Cited by 604Diabetes, Cardiovascular Risks, and LipoproteinsAdipokines, Inflammation, and Metabolic DiseasesMetabolism, Diabetes, and Cancer

The DOI matches its Crossref record; 55 of the 56 references it cites were found in a registry or an index.

Characterization of selective resistance to insulin signaling in the vasculature of obese Zucker (fa/fa) rats

Open access

Jiang, Zhen Y., Lin, You-Wei, Clemont, Allen, Feener, Edward P., Hein, Katherine D., Igarashi, Masahiko, Yamauchi, Teruaki, White, Morris F., King, George L.·1999·Journal of Clinical Investigation

DOI 10.1172/jci5971PMC PMC408521

Open this paper in CoChat — free account Open PDF

Abstract

Both insulin resistance and hyperinsulinemia have been reported to be independent risk factors for cardiovascular diseases. However, little is known regarding insulin signaling in the vascular tissues in insulin-resistant states. In this report, insulin signaling on the phosphatidylinositol 3-kinase (PI 3-kinase) and mitogen-activated protein (MAP) kinase pathways were compared in vascular tissues of lean and obese Zucker (fa/fa) rats in both ex vivo and in vivo studies. Ex vivo, insulin-stimulated tyrosine phosphorylation of insulin receptor beta subunits (IRbeta) in the aorta and microvessels of obese rats was significantly decreased compared with lean rats, although the protein levels of IRbeta in the 2 groups were not different. Insulin-induced tyrosine phosphorylation of insulin receptor substrates 1 and 2 (IRS-1 and IRS-2) and their protein levels were decreased in the aorta of obese rats compared with lean rats. The association of p85 subunit to the IRS proteins and the IRS-associated PI 3-kinase activities stimulated by insulin in the aorta of obese rats were significantly decreased compared with the lean rats. In addition, insulin-stimulated serine phosphorylation of Akt, a downstream kinase of PI 3-kinase pathway, was also reduced significantly in isolated microvessels from obese rats compared with the lean rats. In euglycemic clamp studies, insulin infusion greatly increased tyrosine phosphorylation of IRbeta- and IRS-2-associated PI 3-kinase activity in the aorta of lean rats, but only slight increases were observed in obese rats. In contrast, insulin stimulated tyrosine phosphorylation of MAP kinase (ERK-1/2) equally in isolated microvessels of lean and obese rats, although basal tyrosine phosphorylation of ERK-1/2 was higher in the obese rats. To our knowledge, these data provided the first direct measurements of insulin signaling in the vascular tissues, and documented a selective resistance to PI 3-kinase (but not to MAP kinase pathway) in the vascular tissues of obese Zucker rats.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1172/jci5971

Cites

55 of 55 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Nitric oxide: physiology, pathophysiology, and pharmacology.
Moncada, S., Palmer, R. M., & Higgs, E. A. (1991) · Pharmacological Reviews · doi:10.1016/s0031-6997(25)06663-3 · Cited by 15,525
Mechanisms of fatty acid-induced inhibition of glucose uptake.
Boden, G., Chen, X., Ruiz, J., White, J. V., & Rossetti, L. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117252 · Cited by 3,720
Hyperinsulinemia as an independent risk factor for ischemic heart disease
Després, J.-P., Lamarche, B., Mauriège, P., Cantin, B., Dagenais, G. R., Moorjani, S., & Lupien, P.-J. (1996) · New England Journal of Medicine · doi:10.1056/nejm199604113341504 · Cited by 1,699
Obesity/insulin resistance is associated with endothelial dysfunction. Implications for the syndrome of insulin resistance
Steinberg, H. O., Chaker, H., Leaming, R., Johnson, A., Brechtel, G., & Baron, A. D. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118709 · Cited by 1,687 · cited 2×
“However, physiological studies have documented that endothelial functions as measured by insulin-induced vasodilatation are reduced in insulin-resistant and diabetic patients (12), suggesting that vascular cells are also resistant to insulin for some of its physiological actions.”
Background
Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein
Sun, X. J., Rothenberg, P., Kahn, C. R., Backer, J. M., Araki, E., Wilden, P. A., Cahill, D. A., Goldstein, B. J., & White, M. F. (1991) · Nature · doi:10.1038/352073a0 · Cited by 1,574
Self-citation
Mechanism of free fatty acid-induced insulin resistance in humans.
Roden, M., Price, T. B., Perseghin, G., Petersen, K. F., Rothman, D. L., Cline, G. W., & Shulman, G. I. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118742 · Cited by 1,539
Insulin-mediated skeletal muscle vasodilation is nitric oxide dependent. A novel action of insulin to increase nitric oxide release.
Steinberg, H. O., Brechtel, G., Johnson, A., Fineberg, N. S., & Baron, A. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117433 · Cited by 1,216
Insulin Stimulates the Phosphorylation of the 95,000-Dalton Subunit of Its Own Receptor
Kasuga, M., Karlsson, F. A., & Kahn, C. R. (1982) · Science · doi:10.1126/science.7031900 · Cited by 1,132
The effect of insulin on renal handling of sodium, potassium, calcium, and phosphate in man.
DeFronzo, R. A., Cooke, C. R., Andres, R., Faloona, G. R., & Davis, P. J. (1975) · Journal of Clinical Investigation · doi:10.1172/jci107996 · Cited by 1,104
Hyperinsulinemia produces both sympathetic neural activation and vasodilation in normal humans.
Anderson, E. A., Hoffman, R. P., Balon, T. W., Sinkey, C. A., & Mark, A. L. (1991) · Journal of Clinical Investigation · doi:10.1172/jci115260 · Cited by 1,075

Flagged first, then by citations

Show all 56 references

1 of the 56 references couldn’t be matched to a known paper.

Research works printed but not linked: 5

Kuboki, 1998, Diabetes, 47(Suppl. 1), A24
Cheatham, 1994, Mol Cell Biol, 14, 4902, 10.1128/MCB.14.7.4902 · DOI
Myers, 1994, Mol Cell Biol, 14, 357
Bray, 1977, Fed Proc, 36, 148
Moncada, 1991, Pharmacol Rev, 43, 109

Sorted by citations

Items 101–200 of 604

Enhanced Mitogenic Signaling in Skeletal Muscle of Women With Polycystic Ovary Syndrome
Corbould, A. M., Zhao, H., Mirzoeva, S., Aird, F., & Dunaif, A. E. (2006) · Diabetes · doi:10.2337/diabetes.55.03.06.db05-0453 · Cited by 166
Insulin-Mediated Hemodynamic Changes Are Impaired in Muscle of Zucker Obese Rats
Wallis, M. G., Wheatley, C. M., Rattigan, S., Barrett, E. J., Clark, A. D. H., & Clark, M. G. (2002) · Diabetes · doi:10.2337/diabetes.51.12.3492 · Cited by 164
Glomerular-specific protein kinase C-β-induced insulin receptor substrate-1 dysfunction and insulin resistance in rat models of diabetes and obesity
Mima, A., Ohshiro, Y., Kitada, M., Matsumoto, M., Geraldes, P., Li, C., Li, Q., White, G. S., Cahill, C., Rask‐Madsen, C., et al. (2011) · Kidney International · doi:10.1038/ki.2010.526 · Cited by 162
Self-citation
Vascular actions of insulin with implications for endothelial dysfunction
Potenza, M. A., Addabbo, F., & Montagnani, M. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00297.2009 · Cited by 176
Insulin resistance and vascular function
Baron, A. (2002) · Journal of Diabetes and its Complications · doi:10.1016/s1056-8727(01)00209-4 · Cited by 158
Control of Vascular Cell Proliferation and Migration by PPAR-γ
Hsueh, W. A., Jackson, S. M., & Law, R. E. (2001) · Diabetes Care · doi:10.2337/diacare.24.2.392 · Cited by 156
Microvascular Dysfunction: A Potential Mechanism in the Pathogenesis of Obesity‐associated Insulin Resistance and Hypertension
de Boer, M. P., Meijer, R. I., Wijnstok, N. J., Jonk, A. M., Houben, A. J. H. M., Stehouwer, C. D. A., Smulders, Y. M., Eringa, E. C., & Serné, E. H. (2011) · Microcirculation · doi:10.1111/j.1549-8719.2011.00130.x · Cited by 155
Insulin Resistance, Obesity, Hypertension, and Renal Sodium Transport
Horita, S., Seki, G., Yamada, H., Suzuki, M., Koike, K., & Fujita, T. (2011) · International Journal of Hypertension · doi:10.4061/2011/391762 · Cited by 158
Metformin and cancer
Rizos, C. V., & Elisaf, M. (2013) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2013.02.038 · Cited by 155
Nitric oxide – the endothelium-derived relaxing factor and its role in endothelial functions
Bauer, V., & Sotníková, R. (2010) · General Physiology and Biophysics · doi:10.4149/gpb_2010_04_319 · Cited by 156
Metabolic remodelling in diabetic cardiomyopathy
Chong, C., Clarke, K., & Levelt, E. (2017) · Cardiovascular Research · doi:10.1093/cvr/cvx018 · Cited by 159
TRB3 Gene Silencing Alleviates Diabetic Cardiomyopathy in a Type 2 Diabetic Rat Model
Ti, Y., Xie, G.-L., Wang, Z., Bi, X., Ding, W., Wang, J., Jiang, G.-H., Bu, P. L., Zhang, Y., Zhong, M., et al. (2011) · Diabetes · doi:10.2337/db11-0549 · Cited by 141
The Macrophage at the Crossroads of Insulin Resistance and Atherosclerosis
Liang, C.-P., Han, S., Senokuchi, T., & Tall, A. R. (2007) · Circulation Research · doi:10.1161/circresaha.107.152165 · Cited by 143
Diabetes Induces Endothelial Dysfunction but Does Not Increase Neointimal Formation in High-Fat Diet Fed C57BL/6J Mice
Molnár, J., Yu, S., Mzhavia, N., Pau, C., Chereshnev, I., & Dansky, H. M. (2005) · Circulation Research · doi:10.1161/01.res.0000168634.74330.ed · Cited by 141
Impairment of PI3-K/Akt Pathway Underlies Attenuated Endothelial Function in Aorta of Type 2 Diabetic Mouse Model
Kobayashi, T., Taguchi, K., Takenouchi, Y., Matsumoto, T., & Kamata, K. (2004) · Hypertension · doi:10.1161/01.hyp.0000147559.10261.a7 · Cited by 141
The Vasculature in Prediabetes
Wasserman, D. H., Wang, T. J., & Brown, N. J. (2018) · Circulation Research · doi:10.1161/circresaha.118.311912 · Cited by 137
Effect of Intensive Insulin Therapy on Insulin Sensitivity in the Critically Ill
Langouche, L., Perre, S. V., Wouters, P. J., D’Hoore, A. J. L., Hansen, T. K., & den Berghe, G. V. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-0813 · Cited by 136
Metabolic actions of insulin in men and women
Magkos, F., Wang, X., & Mittendorfer, B. (2010) · Nutrition · doi:10.1016/j.nut.2009.10.013 · Cited by 129
Intestinal Insulin Resistance and Aberrant Production of Apolipoprotein B48 Lipoproteins in an Animal Model of Insulin Resistance and Metabolic Dyslipidemia
Federico, L. M., Naples, M., Taylor, D., & Adeli, K. (2006) · Diabetes · doi:10.2337/db04-1084 · Cited by 132
Endothelial Function and Dysfunction: Impact of Metformin
Nafisa, A., Gray, S. G., Cao, Y., Wang, T., Xu, S., Wattoo, F. H., Barras, M., Cohen, N., Kamato, D., & Little, P. J. (2018) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2018.07.007 · Cited by 128
Reduction of obesity, as induced by leptin, reverses endothelial dysfunction in obese (Lepob ) mice
Winters, B. D., Mo, Z., Brooks-Asplund, E. M., Kim, S., Shoukas, A. A., Li, D., Nyhan, D. P., & Berkowitz, D. E. (2000) · Journal of Applied Physiology · doi:10.1152/jappl.2000.89.6.2382 · Cited by 126
Insulin Action Is Associated With Endothelial Function in Hypertension and Type 2 Diabetes
Cleland, S. J., Petrie, J. R., SMALL, M. P., Elliott, H. L., & Connell, J. (2000) · Hypertension · doi:10.1161/01.hyp.35.1.507 · Cited by 125
Endothelial dysfunction in (pre)diabetes: Characteristics, causative mechanisms and pathogenic role in type 2 diabetes
Eringa, E. C., Serné, E. H., Meijer, R. I., Schalkwijk, C. G., Houben, A. J. H. M., Stehouwer, C. D. A., Smulders, Y. M., & van Hinsbergh, V. W. M. (2013) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-013-9239-7 · Cited by 126
The role of protein tyrosine phosphatase 1B (PTP1B) in the pathogenesis of type 2 diabetes mellitus and its complications
Teimouri, M., Hosseini, H., Sadeghabadi, Z. A., Khorzoughi, R. B., Gorgani‐Firuzjaee, S., & Meshkani, R. (2022) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-021-00860-7 · Cited by 126
Insulin Resistance With Enhanced Insulin Signaling in High-Salt Diet–Fed Rats
Ogihara, T., Asano, T., Ando, K., Chiba, Y., Sekine, N., Sakoda, H., Anai, M., Onishi, Y., Fujishiro, M., Ono, H., et al. (2001) · Diabetes · doi:10.2337/diabetes.50.3.573 · Cited by 120
Physiological concentrations of insulin induce endothelin-mediated vasoconstriction during inhibition of NOS or PI3-kinase in skeletal muscle arterioles
Eringa, E. (2002) · Cardiovascular Research · doi:10.1016/s0008-6363(02)00593-x · Cited by 118
Mechanisms of Lipotoxicity in the Cardiovascular System
Wende, A. R., Symons, J. D., & Abel, E. D. (2012) · Current Hypertension Reports · doi:10.1007/s11906-012-0307-2 · Cited by 110
New insights into insulin action and resistance in the vasculature
Manrique, C. M., Lastra, G., & Sowers, J. R. (2014) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12395 · Cited by 121
Regulation of Vascular Function and Insulin Sensitivity by Adipose Tissue: Focus on Perivascular Adipose Tissue
Eringa, E. C., Bakker, W., Smulders, Y. M., Serné, E. H., Yudkin, J. S., & Stehouwer, C. D. A. (2007) · Microcirculation · doi:10.1080/10739680701303584 · Cited by 116
Lack of Insulin Receptor Substrate-2 Causes Progressive Neointima Formation in Response to Vessel Injury
Kubota, T., Kubota, N., Moroi, M., Terauchi, Y., Kobayashi, T., Kamata, K., Suzuki, R., Tobe, K., Namiki, A., Aizawa, S., et al. (2003) · Circulation · doi:10.1161/01.cir.0000070937.52035.25 · Cited by 116
Endothelin Limits Insulin Action in Obese/Insulin-Resistant Humans
Lteif, A. A., Vaishnava, P., Baron, A., & Mather, K. J. (2007) · Diabetes · doi:10.2337/db06-1406 · Cited by 115
Selective Insulin Resistance in Adipocytes
Tan, S., Fisher‐Wellman, K. H., Fazakerley, D. J., Ng, Y., Pant, H., Li, J., Meoli, C. C., Coster, A. C. F., Stöckli, J., & James, D. E. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.623686 · Cited by 116
Vascular insulin resistance: A potential link between cardiovascular and metabolic diseases
Schulman, I. H., & Zhou, M.-S. (2009) · Current Hypertension Reports · doi:10.1007/s11906-009-0010-0 · Cited by 114
Endothelial dysfunction, inflammation, and insulin resistance: A focus on subjects at risk for type 2 diabetes
Caballero, A. E. (2004) · Current Diabetes Reports · doi:10.1007/s11892-004-0074-9 · Cited by 114
Tetrahydrobiopterin restores endothelial dysfunction induced by an oral glucose challenge in healthy subjects
Ihlemann, N., Rask-Madsen, C., Perner, A., Dominguez, H., Hermann, T., Køber, L., & Torp-Pedersen, C. (2003) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00008.2003 · Cited by 113
Reversibility of endothelial dysfunction in diabetes: role of polyphenols
Suganya, N., Bhakkiyalakshmi, E., Sarada, D. V. L., & Ramkumar, K. M. (2016) · British Journal Of Nutrition · doi:10.1017/s0007114516001884 · Cited by 116
Endothelin-1 in Health and Disease
Banecki, K. M. R. M., & Dora, K. A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241411295 · Cited by 113
Nitric Oxide, Oxidative Stress, and p66Shc Interplay in Diabetic Endothelial Dysfunction
Magenta, A., Greco, S., Capogrossi, M. C., Gaetano, C., & Martelli, F. (2014) · BioMed Research International · doi:10.1155/2014/193095 · Cited by 112
Troglitazone Therapy Improves Endothelial Function to Near Normal Levels in Women with Polycystic Ovary Syndrome
Paradisi, G., Steinberg, H. O., Shepard, M. K., Brechtel, G., & Baron, A. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-020386 · Cited by 111
Insulin and Endothelin: An Interplay Contributing to Hypertension Development?
Sarafidis, P. A., & Bakris, G. L. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-1819 · Cited by 108
Characterization of Multiple Signaling Pathways of Insulin in the Regulation of Vascular Endothelial Growth Factor Expression in Vascular Cells and Angiogenesis
Jiang, Z. Y., He, Z., King, B. L., Kuroki, T., Opland, D. M., Suzuma, K., Suzuma, I., Ueki, K., Kulkarni, R., Kahn, C. R., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m303314200 · Cited by 110
Self-citation
Increased cell proliferation and contractility of prostate in insulin resistant rats: Linking hyperinsulinemia with benign prostate hyperplasia
Vikram, A., Jena, G., & Ramarao, P. (2009) · The Prostate · doi:10.1002/pros.21041 · Cited by 111
Lipotoxicity contributes to endothelial dysfunction: A focus on the contribution from ceramide
Symons, J. D., & Abel, E. D. (2013) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-012-9235-3 · Cited by 112
Increased MAPK Activation and Impaired Insulin Signaling in Subcutaneous Microvascular Endothelial Cells in Type 2 Diabetes: The Role of Endothelin-1
Gogg, S., Smith, U., & Jansson, P. (2009) · Diabetes · doi:10.2337/db08-0961 · Cited by 112
Mineralocorticoid Receptor Antagonism Treats Obesity-Associated Cardiac Diastolic Dysfunction
Bender, S. B., DeMarco, V. G., Padilla, J., Jenkins, N. T., Habibi, J., Garro, M., Pulakat, L., Aroor, A. R., Jaffe, I. Z., & Sowers, J. R. (2015) · Hypertension · doi:10.1161/hypertensionaha.114.04912 · Cited by 109
Vasoconstrictor effects of insulin in skeletal muscle arterioles are mediated by ERK1/2 activation in endothelium
Eringa, E. C., Stehouwer, C. D. A., van Nieuw Amerongen, G. P., Ouwehand, L., Westerhof, N., & Sipkema, P. (2004) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00067.2004 · Cited by 107
Rho‐kinase as a molecular target for insulin resistance and hypertension
Kanda, T., Wakino, S., Homma, K., Yoshioka, K., Tatematsu, S., Hasegawa, K., Takamatsu, I., Sugano, N., Hayashi, K., & Saruta, T. (2005) · The FASEB Journal · doi:10.1096/fj.05-4197fje · Cited by 107
Ghrelin has novel vascular actions that mimic PI 3-kinase-dependent actions of insulin to stimulate production of NO from endothelial cells
Iantorno, M., Chen, H., Kim, J., Tesauro, M., Lauro, D., Cardillo, C., & Quon, M. J. (2006) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00570.2006 · Cited by 107
In Vivo Phosphorylation of Insulin Receptor Substrate 1 at Serine 789 by a Novel Serine Kinase in Insulin-resistant Rodents
Qiao, L.-Y., Zhande, R., Jetton, T. L., Zhou, G., & Sun, X. J. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m201494200 · Cited by 104
Insulin's actions on vascular tissues: Physiological effects and pathophysiological contributions to vascular complications of diabetes
Fu, J., Yu, M. G., Li, Q., Park, K., & King, G. L. (2021) · Molecular Metabolism · doi:10.1016/j.molmet.2021.101236 · Cited by 112
Self-citation
A Rho-kinase inhibitor, fasudil, prevents development of diabetes and nephropathy in insulin-resistant diabetic rats
Kikuchi, Y., Yamada, M., Imakiire, T., Kushiyama, T., Higashi, K., Hyodo, N., Yamamoto, K., Oda, T., Suzuki, S., & Miura, S. (2007) · Journal of Endocrinology · doi:10.1677/joe-06-0045 · Cited by 106
Dehydroepiandrosterone Mimics Acute Actions of Insulin to Stimulate Production of Both Nitric Oxide and Endothelin 1 via Distinct Phosphatidylinositol 3-Kinase- and Mitogen-Activated Protein Kinase-Dependent Pathways in Vascular Endothelium
Formoso, G., Chen, H., Kim, J., Montagnani, M., Consoli, A., & Quon, M. J. (2005) · Molecular Endocrinology · doi:10.1210/me.2005-0266 · Cited by 99
Insulin action in vascular endothelium: potential mechanisms linking insulin resistance with hypertension
Montagnani, M., & Quon, M. J. (2000) · Diabetes Obesity and Metabolism · doi:10.1046/j.1463-1326.2000.00092.x · Cited by 102
Insulin Therapy Improves Insulin-Stimulated Endothelial Function in Patients With Type 2 Diabetes and Ischemic Heart Disease
Rask‐Madsen, C., Ihlemann, N., Krarup, T., Christiansen, E., Køber, L., Kistorp, C. N., & Torp-Pedersen, C. T. (2001) · Diabetes · doi:10.2337/diabetes.50.11.2611 · Cited by 106
The Insulin Receptor: A New Target for Cancer Therapy
Malaguarnera, R., & Belfiore, A. (2011) · Frontiers in Endocrinology · doi:10.3389/fendo.2011.00093 · Cited by 98
Regulation of Vascular Endothelial Growth Factor Expression and Vascularization in the Myocardium by Insulin Receptor and PI3K/Akt Pathways in Insulin Resistance and Ischemia
He, Z., Opland, D. M., Way, K. J., Ueki, K., Bodyak, N., Kang, P. M., Izumo, S., Kulkarni, R. N., Wang, B., Liao, R., et al. (2006) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.0000209500.15801.4e · Cited by 94
Self-citation
The role of insulin and the adipocytokines in regulation of vascular endothelial function
Ritchie, S. A., Ewart, M., Perry, C. G., Connell, J., & Salt, I. P. (2004) · Clinical Science · doi:10.1042/cs20040190 · Cited by 98
GPR43 deficiency protects against podocyte insulin resistance in diabetic nephropathy through the restoration of AMPKα activity
Lu, J. G., Chen, P. P., Zhang, J. X., Li, X. Q., Wang, G. H., Yuan, B. Y., Huang, S. J., Liu, X. Q., Jiang, T., Wang, M. Y., et al. (2021) · Theranostics · doi:10.7150/thno.56598 · Cited by 96
Endothelial Dysfunction in Metabolic and Vascular Disorders
Polovina, M. M., & Potpara, T. (2014) · Postgraduate Medicine · doi:10.3810/pgm.2014.03.2739 · Cited by 97
Pathway-selective Insulin Resistance and Metabolic Disease: The Importance of Nutrient Flux
Otero, Y. F., Stafford, J. M., & McGuinness, O. P. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.r114.576355 · Cited by 97
Tear film and ocular surface changes in diabetes mellitus
Alves, M., Carvalheira, J. B. C., Módulo, C. M., & Rocha, E. M. (2008) · Arquivos Brasileiros de Oftalmologia · doi:10.1590/s0004-27492008000700018 · Cited by 94
Vascular and Metabolic Actions of the Green Tea Polyphenol Epigallocatechin Gallate
Keske, M. A., Ng, H., Premilovac, D., Rattigan, S., Kim, J., Munir, K. M., Yang, P., & Quon, M. J. (2014) · Current Medicinal Chemistry · doi:10.2174/0929867321666141012174553 · Cited by 92
Exercise training improves muscle insulin resistance but not insulin receptor signaling in obese Zucker rats
Christ-Roberts, C. Y., Hunt, D. G., Hancock, J., García-Macedo, R., Mandarino, L. J., & Ivy, J. L. (2002) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00784.2001 · Cited by 91
Selective resistance to vasoactive effects of insulin in muscle resistance arteries of obese Zucker (fa/fa) rats
Eringa, E. C., Stehouwer, C. D. A., Roos, M. H., Westerhof, N., & Sipkema, P. (2007) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00516.2006 · Cited by 92
Obesity, Insulin Resistance, and Renal Function
Knight, S. F., & Imig, J. D. (2007) · Microcirculation · doi:10.1080/10739680701283018 · Cited by 89
The Insulin-Like Growth Factor-1 Receptor Is a Negative Regulator of Nitric Oxide Bioavailability and Insulin Sensitivity in the Endothelium
Abbas, A., Imrie, H., Viswambharan, H., Sukumar, P., Rajwani, A., Cubbon, R. M., Gage, M., Smith, J., Galloway, S. L., Yuldasheva, N. Y., et al. (2011) · Diabetes · doi:10.2337/db11-0197 · Cited by 92
Induction of Vascular Insulin Resistance and Endothelin-1 Expression and Acceleration of Atherosclerosis by the Overexpression of Protein Kinase C-β Isoform in the Endothelium
Li, Q., Park, K., Li, C.-Z., Rask‐Madsen, C., Mima, A., Qi, W., Mizutani, K., Huang, P. L., & King, G. L. (2013) · Circulation Research · doi:10.1161/circresaha.113.301074 · Cited by 93
Self-citation
Eicosapentaenoic Acid Improves Imbalance between Vasodilator and Vasoconstrictor Actions of Endothelium-Derived Factors in Mesenteric Arteries from Rats at Chronic Stage of Type 2 Diabetes
Matsumoto, T., Nakayama, N., Ishida, K., Kobayashi, T., & Kamata, K. (2009) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.108.148718 · Cited by 90
Insulin down-regulates insulin receptor substrate-2 expression through the phosphatidylinositol 3-kinase/Akt pathway
Hirashima, Y., Tsuruzoe, K., Kodama, S., Igata, M., Toyonaga, T., Ueki, K., Kahn, C. R., & Araki, E. (2003) · Journal of Endocrinology · doi:10.1677/joe.0.1790253 · Cited by 89
Metabolic actions of angiotensin II and insulin: A microvascular endothelial balancing act
Muniyappa, R., & Yavuz, S. (2012) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2012.05.017 · Cited by 96
The endothelial cell: An “early responder” in the development of insulin resistance
Barrett, E. J., & Liu, Z. (2013) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-012-9232-6 · Cited by 90
Microvascular dysfunction: An emerging pathway in the pathogenesis of obesity-related insulin resistance
Muris, D. M. J., Houben, A. J. H. M., Schram, M. T., & Stehouwer, C. D. A. (2013) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-012-9231-7 · Cited by 86
Treatment of Spontaneously Hypertensive Rats With Rosiglitazone and/or Enalapril Restores Balance Between Vasodilator and Vasoconstrictor Actions of Insulin With Simultaneous Improvement in Hypertension and Insulin Resistance
Potenza, M. A., Marasciulo, F. L., Tarquinio, M., Quon, M. J., & Montagnani, M. (2006) · Diabetes · doi:10.2337/db06-0667 · Cited by 87
The metabolic syndrome
Nugent, A. P. (2004) · Nutrition Bulletin · doi:10.1111/j.1467-3010.2004.00403.x · Cited by 85
miRNAs as cornerstones in diabetic microvascular complications
Ismail, A., El‐Mahdy, H. A., Eldeib, M. G., & Doghish, A. S. (2022) · Molecular Genetics and Metabolism · doi:10.1016/j.ymgme.2022.106978 · Cited by 85
MicroRNAs and Cardiovascular Diseases
Nishiguchi, T., Imanishi, T., & Akasaka, T. (2015) · BioMed Research International · doi:10.1155/2015/682857 · Cited by 83
Coronary microvascular dysfunction in diabetes mellitus: A review
Picchi, A. (2010) · World Journal of Cardiology · doi:10.4330/wjc.v2.i11.377 · Cited by 84
Diabetes in the Goto-Kakizaki rat is accompanied by impaired insulin-mediated myosin-bound phosphatase activation and vascular smooth muscle cell relaxation.
Sandu, O. A., Ragolia, L., & Begum, N. (2000) · Diabetes · doi:10.2337/diabetes.49.12.2178 · Cited by 84
Imbalanced insulin action in chronic over nutrition: Clinical harm, molecular mechanisms, and a way forward
Williams, K. J., & Wu, X. (2016) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2016.02.004 · Cited by 83
Palmitate and insulin synergistically induce IL-6 expression in human monocytes
Bunn, R. C., Cockrell, G. E., Ou, Y., Thrailkill, K. M., Lumpkin, C. K., & Fowlkes, J. L. (2010) · Cardiovascular Diabetology · doi:10.1186/1475-2840-9-73 · Cited by 86
Metabolic and Vascular Abnormalities in Subjects at Risk for Type 2 Diabetes: The Early Start of a Dangerous Situation
Caballero, A. E. (2005) · Archives of Medical Research · doi:10.1016/j.arcmed.2005.03.013 · Cited by 82
Microcirculation and the Metabolic Syndrome
Wiernsperger, N. F., Nivoit, P., Kraemer‐Aguiar, L. G., & Bouskela, E. (2007) · Microcirculation · doi:10.1080/10739680701285617 · Cited by 81
Adipose‐specific effect of rosiglitazone on vascular permeability and protein kinase C activation: novel mechanism for PPARγ agonist's effects on edema and weight gain
Sotiropoulos, K. B., Clermont, A. C., Yasuda, Y., Rask‐Madsen, C., Mastumoto, M., Takahashi, J., Vecchia, K. M. D., Kondo, T., Aiello, L. P., & King, G. L. (2006) · The FASEB Journal · doi:10.1096/fj.05-4617fje · Cited by 81
Self-citation
Influence of insulin and of insulin resistance on platelet and vascular smooth muscle cell function
Trovati, M., & Anfossi, G. (2002) · Journal of Diabetes and its Complications · doi:10.1016/s1056-8727(01)00196-9 · Cited by 81
Effects of insulin resistance on endothelial progenitor cells and vascular repair
Cubbon, R. M., Kahn, M., & Wheatcroft, S. B. (2009) · Clinical Science · doi:10.1042/cs20080263 · Cited by 81
Insulin activates vascular endothelial growth factor in vascular smooth muscle cells: influence of nitric oxide and of insulin resistance
Doronzo, G., Russo, I., Mattiello, L., Anfossi, G., Bosìa, A., & Trovati, M. (2004) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.2004.01412.x · Cited by 79
Vascular complications in diabetes: Microparticles and microparticle associated microRNAs as active players
Alexandru, N., Bădilă, E., Weiss, E., Cochior, D., Stępień, E. Ł., & Georgescu, A. (2016) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2016.02.038 · Cited by 79
Physiological Concentrations of Insulin Induce Endothelin-Dependent Vasoconstriction of Skeletal Muscle Resistance Arteries in the Presence of Tumor Necrosis Factor-α Dependence on c-Jun N-Terminal Kinase
Eringa, E. C., Stehouwer, C. D. A., Walburg, K. V., Clark, A. D., Amerongen, G. P. V. N., Westerhof, N., & Sipkema, P. (2005) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000198248.19391.3e · Cited by 79
Putative roles of kinin receptors in the therapeutic effects of angiotensin 1-converting enzyme inhibitors in diabetes mellitus
Couture, R., & Girolami, J. (2004) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2004.07.045 · Cited by 79
Insulin resistance and endothelial dysfunction
Yki‐Järvinen, H. (2003) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/s1521-690x(03)00033-2 · Cited by 77
Insulin Resistance the Link between T2DM and CVD: Basic Mechanisms and Clinical Implications
Abdul‐Ghani, M. A., Jayyousi, A., DeFronzo, R. A., Asaad, N., & Suwaidi, J. M. S. A. (2017) · Current Vascular Pharmacology · doi:10.2174/1570161115666171010115119 · Cited by 79
Insulin resistance uncoupled from dyslipidemia due to C-terminal PIK3R1 mutations
Huang-Doran, I., Tomlinson, P., Payne, F., Gast, A., Sleigh, A., Bottomley, W., Harris, J., Daly, A., Rocha, N., Rudge, S. A., et al. (2016) · JCI Insight · doi:10.1172/jci.insight.88766 · Cited by 69
Saturated fatty acids inhibit hepatic insulin action by modulating insulin receptor expression and post-receptor signalling.
Ruddock, M. W., Stein, A., Landaker, E., Park, J., Cooksey, R. C., McClain, D., & Patti, M.-E. (2008) · Journal of Biochemistry · doi:10.1093/jb/mvn105 · Cited by 75
Akt1/PKB upregulation leads to vascular smooth muscle cell hypertrophy and polyploidization
Hixon, M. L., Muro‐Cacho, C., Wagner, M. W., Obejero‐Paz, C. A., Millie, E. A., Fujio, Y., Kureishi, Y., Hassold, T. J., Walsh, K. X., & Gualberto, A. (2000) · Journal of Clinical Investigation · doi:10.1172/jci8252 · Cited by 76
Differential Roles of Hyperglycemia and Hypoinsulinemia in Diabetes Induced Retinal Cell Death: Evidence for Retinal Insulin Resistance
Fort, P. E., Losiewicz, M. K., Reiter, C. E. N., Singh, R. S., Nakamura, M., Abcouwer, S. F., Barber, A. J., & Gardner, T. W. (2011) · PLoS ONE · doi:10.1371/journal.pone.0026498 · Cited by 74
Long-term high-fat diet induces hippocampal microvascular insulin resistance and cognitive dysfunction
Fu, Z., Wu, J., Nesil, T., Li, M. D., Aylor, K. W., & Liu, Z. (2016) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00297.2016 · Cited by 74
Does a strict glycemic control during acute coronary syndrome play a cardioprotective effect? Pathophysiology and clinical evidence
Caturano, A., Galiero, R., Pafundi, P. C., Cesaro, A., Vetrano, E., Palmiero, G., Rinaldi, L., Salvatore, T., Marfella, R., Sardu, C., et al. (2021) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2021.108959 · Cited by 73
Effects of Pioglitazone on Endothelial Function, Insulin Sensitivity, and Glucose Control in Subjects With Coronary Artery Disease and New-Onset Type 2 Diabetes
Sourij, H., Zweiker, R., & Wascher, T. C. (2006) · Diabetes Care · doi:10.2337/dc05-2226 · Cited by 73
Angiotensin-Converting enzyme inhibition and angiogenesis in myocardium of obese Zucker rats
Toblli, J. (2004) · American Journal of Hypertension · doi:10.1016/j.amjhyper.2003.10.006 · Cited by 71
Insulin resistance metabolic stress and atherosclerosis
Wang, H. (2012) · Frontiers in Bioscience-Scholar · doi:10.2741/s308 · Cited by 75

Authors: Jiang, Z. Y., Lin, Y.-W., Clemont, A., Feener, E. P., Hein, K. D., Igarashi, M., Yamauchi, T., White, M. F., & King, G. L.
Affiliations: Joslin Diabetes Center (US)
Corresponding author: King, George L.
ORCID: Jiang, Zhen Y.
Feener, Edward P.
White, Morris F.
King, George L.
Venue: Journal of Clinical Investigation
Publisher: American Society for Clinical Investigation
Published: 1999-08-15
Volume: 104
Issue: 4
Pages: 447-457
ISSN: 0021-9738 (ISSN-L)
DOI: 10.1172/jci5971
PMC: PMC408521
OpenAlex: W2051269098
Cited by: 604
References: 56
Citations by year: 2026: 7 · 2025: 14 · 2024: 10 · 2023: 15 · 2022: 15 · 2021: 19 · 2020: 13 · 2019: 13 · 2018: 10 · 2017: 24 · 2016: 28 · 2015: 24 · 2014: 23 · 2013: 27 · 2012: 35
FWCI: 12.03
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Clinical Investigation (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Joslin Diabetes Center
National Institutes of Health (DK 36836)
National Institute of Diabetes and Digestive and Kidney Diseases (DK-53105, DK36836, R01DK053105, P30DK036836)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Keywords: insulin resistance, MAPK signaling, ERK1/2, insulin receptor beta, IRS-1, insulin receptor substrate 2, p85 regulatory subunit, aorta, microvessels, obesity, Zucker rats, hyperinsulinemia, cardiovascular risk
MeSH terms: Animals, Aorta, Insulin, Insulin Resistance, Liver, Male, Microcirculation, Obesity, Phosphoproteins, Phosphorylation, Rats, Zucker, Receptor, Insulin, Recombinant Proteins, Tyrosine, Signal Transduction, Calcium-Calmodulin-Dependent Protein Kinases, Phosphatidylinositol 3-Kinases, Intracellular Signaling Peptides and Proteins, Rats, Insulin Receptor Substrate Proteins, In Vitro Techniques

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Characterization of selective resistance to insulin signaling in the vasculature of obese Zucker (fa/fa) rats

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks