The DOI matches its Crossref record; 83 of the 83 references it cites were found in a registry or an index.
Differentiation of progenitors in the liver: a matter of local choice
Open accessAbstract
The liver is a complex organ that requires multiple rounds of cell fate decision for development and homeostasis throughout the lifetime. During the earliest phases of organogenesis, the liver acquires a separate lineage from the pancreas and the intestine, and subsequently, the liver bud must appropriately differentiate to form metabolic hepatocytes and cholangiocytes for proper hepatic physiology. In addition, throughout life, the liver is bombarded with chemical and pathological insults, which require the activation and correct differentiation of adult progenitor cells. This Review seeks to provide an overview of the complex signaling relationships that allow these tightly regulated processes to occur.
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“Ductular reactions are activated in chronic liver injury and are thought to contain putative hepatic progenitor cells (HPCs) with the potential to regenerate hepatocytes and cholangiocytes6, 7.”
From Hepatic progenitor cells of biliary origin with liver repopulation capacity (2015) · cites this paper as [7]
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Self-citationGeneration and Regeneration of Cells of the Liver and Pancreas
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Metadata
- Authors
- Boulter, L., Lu, W.-Y., & Forbes, S. J.
- Affiliations
- MRC Centre for Regenerative Medicine (GB)
- Corresponding author
- Forbes, Stuart J.
- Venue
- Journal of Clinical Investigation
- Published
- 2013-05-01
- Volume
- 123
- Issue
- 5
- Pages
- 1867-1873
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC3635730
- OpenAlex
- W2095876709
- Cited by
- 116
- References
- 83
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 7 · 2023: 6 · 2022: 3 · 2021: 7 · 2020: 16 · 2019: 8 · 2018: 11 · 2017: 16 · 2016: 10 · 2015: 16 · 2014: 6 · 2013: 5
- FWCI
- 1.56
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Clinical Investigation (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Edinburgh Research Explorer (University of Edinburgh) (submittedVersion, other-oa)
- Funders
- Wellcome Trust
- Cancer Research UK
- Medical Research Council (MR/K017047/1)
- Topics
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Mesenchymal stem cell research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- liver development, liver progenitor cells, cell fate determination, hepatocyte differentiation, cholangiocyte differentiation, signaling pathways, liver regeneration, liver homeostasis, organogenesis
- MeSH terms
- Animals, Cell Cycle, Cell Differentiation, Hepatectomy, Humans, Inflammation, Ligands, Liver, Liver Neoplasms, Mitosis, Neoplasms, Stem Cells, Signal Transduction, Liver Transplantation, Cell Lineage, Living Donors, Mice, Rats
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