The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Inflammation-associated lymphangiogenesis: a double-edged sword?
Open accessAbstract
Lymphangiogenesis and lymphatic vessel remodeling are complex biological processes frequently observed during inflammation. Accumulating evidence indicates that inflammation-associated lymphangiogenesis (IAL) is not merely an endpoint event, but actually a phenomenon actively involved in the pathophysiology of various inflammatory disorders. The VEGF-C/VEGFR-3 and VEGF-A/VEGF-R2 signaling pathways are two of the best-studied pathways in IAL. Methods targeting these molecules, such as prolymphangiogenic or antilymphatic treatments, were found to be beneficial in various preclinical and/or clinical studies. This Review focuses on the most recent achievements in the fields of lymphatic biology relevant to inflammatory conditions. Additionally, preclinical and clinical therapies that modulate IAL are summarized.
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Inflammation and insulin resistance
Shoelson, S. E. (2006) · Journal of Clinical Investigation · doi:10.1172/jci29069 · Cited by 4,769
Type 2 diabetes as an inflammatory disease
Donath, M. Y., & Shoelson, S. E. (2011) · Nature Reviews Immunology · doi:10.1038/nri2925 · Cited by 3,737
Resolution of inflammation: the beginning programs the end
Serhan, C. N., & Savill, J. (2005) · Nature Immunology · doi:10.1038/ni1276 · Cited by 2,552
CCR7 and its ligands: balancing immunity and tolerance
Förster, R., Davalos-Misslitz, A. C., & Rot, A. (2008) · Nature Reviews Immunology · doi:10.1038/nri2297 · Cited by 1,410
An inflammation-induced mechanism for leukocyte transmigration across lymphatic vessel endothelium
Johnson, L. A., Clasper, S., Holt, A. P., Lalor, P. F., Baban, D., & Jackson, D. G. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20051759 · Cited by 346
Cited by
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Petrova, T. V., & Koh, G. Y. (2018) · Journal of Experimental Medicine · doi:10.1084/jem.20171868 · Cited by 304
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Ly, C., Kataru, R., & Mehrara, B. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18010171 · Cited by 164
Self-citationBrain-to-cervical lymph node signaling after stroke.
Esposito, E., Ahn, B. J., Shi, J., Nakamura, Y., Park, J. H., Mandeville, E. T., Yu, Z., Chan, S. J., Desai, R., Hayakawa, A., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-13324-w · Cited by 123
Metadata
- Authors
- Kim, H., Kataru, R. P., & Koh, G. Y.
- Venue
- Journal of Clinical Investigation
- Published
- 2014-03-03
- Volume
- 124
- Issue
- 3
- Pages
- 936-942
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2157933861
- Cited by
- 229
- References
- 5
- FWCI
- 9.34
- Type
- journal article
- Language
- en
- Open access
- bronze
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