Cited by 854Metabolism, Diabetes, and CancerAdipokines, Inflammation, and Metabolic DiseasesPI3K/AKT/mTOR signaling in cancer

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Protein–protein interaction in insulin signaling and the molecular mechanisms of insulin resistance

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Virkamäki, Antti, Ueki, Kohjiro, Kahn, C. Ronald·1999·Journal of Clinical Investigation

DOI 10.1172/jci6609PMC PMC408269

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Abstract

Perspective Figure 1 Schematic illustration of major signaling pathways of insulin action.The phosphorylated insulin receptor binds and phosphorylates IRS proteins and Shc, which bind differentially to various downstream signaling proteins.PI3-kinase is critical for metabolic actions of insulin, such as glucose transport, glycogen synthesis, and protein synthesis, whereas Grb-2/SOS complex, which activates the MAP kinase cascade, is critical in mitogenic response.PI3-kinase probably modulates the mitogenic response as well.This series continues from the March 1999, no.6, issue.

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CAN NITRIC OXIDE‐GENERATING COMPOUNDS IMPROVE THE OXIDATIVE STRESS RESPONSE IN EXPERIMENTALLY DIABETIC RATS?
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IP-GCN: A deep learning model for prediction of insulin using graph convolutional network for diabetes drug design
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Sam68 associates with the SH3 domains of Grb2 recruiting GAP to the Grb2‐SOS complex in insulin receptor signaling
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Insulin-Like Growth Factor Binding Protein-6 Promotes the Differentiation of Placental Mesenchymal Stem Cells into Skeletal Muscle Independent of Insulin-Like Growth Factor Receptor-1 and Insulin Receptor
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Authors: Virkamäki, A., Ueki, K., & Kahn, C. R.
Affiliations: Joslin Diabetes Center (US)
Corresponding author: Kahn, C. Ronald
ORCID: Ueki, Kohjiro
Kahn, C. Ronald
Venue: Journal of Clinical Investigation
Publisher: American Society for Clinical Investigation
Published: 1999-04-01
Volume: 103
Issue: 7
Pages: 931-943
ISSN: 0021-9738 (ISSN-L)
DOI: 10.1172/jci6609
PMC: PMC408269
OpenAlex: W2095252238
Cited by: 854
References: 176
Citations by year: 2026: 4 · 2025: 4 · 2024: 15 · 2023: 8 · 2022: 15 · 2021: 12 · 2020: 13 · 2019: 16 · 2018: 13 · 2017: 21 · 2016: 22 · 2015: 26 · 2014: 24 · 2013: 27 · 2012: 31
FWCI: 4.88
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Clinical Investigation (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: European Foundation for the Study of Diabetes
National Institutes of Health (DK31036)
National Institute of Diabetes and Digestive and Kidney Diseases (R37DK031036, DK 33201, R01DK031036, DK45935, DK31036, R01DK045935, R01DK033201)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
Keywords: insulin signaling, insulin resistance, protein-protein interaction, insulin receptor, Shc, PI3-kinase, MAP kinase cascade, glucose transport, glycogen synthesis, mitogen response
MeSH terms: Animals, Humans, Insulin, Insulin Resistance, Phosphorylation, Protein Binding, Receptor, Insulin, Signal Transduction, Gene Targeting, src Homology Domains, Phosphatidylinositol 3-Kinases

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Protein–protein interaction in insulin signaling and the molecular mechanisms of insulin resistance

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