Cited by 268Gut microbiota and healthPharmacogenetics and Drug MetabolismDrug Transport and Resistance Mechanisms

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Host-microbial interactions in the metabolism of therapeutic and diet-derived xenobiotics

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Carmody, Rachel N., Turnbaugh, Peter J.·2014·Journal of Clinical Investigation

DOI 10.1172/jci72335PMC PMC4191041

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Abstract

Our associated microbial communities play a critical role in human health and predisposition to disease, but the degree to which they also shape therapeutic interventions is not well understood. Here, we integrate results from classic and current studies of the direct and indirect impacts of the gut microbiome on the metabolism of therapeutic drugs and diet-derived bioactive compounds. We pay particular attention to microbial influences on host responses to xenobiotics, adding to the growing consensus that treatment outcomes reflect our intimate partnership with the microbial world, and providing an initial framework from which to consider a more comprehensive view of pharmacology and nutrition.

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Additional file 13 of The pregnane X receptor drives sexually dimorphic hepatic changes in lipid and xenobiotic metabolism in response to gut microbiota in mice
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Additional file 2 of The pregnane X receptor drives sexually dimorphic hepatic changes in lipid and xenobiotic metabolism in response to gut microbiota in mice
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Additional file 14 of The pregnane X receptor drives sexually dimorphic hepatic changes in lipid and xenobiotic metabolism in response to gut microbiota in mice
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Additional file 8 of The pregnane X receptor drives sexually dimorphic hepatic changes in lipid and xenobiotic metabolism in response to gut microbiota in mice
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Additional file 10 of The pregnane X receptor drives sexually dimorphic hepatic changes in lipid and xenobiotic metabolism in response to gut microbiota in mice
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Additional file 12 of The pregnane X receptor drives sexually dimorphic hepatic changes in lipid and xenobiotic metabolism in response to gut microbiota in mice
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Authors: Carmody, R. N., & Turnbaugh, P. J.
Corresponding author: Turnbaugh, Peter J.
ORCID: Carmody, Rachel N.
Turnbaugh, Peter J.
Venue: Journal of Clinical Investigation
Publisher: American Society for Clinical Investigation
Published: 2014-08-08
Volume: 124
Issue: 10
Pages: 4173-4181
ISSN: 0021-9738 (ISSN-L)
DOI: 10.1172/jci72335
PMC: PMC4191041
OpenAlex: W1964115194
Cited by: 268
References: 91
Citations by year: 2026: 17 · 2025: 16 · 2024: 10 · 2023: 15 · 2022: 23 · 2021: 47 · 2020: 33 · 2019: 26 · 2018: 21 · 2017: 19 · 2016: 23 · 2015: 14 · 2014: 3
FWCI: 1.85
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Clinical Investigation (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
eScholarship (California Digital Library) (submittedVersion)
Funders: Harvard University
National Institutes of Health
FAS Center for Systems Biology, Harvard University
National Institute of General Medical Sciences (P50GM068763)
National Institute of Diabetes and Digestive and Kidney Diseases (F32DK101154)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
Keywords: host-microbe interactions, gut microbiota, xenobiotic metabolism, drug metabolism, therapeutic drugs, personalized medicine
MeSH terms: Animals, Binding Sites, Diet, Humans, Intestines, Mice, Transgenic, Protein Binding, Xenobiotics, Gene Expression Regulation, Bacterial, Probiotics, Gastrointestinal Tract, Mice, Microbial Interactions, Microbiota

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Host-microbial interactions in the metabolism of therapeutic and diet-derived xenobiotics

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