The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
Rapid generation of broad T-cell immunity in humans after a single injection of mature dendritic cells
Open accessAbstract
Dendritic cells (DCs) are potent antigen-presenting cells that initiate protective T-cell immunity in mice. To study the immunogenicity of DCs in humans, we injected 9 healthy subjects subcutaneously with a control injection of autologous monocyte-derived, mature DCs, followed 4-6 weeks later by DCs pulsed with keyhole limpet hemocyanin (KLH), HLA-A*0201-positive restricted influenza matrix peptide (MP), and tetanus toxoid (TT). Four more subjects received these antigens without DCs. Injection of unpulsed DCs, or antigens alone, failed to immunize. Priming of CD4(+) T cells to KLH was observed in all 9 subjects injected with KLH-pulsed DCs, and boosting of TT-specific T-cell immunity was seen in 5 of 6 subjects injected with TT-pulsed DCs. Injection of antigen-pulsed DCs led to a severalfold increase in freshly isolated MP-specific, IFN-gamma-secreting CD8(+) T cells in all 6 HLA-A*0201-positive subjects, as early as 7 days after injection. When T cells were boosted in culture, there was an increase in MHC tetramer-binding cells and cytotoxic T cells after DC vaccination. These data provide the first controlled evidence of the immunogenicity of DCs in humans, and demonstrate that a single injection of mature DCs rapidly expands T-cell immunity.
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Citations
Cites
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Cited by
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Self-citationImmunosuppressive networks in the tumour environment and their therapeutic relevance
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Antigen Presentation and T Cell Stimulation by Dendritic Cells
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T-Cell Function and Migration — Two Sides of the Same Coin
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Self-citation
Metadata
- Authors
- Dhodapkar, M. V., Steinman, R. M., Sapp, M., Desai, H., Fossella, C., Krasovsky, J., Donahoe, S. M., Dunbar, P. R., Cerundolo, V., Nixon, D. F., & Bhardwaj, N.
- Venue
- Journal of Clinical Investigation
- Published
- 1999-07-15
- Volume
- 104
- Issue
- 2
- Pages
- 173-180
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2027351381
- Cited by
- 468
- References
- 29
- FWCI
- 15.70
- Type
- journal article
- Language
- en
- Open access
- bronze
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