The DOI matches its Crossref record; 55 of the 56 references it cites were found in a registry or an index.
Characterization of selective resistance to insulin signaling in the vasculature of obese Zucker (fa/fa) rats
Open accessAbstract
Both insulin resistance and hyperinsulinemia have been reported to be independent risk factors for cardiovascular diseases. However, little is known regarding insulin signaling in the vascular tissues in insulin-resistant states. In this report, insulin signaling on the phosphatidylinositol 3-kinase (PI 3-kinase) and mitogen-activated protein (MAP) kinase pathways were compared in vascular tissues of lean and obese Zucker (fa/fa) rats in both ex vivo and in vivo studies. Ex vivo, insulin-stimulated tyrosine phosphorylation of insulin receptor beta subunits (IRbeta) in the aorta and microvessels of obese rats was significantly decreased compared with lean rats, although the protein levels of IRbeta in the 2 groups were not different. Insulin-induced tyrosine phosphorylation of insulin receptor substrates 1 and 2 (IRS-1 and IRS-2) and their protein levels were decreased in the aorta of obese rats compared with lean rats. The association of p85 subunit to the IRS proteins and the IRS-associated PI 3-kinase activities stimulated by insulin in the aorta of obese rats were significantly decreased compared with the lean rats. In addition, insulin-stimulated serine phosphorylation of Akt, a downstream kinase of PI 3-kinase pathway, was also reduced significantly in isolated microvessels from obese rats compared with the lean rats. In euglycemic clamp studies, insulin infusion greatly increased tyrosine phosphorylation of IRbeta- and IRS-2-associated PI 3-kinase activity in the aorta of lean rats, but only slight increases were observed in obese rats. In contrast, insulin stimulated tyrosine phosphorylation of MAP kinase (ERK-1/2) equally in isolated microvessels of lean and obese rats, although basal tyrosine phosphorylation of ERK-1/2 was higher in the obese rats. To our knowledge, these data provided the first direct measurements of insulin signaling in the vascular tissues, and documented a selective resistance to PI 3-kinase (but not to MAP kinase pathway) in the vascular tissues of obese Zucker rats.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“This observation is of important clinical significance, since diacylglycerol, long-chain fatty acyl CoAs, and ceramides all have been shown to cause serine phosphorylation of insulin resistance and IRS-1 and lead to the development of insulin resistance in skeletal muscle ( 59 , 60 ).”
From Skeletal Muscle Insulin Resistance Is the Primary Defect in Type 2 Diabetes (2009) · cites this paper as [60]
Experimental — accuracy not yet measuredIn the citing paper
“Vascular insulin resistance leads to downregulation of IRS-1 and 2 and decreased phosphorylation of Akt and eNOS, whereas the ET-1 pathway remains unaffected.”
From The Vasculature in Prediabetes (2018) · cites this paper as [48]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Nitric oxide: physiology, pathophysiology, and pharmacology.
Moncada, S., Palmer, R. M., & Higgs, E. A. (1991) · Pharmacological Reviews · doi:10.1016/s0031-6997(25)06663-3 · Cited by 15,525
Mechanisms of fatty acid-induced inhibition of glucose uptake.
Boden, G., Chen, X., Ruiz, J., White, J. V., & Rossetti, L. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117252 · Cited by 3,720
Hyperinsulinemia as an independent risk factor for ischemic heart disease
Després, J.-P., Lamarche, B., Mauriège, P., Cantin, B., Dagenais, G. R., Moorjani, S., & Lupien, P.-J. (1996) · New England Journal of Medicine · doi:10.1056/nejm199604113341504 · Cited by 1,699
Steinberg, H. O., Chaker, H., Leaming, R., Johnson, A., Brechtel, G., & Baron, A. D. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118709 · Cited by 1,687 · cited 2×
“However, physiological studies have documented that endothelial functions as measured by insulin-induced vasodilatation are reduced in insulin-resistant and diabetic patients (12), suggesting that vascular cells are also resistant to insulin for some of its physiological actions.”
BackgroundStructure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein
Sun, X. J., Rothenberg, P., Kahn, C. R., Backer, J. M., Araki, E., Wilden, P. A., Cahill, D. A., Goldstein, B. J., & White, M. F. (1991) · Nature · doi:10.1038/352073a0 · Cited by 1,574
Self-citationMechanism of free fatty acid-induced insulin resistance in humans.
Roden, M., Price, T. B., Perseghin, G., Petersen, K. F., Rothman, D. L., Cline, G. W., & Shulman, G. I. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118742 · Cited by 1,539
Steinberg, H. O., Brechtel, G., Johnson, A., Fineberg, N. S., & Baron, A. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117433 · Cited by 1,216
Insulin Stimulates the Phosphorylation of the 95,000-Dalton Subunit of Its Own Receptor
Kasuga, M., Karlsson, F. A., & Kahn, C. R. (1982) · Science · doi:10.1126/science.7031900 · Cited by 1,132
The effect of insulin on renal handling of sodium, potassium, calcium, and phosphate in man.
DeFronzo, R. A., Cooke, C. R., Andres, R., Faloona, G. R., & Davis, P. J. (1975) · Journal of Clinical Investigation · doi:10.1172/jci107996 · Cited by 1,104
Hyperinsulinemia produces both sympathetic neural activation and vasodilation in normal humans.
Anderson, E. A., Hoffman, R. P., Balon, T. W., Sinkey, C. A., & Mark, A. L. (1991) · Journal of Clinical Investigation · doi:10.1172/jci115260 · Cited by 1,075
Research works printed but not linked: 5
- Kuboki, 1998, Diabetes, 47(Suppl. 1), A24
- Cheatham, 1994, Mol Cell Biol, 14, 4902, 10.1128/MCB.14.7.4902 · DOI
- Myers, 1994, Mol Cell Biol, 14, 357
- Bray, 1977, Fed Proc, 36, 148
- Moncada, 1991, Pharmacol Rev, 43, 109
Cited by
Sorted by citations
Items 501–600 of 604
Abdelaziz, H. M., Abdelmageed, M. E., & Suddek, G. M. (2025) · Life Sciences · doi:10.1016/j.lfs.2025.123747 · Cited by 3
Lee, Y. J., Yoom, K. H., Joo, Y. J., Min, L. S., 고정현, Sub, L. H., Choi, K.-M., & 강대길 (2012) · doi:10.14374/hfs.2012.20.1.001 · Cited by 3
Effects of Diabetes and Insulin Resistance on Endothelial Functions
He, Z., Naruse, K., & King, G. L. (2005) · Humana Press eBooks · doi:10.1385/1-59259-908-7:025 · Cited by 3
Self-citationLee, Y. J., Lee, Y. J., Yoon, J. J., Lee, S. M., Kim, H. Y., Shin, S. H., Kang, D. G., & Lee, H. S. (2012) · The Korea Journal of Herbology · doi:10.6116/kjh.2012.27.6.107 · Cited by 2
Vercalsteren, E., Karampatsi, D., Dekens, D. W., Letsiou, A., Zabala, A., Romanitan, M. O., Klein, T., Nyström, T., Darsalia, V., & Patrone, C. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24043989 · Cited by 2
Zou, M., & Wu, S. (2021) · Cardiology Discovery · doi:10.1097/cd9.0000000000000009 · Cited by 2
Medina, M. G., Liu, Z., Wang, J., Zhang, C., Cash, S. B., Cummins, C. L., & Giacca, A. (2024) · Cells · doi:10.3390/cells13161387 · Cited by 2
Does microvascular dysfunction link obesity with insulin resistance and hypertension?
de Jongh, R. T., Serné, E. H., Eringa, E. C., IJzerman, R. G., & Stehouwer, C. D. A. (2006) · Expert Review of Endocrinology & Metabolism · doi:10.1586/17446651.1.2.181 · Cited by 2
Metabolic syndrome and insulin signaling in kidney
Horita, S., Seki, G., & Yamada, H. (2011) · Endocrinology & Metabolic Syndrome · doi:10.4172/2161-1017.s1-005 · Cited by 2
Cellular Basis of Insulin Resistance: A Tale of the Microvasculature
Liu, Z. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-819801-8.00015-6 · Cited by 2
Singleton, J. (2005) · Neurological disease and therapy · doi:10.1201/b14157-15 · Cited by 2
Insulin Resistance and Atherosclerosis
Singh, K., & Raghavan, V. A. (2013) · Contemporary diabetes · doi:10.1007/978-1-4614-7554-5_3 · Cited by 2
PTP1B in Obesity-Related Cardiovascular Function
Ketsawatsomkron, P., Stepp, D. W., & de Chantemèle, E. J. B. (2013) · Springer eBooks · doi:10.1007/978-1-4614-7855-3_7 · Cited by 2
Oxidative Stress Mechanisms in Type 2 Diabetes Induced Coronary Heart Disease
Kupsal, K., & Hanumanth, S. R. (2019) · Springer eBooks · doi:10.1007/978-981-13-8273-4_22 · Cited by 2
Jonk, A. M. (2011) · Research Publications (Maastricht University) · doi:10.26481/dis.20111215aj · Cited by 2
Adipose Tissue and Blood Pressure Regulation
Cassis, L. A., & Police, S. B. (2010) · Wiley eBooks · doi:10.1002/9783527629527.ch13 · Cited by 2
The Renin—Angiotensin System in Diabetic Cardiovascular Complications
Feener, E. P. (2005) · Humana Press eBooks · doi:10.1385/1-59259-908-7:073 · Cited by 2
Self-citationIshibashi, S. (2007) · Hypertension Research · doi:10.1291/hypres.30.375 · Cited by 2
Invited review Metabolic management of diabetic patients with ischaemic heart disease
Caminiti, G., Marazzi, G., Vitale, C., & Rosano, G. M. C. (2007) · Archives of Medical Science · Cited by 2
Tchaikovski, V., & Waltenberger, J. L. (2007) · Springer eBooks · doi:10.1007/1-4020-5955-8_3 · Cited by 2
Effects of Diabetes and Insulin Resistance on Endothelial Functions
Fu, J., Yu, M. G., Li, Q., Park, K., & King, G. L. (2023) · Contemporary cardiology · doi:10.1007/978-3-031-13177-6_3 · Cited by 1
Self-citationKrentz, A. J. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-91707-0.00001-2 · Cited by 1
Olive Oil’s Attenuating Effects on Lipotoxicity
Basheer, M., Boulos, M., Basheer, A., Loai, A., & Assy, N. (2024) · Advances in experimental medicine and biology · doi:10.1007/978-3-031-63657-8_29 · Cited by 1
Renklint, R., Liv, P., Katsoularis, I., Olsson, T., & Otten, J. (2025) · Journal of Diabetes · doi:10.1111/1753-0407.70161 · Cited by 1
Zhong, Q., Xiong, Y., Zhu, Y., Ouyang, Q., Chen, X., Qin, F., Xu, F., An, K., Yu, B., & Qin, M. (2026) · Journal of Controlled Release · doi:10.1016/j.jconrel.2026.114940 · Cited by 3
Fouillioux, C., Contreras, F., Lares, M., Magaldi, L., Velasco, M., Mayda, C. L., Pacheco, B., Rojas, J., Chacín, M., Cano, R., et al. (2010) · American Journal of Therapeutics · doi:10.1097/mjt.0b013e3181c2de61 · Cited by 1
Martín-Conejero, A., Modrego, J., Mateo, M. M. H., Rodríguez‐Sierra, P., Hernando, F. J. S., & López-Farré, A. J. (2014) · Angiología · doi:10.1016/j.angio.2014.09.001 · Cited by 1
Javanmard, S. H., Nematbakhsh, M., Feghhi, A., & Dana, N. (2012) · Journal of Diabetes & Metabolic Disorders · doi:10.1186/2251-6581-11-5 · Cited by 1
Guiu, B. (2012) · European Society of Radiology · doi:10.1594/ecr2012/c-1019 · Cited by 1
Drug Treatment in the Metabolic Syndrome
Karathanasis, S. K., & SCHIEBINGER, R. J. (2005) · Elsevier eBooks · doi:10.1016/b978-84-8174-892-5.50027-9 · Cited by 1
Prevention of Hyperglycemic Signal Pathways in Metabolic Syndrome Carotid Artery of Rats
Kawai, H., Tian, F., Kurata, T., Deguchi, K., Yamashita, T., Omote, Y., Kono, S., & Abe, K. (2012) · Translational Stroke Research · doi:10.1007/s12975-012-0205-6 · Cited by 1
Molecular mechanisms and modulation of endothelial progenitor cell function in South Asian men
Baliga, V. (2012) · White Rose eTheses Online (University of Leeds, The University of Sheffield, University of York) · Cited by 1
Vehkavaara, S. (2001) · Työväentutkimus Vuosikirja · Cited by 1
Ikezawa, Y., Yamatani, K., Ohnuma, H., Daimon, M., Manaka, H., & Sasaki, H. (2005) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2004.12.008 · Cited by 1
Qi, Y., Guo, X., & Guo, S. (2015) · Springer eBooks · doi:10.1007/978-3-319-12125-3_28-1 · Cited by 1
Rask‐Madsen, C., Park, K., Li, Q., & King, G. L. (2017) · Circulation Research · doi:10.1161/circresaha.116.310491 · Cited by 1
Self-citationIs Insulin Resistance a Disorder of the Brain?
Das, U. N. (2010) · doi:10.1002/9780813820637.ch5 · Cited by 1
SELECTIVE REGULATION OF CARDIOMYOCYTE SIGNALING BY RGL2
Allen, L. (2008) · UKnowledge (University of Kentucky)
Gatenby, V. K. (2014) · White Rose eTheses Online (University of Leeds, The University of Sheffield, University of York)
Ashley, D. T. (2010) · Dublin City University Open Access Institutional Repository (Dublin City University)
Metabolic Stress and Atherosclerosis
Reusch, J. E. B., & Brownlee, M. (2003) · Wiley eBooks · doi:10.1002/0470862092.d1011
Overlaps Between the Insulin and IGF-I Receptor and Cancer
Belfiore, A., & Malaguarnera, R. (2011) · Springer eBooks · doi:10.1007/978-1-4614-0598-6_14
Endothelin-1 in the regulation of vascular function and glucose metabolism in insulin resistance
Shemyakin, A. S. (2010) · Figshare
Fouillioux, C., Contreras, F., Lares, M., Magaldi, L., Mayda, C. L., Pacheco, B., & Velasco, M. (2008) · Redalyc (Universidad Autónoma del Estado de México)
On endothelial function in type 2 diabetic patients with coronary artery disease
Nyström, T. (2005) · Figshare
Obesity and endothelial dysfunction : mechanisms, method development and interventions.
Cerri, E. (2010) · University of Birmingham Institutional Research Archive (University of Birmingham)
GRK2-Deficiency Reduces Insulin Activation of ERK1/2 and Mitogenesis in Mouse Liver FL83B Cells
Shahid, G., & Hussain, T. (2009) · The Open Diabetes Journal · doi:10.2174/1876524600902010044
Lapointe, N., Nguyen, Q. T., Desjardins, J., Tsoporis, J., Marcotte, F., Pourdjabbar, A., Parker, T. G., Moe, G. W. P. L., Adam, A. A., & Rouleau, J. L. (2005) · Cardiovascular Drugs and Therapy · doi:10.1007/s10557-005-4389-9
Yasuda, Y., & King, G. L. (2004) · International Congress Series · doi:10.1016/j.ics.2003.12.012
Self-citationHiperinsulinemia y cambios en el espesor intima media de la pared arterial
Vergara, M. A. (2007) · Americanae (AECID Library)
Prakaschandra, R. (2013) · ResearchSpace (University of KwaZulu-Natal)
Smail, L. (2012) · Journal of Diabetes & Metabolism · doi:10.4172/2155-6156.1000203
Metabolic regulation of human vascular endothelial cell function in vitro
Kohlhaas, C. F. (2008) · Enlighten: Theses (The University of Glasgow)
Efeito dos ácidos palmítico e palmitoléico sobre o metabolismo de glicose no músculo sóleo de ratos.
Nachbar, R. T. (2012) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.42.2012.tde-29012013-102458
Mandarino, L. J., Ivy, J. L., Hunt, D. G., Hancock, J., García-Macedo, R., Kleinert, M., Liao, Y., Nelson, J. L., Bernard, J. R., Wang, W., et al. (2015)
Insulin resistance, alcohol and coronary heart disease (CHD) mortality
Onaemo, V. N. (2012) · UEF eRepo (University of Eastern Finland)
MicroRNAs and Endothelial Dysfunction in Relation to Obesity and Type
Maskomani, S., Armugam, A., & Jeyaseelan, K. (2014)
Insulin action on large artery stiffness in normal and insulin resistant subjects
Westerbacka, J. (2001) · Työväentutkimus Vuosikirja
Circulating angiogenic stem cells in diabetes.
Zafar, N. (2015) · doi:10.18297/etd/2318
Sengupta, A. (2015) · White Rose eTheses Online (University of Leeds, The University of Sheffield, University of York)
Meijer, R. I. (2014) · Digital Academic REpository of VU University Amsterdam (Vrije Universiteit Amsterdam)
Rodrigues, S. (2016) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/d.5.2016.tde-24102016-115125
The Effects of Interleukin-10 on Skeletal Muscle Insulin Resistance and Myogenesis
Dağdeviren, S. (2016) · eScholarship@UMassChan · doi:10.13028/m2qp42 · Cited by 1
Viswambharan, H., & Kearney, M. T. (2017) · Circulation Research · doi:10.1161/circresaha.117.310510
Neves, K. B. (2016) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.60.2016.tde-05102016-091840
Investigating the Role of the Vascular Endothelium in Insulin Delivery
Tokarz, V. L., Gao, Y. K., Sugiyama, M. G., Klip, A., & Lee, W. (2017) · The FASEB Journal · doi:10.1096/fasebj.31.1_supplement.883.12
[Microscopic anatomy of the lion's ovary].
Kladetzky, J., & Rosenbauer, K. A. (1965) · PubMed
Brown, A. (2017) · UTAS Research Repository · doi:10.25959/23238647
Nugrahenny, D., Mardhiyyah, K., Bekti, R. S., Mayangsari, E., Nurdiana, N., Kalsum, U., Winedar, T. I., Insanitaqwa, A., Prawira, M. E. D., Khasanah, A., et al. (2019) · Journal of Physics Conference Series · doi:10.1088/1742-6596/1146/1/012042
Kokaji, T., Hatano, A., Ito, Y., Yugi, K., Eto, M., Ohno, S., Fujii, M., Hironaka, K., Egami, R., Inoue, H., et al. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/653758
Pathophysiology of Type 2 diabetes mellitus & vascular disease
Forst, T. M., Theodor, R., & Weber, M. M. (2015) · doi:10.4155/fseb2013.13.108
Rojas, J., Chávez-Castillo, M., Olivar, L. C., & Bermúdez, V. (2013) · Redalyc (Universidad Autónoma del Estado de México)
The Endothelial Barrier is not Rate-limiting to Insulin Action in the Myocardium
Sanwal, R. (2020) · TSpace (University of Toronto)
Diabetes Mellitus: Alterations in Vessel Wall Properties
Cardoso, C. R. L., & Salles, G. F. (2015) · Springer eBooks · doi:10.1007/978-3-319-14556-3_16
Nutrient and Energy Metabolism in Cell Proliferation
(2006) · Kluwer Academic Publishers eBooks · doi:10.1007/0-306-48529-x_3
Fatty Acids and Mitochondria, Cell Growth and Injury: Broader Implications
(2006) · Kluwer Academic Publishers eBooks · doi:10.1007/0-306-48529-x_7
Mechanisms of Macrovascular Disease in Diabetes
Kearney, M. T., Patel, P. A., & Cubbon, R. M. (2022) · doi:10.1093/med/9780198870197.003.0279
Qi, Y., Guo, X., & Guo, S. (2015) · Springer eBooks · doi:10.1007/978-3-319-12125-3_28-2
Pathogenesis of Alzheimer Disease: Metabolic Factors
(2004) · Springer eBooks · doi:10.1007/0-306-48529-x_15
Dastyar, M., Eizadi, M., & Roozbayani, M. (2022) · Avicenna Journal of Medical Biochemistry · doi:10.34172/ajmb.2022.2321
The Effect of Resistance Training on PI3K/mTORc1 Signaling in Left Ventricle of Diabetic Rats
Dastyar, M., Eizadi, M., & Roozbayani, M. (2021) · Research in Molecular Medicine · doi:10.32598/rmm.9.3.927.3
Khajehlandi, M., & Bolboli, L. (2024) · Research Square · doi:10.21203/rs.3.rs-3858207/v1
Fu, J., Yu, M. G., Li, Q., Park, K., & King, G. L. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-91707-0.00011-5
Self-citation2: Insulin Resistance: Molecular Biology and Pathophysiology
Low, C., & Draznin, B. (2018) · American Diabetes Association eBooks · doi:10.2337/9781580406666.ch02
The Renin-Angiotensin System in Diabetic Cardiovascular Complications
Feener, E. P. (2001) · Humana Press eBooks · doi:10.1007/978-1-59259-091-9_6 · Cited by 1
Self-citationHuang, X., Yin, B., Hu, Q., Zheng, Q., Chen, B., Wang, J., Ji, X., & Su, K. (2025) · Molecular Neurobiology · doi:10.1007/s12035-025-04987-2
Liu, Z., Jahn, L. A., & Barrett, E. J. (2025) · Endocrines · doi:10.3390/endocrines6030036
Wang, X., Qiu, C., Du, X., Qin, J., Zhang, Y., Hu, Z., Luo, Y., Zhu, J., Xie, S., & Shen, W. (2025) · Magnetic Resonance Materials in Physics Biology and Medicine · doi:10.1007/s10334-025-01279-7
Microvascular dysfunction and the development of muscle insulin resistance
Premilovac, D. (2012) · UTAS Research Repository · doi:10.25959/23205530
Effets de l’adiposité sur la microcirculation et les complications cutanées au cours de l’obésité
Nguyen‐Tu, M. (2013) · theses.fr (ABES) · doi:10.70675/7b9cc851z0ca7z4a23z87cbz7d788350ee0f
de Fondaumière, M. (2023) · theses.fr (ABES) · doi:10.70675/9dc73a0az2db9z4547zb5b3z6d65b7b632bc
Kardiometabolisches Syndrom – Pathophysiologie, Therapie und Prävention
Raeder, S. (2026) · Kardiologie up2date · doi:10.1055/a-2654-6802
Feeding the invaders: how metabolic imbalance shapes infection and biofilm development
Mahajan, S., Macdowell, S., Mitchem, C. F., Alexander, E., & Wozniak, D. J. (2026) · FEMS Microbiology Reviews · doi:10.1093/femsre/fuag029
Insulin Action in the Cardiovascular System
Tai, W. C., & Abel, E. D. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-11985-9.00011-1
Molecular and Cellular Underpinnings of Primary Hypertension: An Integrative Mechanistic Framework
Nasrallah, D., Abdelhamid, A. H., Tluli, O., Al-Haneedi, Y., Hussien, M. A., & Eid, A. H. (2026) · Journal of Cellular Physiology · doi:10.1002/jcp.70233
Metadata
- Authors
- Jiang, Z. Y., Lin, Y.-W., Clemont, A., Feener, E. P., Hein, K. D., Igarashi, M., Yamauchi, T., White, M. F., & King, G. L.
- Affiliations
- Joslin Diabetes Center (US)
- Corresponding author
- King, George L.
- Venue
- Journal of Clinical Investigation
- Published
- 1999-08-15
- Volume
- 104
- Issue
- 4
- Pages
- 447-457
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC408521
- OpenAlex
- W2051269098
- Cited by
- 604
- References
- 56
- Citations by year
- 2026: 7 · 2025: 14 · 2024: 10 · 2023: 15 · 2022: 15 · 2021: 19 · 2020: 13 · 2019: 13 · 2018: 10 · 2017: 24 · 2016: 28 · 2015: 24 · 2014: 23 · 2013: 27 · 2012: 35
- FWCI
- 12.03
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Joslin Diabetes Center
- National Institutes of Health (DK 36836)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK-53105, DK36836, R01DK053105, P30DK036836)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Keywords
- insulin resistance, MAPK signaling, ERK1/2, insulin receptor beta, IRS-1, insulin receptor substrate 2, p85 regulatory subunit, aorta, microvessels, obesity, Zucker rats, hyperinsulinemia, cardiovascular risk
- MeSH terms
- Animals, Aorta, Insulin, Insulin Resistance, Liver, Male, Microcirculation, Obesity, Phosphoproteins, Phosphorylation, Rats, Zucker, Receptor, Insulin, Recombinant Proteins, Tyrosine, Signal Transduction, Calcium-Calmodulin-Dependent Protein Kinases, Phosphatidylinositol 3-Kinases, Intracellular Signaling Peptides and Proteins, Rats, Insulin Receptor Substrate Proteins, In Vitro Techniques
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review