The DOI matches its Crossref record; 61 of the 61 references it cites were found in a registry or an index.
MicroRNA-155 promotes atherosclerosis by repressing Bcl6 in macrophages
Open accessAbstract
Macrophages in atherosclerotic plaques drive inflammatory responses, degrade lipoproteins, and phagocytose dead cells. MicroRNAs (miRs) control the differentiation and activity of macrophages by regulating the signaling of key transcription factors. However, the functional role of macrophage-related miRs in the immune response during atherogenesis is unknown. Here, we report that miR-155 is specifically expressed in atherosclerotic plaques and proinflammatory macrophages, where it was induced by treatment with mildly oxidized LDL (moxLDL) and IFN-γ. Leukocyte-specific Mir155 deficiency reduced plaque size and number of lesional macrophages after partial carotid ligation in atherosclerotic (Apoe-/-) mice. In macrophages stimulated with moxLDL/IFN-γ in vitro, and in lesional macrophages, loss of Mir155 reduced the expression of the chemokine CCL2, which promotes the recruitment of monocytes to atherosclerotic plaques. Additionally, we found that miR-155 directly repressed expression of BCL6, a transcription factor that attenuates proinflammatory NF-κB signaling. Silencing of Bcl6 in mice harboring Mir155-/- macrophages enhanced plaque formation and CCL2 expression. Taken together, these data demonstrated that miR-155 plays a key role in atherogenic programming of macrophages to sustain and enhance vascular inflammation.
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Cites
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Self-citationMicroRNA-155 is induced during the macrophage inflammatory response
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Schober, A., Nazari-Jahantigh, M., Wei, Y., Bidzhekov, K., Gremse, F., Grommes, J., Megens, R. T. A., Heyll, K., Noels, H., Hristov, M., et al. (2014) · Nature Medicine · doi:10.1038/nm.3487 · Cited by 630
Self-citationNoncoding RNAs, cytokines, and inflammation-related diseases
Marques-Rocha, J. L., Samblas, M., Milagro, F. I., Bressan, J., Martínez, J. A., & Marti, A. (2015) · The FASEB Journal · doi:10.1096/fj.14-260323 · Cited by 477
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Metadata
- Authors
- Nazari-Jahantigh, M., Wei, Y., Noels, H., Akhtar, S., Zhou, Z., Koenen, R. R., Heyll, K., Gremse, F., Kiessling, F., Grommes, J., Weber, C., & Schober, A.
- Venue
- Journal of Clinical Investigation
- Published
- 2012-10-08
- Volume
- 122
- Issue
- 11
- Pages
- 4190-4202
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2085185881
- Cited by
- 536
- References
- 61
- FWCI
- 16.89
- Type
- journal article
- Language
- en
- Open access
- green
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- Nazari-Jahantigh, M., Wei, Y., Noels, H., Akhtar, S., Zhou, Z., Koenen, R. R., Heyll, K., Gremse, F., Kiessling, F., Grommes, J., Weber, C., & Schober, A. (2012). MicroRNA-155 promotes atherosclerosis by repressing Bcl6 in macrophages. Journal of Clinical Investigation. https://doi.org/10.1172/jci61716
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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