The DOI matches its Crossref record; 83 of the 83 references it cites were found in a registry or an index.
Differentiation of progenitors in the liver: a matter of local choice
Open accessAbstract
The liver is a complex organ that requires multiple rounds of cell fate decision for development and homeostasis throughout the lifetime. During the earliest phases of organogenesis, the liver acquires a separate lineage from the pancreas and the intestine, and subsequently, the liver bud must appropriately differentiate to form metabolic hepatocytes and cholangiocytes for proper hepatic physiology. In addition, throughout life, the liver is bombarded with chemical and pathological insults, which require the activation and correct differentiation of adult progenitor cells. This Review seeks to provide an overview of the complex signaling relationships that allow these tightly regulated processes to occur.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Ductular reactions are activated in chronic liver injury and are thought to contain putative hepatic progenitor cells (HPCs) with the potential to regenerate hepatocytes and cholangiocytes6, 7.”
From Hepatic progenitor cells of biliary origin with liver repopulation capacity (2015) · cites this paper as [7]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Identification of stem cells in small intestine and colon by marker gene Lgr5
Barker, N., van Es, J. H., Kuipers, J., Kujala, P., van den Born, M., Cozijnsen, M., Haegebarth, A., Korving, J., Begthel, H., Peters, P. J., et al. (2007) · Nature · doi:10.1038/nature06196 · Cited by 5,687
Notch signalling: a simple pathway becomes complex
Bray, S. J. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2009 · Cited by 2,620
Adult pancreatic β-cells are formed by self-duplication rather than stem-cell differentiation
Dor, Y., Brown, J., Martinez, O. I., & Melton, D. A. (2004) · Nature · doi:10.1038/nature02520 · Cited by 2,219
Intestinal polyposis in mice with a dominant stable mutation of the β‐catenin gene
Harada, N., Tamai, Y., Ishikawa, T., Sauer, B., Takaku, K., Oshima, M., & Taketo, M. M. (1999) · The EMBO Journal · doi:10.1093/emboj/18.21.5931 · Cited by 1,212
Normal and neoplastic nonstem cells can spontaneously convert to a stem-like state
Chaffer, C. L., Brueckmann, I., Scheel, C., Kaestli, A. J., Wiggins, P. A., Rodrigues, L. O., Brooks, M. W., Reinhardt, F., Su, Y., Polyák, K., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1102454108 · Cited by 1,170
Rawlins, E. L., Okubo, T., Xue, Y., Brass, D. M., Auten, R. L., Hasegawa, H., Wang, F., & Hogan, B. L. M. (2009) · Cell stem cell · doi:10.1016/j.stem.2009.04.002 · Cited by 872
Furuyama, K., Kawaguchi, Y., Akiyama, H., Horiguchi, M., Kodama, S., Kuhara, T., Hosokawa, S., Elbahrawy, A., Soeda, T., Koizumi, M., et al. (2010) · Nature Genetics · doi:10.1038/ng.722 · Cited by 841
Kretzschmar, K., & Watt, F. M. (2012) · Cell · doi:10.1016/j.cell.2012.01.002 · Cited by 756
Boulter, L., Govaere, O., Bird, T. G., Radulescu, S., Ramachandran, P., Pellicoro, A., Ridgway, R. A., Seo, S. S., Spee, B., Van Rooijen, N., et al. (2012) · Nature Medicine · doi:10.1038/nm.2667 · Cited by 747
Self-citationGeneration and Regeneration of Cells of the Liver and Pancreas
Zaret, K. S., & Grompe, M. (2008) · Science · doi:10.1126/science.1161431 · Cited by 598
Cited by
Sorted by citations
Liver fibrosis and repair: Immune regulation of wound healing in a solid organ
Pellicoro, A., Ramachandran, P., Iredale, J. P., & Fallowfield, J. A. (2014) · Nature Reviews Immunology · doi:10.1038/nri3623 · Cited by 1,310
Hepatic progenitor cells of biliary origin with liver repopulation capacity
Lu, W.-Y., Bird, T. G., Boulter, L., Tsuchiya, A., Cole, A. M., Hay, T., Guest, R. V., Wojtacha, D., Man, T. Y., Mackinnon, A., et al. (2015) · Nature Cell Biology · doi:10.1038/ncb3203 · Cited by 479
Self-citationSingle-cell technologies in hepatology: new insights into liver biology and disease pathogenesis
Ramachandran, P., Matchett, K. P., Dobie, R., Wilson-Kanamori, J. R., & Henderson, N. C. (2020) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-020-0304-x · Cited by 253
Hepatic Ischemia/Reperfusion: Mechanisms of Tissue Injury, Repair, and Regeneration
Konishi, T., & Lentsch, A. B. (2017) · Gene Expression · doi:10.3727/105221617x15042750874156 · Cited by 243
The balancing act of the liver: tissue regeneration versus fibrosis
Cordero-Espinoza, L., & Huch, M. (2018) · Journal of Clinical Investigation · doi:10.1172/jci93562 · Cited by 233
Hepatocellular carcinoma originates from hepatocytes and not from the progenitor/biliary compartment
Mu, X., Español‐Suñer, R., Mederacke, I., Affò, S., Manco, R., Sempoux, C. L., Lemaigre, F. P., Adili, A., Yuan, D., Weber, A., et al. (2015) · Journal of Clinical Investigation · doi:10.1172/jci77995 · Cited by 224
Lee, D.-H., Park, J. O., Kim, T.-S., Kim, S.-K., Kim, T.-H., Kim, M.-C., Park, G. S., Kim, J.-H., Kuninaka, S., Olson, E. N., et al. (2016) · Nature Communications · doi:10.1038/ncomms11961 · Cited by 196
Emerging evidence on the role of the Hippo/YAP pathway in liver physiology and cancer
Yimlamai, D., Fowl, B. H., & Camargo, F. D. (2015) · Journal of Hepatology · doi:10.1016/j.jhep.2015.07.008 · Cited by 177
Alisi, A., Carpino, G., de Oliveira, F. L., Panera, N., Nobili, V., & Gaudio, E. (2017) · Mediators of Inflammation · doi:10.1155/2017/8162421 · Cited by 172
Liver Cancer: Molecular Characterization, Clonal Evolution and Cancer Stem Cells
Castelli, G., Pelosi, E., & Testa, U. (2017) · Cancers · doi:10.3390/cancers9090127 · Cited by 162
EpCAM and the biology of hepatic stem/progenitor cells
Dollé, L., Theise, N. D., Schmelzer, E., Boulter, L., Gires, O., & van Grunsven, L. A. (2014) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00069.2014 · Cited by 129
Self-citationDisease Modeling and Gene Therapy of Copper Storage Disease in Canine Hepatic Organoids
Assawarachan, S. N., Spee, B., Kruitwagen, H. S., Chen, C., Geijsen, N., Oosterhoff, L. A., van Wolferen, M. E., Pelaez-Llaneza, N., Fieten, H., Wubbolts, R., et al. (2015) · Stem Cell Reports · doi:10.1016/j.stemcr.2015.09.002 · Cited by 119
Specific fate decisions in adult hepatic progenitor cells driven by MET and EGFR signalingPreprint
Kitade, M., Factor, V. M., Andersen, J. B., Tomokuni, A., Kaji, K., Akita, H., Holczbauer, Á., Seo, D., Marquardt, J. U., Conner, E. A., et al. (2013) · Genes & Development · doi:10.1101/gad.214601.113 · Cited by 111
Sutherland, J. J., Webster, Y., Willy, J. A., Searfoss, G. H., Goldstein, K. M., Irizarry, A. R., Hall, D. G., & Stevens, J. L. (2017) · The Pharmacogenomics Journal · doi:10.1038/tpj.2017.17 · Cited by 95
Verstegen, M. M. A., Roos, F. J. M., Burka, K., Gehart, H., Jager, M., de Wolf, M., Bijvelds, M. J. C., de Jonge, H. R., Ardisasmita, A. I., van Huizen, N. A., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-79082-8 · Cited by 86
Interleukin 22 in Liver Injury, Inflammation and Cancer
Wu, Y., Min, J., Ge, C., Shu, J., Tian, D., Yuan, Y., & Zhou, D. (2020) · International Journal of Biological Sciences · doi:10.7150/ijbs.38925 · Cited by 87
Carpino, G., Cardinale, V., Folseraas, T., Overi, D., Floreani, A., Franchitto, A., Onori, P., Cazzagon, N., Berloco, P. B., Karlsen, T. H., et al. (2017) · American Journal Of Pathology · doi:10.1016/j.ajpath.2017.11.010 · Cited by 80
Cordero-Espinoza, L., Dowbaj, A. M., Kohler, T. N., Strauss, B., Sarlidou, O., Belenguer, G., Pacini, C., Martins, N. P., Dobie, R., Wilson-Kanamori, J. R., et al. (2021) · Cell Stem Cell · doi:10.1016/j.stem.2021.07.002 · Cited by 74
“The regenerative capacity of the liver epithelium bespeaks not only cell-intrinsic plasticity but also an instructive microenvironment capable of guiding epithelial fate choices (Boulter et al., 2013).”
BackgroundThe Therapeutic Promise of Mesenchymal Stem Cells for Liver Restoration
Christ, B., Brückner, S., & Winkler, S. (2015) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2015.09.004 · Cited by 77
Stem/Progenitor Cell Niches Involved in Hepatic and Biliary Regeneration
Carpino, G., Renzi, A., Franchitto, A., Cardinale, V., Onori, P., Reid, L. M., Alvaro, D., & Gaudio, E. (2016) · Stem Cells International · doi:10.1155/2016/3658013 · Cited by 75
Underlying potential: cellular and molecular determinants of adult liver repair
Diehl, A. M., & Chute, J. P. (2013) · Journal of Clinical Investigation · doi:10.1172/jci69966 · Cited by 72
Terai, S., & Tsuchiya, A. (2016) · Journal of Gastroenterology · doi:10.1007/s00535-016-1258-1 · Cited by 71
Carpino, G., Renzi, A., Onori, P., & Gaudio, E. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms141020112 · Cited by 69
Regulation of hepatocyte identity and quiescence
Berasain, C., & Avila, M. A. (2015) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-015-1970-7 · Cited by 64
Hepatocyte Injury and Hepatic Stem Cell Niche in the Progression of Non-Alcoholic Steatohepatitis
Overi, D., Carpino, G., Franchitto, A., Onori, P., & Gaudio, E. (2020) · Cells · doi:10.3390/cells9030590 · Cited by 62
Carpino, G., Pastori, D., Baratta, F., Overi, D., Labbadia, G., Polimeni, L., Costanzo, A. D., Pannitteri, G., Carnevale, R., Ben, M. D., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-15943-z · Cited by 59
The hippo pathway: A master regulator of liver metabolism, regeneration, and disease
Nguyen‐Lefebvre, A. T., Selzner, N., Wrana, J. L., & Bhat, M. (2021) · The FASEB Journal · doi:10.1096/fj.202002284rr · Cited by 58
A Hepatic Scaffold from Decellularized Liver Tissue: Food for Thought
Croce, S., Peloso, A., Zoro, T., Avanzini, M. A., & Cobianchi, L. (2019) · Biomolecules · doi:10.3390/biom9120813 · Cited by 59
Rizvi, F., Lee, Y., Díaz‐Aragon, R., Bawa, P., So, J., Florentino, R. M., Wu, S. Y., Sarjoo, A., Truong, E., Smith, A. R., et al. (2023) · Cell stem cell · doi:10.1016/j.stem.2023.10.008 · Cited by 59
The role of liver progenitor cells during liver regeneration, fibrogenesis, and carcinogenesis
Köhn‐Gaone, J., Gogoi-Tiwari, J., Ramm, G. A., Olynyk, J. K., & Tirnitz‐Parker, J. E. E. (2015) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00215.2015 · Cited by 58
Lua, I., James, D., Wang, J., Wang, K. S., & Asahina, K. (2014) · Hepatology · doi:10.1002/hep.27035 · Cited by 55
Carpino, G., Nevi, L., Overi, D., Cardinale, V., Lu, W., Matteo, S. D., Safarikia, S., Berloco, P. B., Venere, R., Onori, P., et al. (2019) · Hepatology · doi:10.1002/hep.30871 · Cited by 56
Self-citationTFEB regulates murine liver cell fate during development and regeneration
Pastore, N., Huynh, T., Herz, N. J., Calcagnì, A., Klisch, T. J., Brunetti, L., Kim, K. H., Giorgi, M. D., Hurley, A. E., Carissimo, A., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-16300-x · Cited by 53
Self-citationThe diversity and plasticity of adult hepatic progenitor cells and their niche
Chen, J., Chen, L., Zern, M. A., Theise, N. D., Diehl, A. M., Liu, P., & Duan, Y. (2017) · Liver International · doi:10.1111/liv.13377 · Cited by 51
GATA4 loss of function in liver cancer impedes precursor to hepatocyte transition
Enane, F. O., Shuen, T. W. H., Gu, X., Ebrahem, Q., Przychodzen, B. P., Makishima, H., Bodo, J., Ng, J., Chee, C. L., Ba, R., et al. (2017) · Journal of Clinical Investigation · doi:10.1172/jci93488 · Cited by 48
Contribution of Resident Stem Cells to Liver and Biliary Tree Regeneration in Human Diseases
Overi, D., Carpino, G., Cardinale, V., Franchitto, A., Safarikia, S., Onori, P., Alvaro, D., & Gaudio, E. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19102917 · Cited by 52
Hepatic progenitor cell activation in liver repair
Bria, A., Marda, J., Zhou, J., Sun, X., Cao, Q., Petersen, B. E., & Pi, L. (2017) · Liver Research · doi:10.1016/j.livres.2017.08.002 · Cited by 49
Fraser, A. R., Pass, C., Burgoyne, P., Atkinson, A. P. M., Bailey, L., Laurie, A., McGowan, N. W. A., Hamid, A., Moore, J. K., Dwyer, B. J., et al. (2017) · Cytotherapy · doi:10.1016/j.jcyt.2017.05.009 · Cited by 45
Self-citationNobili, V., Carpino, G., PEPPO, F. D., Caccamo, R., Mosca, A., Romito, I., Overi, D., Franchitto, A., Onori, P., Alisi, A., et al. (2017) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2017.10.036 · Cited by 44
TWEAK and LTβ Signaling during Chronic Liver Disease
Dwyer, B. J., Olynyk, J. K., Ramm, G. A., & Tirnitz‐Parker, J. E. E. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00039 · Cited by 41
Haele, M. V., & Roskams, T. (2017) · Gastroenterology Clinics of North America · doi:10.1016/j.gtc.2017.01.011 · Cited by 41
Köhn‐Gaone, J., Dwyer, B. J., Grzelak, C. A., Miller, G. C., Shackel, N. A., Ramm, G. A., McCaughan, G. W., Elsegood, C. L., Olynyk, J. K., & Tirnitz‐Parker, J. E. E. (2016) · American Journal Of Pathology · doi:10.1016/j.ajpath.2016.03.005 · Cited by 38
Implantable Vascularized Liver Chip for Cross‐Validation of Disease Treatment with Animal Model
Lee, J. B., Park, J. S., Shin, Y. M., Lee, D. H., Yoon, J., Kim, D., Ko, U. H., Kim, Y., Bae, S. H., & Sung, H. (2019) · Advanced Functional Materials · doi:10.1002/adfm.201900075 · Cited by 38
Pathogenesis and Prognosis of Hepatocellular Carcinoma at the Cellular and Molecular Levels
Govaere, O., & Roskams, T. (2015) · Clinics in Liver Disease · doi:10.1016/j.cld.2015.01.002 · Cited by 37
Human Amnion Epithelial Cell Therapy for Chronic Liver Disease
Andrewartha, N., & Yeoh, G. C. (2019) · Stem Cells International · doi:10.1155/2019/8106482 · Cited by 34
Wang, W., Feng, Y., Yasen, A., Jin, X., Mao, X., & Li, D. (2017) · Journal of Cellular Physiology · doi:10.1002/jcp.26304 · Cited by 31
Macrophages and Stem Cells—Two to Tango for Tissue Repair?
Manole, E., Niculite, C. M., Lambrescu, I. M., Gaina, G. F., Ioghen, O. C., Ceafalan, L. C., & Hinescu, M. E. (2021) · Biomolecules · doi:10.3390/biom11050697 · Cited by 33
GODDI, A. A., Schroedl, L. M., Brey, E. M., & Cohen, R. (2021) · Metabolism · doi:10.1016/j.metabol.2021.154775 · Cited by 33
Extracellular Vesicles for the Treatment of Radiation Injuries
Nanduri, L. S. Y., Duddempudi, P. K., Yang, W.-L., Tamarat, R., & Guha, C. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.662437 · Cited by 30
Xue, F., Hu, L., Ge, R., Yang, L., Liu, K., Li, Y., Sun, Y., & Wang, K. (2015) · Cancer Letters · doi:10.1016/j.canlet.2015.11.022 · Cited by 32
Asbestos and Intrahepatic Cholangiocarcinoma
Brandi, G., & Tavolari, S. (2020) · Cells · doi:10.3390/cells9020421 · Cited by 29
ADAM-Mediated Signalling Pathways in Gastrointestinal Cancer Formation
Schumacher, N., Rose‐John, S., & Schmidt‐Arras, D. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21145133 · Cited by 27
Unmasking the Deceptive Nature of Cancer Stem Cells: The Role of CD133 in Revealing Their Secrets
Pospieszna, J., Dams‐Kozlowska, H., Udomsak, W., Murias, M., & Kucińska, M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241310910 · Cited by 27
Role of YAP1 Signaling in Biliary Development, Repair, and Disease
Molina, L. M., Nejak‐Bowen, K. N., & Monga, S. P. (2022) · Seminars in Liver Disease · doi:10.1055/s-0041-1742277 · Cited by 29
Li, H., Sun, S., Lei, Q., Lei, P., Cai, X., Wan, C., & Shen, G. (2018) · Journal of Immunology Research · doi:10.1155/2018/4807145 · Cited by 24
Fibrotic liver has prompt recovery after ischemia-reperfusion injury
Konishi, T., Schuster, R. M., Goetzman, H. S., Caldwell, C. C., & Lentsch, A. B. (2020) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00137.2019 · Cited by 24
Improved Human Mesenchymal Stem Cell Isolation
Chan, T.-M., Harn, H., Lin, H.-P., Chou, P.-W., Chen, J. Y.-R., Ho, T., Chiou, T., Chuang, H.-M., Chiu, S., Chen, Y., et al. (2014) · Cell Transplantation · doi:10.3727/096368914x678292 · Cited by 23
Advances in hepatic stem/progenitor cell biology
Verhulst, S., Best, J., van Grunsven, L. A., & Dollé, L. (2015) · PubMed Central · doi:10.17179/excli2014-576 · Cited by 23
Synthetic symmetry breaking and programmable multicellular structure formation
Wauford, N., Patel, A. M., Tordoff, J., Enghuus, C., Jin, A., Toppen, J., Kemp, M. L., & Weiss, R. (2023) · Cell Systems · doi:10.1016/j.cels.2023.08.001 · Cited by 21
Loss ofAnks6leads to YAP deficiency and liver abnormalities
Airik, M., Schüler, M., McCourt, B. T., Weiss, A., Herdman, N., Lüdtke, T. H., Widmeier, E., Stolz, D. B., Nejak‐Bowen, K. N., Yimlamai, D., et al. (2020) · Human Molecular Genetics · doi:10.1093/hmg/ddaa197 · Cited by 21
Zhao, L., Gong, Y.-Q., Wang, Y., Liu, B., Chu, Y., Gui, S., Zheng, Y., & Chen, X. (2021) · Frontiers in Nutrition · doi:10.3389/fnut.2021.791861 · Cited by 19
Molecular Survey of Cell Source Usage during Subtotal Hepatectomy-Induced Liver Regeneration in Rats
Elchaninov, A. V., Fatkhudinov, T., Usman, N. Y., Kananykhina, E. Y., Arutyunyan, I. V., Макаров, А. В., Bolshakova, G. B., Goldshtein, D. V., & Sukhikh, G. T. (2016) · PLoS ONE · doi:10.1371/journal.pone.0162613 · Cited by 19
Redox cell signaling and hepatic progenitor cells
di Bello, G., Vendemiale, G., & Bellanti, F. (2018) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2018.09.004 · Cited by 18
Cardiomyocyte proliferation vs progenitor cells in myocardial regeneration: The debate continues
Malliaras, K. G., & Terrovitis, J. V. (2013) · Global Cardiology Science and Practice · doi:10.5339/gcsp.2013.37 · Cited by 17
Brouard, N., Jost, C., Matthias, N., Albrecht, C., Egard, S., Gandhi, P., Strassel, C., Inoue, T., Sugiyama, D., Simmons, P. J., et al. (2017) · Blood Advances · doi:10.1182/bloodadvances.2016003541 · Cited by 16
Miura, Y., Matsui, S., Miyata, N., Harada, K., Kikkawa, Y., Ohmuraya, M., Araki, K., Tsurusaki, S., Okochi, H., Goda, N., et al. (2018) · eLife · doi:10.7554/elife.36572 · Cited by 14
The versatile and plastic liver
Huch, M. (2015) · Nature · doi:10.1038/517155a · Cited by 12
Ductular reaction in non-alcoholic fatty liver disease: When Macbeth is perverted
He, Y.-H., Pan, J., Xu, L., Gu, T., & Chen, Y. (2023) · World Journal of Hepatology · doi:10.4254/wjh.v15.i6.725 · Cited by 11
Shi, D., Xin, J., Lu, Y., Ding, W., Jiang, J., Zhou, Q., Sun, S., Guo, B., Zhou, X., & Li, . (2020) · International Journal of Medical Sciences · doi:10.7150/ijms.36255 · Cited by 11
Syndecan-4 promotes vascular beds formation in tissue engineered liver via thrombospondin 1
Hu, X. V., Chen, J., Huang, H., Yin, S., Zheng, S., & Zhou, L. (2020) · Bioengineered · doi:10.1080/21655979.2020.1846897 · Cited by 11
Tsang, H. Y., Lo, P. H. Y., & Lee, K. K. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.06.29.450347 · Cited by 10
Innate heart regeneration: endogenous cellular sources and exogenous therapeutic amplification
Malliaras, K. G., Vakrou, S., Kapelios, C. J., & Nanas, J. N. (2016) · Expert Opinion on Biological Therapy · doi:10.1080/14712598.2016.1218846 · Cited by 9
Mir-382 Promotes Differentiation of Rat Liver Progenitor Cell WB-F344 by Targeting Ezh2
Zheng, Y., Zhou, J.-S., Li, X., Xu, G., Jin, M., Shen, R., Su, R., Zhan, S., Ding, B., Jia, M., et al. (2018) · Cellular Physiology and Biochemistry · doi:10.1159/000492654 · Cited by 9
Zhang, R., Zeng, X., Lin, Z., Ming-Fu, Tong, Y., Lui, V. C. H., Tam, P. K. H., Lamb, J. R., Xia, H.-M., & Chen, Y. (2018) · World Journal of Gastroenterology · doi:10.3748/wjg.v24.i29.3260 · Cited by 8
Exploring the roles of non-coding RNAs in liver regeneration
Li, P., Ma, X., Huang, D., & Gu, X. (2024) · Non-coding RNA Research · doi:10.1016/j.ncrna.2024.04.003 · Cited by 8
Navigating the Paradox of IL‐22: Friend or Foe in Hepatic Health?
Qin, J., Zhu, W., & Zhou, W. (2025) · Journal of Gastroenterology and Hepatology · doi:10.1111/jgh.16991 · Cited by 8
Une seule cellule souche dans le foie : l’hépatocyte !
Gilgenkrantz, H. (2015) · médecine/sciences · doi:10.1051/medsci/20153104004 · Cited by 7
Potential of regenerative medicine techniques in canine hepatology
Schotanus, B. A., Penning, L. C., & Spee, B. (2013) · Veterinary Quarterly · doi:10.1080/01652176.2013.875240 · Cited by 7
Redox Control of the Immune Response in the Hepatic Progenitor Cell Niche
Bellanti, F., Pannone, G., Tartaglia, N., & Serviddio, G. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00295 · Cited by 6
Plant-Derived Nrf2 Activators to Enhance Liver Antioxidative and Regenerative Potentials
Tee, T.-X., Kee, L. T., Chai, T., Yam, H. C., Reza, H. M., Wong, F., Law, J. X., & Tan, S.-A. S. W. (2024) · Revista Brasileira de Farmacognosia · doi:10.1007/s43450-024-00609-5 · Cited by 6
Chemical Screening Using a Zebrafish Model for Liver Progenitor Cell-Driven Liver Regeneration
Ko, S., & Shin, D. (2018) · Methods in molecular biology · doi:10.1007/978-1-4939-8961-4_8 · Cited by 5
Liver Progenitor Cells: Cellular Origins, Plasticity, and Signaling Pathways in Liver Regeneration
Han, J., Sung, A., Jeong, H., & Jung, Y. (2025) · Biology · doi:10.3390/biology14101361 · Cited by 5
Aripov, A. N., Akhunzhanova, L. L., Nabiev, A. U., Aripov, O. A., & Khamroev, T. T. (2024) · Biomedical & Pharmacology Journal · doi:10.13005/bpj/3063 · Cited by 7
Rókusz, A., Bugyik, E., Szabó, V., Szücs, A., Paku, S., Nagy, P., & Dezső, K. (2016) · International Journal of Experimental Pathology · doi:10.1111/iep.12209 · Cited by 4
Update on Hepatobiliary Plasticity
Kim, M., Rizvi, F., Shin, D., & Gouon–Evans, V. (2023) · Seminars in Liver Disease · doi:10.1055/s-0042-1760306 · Cited by 5
Omabe, M., Omabe, K. N., Igwe, D. O., John, O. C., Uchenna, S. K., & Elom, S. O. (2018) · Health · doi:10.4236/health.2018.103025 · Cited by 4
Biliary-derived hepatocytes in chronic liver injury: Bringing new troops to the battlefield?
Aleksieva, N., & Forbes, S. J. (2019) · Journal of Hepatology · doi:10.1016/j.jhep.2019.03.015 · Cited by 4
Self-citationZhou, T., Wang, W., Yasen, A., Jin, X., Chen, Z., Chen, L., & Li, D. (2019) · Cytotechnology · doi:10.1007/s10616-018-0282-9 · Cited by 3
Gilloteaux, J. (2020) · Translational Research in Anatomy · doi:10.1016/j.tria.2020.100063 · Cited by 3
Non-canonical Wnt signalling initiates scarring in biliary diseasePreprint
Wilson, D. H., Mellin, R., Younger, N. T., Jarman, E. J., Raven, A., Chen, P., Dean, C. H., Henderson, D. J., Kendall, T. J., & Boulter, L. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/276196 · Cited by 3
Self-citationLee, S., Memon, A., Chae, S., Shin, D., & Choi, T. (2024) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2024.149512 · Cited by 2
He, X., Tang, R., Lou, J., & Wang, R. (2024) · Journal of Biological Physics · doi:10.1007/s10867-024-09665-3 · Cited by 2
Hepatic Progenitor Cells and Biliary Tree Stem Cells
Carpino, G., Morini, S., Carotti, S., & Gaudio, E. (2020) · Springer eBooks · doi:10.1007/978-3-030-24432-3_3 · Cited by 2
Mass production of stem cell derived human hepatocytes for experimental medicine
Wang, Y., & Hay, D. C. (2016) · Expert Review of Gastroenterology & Hepatology · doi:10.1080/17474124.2016.1182862 · Cited by 1
Wu, M., Rudenko, Y., & Griffin, C. T. (2026) · Development · doi:10.1242/dev.205538 · Cited by 1
Macrophage Therapy for Liver Fibrosis and Regeneration
Tsuchiya, A., & Forbes, S. J. (2015) · Springer eBooks · doi:10.1007/978-4-431-55666-4_2 · Cited by 1
Self-citationBrown, R. M. (2015) · Springer eBooks · doi:10.1007/978-3-319-19207-9_22
Role of Developmental Morphogens in Liver Regeneration
Machado, M. V., & Diehl, A. M. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-420128-6.00010-5
The Role of Biomechanics in Liver Tissue Engineering
Moran, E. C. (2015) · WakeSpace Scholarship (Wake Forest University)
Ectopic Hepatocellular Carcinoma
Zimmermann, A. (2016) · Springer eBooks · doi:10.1007/978-3-319-26587-2_15-1
Metadata
- Authors
- Boulter, L., Lu, W.-Y., & Forbes, S. J.
- Affiliations
- MRC Centre for Regenerative Medicine (GB)
- Corresponding author
- Forbes, Stuart J.
- Venue
- Journal of Clinical Investigation
- Published
- 2013-05-01
- Volume
- 123
- Issue
- 5
- Pages
- 1867-1873
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC3635730
- OpenAlex
- W2095876709
- Cited by
- 116
- References
- 83
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 7 · 2023: 6 · 2022: 3 · 2021: 7 · 2020: 16 · 2019: 8 · 2018: 11 · 2017: 16 · 2016: 10 · 2015: 16 · 2014: 6 · 2013: 5
- FWCI
- 1.56
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Clinical Investigation (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Edinburgh Research Explorer (University of Edinburgh) (submittedVersion, other-oa)
- Funders
- Wellcome Trust
- Cancer Research UK
- Medical Research Council (MR/K017047/1)
- Topics
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Mesenchymal stem cell research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- liver development, liver progenitor cells, cell fate determination, hepatocyte differentiation, cholangiocyte differentiation, signaling pathways, liver regeneration, liver homeostasis, organogenesis
- MeSH terms
- Animals, Cell Cycle, Cell Differentiation, Hepatectomy, Humans, Inflammation, Ligands, Liver, Liver Neoplasms, Mitosis, Neoplasms, Stem Cells, Signal Transduction, Liver Transplantation, Cell Lineage, Living Donors, Mice, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review