, insulin-stimulated tyrosine phosphorylation of insulin receptor beta subunits (IRbeta) in the aorta and microvessels of obese rats was significantly decreased compared with lean rats, although the protein levels of IRbeta in the 2 groups were not different. Insulin-induced tyrosine phosphorylation of insulin receptor substrates 1 and 2 (IRS-1 and IRS-2) and their protein levels were decreased in the aorta of obese rats compared with lean rats. The association of p85 subunit to the IRS proteins and the IRS-associated PI 3-kinase activities stimulated by insulin in the aorta of obese rats were significantly decreased compared with the lean rats. In addition, insulin-stimulated serine phosphorylation of Akt, a downstream kinase of PI 3-kinase pathway, was also reduced significantly in isolated microvessels from obese rats compared with the lean rats. In euglycemic clamp studies, insulin infusion greatly increased tyrosine phosphorylation of IRbeta- and IRS-2-associated PI 3-kinase activity in the aorta of lean rats, but only slight increases were observed in obese rats. In contrast, insulin stimulated tyrosine phosphorylation of MAP kinase (ERK-1/2) equally in isolated microvessels of lean and obese rats, although basal tyrosine phosphorylation of ERK-1/2 was higher in the obese rats. To our knowledge, these data provided the first direct measurements of insulin signaling in the vascular tissues, and documented a selective resistance to PI 3-kinase (but not to MAP kinase pathway) in the vascular tissues of obese Zucker rats.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“This observation is of important clinical significance, since diacylglycerol, long-chain fatty acyl CoAs, and ceramides all have been shown to cause serine phosphorylation of insulin resistance and IRS-1 and lead to the development of insulin resistance in skeletal muscle ( 59 , 60 ).”
From Skeletal Muscle Insulin Resistance Is the Primary Defect in Type 2 Diabetes (2009) · cites this paper as [60]
Experimental — accuracy not yet measuredIn the citing paper
“Vascular insulin resistance leads to downregulation of IRS-1 and 2 and decreased phosphorylation of Akt and eNOS, whereas the ET-1 pathway remains unaffected.”
From The Vasculature in Prediabetes (2018) · cites this paper as [48]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Nitric oxide: physiology, pathophysiology, and pharmacology.
Moncada, S., Palmer, R. M., & Higgs, E. A. (1991) · Pharmacological Reviews · doi:10.1016/s0031-6997(25)06663-3 · Cited by 15,525
Mechanisms of fatty acid-induced inhibition of glucose uptake.
Boden, G., Chen, X., Ruiz, J., White, J. V., & Rossetti, L. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117252 · Cited by 3,720
Hyperinsulinemia as an independent risk factor for ischemic heart disease
Després, J.-P., Lamarche, B., Mauriège, P., Cantin, B., Dagenais, G. R., Moorjani, S., & Lupien, P.-J. (1996) · New England Journal of Medicine · doi:10.1056/nejm199604113341504 · Cited by 1,699
Steinberg, H. O., Chaker, H., Leaming, R., Johnson, A., Brechtel, G., & Baron, A. D. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118709 · Cited by 1,687 · cited 2×
“However, physiological studies have documented that endothelial functions as measured by insulin-induced vasodilatation are reduced in insulin-resistant and diabetic patients (12), suggesting that vascular cells are also resistant to insulin for some of its physiological actions.”
BackgroundStructure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein
Sun, X. J., Rothenberg, P., Kahn, C. R., Backer, J. M., Araki, E., Wilden, P. A., Cahill, D. A., Goldstein, B. J., & White, M. F. (1991) · Nature · doi:10.1038/352073a0 · Cited by 1,574
Self-citationMechanism of free fatty acid-induced insulin resistance in humans.
Roden, M., Price, T. B., Perseghin, G., Petersen, K. F., Rothman, D. L., Cline, G. W., & Shulman, G. I. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118742 · Cited by 1,539
Steinberg, H. O., Brechtel, G., Johnson, A., Fineberg, N. S., & Baron, A. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117433 · Cited by 1,216
Insulin Stimulates the Phosphorylation of the 95,000-Dalton Subunit of Its Own Receptor
Kasuga, M., Karlsson, F. A., & Kahn, C. R. (1982) · Science · doi:10.1126/science.7031900 · Cited by 1,132
The effect of insulin on renal handling of sodium, potassium, calcium, and phosphate in man.
DeFronzo, R. A., Cooke, C. R., Andres, R., Faloona, G. R., & Davis, P. J. (1975) · Journal of Clinical Investigation · doi:10.1172/jci107996 · Cited by 1,104
Hyperinsulinemia produces both sympathetic neural activation and vasodilation in normal humans.
Anderson, E. A., Hoffman, R. P., Balon, T. W., Sinkey, C. A., & Mark, A. L. (1991) · Journal of Clinical Investigation · doi:10.1172/jci115260 · Cited by 1,075
Research works printed but not linked: 5
- Kuboki, 1998, Diabetes, 47(Suppl. 1), A24
- Cheatham, 1994, Mol Cell Biol, 14, 4902, 10.1128/MCB.14.7.4902 · DOI
- Myers, 1994, Mol Cell Biol, 14, 357
- Bray, 1977, Fed Proc, 36, 148
- Moncada, 1991, Pharmacol Rev, 43, 109
Cited by
Sorted by citations
Items 201–300 of 604
Giani, J. F., Muñoz, M. C., Mayer, M. A., Veiras, L. C., Arranz, C. T., Taira, C. A., Turyn, D., Toblli, J. E., & Dominici, F. P. (2010) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00803.2009 · Cited by 70
Vascular insulin resistance in prehypertensive rats: Role of PI3-kinase/Akt/eNOS signaling
Li, R., Zhang, H., Wang, W., Wang, X., Huang, Y., Huang, C., & Gao, F. (2009) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2009.11.038 · Cited by 70
Role of Inflammation and Insulin Resistance in Endothelial Progenitor Cell Dysfunction
Desouza, C. V., Hamel, F. G., Bidasee, K. R., & O’Connell, K. A. (2011) · Diabetes · doi:10.2337/db10-0875 · Cited by 70
Zecchin, H. G., Priviero, F. B. M., de Souza, C. T., Zecchin, K. G., Prada, P. O., Carvalheira, J. B. C., Velloso, L. A., Antunes, E., & Saad, M. J. A. (2007) · Diabetes · doi:10.2337/db05-1147 · Cited by 73
Selective Insulin Resistance in the Kidney
Horita, S., Nakamura, M., Suzuki, M., Satoh, N., Suzuki, A., & Seki, G. (2016) · BioMed Research International · doi:10.1155/2016/5825170 · Cited by 71
Human Leptin Stimulates Systemic Nitric Oxide Production in the Rat
Bełtowski, J., Wójcicka, G., & Borkowska, E. (2002) · Obesity Research · doi:10.1038/oby.2002.128 · Cited by 70
Enhanced Endothelin Activity Prevents Vasodilation to Insulin in Insulin Resistance
Miller, A. W., Tulbert, C. D., Puskar, M., & Busija, D. W. (2002) · Hypertension · doi:10.1161/01.hyp.0000022806.87281.62 · Cited by 70
Lee, Y., Fluckey, J. D., Chakraborty, S., & Muthuchamy, M. (2017) · The FASEB Journal · doi:10.1096/fj.201600887r · Cited by 69
Liang, H., Habte‐Tsion, H., Ge, X., Ren, M., Xie, J., Miao, L., Zhou, Q., Lin, Y., & Pan, W. (2017) · Scientific Reports · doi:10.1038/s41598-017-06104-3 · Cited by 69
Self-citationNovel Role of the IGF-1 Receptor in Endothelial Function and Repair
Imrie, H., Viswambharan, H., Sukumar, P., Abbas, A., Cubbon, R. M., Yuldasheva, N. Y., Gage, M., Smith, J., Galloway, S. L., Skromna, A., et al. (2012) · Diabetes · doi:10.2337/db11-1494 · Cited by 68
The impact of insulin resistance on endothelial function, progenitor cells and repair
Cubbon, R. M., Rajwani, A., & Wheatcroft, S. B. (2007) · Diabetes and Vascular Disease Research · doi:10.3132/dvdr.2007.027 · Cited by 69
Rapamycin partially prevents insulin resistance induced by chronic insulin treatment
Berg, C. E., Lavan, B. E., & Rondinone, C. M. (2002) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(02)00333-9 · Cited by 69
Sekine, O., Nishio, Y., Egawa, K., Nakamura, T., Maegawa, H., & Kashiwagi, A. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m206266200 · Cited by 68
Endothelial Dysfunction in Obesity and Therapeutic Targets
Engin, A. (2024) · Advances in experimental medicine and biology · doi:10.1007/978-3-031-63657-8_17 · Cited by 78
NOX4 Pathway as a Source of Selective Insulin Resistance and Responsiveness
Wu, X., & Williams, K. J. (2012) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.111.244525 · Cited by 67
Oxidative Stress and Inflammation in Diabetic Complications
Vikram, A., Tripathi, D. N., Kumar, A., & Singh, S. (2014) · International Journal of Endocrinology · doi:10.1155/2014/679754 · Cited by 67
Jonas, M., Edelman, E. R., Groothuis, A., Baker, A. B., Seifert, P. A., & Rogers, C. (2005) · Circulation Research · doi:10.1161/01.res.0000183730.52908.c6 · Cited by 67
Rajasekar, N., Nath, C., Hanif, K., & Shukla, R. (2017) · Life Science · doi:10.1016/j.lfs.2016.09.020 · Cited by 65
Sartipy, P., & Loskutoff, D. J. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m306922200 · Cited by 67
Paulo, J. A., McAllister, F. E., Everley, R. A., Beausoleil, S. A., Banks, A. S., & Gygi, S. P. (2014) · PROTEOMICS · doi:10.1002/pmic.201400154 · Cited by 67
Hartell, N. A., Archer, H. E., & Bailey, C. J. (2005) · Biochemical Pharmacology · doi:10.1016/j.bcp.2004.11.022 · Cited by 67
Deciphering Brain Insulin Receptor and Insulin‐Like Growth Factor 1 Receptor Signalling
Kleinridders, A. (2016) · Journal of Neuroendocrinology · doi:10.1111/jne.12433 · Cited by 67
Zecchin, H. G., Bezerra, R. M. N., Carvalheira, J. B. C., Carvalho-Filho, M. A., Metze, K., Franchini, K. G., & Saad, M. J. A. (2003) · Diabetologia · doi:10.1007/s00125-003-1073-0 · Cited by 65
Houben, A. J. H. M., Eringa, E. C., Jonk, A. M., Serné, E. H., Smulders, Y. M., & Stehouwer, C. D. A. (2011) · Current Cardiovascular Risk Reports · doi:10.1007/s12170-011-0214-0 · Cited by 62
Wu, X.-K., Sallinen, K., Anttila, L., Mäkinen, M., Luo, C., Pöllänen, P., & Erkkola, R. U. (2000) · Fertility and Sterility · doi:10.1016/s0015-0282(00)00688-9 · Cited by 64
Muscle microvasculature's structural and functional specializations facilitate muscle metabolism
Kusters, Y. H. A. M., & Barrett, E. J. (2015) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00443.2015 · Cited by 66
The effects of thiazolidinediones on blood pressure levels – A systematic review
Sarafidis, P. A., & Nilsson, P. M. (2006) · Blood Pressure · doi:10.1080/08037050600853720 · Cited by 64
Nakamura, M., Yamazaki, O., Shirai, A., Horita, S., Satoh, N., Suzuki, M., Hamasaki, Y., Noiri, E., Kume, H., Enomoto, Y., et al. (2014) · Kidney International · doi:10.1038/ki.2014.351 · Cited by 63
Protein Kinase C θ Activation Induces Insulin-Mediated Constriction of Muscle Resistance Arteries
Bakker, W., Sipkema, P., Stehouwer, C. D. A., Serné, E. H., Smulders, Y. M., van Hinsbergh, V. W. M., & Eringa, E. C. (2007) · Diabetes · doi:10.2337/db07-0792 · Cited by 62
Assessment of Endothelial Dysfunction in Childhood Obesity and Clinical Use
Bruyndonckx, L., Hoymans, V. Y., Craenenbroeck, A. H. V., Vissers, D. K., Vrints, C. J., Ramet, J., & Conraads, V. M. (2013) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2013/174782 · Cited by 66
Considerations of Sex and Gender Differences in Preclinical and Clinical Trials
Raz, L., & Miller, V. M. (2012) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-30726-3_7 · Cited by 61
Park, K., Li, Q., Rask‐Madsen, C., Mima, A., Mizutani, K., Winnay, J. N., Maeda, Y., D’Aquino, K. E., White, M. F., Feener, E. P., et al. (2013) · Molecular and Cellular Biology · doi:10.1128/mcb.00506-13 · Cited by 60
Self-citationRole of angiotensin II and oxidative stress in vascular insulin resistance linked to hypertension
Zhou, M.-S., Schulman, I. H., & Raij, L. R. (2009) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01096.2008 · Cited by 60
Batumalaie, K., Amin, M. A., Murugan, D. D., Sattar, M. Z. A., & Abdullah, N. A. (2016) · Scientific Reports · doi:10.1038/srep27236 · Cited by 60
The PI3-K/Akt pathway: roles related to alterations in vasomotor responses in diabetic models
Kobayashi, T., Matsumoto, T., & Kamata, K. (2005) · Journal of Smooth Muscle Research · doi:10.1540/jsmr.41.283 · Cited by 61
Czyżyk, A., & Szczepanik, Z. (2000) · European Journal of Internal Medicine · doi:10.1016/s0953-6205(00)00106-0 · Cited by 59
Insulin decreases atherosclerosis by inducing endothelin receptor B expression
Park, K., Mima, A., Li, Q., Rask‐Madsen, C., He, P., Mizutani, K., Katagiri, S., Maeda, Y., Wu, I., Khamaisi, M., et al. (2016) · JCI Insight · doi:10.1172/jci.insight.86574 · Cited by 65
Self-citationAtherosclerosis in diabetes and insulin resistance
Reusch, J. E. B., & Draznin, B. (2006) · Diabetes Obesity and Metabolism · doi:10.1111/j.1463-1326.2006.00620.x · Cited by 58
Lew, K. S., Pearson, J. T., Schwenke, D. O., & Katare, R. (2017) · Cardiovascular Diabetology · doi:10.1186/s12933-016-0484-4 · Cited by 57
STIM1 promotes angiogenesis by reducing exosomal miR-145 in breast cancer MDA-MB-231 cells
Pan, S., Zhao, X., Shao, C., Fu, B., Huang, Y., Zhang, N., Dou, X., Zhang, Z., Qiu, Y., Wang, R., et al. (2021) · Cell Death and Disease · doi:10.1038/s41419-020-03304-0 · Cited by 57
Chapter 13 Phosphorylation of IRS Proteins
Sun, X., & Liu, F. (2009) · Vitamins and hormones · doi:10.1016/s0083-6729(08)00613-4 · Cited by 57
Maeno, Y., Li, Q., Park, K., Rask‐Madsen, C., Gao, B., Matsumoto, M., Liu, Y., Wu, I., White, M. F., Feener, E. P., et al. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.286591 · Cited by 63
Self-citationZhao, Y., Biswas, S. K., McNulty, P. H., Kozak, M., Jun, J. Y., & Segar, L. (2011) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00670.2008 · Cited by 56
Diabetes pathogenesis and management: the endothelium comes of age
Love, K. M., Barrett, E. J., Malin, S. K., Reusch, J. E. B., Regensteiner, J. G., & Liu, Z. (2021) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjab024 · Cited by 55
Hermann, T. S., Li, W., Domínguez, H., Ihlemann, N., Rask‐Madsen, C., Major‐Pedersen, A., Nielsen, D. B., Hansen, K. W., Hawkins, M. A., Køber, L., et al. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-1231 · Cited by 55
Effect of alogliptin, pioglitazone and glargine on pancreatic β-cells in diabetic db/db mice
Kawashima, S., Matsuoka, T., Kaneto, H., Tochino, Y., Kato, K., Yamamoto, K., Yamamoto, T., Matsuhisa, M., & Shimomura, I. (2010) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2010.12.021 · Cited by 54
Vascular Insulin-Like Growth Factor-I Resistance and Diet-Induced Obesity
Imrie, H., Abbas, A., Viswambharan, H., Rajwani, A., Cubbon, R. M., Gage, M., Kahn, M., Ezzat, V., Duncan, E. R., Grant, P. J., et al. (2009) · Endocrinology · doi:10.1210/en.2008-1641 · Cited by 54
Wang, C. C. L., Sorribas, V., Sharma, G. D., Levi, M., & Draznin, B. (2007) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2007.02.032 · Cited by 54
Park, K., Li, Q., Evcimen, N. D., Rask‐Madsen, C., Maeda, Y., Maddaloni, E., Yokomizo, H., Shinjo, T., St-Louis, R., Fu, J., et al. (2017) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.117.310291 · Cited by 54
Self-citationWesterbacka, J., Uosukainen, A., Mäkimattila, S., Schlenzka, A., & Yki‐Järvinen, H. (2000) · Hypertension · doi:10.1161/01.hyp.35.5.1043 · Cited by 53
eNOS plays a major role in adiponectin synthesis in adipocytes
Koh, E. H., Kim, M. K., Ranjan, K. C., Kim, H. S., Park, H., Oh, K. S., Park, I.-S., Lee, W. J., Kim, M., Park, J., et al. (2010) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00008.2010 · Cited by 53
Pereira, R. I., & Draznin, B. (2005) · Metabolism · doi:10.1016/j.metabol.2005.07.002 · Cited by 50
Arikawa, E., Ronald, C. W., Isshiki, K., Luptak, I., He, Z., Yasuda, Y., Maeno, Y., Patti, M., Weir, G. C., Harris, R. A., et al. (2007) · Diabetes · doi:10.2337/db06-0655 · Cited by 51
Self-citationIn Vivo Effects of Insulin and Free Fatty Acids on Matrix Metalloproteinases in Rat Aorta
Boden, G. H., Song, W., Pashko, L. L., & Kresge, K. M. (2007) · Diabetes · doi:10.2337/db07-1261 · Cited by 49
Russo, I., Mese, P. D., Doronzo, G., Mattiello, L., Viretto, M., Bosìa, A., Anfossi, G., & Trovati, M. (2007) · Endocrinology · doi:10.1210/en.2007-0920 · Cited by 48
Whytock, K. L., & Goodpaster, B. H. (2025) · Circulation Research · doi:10.1161/circresaha.125.325532 · Cited by 57
Hypoglycemic pharmacological treatment of type 2 diabetes: Targeting the endothelium
Nathanson, D., & Nyström, T. (2008) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2008.11.016 · Cited by 48
Muscle Insulin Resistance and the Inflamed Microvasculature: Fire from Within
Liu, J., & Liu, Z. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20030562 · Cited by 49
Toblli, J. E., Cao, G., DeRosa, G., & Forcada, P. (2005) · Heart · doi:10.1136/hrt.2003.022707 · Cited by 47
Hypertension in Patients with Insulin Resistance: Etiopathogenesis and Management in Children
Tagi, V. M., Mainieri, F., & Chiarelli, F. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23105814 · Cited by 48
The role of pathway-selective insulin resistance and responsiveness in diabetic dyslipoproteinemia
Wu, X., Chen, K., & Williams, K. J. (2012) · Current Opinion in Lipidology · doi:10.1097/mol.0b013e3283544424 · Cited by 48
Engberding, N., Martín, A. S., Martín-Garrido, A., Koga, M., Pounkova, L., Lyons, E., Lassegue, B. P., & Griendling, K. K. (2009) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.108.181727 · Cited by 47
Liver Fat Content in Type 2 Diabetes: Relationship With Hepatic Perfusion and Substrate Metabolism
Rijzewijk, L. J., van der Meer, R. W., Lubberink, M., Lamb, H. J., Romijn, J. A., Roos, A., Twisk, J. W. R., Heine, R. J., Lammertsma, A. A., Smit, J. W. A., et al. (2010) · Diabetes · doi:10.2337/db09-1201 · Cited by 46
Contribution of insulin resistance to vascular dysfunction
Anfossi, G., Russo, I., Doronzo, G., & Trovati, M. (2009) · Archives of Physiology and Biochemistry · doi:10.1080/13813450903136791 · Cited by 49
Kim, F., Tysseling, K. A., RICE, J., Gallis, B. M., Haji, L., Giachelli, C. M., Raines, E. W., Corson, M. A., & Schwartz, M. (2005) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2005.05.009 · Cited by 46
Fructose-Fed Rats Are Protected against Ischemia/Reperfusion Injury
Jordan, J. E., Simandle, S. A., Tulbert, C. D., Busija, D. W., & Miller, A. W. (2003) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.103.055970 · Cited by 46
Effects of insulin resistance on endothelial function: possible mechanisms and clinical implications
Tousoulis, D., Tsarpalis, K., Cokkinos, D. V., & Stefanadis, C. (2007) · Diabetes Obesity and Metabolism · doi:10.1111/j.1463-1326.2007.00818.x · Cited by 45
Novel iodinated tracers, MIBG and BMIPP, for nuclear cardiology
Tamaki, N., & Yoshinaga, K. (2010) · Journal of Nuclear Cardiology · doi:10.1007/s12350-010-9305-4 · Cited by 43
Taguchi, K., Kobayashi, T., Matsumoto, T., & Kamata, K. (2011) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01189.2010 · Cited by 44
Nadeau, K. J., Leitner, J. W., Gurerich, I., & Draznin, B. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m403596200 · Cited by 48
Muñoz, M. C., Argentino, D. P., Dominici, F. P., Turyn, D., & Toblli, J. E. (2006) · Journal of Hypertension · doi:10.1097/01.hjh.0000239297.63377.3f · Cited by 44
Exercise and insulin signaling: a historical perspective
Tomás, E., Zorzano, A., & Ruderman, N. B. (2002) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00267.2002 · Cited by 43
Targeting the vasculature in cardiometabolic disease
Boutagy, N. E., Singh, A. K., & Sessa, W. C. (2022) · Journal of Clinical Investigation · doi:10.1172/jci148556 · Cited by 45
Implications of Treatment That Target Protective Mechanisms Against Diabetic Nephropathy
Mima, A., Qi, W., & King, G. L. (2012) · Seminars in Nephrology · doi:10.1016/j.semnephrol.2012.07.010 · Cited by 42
Self-citationThe role of endothelial insulin signaling in the regulation of glucose metabolism
Kubota, T., Kubota, N., & Kadowaki, T. (2013) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-013-9242-z · Cited by 46
WNT5A-JNK regulation of vascular insulin resistance in human obesity
Farb, M. G., Karki, S., Park, S., Saggese, S. M., Carmine, B. J., Hess, D. T., Apovian, C. M., Fetterman, J. L., Bretón‐Romero, R., Hamburg, N. M., et al. (2016) · Vascular Medicine · doi:10.1177/1358863x16666693 · Cited by 42
Erectile dysfunction: does insulin resistance play a part?
Trussell, J. C., & Legro, R. S. (2007) · Fertility and Sterility · doi:10.1016/j.fertnstert.2007.01.116 · Cited by 44
Vehkavaara, S., Westerbacka, J., Hakala‐Ala‐Pietilä, T., Virkamäki, A., Hovatta, O., & Yki‐Järvinen, H. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.12.7034 · Cited by 43
Fang, S., Ma, X., Guo, S., & Lu, J. (2017) · Oncology Letters · doi:10.3892/ol.2017.6695 · Cited by 41
Doronzo, G., Russo, I., Mattiello, L., Riganti, C., Anfossi, G., & Trovati, M. (2006) · Diabetologia · doi:10.1007/s00125-006-0156-0 · Cited by 41
Love, K. M., Liu, J., Regensteiner, J. G., Reusch, J. E. B., & Liu, Z. (2020) · Journal of Diabetes · doi:10.1111/1753-0407.13045 · Cited by 40
Perlstein, T. S., Gerhard-Herman, M., Hollenberg, N. K., Williams, G. H., & Thomas, A. (2007) · Journal of the American Society of Nephrology · doi:10.1681/asn.2006091026 · Cited by 39
Arctium lappa ameliorates endothelial dysfunction in rats fed with high fat/cholesterol diets
Lee, Y. J., Choi, D. H., Cho, G.-H., Kim, J. S., Kang, D. G., & Lee, H. S. (2012) · BMC Complementary and Alternative Medicine · doi:10.1186/1472-6882-12-116 · Cited by 40
Insulin augments matrix metalloproteinase-9 expression in monocytes
Fischoeder, A., Meýborg, H., Stibenz, D., Fleck, E., Graf, K., & Stawowy, P. (2006) · Cardiovascular Research · doi:10.1016/j.cardiores.2006.12.006 · Cited by 41
Fegan, P. G., Shore, A., Mawson, D., Tooke, J., & MacLeod, K. (2005) · Diabetic Medicine · doi:10.1111/j.1464-5491.2005.01719.x · Cited by 42
Endothelial dysfunction in human diabetes
Mäkimattila, S., & Yki‐Järvinen, H. (2002) · Current Diabetes Reports · doi:10.1007/s11892-002-0054-x · Cited by 40
Kujiraoka, T., Satoh, Y., Ayaori, M., Shiraishi, Y., Arai‐Nakaya, Y., Hakuno, D., Yada, H., Kuwada, N., Endo, S., Isoda, K., et al. (2013) · Journal of the American Heart Association · doi:10.1161/jaha.113.000361 · Cited by 39
Mahmoud, A. M. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-981-10-4307-9_12 · Cited by 37
Diabetic nephropathy: protective factors and a new therapeutic paradigm
Mima, A. (2013) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2013.03.003 · Cited by 37
Skov, V., Knudsen, S., Olesen, M., Hansen, M. L., & Rasmussen, L. M. (2012) · Cardiovascular Diabetology · doi:10.1186/1475-2840-11-15 · Cited by 37
Arbin, V., Claperon, N., Fournié‐Zaluski, M., Roques, B. P., & Peyroux, J. (2003) · Journal of Cardiovascular Pharmacology · doi:10.1097/00005344-200302000-00015 · Cited by 37
Protein Kinase Cβ Isoform Inhibitors
He, Z., & King, G. L. (2004) · Circulation · doi:10.1161/01.cir.0000133428.02295.6c · Cited by 37
Self-citationPI3K-C2α Knockdown Results in Rerouting of Insulin Signaling and Pancreatic Beta Cell Proliferation
Leibiger, B., Moede, T., Paschen, M., Yunn, N.-O., Lim, J. H., Ryu, S. H., Pereira, T., Berggren, P., & Leibiger, I. B. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.08.058 · Cited by 36
High HOMA-IR Index in Healthcare Shift Workers
Ledda, C., Cinà, D., Matera, S., Mucci, N., Bracci, M., & Rapisarda, V. (2019) · Medicina · doi:10.3390/medicina55050186 · Cited by 37
Sato, Y., Nishio, Y., Sekine, O., Kodama, K., Nagai, Y., Nakamura, T., Maegawa, H., & Kashiwagi, A. (2006) · Diabetologia · doi:10.1007/s00125-006-0480-4 · Cited by 36
Choi, D. H., Lee, Y. J., Kim, J. S., Kang, D. G., & Lee, H. S. (2011) · Immunopharmacology and Immunotoxicology · doi:10.3109/08923973.2011.569889 · Cited by 35
Impaired Vascular Redox Signaling in the Vascular Complications of Obesity and Diabetes Mellitus
Akoumianakis, I., & Antoniades, C. A. (2017) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7421 · Cited by 37
Sung, K., Lim, S. K., & Rosenson, R. S. (2011) · American Journal of Hypertension · doi:10.1038/ajh.2011.89 · Cited by 35
Nagareddy, P. R., MacLeod, K. M., & McNeill, J. H. (2010) · Cardiovascular Research · doi:10.1093/cvr/cvq030 · Cited by 36
Thiazolidinedione regulation of smooth muscle cell proliferation
Bruemmer, D., & Law, R. E. (2003) · The American Journal of Medicine · doi:10.1016/j.amjmed.2003.09.014 · Cited by 35
Metadata
- Authors
- Jiang, Z. Y., Lin, Y.-W., Clemont, A., Feener, E. P., Hein, K. D., Igarashi, M., Yamauchi, T., White, M. F., & King, G. L.
- Affiliations
- Joslin Diabetes Center (US)
- Corresponding author
- King, George L.
- Venue
- Journal of Clinical Investigation
- Published
- 1999-08-15
- Volume
- 104
- Issue
- 4
- Pages
- 447-457
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC408521
- OpenAlex
- W2051269098
- Cited by
- 604
- References
- 56
- Citations by year
- 2026: 7 · 2025: 14 · 2024: 10 · 2023: 15 · 2022: 15 · 2021: 19 · 2020: 13 · 2019: 13 · 2018: 10 · 2017: 24 · 2016: 28 · 2015: 24 · 2014: 23 · 2013: 27 · 2012: 35
- FWCI
- 12.03
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Joslin Diabetes Center
- National Institutes of Health (DK 36836)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK-53105, DK36836, R01DK053105, P30DK036836)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Keywords
- insulin resistance, MAPK signaling, ERK1/2, insulin receptor beta, IRS-1, insulin receptor substrate 2, p85 regulatory subunit, aorta, microvessels, obesity, Zucker rats, hyperinsulinemia, cardiovascular risk
- MeSH terms
- Animals, Aorta, Insulin, Insulin Resistance, Liver, Male, Microcirculation, Obesity, Phosphoproteins, Phosphorylation, Rats, Zucker, Receptor, Insulin, Recombinant Proteins, Tyrosine, Signal Transduction, Calcium-Calmodulin-Dependent Protein Kinases, Phosphatidylinositol 3-Kinases, Intracellular Signaling Peptides and Proteins, Rats, Insulin Receptor Substrate Proteins, In Vitro Techniques
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
