Cited by 116Liver physiology and pathologyMesenchymal stem cell researchDevelopmental Biology and Gene Regulation

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Differentiation of progenitors in the liver: a matter of local choice

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Boulter, Luke, Lu, Wei-Yu, Forbes, Stuart J.·2013·Journal of Clinical Investigation

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Abstract

The liver is a complex organ that requires multiple rounds of cell fate decision for development and homeostasis throughout the lifetime. During the earliest phases of organogenesis, the liver acquires a separate lineage from the pancreas and the intestine, and subsequently, the liver bud must appropriately differentiate to form metabolic hepatocytes and cholangiocytes for proper hepatic physiology. In addition, throughout life, the liver is bombarded with chemical and pathological insults, which require the activation and correct differentiation of adult progenitor cells. This Review seeks to provide an overview of the complex signaling relationships that allow these tightly regulated processes to occur.

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Authors: Boulter, L., Lu, W.-Y., & Forbes, S. J.
Affiliations: MRC Centre for Regenerative Medicine (GB)
Corresponding author: Forbes, Stuart J.
ORCID: Boulter, Luke
Lu, Wei-Yu
Forbes, Stuart J.
Venue: Journal of Clinical Investigation
Publisher: American Society for Clinical Investigation
Published: 2013-05-01
Volume: 123
Issue: 5
Pages: 1867-1873
ISSN: 0021-9738 (ISSN-L)
DOI: 10.1172/jci66026
PMC: PMC3635730
OpenAlex: W2095876709
Cited by: 116
References: 83
Citations by year: 2026: 2 · 2025: 3 · 2024: 7 · 2023: 6 · 2022: 3 · 2021: 7 · 2020: 16 · 2019: 8 · 2018: 11 · 2017: 16 · 2016: 10 · 2015: 16 · 2014: 6 · 2013: 5
FWCI: 1.56
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Journal of Clinical Investigation (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Edinburgh Research Explorer (University of Edinburgh) (submittedVersion, other-oa)
Funders: Wellcome Trust
Cancer Research UK
Medical Research Council (MR/K017047/1)
Topics: Health Sciences › Medicine › Hepatology › Liver physiology and pathology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Mesenchymal stem cell research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Keywords: liver development, liver progenitor cells, cell fate determination, hepatocyte differentiation, cholangiocyte differentiation, signaling pathways, liver regeneration, liver homeostasis, organogenesis
MeSH terms: Animals, Cell Cycle, Cell Differentiation, Hepatectomy, Humans, Inflammation, Ligands, Liver, Liver Neoplasms, Mitosis, Neoplasms, Stem Cells, Signal Transduction, Liver Transplantation, Cell Lineage, Living Donors, Mice, Rats

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Differentiation of progenitors in the liver: a matter of local choice

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