The DOI matches its Crossref record; 97 of the 97 references it cites were found in a registry or an index.
MicroRNA-181b regulates NF-κB–mediated vascular inflammation
Open accessAbstract
EC activation and dysfunction have been linked to a variety of vascular inflammatory disease states. The function of microRNAs (miRNAs) in vascular EC activation and inflammation remains poorly understood. Herein, we report that microRNA-181b (miR-181b) serves as a potent regulator of downstream NF-κB signaling in the vascular endothelium by targeting importin-α3, a protein that is required for nuclear translocation of NF-κB. Overexpression of miR-181b inhibited importin-α3 expression and an enriched set of NF-κB-responsive genes such as adhesion molecules VCAM-1 and E-selectin in ECs in vitro and in vivo. In addition, treatment of mice with proinflammatory stimuli reduced miR-181b expression. Rescue of miR-181b levels by systemic administration of miR-181b "mimics" reduced downstream NF-κB signaling and leukocyte influx in the vascular endothelium and decreased lung injury and mortality in endotoxemic mice. In contrast, miR-181b inhibition exacerbated endotoxin-induced NF-κB activity, leukocyte influx, and lung injury. Finally, we observed that critically ill patients with sepsis had reduced levels of miR-181b compared with control intensive care unit (ICU) subjects. Collectively, these findings demonstrate that miR-181b regulates NF-κB-mediated EC activation and vascular inflammation in response to proinflammatory stimuli and that rescue of miR-181b expression could provide a new target for antiinflammatory therapy and critical illness.
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Noncoding RNAs, cytokines, and inflammation-related diseases
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Tabet, F., Vickers, K. C., Cuesta Torres, L. F., Wiese, C. B., Shoucri, B. M., Lambert, G., Catherinet, C., Prado-Lourenco, L., Levin, M. G., Thacker, S., et al. (2014) · Nature Communications · doi:10.1038/ncomms4292 · Cited by 428
Interplay between miRNAs and human diseases
Paul, P., Chakraborty, A., Sarkar, D., Langthasa, M., Rahman, M., Bari, M., Singha, R. S., Malakar, A. K., & Chakraborty, S. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.25854 · Cited by 420
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Cheng, H. S., Sivachandran, N., Lau, A., Boudreau, E., Zhao, J. L., Baltimore, D., Delgado‐Olguin, P., Cybulsky, M. I., & Fish, J. E. (2013) · EMBO Molecular Medicine · doi:10.1002/emmm.201202318 · Cited by 417
Metadata
- Authors
- Sun, X., Icli, B., Wara, A. K., Belkin, N., He, S., Kobzik, L., Hunninghake, G. M., Vera, M. P., Blackwell, T. S., Baron, R. M., & Feinberg, M. W.
- Venue
- Journal of Clinical Investigation
- Published
- 2012-05-24
- Volume
- 122
- Issue
- 6
- Pages
- 1973-90
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2123137429
- Cited by
- 444
- References
- 97
- FWCI
- 12.25
- Type
- journal article
- Language
- en
- Open access
- green
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- Sun, X., Icli, B., Wara, A. K., Belkin, N., He, S., Kobzik, L., Hunninghake, G. M., Vera, M. P., Blackwell, T. S., Baron, R. M., & Feinberg, M. W. (2012). MicroRNA-181b regulates NF-κB–mediated vascular inflammation. Journal of Clinical Investigation. https://doi.org/10.1172/jci61495
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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