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Additional file 1 of Pyruvate carboxylase promotes thyroid cancer aggressiveness through fatty acid synthesis

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Additional file 4 of Metabolic plasticity of IDH1-mutant glioma cell lines is responsible for low sensitivity to glutaminase inhibition

Ruiz‐Rodado, V., Lita, A., Dowdy, T., Celiku, O., Saldana, A. C., Wang, H., Yang, C. Z., Chari, R., Li, A., Zhang, W., et al. (2020) · Figshare · doi:10.6084/m9.figshare.13126629

Additional file 2 of Hypoxia-mediated repression of pyruvate carboxylase drives immunosuppression

Coleman, M. F., Cotul, E. K., Pfeil, A. J., Devericks, E. N., Safdar, M. H., Monteiro, M., Chen, H., Ho, A. N., Attaar, N., Malian, H. M., et al. (2024) · Figshare · doi:10.6084/m9.figshare.25997082

Additional file 5 of Hypoxia-mediated repression of pyruvate carboxylase drives immunosuppression

Coleman, M. F., Cotul, E. K., Pfeil, A. J., Devericks, E. N., Safdar, M. H., Monteiro, M., Chen, H., Ho, A. N., Attaar, N., Malian, H. M., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26731231

Additional file 1 of Hypoxia-mediated repression of pyruvate carboxylase drives immunosuppression

Coleman, M. F., Cotul, E. K., Pfeil, A. J., Devericks, E. N., Safdar, M. H., Monteiro, M., Chen, H., Ho, A. N., Attaar, N., Malian, H. M., et al. (2024) · Figshare · doi:10.6084/m9.figshare.25996812

Additional file 2 of Bayesian kinetic modeling for tracer-based metabolomic data

Zhang, X., Su, Y., Lane, A. N., Stromberg, A. J., Fan, T. W. M., & Wang, C. (2024) · Figshare · doi:10.6084/m9.figshare.26576969

Additional file 2 of Metabolic plasticity of IDH1-mutant glioma cell lines is responsible for low sensitivity to glutaminase inhibition

Ruiz‐Rodado, V., Lita, A., Dowdy, T., Celiku, O., Saldana, A. C., Wang, H., Yang, C. Z., Chari, R., Li, A., Zhang, W., et al. (2020) · Figshare · doi:10.6084/m9.figshare.13126623

Additional file 7 of Hypoxia-mediated repression of pyruvate carboxylase drives immunosuppression

Coleman, M. F., Cotul, E. K., Pfeil, A. J., Devericks, E. N., Safdar, M. H., Monteiro, M., Chen, H., Ho, A. N., Attaar, N., Malian, H. M., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26731237

Additional file 1 of Metabolic plasticity of IDH1-mutant glioma cell lines is responsible for low sensitivity to glutaminase inhibition

Ruiz‐Rodado, V., Lita, A., Dowdy, T., Celiku, O., Saldana, A. C., Wang, H., Yang, C. Z., Chari, R., Li, A., Zhang, W., et al. (2020) · Figshare · doi:10.6084/m9.figshare.13126620

Additional file 8 of Hypoxia-mediated repression of pyruvate carboxylase drives immunosuppression

Coleman, M. F., Cotul, E. K., Pfeil, A. J., Devericks, E. N., Safdar, M. H., Monteiro, M., Chen, H., Ho, A. N., Attaar, N., Malian, H. M., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26731240

Additional file 9 of Hypoxia-mediated repression of pyruvate carboxylase drives immunosuppression

Coleman, M. F., Cotul, E. K., Pfeil, A. J., Devericks, E. N., Safdar, M. H., Monteiro, M., Chen, H., Ho, A. N., Attaar, N., Malian, H. M., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26731243

Additional file 6 of Metabolic plasticity of IDH1-mutant glioma cell lines is responsible for low sensitivity to glutaminase inhibition

Ruiz‐Rodado, V., Lita, A., Dowdy, T., Celiku, O., Saldana, A. C., Wang, H., Yang, C. Z., Chari, R., Li, A., Zhang, W., et al. (2020) · Figshare · doi:10.6084/m9.figshare.13126635

Additional file 1 of In vivo assessment of glutamine anaplerosis into the TCA cycle in human pre-malignant and malignant clonal plasma cells

Gonsalves, W. I., Jang, J. S., Jessen, E., Hitosugi, T., Evans, L. A., Jevremović, D., Pettersson, X.-M., Bush, A. G., Gransee, J., Anderson, E. I., et al. (2020) · Figshare · doi:10.6084/m9.figshare.13467787

Additional file 4 of Hypoxia-mediated repression of pyruvate carboxylase drives immunosuppression

Coleman, M. F., Cotul, E. K., Pfeil, A. J., Devericks, E. N., Safdar, M. H., Monteiro, M., Chen, H., Ho, A. N., Attaar, N., Malian, H. M., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26731228

Additional file 6 of Hypoxia-mediated repression of pyruvate carboxylase drives immunosuppression

Coleman, M. F., Cotul, E. K., Pfeil, A. J., Devericks, E. N., Safdar, M. H., Monteiro, M., Chen, H., Ho, A. N., Attaar, N., Malian, H. M., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26731234

Additional file 3 of Metabolic plasticity of IDH1-mutant glioma cell lines is responsible for low sensitivity to glutaminase inhibition

Ruiz‐Rodado, V., Lita, A., Dowdy, T., Celiku, O., Saldana, A. C., Wang, H., Yang, C. Z., Chari, R., Li, A., Zhang, W., et al. (2020) · Figshare · doi:10.6084/m9.figshare.13126626

Additional file 3 of Hypoxia-mediated repression of pyruvate carboxylase drives immunosuppression

Coleman, M. F., Cotul, E. K., Pfeil, A. J., Devericks, E. N., Safdar, M. H., Monteiro, M., Chen, H., Ho, A. N., Attaar, N., Malian, H. M., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26731225

Additional file 5 of Metabolic plasticity of IDH1-mutant glioma cell lines is responsible for low sensitivity to glutaminase inhibition

Ruiz‐Rodado, V., Lita, A., Dowdy, T., Celiku, O., Saldana, A. C., Wang, H., Yang, C. Z., Chari, R., Li, A., Zhang, W., et al. (2020) · Figshare · doi:10.6084/m9.figshare.13126632

Additional file 1 of Bayesian kinetic modeling for tracer-based metabolomic data

Zhang, X., Su, Y., Lane, A. N., Stromberg, A. J., Fan, T. W. M., & Wang, C. (2024) · Figshare · doi:10.6084/m9.figshare.26576966

Metabolic circuitry of NADH buffering reveals a vulnerability in redox-adaptive cancer cells

Li, X., Hou, P., Zhai, X., Li, L., Guo, Z., Qiao, L., Fu, Y., Niu, J., Chen, P., Yang, R., et al. (2026) · The Innovation · doi:10.1016/j.xinn.2026.101365

The anti-tumoral effects of a low protein diet and of the IRE1α signaling

Turtos, A. M. (2022) · theses.fr (ABES) · doi:10.70675/fd90a3e8ze35az42fdzbd0ez966f12ddad22

Isotope In-Phase/Opposite-Phase-Edited 2D 1 H– 1 H ( 12 C/ 13 C) TOCSY and Complementary 1D 1 H Selective NMR Experiments for Carbon Tracing in Complex Samples

Steiner, K., Bermel, W., Wolff, W. W., Costa, P. M., Lysak, D. H., Pellizzari, J., Terry, C., Dowd, W. W., Downey, K., Jenne, A., et al. (2026) · Analytical Chemistry · doi:10.1021/acs.analchem.6c00593

Design, Synthesis, and Evaluation of Bibenzyl Analogues against Hepatocellular Carcinoma by Targeting Pyruvate Carboxylase

Qiao, Z., Li, L., Sheng, Y., Yang, J., Yu, J., Wu, F., Ji, M., Xi, R., Yang, L., Zhang, G., et al. (2026) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.6c00075

Targeting Lung Cancer Metabolism: Therapeutic Opportunities and Challenges

Freitas-Dias, C., & Mendes, C. (2026) · Advances in experimental medicine and biology · doi:10.1007/978-3-032-12166-0_14

Adaptive plasticity of aspartate metabolism in succinate dehydrogenase-deficient cancer cellsPreprint

Sokolov, D., Zheng, E., Danquah, S., Hart, M. L., & Sullivan, L. B. (2026) · eLife · doi:10.7554/elife.112378.1

Adaptive plasticity of aspartate metabolism in succinate dehydrogenase-deficient cancer cellsPreprint

Sokolov, D., Zheng, E., Danquah, S., Hart, M. L., & Sullivan, L. B. (2026) · eLife · doi:10.7554/elife.112378

Pyruvate carboxylase promotes progression of endometriosis by activating the AKT pathway

Wu, Y., Ye, X., Jin, O., Liu, B., Yu, S., Zheng, A., Lv, F., Zheng, Y., Liu, F., Xu, S., et al. (2026) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2026.105889

PHGDH: metabolic enzyme or signaling hub? From broad-spectrum inhibition toward context-adapted therapeutic targeting

Sun, C., Wu, S., Li, Z., Huang, C., & Wu, D. (2026) · Biochemical Pharmacology · doi:10.1016/j.bcp.2026.118376

Activation of KIF18B-MYC axis by autophagic CUL3 degradation promotes copper imbalance essential for gastric cancer progression

Tian, M., Cai, S.-F., Yang, C., Qu, J., Wang, X.-J., Wang, Z.-J.-Z.-X.-Z.-X., Li, X.-Y., Zhou, S., Tong, Q., & Zheng, L.-D. (2026) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2026.08.024

Early metabolic rewiring precedes arsenic-induced carcinogenesis in human lung epithelial cells

Cassidy, R. N., Seburn, E., Pyman, A., Saintilnord, W. N., Mittendorf, S., Hegazy, Y. A., Sheldon, R. D., Chandler, D. P., & Fondufe‐Mittendorf, Y. N. (2026) · Archives of Toxicology · doi:10.1007/s00204-026-04555-0

Lung cancer metabolism: a dynamic and adaptive network

Najjar, S. G., & Frezza, C. (2026) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-026-06417-5

BindingDB Entry 50022051: Synthesis and Evaluation of 1,3-Disubstituted Imidazolidine-2,4,5-triones as Inhibitors of Pyruvate Carboxylase.

BindingDB (2025) · UC San Diego · doi:10.7270/q27949c2

Processed data and code for Manuscript: Global quantification of mammalian gene expression noise

Welter, A. S., Mutschler, F., Simon, M. C., Giacomelli, C., Branscheid, A.-C., Manukyan, A., Alves, L. G. T., Gerwien, M., Kerridge, R., Landthaler, M., et al. (2026) · Zenodo (CERN European Organization for Nuclear Research) · doi:10.5281/zenodo.20067989

Abstract 1424: Enhanced pyruvate carboxylation is crucial to non-small cell lung cancer proliferation and anabolism

Sellers, K., Fox, M. P., Bousamra, M., Yan, J., Yuneva, M. O., Higashi, R. M., Lane, A. N., & Fan, T. W. ‐. (2014) · Cancer Research · doi:10.1158/1538-7445.am2014-1424

Abstract 1271: Human non small cell lung cancer tissue has enhanced expression of pyruvate carboxylase, but not glutaminase

Fox, M. P., Bousamra, M., Slone, S. P., Lane, A. N., & Fan, T. W. ‐. (2011) · Cancer Research · doi:10.1158/1538-7445.am2011-1271 · Cited by 1

Pyruvate carboxylase is upregulated in NSCLC to support proliferation and anabolism.

Sellers, K. (2013) · doi:10.18297/etd/1297

Pyruvate carboxylase is required for glutamine-independent growth of tumor cells

Cheng, T., Sudderth, J., Yang, C., Mullen, A. R., Jin, E. S., Matés, J. M., & DeBerardinis, R. J. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1016627108 · Cited by 475

Breast Cancer-Derived Lung Metastases Show Increased Pyruvate Carboxylase-Dependent Anaplerosis

Christen, S., Lorendeau, D., Schmieder, R., Broekaert, D., Metzger, K., Veys, K., Elia, I., Buescher, J. M., Orth, M. F., Davidson, S. M., et al. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.09.042 · Cited by 258