The DOI matches its Crossref record; 106 of the 106 references it cites were found in a registry or an index.
Essential role for autophagy in life span extension
Open accessAbstract
Life and health span can be prolonged by calorie limitation or by pharmacologic agents that mimic the effects of caloric restriction. Both starvation and the genetic inactivation of nutrient signaling converge on the induction of autophagy, a cytoplasmic recycling process that counteracts the age-associated accumulation of damaged organelles and proteins as it improves the metabolic fitness of cells. Here we review experimental findings indicating that inhibition of the major nutrient and growth-related signaling pathways as well as the upregulation of anti-aging pathways mediate life span extension via the induction of autophagy. Furthermore, we discuss mounting evidence suggesting that autophagy is not only necessary but, at least in some cases, also sufficient for increasing longevity.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Because resveratrol activates mitochondrial biogenesis through the AMPK-SIRT1-PGC1α axis, it prompts mitochondrial biogenesis, the unfolded protein response, and autophagy machinery that are known to extend longevity in animals (37, 249).”
From Metabolic Flexibility as an Adaptation to Energy Resources and Requirements in Health and Disease (2018) · cites this paper as [37]
In the citing paper
“It has been shown in model organisms (yeast, Drosophila, Caenorhabditis elegans and mice) that many paradigms of life extension depend on autophagy [34,130,135,136].”
From The mitochondrial permeability transition: Nexus of aging, disease and longevity (2021) · cites this paper as [135]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2013) · Cell · doi:10.1016/j.cell.2013.05.039 · Cited by 14,982
Self-citationResveratrol improves health and survival of mice on a high-calorie diet
Baur, J. A., Pearson, K. J., Price, N. L., Jamieson, H. A., Lerin, C., Kalra, A., Prabhu, V. V., Allard, J. S., Lopez-Lluch, G., Lewis, K., et al. (2006) · Nature · doi:10.1038/nature05354 · Cited by 4,290
Autophagy regulates lipid metabolism
Singh, R., Kaushik, S., Wang, Y., Xiang, Y., Novak, I., Komatsu, M., Tanaka, K., Cuervo, A. M., & Czaja, M. J. (2009) · Nature · doi:10.1038/nature07976 · Cited by 3,975
Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan
Howitz, K. T., Bitterman, K. J., Cohen, H. Y., Lamming, D. W., Lavu, S., Wood, J. G., Zipkin, R. E., Chung, P., Kisielewski, A., Zhang, L.-L., et al. (2003) · Nature · doi:10.1038/nature01960 · Cited by 3,796
Rapamycin fed late in life extends lifespan in genetically heterogeneous mice
Harrison, D. E., Strong, R., Sharp, Z. D., Nelson, J. F., Astle, C. M., Flurkey, K., Nadon, N. L., Wilkinson, J. E., Frenkel, K., Carter, C. S., et al. (2009) · Nature · doi:10.1038/nature08221 · Cited by 3,766
Bcl-2 Antiapoptotic Proteins Inhibit Beclin 1-Dependent Autophagy
Pattingre, S., Tassa, A., Qu, X., Garuti, R., Liang, X. H., Mizushima, N., Packer, M., Schneider, M. D., & Levine, B. (2005) · Cell · doi:10.1016/j.cell.2005.07.002 · Cited by 3,536
The Beclin 1 network regulates autophagy and apoptosis
Kang, R., Zeh, H. J., Lotze, M. T., & Tang, D. (2011) · Cell Death & Differentiation · doi:10.1038/cdd.2010.191 · Cited by 2,485
Caloric Restriction Delays Disease Onset and Mortality in Rhesus Monkeys
Colman, R. J., Anderson, R. M., Johnson, S. C., Kastman, E. K., Kosmatka, K. J., Beasley, T. M., Allison, D. B., Cruzen, C., Simmons, H. A., Kemnitz, J. W., et al. (2009) · Science · doi:10.1126/science.1173635 · Cited by 2,277
Autophagosome formation: core machinery and adaptations
Xie, Z., & Klionsky, D. J. (2007) · Nature Cell Biology · doi:10.1038/ncb1007-1102 · Cited by 2,237
Rubinsztein, D. C., Mariño, G., & Kroemer, G. (2011) · Cell · doi:10.1016/j.cell.2011.07.030 · Cited by 2,107
Self-citation
Flagged first, then by citations
Research works printed but not linked: 3
- Willcox, 2014, Curr Opin Clin Nutr Metab Care., 17, 51
- Nicoli, 2014, Rom J Morphol Embryol., 55, 57
- Zhang, 2014, Autophagy., 10, 22
Cited by
Sorted by citations
Items 201–300 of 465
Insights into the Conserved Regulatory Mechanisms of Human and Yeast Aging
Dahiya, R., Mohammad, T., Alajmi, M. F., Rehman, M. T., Hasan, G. M., Hussain, A., & Hassan, M. I. (2020) · Biomolecules · doi:10.3390/biom10060882 · Cited by 30
The role of lysine acetylation in metabolic sensing and proteostasis
Eftekhari, A., Sabir, U., & Kasumov, T. (2025) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2025.108908 · Cited by 30
Recent insights into the cellular and molecular determinants of aging
Ruan, L., Zhang, X., & Li, R. (2018) · Journal of Cell Science · doi:10.1242/jcs.210831 · Cited by 28
Integrative metabolomics as emerging tool to study autophagy regulation
Stryeck, S., Birner‐Gruenberger, R., & Madl, T. (2017) · Microbial Cell · doi:10.15698/mic2017.08.584 · Cited by 28
Calvo-Rubio, M., Burón, M. I., López-Lluch, G., Navas, P., de Cabo, R., Ramsey, J. J., Villalba, J. M., & González-Reyes, J. A. (2016) · Aging Cell · doi:10.1111/acel.12451 · Cited by 26
Axin-Mediated Regulation of Lifespan and Muscle Health in C. elegans Requires AMPK-FOXO Signaling
Mallick, A., Ranawade, A., van den Berg, W., & Gupta, B. P. (2020) · iScience · doi:10.1016/j.isci.2020.101843 · Cited by 26
Barth, E., Srivastava, A., Wengerodt, D., Stojiljkovic, M. R., Axer, H., Witte, O. W., Kretz, A., & Marz, M. (2021) · Aging · doi:10.18632/aging.203788 · Cited by 27
Longevity-modulating effects of symbiosis: insights from Drosophila–Wolbachia interaction
Maistrenko, O. M., Serga, S. V., Vaiserman, A. M., & Kozeretska, I. A. (2016) · Biogerontology · doi:10.1007/s10522-016-9653-9 · Cited by 26
Aging: A cell source limiting factor in tissue engineering
Khorraminejad‐Shirazi, M., Dorvash, M., Estedlal, A., Hoveidaei, A. H., Mazloomrezaei, M., & Mosaddeghi, P. (2019) · World Journal of Stem Cells · doi:10.4252/wjsc.v11.i10.787 · Cited by 28
Leukocyte telomere length in paediatric critical illness: effect of early parenteral nutrition
Verstraete, S., Vanhorebeek, I., van Puffelen, E., Derese, I., Ingels, C., Verbruggen, S. C. A. T., Wouters, P. J., Joosten, K., Hanot, J., Guerra, G. G., et al. (2018) · Critical Care · doi:10.1186/s13054-018-1972-6 · Cited by 25
Mosaddeghi, P., Eslami, M., Farahmandnejad, M., Akhavein, M., Ranjbarfarrokhi, R., Khorraminejad‐Shirazi, M., Shahabinezhad, F., Taghipour, M. J., Dorvash, M., Sakhteman, A., et al. (2021) · Scientific Reports · doi:10.1038/s41598-020-79472-y · Cited by 27
Li, W., Zou, J., Yue, F., Song, K., Chen, Q., McKeehan, W. L., Wang, F., Xu, G., Huang, H. W., Yi, J., et al. (2016) · Aging Cell · doi:10.1111/acel.12441 · Cited by 25
Fajardo, V. A., LeBlanc, P. J., & Fajardo, V. A. (2017) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2017-0653 · Cited by 25
Amyotrophic lateral sclerosis alters the metabolic aging profile in patient derived fibroblasts
Gerou, M., Hall, B., Woof, R., Allsop, J., Kolb, S. J., Meyer, K., Shaw, P. J., & Allen, S. P. (2021) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2021.04.013 · Cited by 26
Tomtheelnganbee, E., Sah, P., & Sharma, R. (2022) · Biogerontology · doi:10.1007/s10522-022-09978-7 · Cited by 26
Bennett, D., Goyala, A., Statzer, C., Beckett, C. W., Tyshkovskiy, A., Gladyshev, V. N., Ewald, C. Y., & de Magalhães, J. P. (2023) · Aging Cell · doi:10.1111/acel.13774 · Cited by 24
Deletion of Nrip1 Extends Female Mice Longevity, Increases Autophagy, and Delays Cell Senescence
Wang, J., Chen, X., Osland, J. M., Gerber, S. D., Luan, C., Delfino, K. R., Goodwin, L. O., & Yuan, R. (2018) · The Journals of Gerontology Series A · doi:10.1093/gerona/glx257 · Cited by 28
Lv, J., Jiang, Y., Feng, Q., Fan, Z., Sun, Y. H., Xu, P., Hou, Y., Zhang, X., Fan, Y., Xu, X., et al. (2020) · Frontiers in Microbiology · doi:10.3389/fmicb.2020.00320 · Cited by 25
Civiletto, G., Brunetti, D., Lizzo, G., Muller, K., Jacot, G. E., Daskalaki, I., Sizzano, F., Huh, M., Meo, I. D., Colombo, M. N., et al. (2025) · Nature Aging · doi:10.1038/s43587-025-00957-4 · Cited by 24
Ochiai, T., Nagayama, T., Matsui, K., Amano, K., Sano, T., Wakabayashi, T., & Iwatsubo, T. (2021) · The Journal of Prevention of Alzheimer s Disease · doi:10.14283/jpad.2021.33 · Cited by 23
Methods to Assess Autophagy and Chronological Aging in Yeast
Kainz, K., Tadić, J., Zimmermann, A., Pendl, T., Carmona‐Gutiérrez, D., Ruckenstuhl, C., Eisenberg, T., & Madeo, F. (2016) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/bs.mie.2016.09.086 · Cited by 24
Self-citationAutophagy: one more Nobel Prize for yeast
Zimmermann, A., Kainz, K., Andryushkova, A., Hofer, S. J., Madeo, F., & Carmona‐Gutiérrez, D. (2016) · Microbial Cell · doi:10.15698/mic2016.12.544 · Cited by 23
Self-citationPlant Hormone Cytokinins for Modulating Human Aging and Age-Related Diseases
Voller, J., Maková, B., Kadlecová, A., González, G., & Strnad, M. (2017) · Healthy ageing and longevity · doi:10.1007/978-3-319-63001-4_14 · Cited by 23
Toxin-induced hormesis may restrain aging
Lajqi, T., Stojiljkovic, M. R., & Wetzker, R. (2019) · Biogerontology · doi:10.1007/s10522-019-09806-5 · Cited by 22
Doeppner, T. R., Coman, C., Burdusel, D., Ancuța, D.-L., Brockmeier, U., Pirici, D. N., Kuang, Y., Hermann, D. M., & Popa‐Wagner, A. (2022) · Aging · doi:10.18632/aging.204069 · Cited by 22
Rapamycin modulation of p70 S6 kinase signaling inhibits Rift Valley fever virus pathogenesis
Bell, T. M., Espina, V. A., Senina, S., Lehman, C. W., Brahms, A., Carey, B. D., Lin, S., Lundberg, L., Pinkham, C., Baer, A., et al. (2017) · Antiviral Research · doi:10.1016/j.antiviral.2017.04.011 · Cited by 22
Caloric Restriction Dramatically Stalls Lesion Growth in Mice With Induced Endometriosis
Yin, B., Liu, X., & Guo, S. (2018) · Reproductive Sciences · doi:10.1177/1933719118756755 · Cited by 22
Obesity, Metabolism, and Aging: A Multiscalar Approach
Bentley, R. A., Ross, C. N., & O’Brien, M. J. (2018) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2017.11.016 · Cited by 22
Linking cellular proteostasis to yeast longevity
Sampaio‐Marques, B., & Ludovico, P. (2018) · FEMS Yeast Research · doi:10.1093/femsyr/foy043 · Cited by 23
Meschini, R., D’Eliseo, D., Filippi, S., Bertini, L., Bizzarri, B. M., Botta, L., Saladino, R., & Velotti, F. (2018) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.8b03630 · Cited by 22
Recent progress regarding the role of autophagy in cardiac disease
Maejima, Y., Titus, A. S., Zablocki, D., & Sadoshima, J. (2025) · Cardiovascular Research · doi:10.1093/cvr/cvaf203 · Cited by 22
Autophagy takes it all – autophagy inducers target immune aging
Zinecker, H., & Simon, A. K. (2022) · Disease Models & Mechanisms · doi:10.1242/dmm.049345 · Cited by 22
Lima, B. S. A., Rocha, F. A. D., Plata‐Rueda, A., Zanuncio, J. C., Cossolin, J. F. S., Martínez, L. C., & Serrão, J. É. (2023) · Journal of Pest Science · doi:10.1007/s10340-023-01642-4 · Cited by 21
Yusri, K., Kumar, S., Fong, S., Gruber, J., & Sorrentino, V. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25126793 · Cited by 23
Reis, A. B., de Oliveira, M. S., Souza, D. D. S., Gomes, D. S., da Silva, L. L., Martínez, L. C., & Serrão, J. É. (2024) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2024.172640 · Cited by 20
Long, T., Tang, Y., He, Y.-N., He, C., Chen, X., Guo, M., Wu, J., Yu, L., Yu, C., Law, B. Y. K., et al. (2022) · The Journals of Gerontology Series A · doi:10.1093/gerona/glac136 · Cited by 21
The impact of autophagy on the development of senescence in primary tubular epithelial cells
Baisantry, A., Bhayana, S., Wrede, C., Hegermann, J., Haller, H. G., Melk, A., & Schmitt, R. (2016) · Cell Cycle · doi:10.1080/15384101.2016.1234547 · Cited by 22
Lipotoxicity, Nutrient-Sensing Signals, and Autophagy in Diabetic Nephropathy
Kume, S., & Maegawa, H. (2020) · JMA Journal · doi:10.31662/jmaj.2020-0005 · Cited by 20
Cardiovascular aging: the mitochondrial influence
Sagar, S., & Gustafsson, Å. B. (2023) · The Journal of Cardiovascular Aging · doi:10.20517/jca.2023.22 · Cited by 18
Fasting and calorie restriction modulate age‐associated immunosenescence and inflammaging
Tizazu, A. M. (2024) · Aging Medicine · doi:10.1002/agm2.12342 · Cited by 19
Drosophila Lipase 3 Mediates the Metabolic Response to Starvation and Aging
Hänschke, L., Heier, C., Palacios, S. J. M., Özek, H. E., Thiele, C., Bauer, R., Kühnlein, R. P., & Bülow, M. H. (2022) · Frontiers in Aging · doi:10.3389/fragi.2022.800153 · Cited by 17
Β-blockers activate autophagy on infantile hemangioma-derived endothelial cells in vitro
Lorusso, B., Cerasoli, G., Falco, A., Frati, C., Graiani, G., Madeddu, D., Nogara, A. M., Corradini, E., Roti, G., Cerretani, E., et al. (2022) · Vascular Pharmacology · doi:10.1016/j.vph.2022.107110 · Cited by 20
Aryl hydrocarbon receptor: Linking environment to aging process in elderly patients with asthma
Yang, T., Wan, R., Tu, W., Avvaru, S. N., & Gao, P. (2024) · Chinese Medical Journal · doi:10.1097/cm9.0000000000002960 · Cited by 18
Lithocholic Acid Improves the Survival of Drosophila Melanogaster
Staats, S., Rimbach, G. H., Künstner, A., Graspeuntner, S., Rupp, J., Busch, H. S., Sina, C., Ipharraguerre, I. R., & Wagner, A. E. (2018) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201800424 · Cited by 19
Blood autophagy defect causes accelerated non-hematopoietic organ aging
Fang, Y., Zhu, L., An, N. A., Jiang, G., Qian, J., Zhao, R., Yuan, N., Zhang, S., & Wang, J. (2019) · Aging · doi:10.18632/aging.102086 · Cited by 17
Sargahydroquinoic acid (SHQA) suppresses cellular senescence through Akt/mTOR signaling pathway
Cao, L., Lee, S. G., Park, S., & Kim, H. (2021) · Experimental Gerontology · doi:10.1016/j.exger.2021.111406 · Cited by 17
Branching Off: New Insight Into Lysosomes as Tubular Organelles
Bohnert, K. A., & Johnson, A. E. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.863922 · Cited by 17
Sampaio-Marques, B., Pereira, H., Santos, A. R., Teixeira, A., & Ludovico, P. (2018) · Aging · doi:10.18632/aging.101675 · Cited by 14
The role of autophagy in abdominal aortic aneurysm: protective but dysfunctional
Wang, L., Liu, S., Pan, B., Cai, H., Zhou, H., Yang, P., & Wang, W. (2020) · Cell Cycle · doi:10.1080/15384101.2020.1823731 · Cited by 17
Escobar, K. A., Welch, A. M., Wells, A. D., Fennel, Z. J., Nava, R. C., Li, Z., Moriarty, T. A., Nitta, C. H., Zuhl, M., VanDusseldorp, T. A., et al. (2020) · Human Nutrition & Metabolism · doi:10.1016/j.hnm.2020.200118 · Cited by 17
Sayed, R. K. A., Fernández‐Ortiz, M., Rahim, I., Fernández‐Martínez, J., Aranda‐Martínez, P., Rusanova, I., Martínez-Ruiz, L., Alsaadawy, R. M., Escames, G., & Acuña-Castroviejo, D. (2021) · Antioxidants · doi:10.3390/antiox10081269 · Cited by 17
Montellà-Manuel, S., Pujol‐Carrion, N., Mechoud, M. A., & de la Torre-Ruiz, M. Á. (2021) · Biochemical Journal · doi:10.1042/bcj20200849 · Cited by 18
Li, X., Zhou, J., Dou, Y., Shi, Y., Wang, Y., Hong, J., Zhao, J., Zhang, J., Yang, Y., Zhou, M., et al. (2020) · BMC Complementary Medicine and Therapies · doi:10.1186/s12906-020-02968-7 · Cited by 15
Abooshahab, R., & Dass, C. R. (2021) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2021.111478 · Cited by 15
Generation of somatic mitochondrial DNA-replaced cells for mitochondrial dysfunction treatment
Maeda, H., Kami, D., Maeda, R., Shikuma, A., & Gojo, S. (2021) · Scientific Reports · doi:10.1038/s41598-021-90316-1 · Cited by 16
C. elegans to model autophagy-related human disorders
Wong, S. Q., Kumar, A. V., Mills, J., & Lapierre, L. R. (2020) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2020.01.007 · Cited by 14
Autophagic activity in BC3H1 cells exposed to yessotoxin
Korsnes, M. S., Kolstad, H., Kleiveland, C. R., Korsnes, R., & Ørmen, E. (2015) · Toxicology in Vitro · doi:10.1016/j.tiv.2015.12.010 · Cited by 15
The intracellular metabolome of starving cells
Durand, S., Grajeda‐Iglesias, C., Aprahamian, F., Nirmalathasan, N., Kepp, O., & Kroemer, G. (2021) · Methods in cell biology · doi:10.1016/bs.mcb.2021.04.001 · Cited by 14
Self-citationRusso, L., Babboni, S., Andreassi, M. G., Daher, J., Canale, P., Turco, S. D., & Basta, G. (2025) · Antioxidants · doi:10.3390/antiox14010099 · Cited by 16
Enhancing autophagy by redox regulation extends lifespan in Drosophila
Lennicke, C., Bjedov, I., Grönke, S., Menger, K. E., James, A. M., Castillo-Quan, J. I., van Leeuwen, L. A. G., Foley, A., Buricova, M., Adcott, J., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-60603-w · Cited by 16
Social perception of young adults prolongs the lifespan of aged Drosophila
Cho, L.-C., Yu, C.-C., & Kao, C.-F. (2021) · npj Aging and Mechanisms of Disease · doi:10.1038/s41514-021-00073-8 · Cited by 13
Wang, Y., Guo, J., Wang, L., Tian, H., & Sui, J. (2019) · BMC Genomics · doi:10.1186/s12864-019-5804-0 · Cited by 14
Domenico, F. D., Zuliani, I., & Tramutola, A. (2019) · Expert Review of Proteomics · doi:10.1080/14789450.2019.1691919 · Cited by 13
Evolutionary analysis of the mTOR pathway provide insights into lifespan extension across mammals
Yang, F. Y., Liu, X., Li, Y., Yu, Z., Huang, X. H., Yang, G. Z., & Xu, S. (2023) · BMC Genomics · doi:10.1186/s12864-023-09554-4 · Cited by 14
C16ORF70/MYTHO promotes healthy aging in C.elegans and prevents cellular senescence in mammals
Franco‐Romero, A., Morbidoni, V., Milan, G., Sartori, R., Wulff, J., Romanello, V., Armani, A., Salviati, L., Conte, M., Salvioli, S., et al. (2024) · Journal of Clinical Investigation · doi:10.1172/jci165814 · Cited by 13
Li, S., Lin, Y., Chiang, C.-H., Wang, P., & Chen, C. (2022) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2022.108944 · Cited by 13
Probiotics: The Next Dietary Strategy against Brain Aging
Ong, J.-S., Lew, L.-C., Hor, Y.-Y., & Liong, M. (2022) · Preventive Nutrition and Food Science · doi:10.3746/pnf.2022.27.1.1 · Cited by 13
Takakura, K., Ito, S., Sonoda, J., Tabata, K., Shiozaki, M., Nagai, K., Shibata, M., Koike, M., Uchiyama, Y., & Gotow, T. (2017) · Heliyon · doi:10.1016/j.heliyon.2017.e00462 · Cited by 14
Zhang, X., Lin, Q., Ren, F., Zhang, J., Dawar, F. U., & Mei, J. (2018) · Aquaculture and Fisheries · doi:10.1016/j.aaf.2018.04.004 · Cited by 13
The Potential Roles of Dec1 and Dec2 in Periodontal Inflammation
Wang, X., Sato, F., Tanimoto, K., Rajeshwaran, N., Thangavelu, L. P., Makishima, M., & BHAWAL, U. K. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms221910349 · Cited by 12
Therapeutic Aspects and Molecular Targets of Autophagy to Control Pancreatic Cancer Management
Rahman, M. A., Ahmed, K. R., Rahman, M. H., Parvez, M. A. K., Lee, I., & Kim, B. (2022) · Biomedicines · doi:10.3390/biomedicines10061459 · Cited by 12
Involvement of Autophagy in Ageing and Chronic Cholestatic Diseases
Pinto, C., Ninfole, E., Benedetti, A., Marzioni, M., & Maroni, L. (2021) · Cells · doi:10.3390/cells10102772 · Cited by 12
Natural Products in Aging: Cellular Mechanisms and Emerging Therapeutics for Age‐Related Disorders
Dixit, V., Chaubey, K. K., Dayal, D., Chole, P. B., Manjunath, B. T., Bachheti, R. K., Gupta, P. C., Bachheti, A., & Worku, L. A. (2025) · Journal of Aging Research · doi:10.1155/jare/6868732 · Cited by 11
Autophagy and longevity: Evolutionary hints from hyper-longevous mammals
Locatelli, A. G., & Cenci, S. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.1085522 · Cited by 11
Zhao, T., Liu, C., Liu, L., Wang, X., & Liu, C. (2022) · Biogerontology · doi:10.1007/s10522-022-10004-z · Cited by 11
Nutritional limitation in early postnatal life and its effect on aging and longevity in rodents
Davis, K., Chamseddine, D., & Harper, J. M. (2016) · Experimental Gerontology · doi:10.1016/j.exger.2016.05.001 · Cited by 12
Caloric restriction reduces the systemic progression of mouse AApoAII amyloidosis
Li, L., Sawashita, J., Ding, X., Yang, M., Xu, Z., Miyahara, H., Mori, M., & Higuchi, K. (2017) · PLoS ONE · doi:10.1371/journal.pone.0172402 · Cited by 12
Carballo, G. M., Vázquez, K. G., García-González, L. A., Río, G. D., & Brizuela, C. A. (2023) · Antibiotics · doi:10.3390/antibiotics12010139 · Cited by 9
Cutting Calories and TXNIP From the Skeletal Muscle to Restore Insulin Sensitivity
Anderson, E. J. (2015) · Diabetes · doi:10.2337/dbi15-0021 · Cited by 9
Calorie Restriction Rescues Mitochondrial Dysfunction in Adck2-Deficient Skeletal Muscle
Hernández‐Camacho, J. D., Fernández‐Ayala, D. J. M., Vicente‐García, C., Navas‐Enamorado, I., López‐Lluch, G., Oliva, C., Artuch, R., García‐Villoria, J., Ribes, A., de Cabo, R., et al. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.898792 · Cited by 10
Coppens, J., Bentea, E., Bayliss, J. A., Demuyser, T., Walrave, L., Albertini, G., Liefferinge, J. V., Deneyer, L., Aourz, N., Eeckhaut, A. V., et al. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18030558 · Cited by 9
Hayat, M. A. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-812146-7.00001-9 · Cited by 10
Oncolytic Virus-Induced Autophagy in Glioblastoma
Kamynina, М., Tskhovrebova, S., Fares, J., Timashev, P. S., Laevskaya, A., & Ulasov, I. V. (2021) · Cancers · doi:10.3390/cancers13143482 · Cited by 9
Insights into the Molecular Basis of Genome Stability and Pristine Proteostasis in Naked Mole-Rats
Narayan, V., McMahon, M. E., O’Brien, J. J., McAllister, F. E., & Buffenstein, R. (2021) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-65943-1_11 · Cited by 9
An exploratory text analysis of the autophagy research field
Yim, W. W., Kurikawa, Y., & Mizushima, N. (2021) · Autophagy · doi:10.1080/15548627.2021.1995151 · Cited by 9
Fang, B., Zheng, C., Ma, Y., Wu, F., Cheng, L., Li, Y., Wang, R., & Ren, F. (2024) · Food, Nutrition and Health. · doi:10.1007/s44403-024-00006-9 · Cited by 11
Su, H., Qian, M., Zhang, N., Zhang, R., Liu, M., Wang, J., Li, F., Zheng, L., & Sun, Z. (2024) · Nutrients · doi:10.3390/nu16244335 · Cited by 9
Liang, N., Liu, S., Wang, Y., Ying, L., Zhang, K., Li, H., Xiao, L., Hu, Y., & Luo, G. (2025) · Pharmaceuticals · doi:10.3390/ph18040553 · Cited by 8
Lifelong restriction of dietary valine has sex-specific benefits for health and lifespan in mice
Calubag, M. F., Ademi, I., Green, C. L., Manchanayake, D. N. H., Jayarathne, H. S. M., Marshall, R. N., Le, S. M., Lialios, P., Breuer, L. E., Yakar, S., et al. (2026) · Nature Aging · doi:10.1038/s43587-026-01169-0 · Cited by 9
Insights into the therapeutic strategies for aging and aging-associated diseases
Dong, R., Wu, Q., Kan, J., Fu, C., Sorrentino, V., Chow, A., Lei, Y., Wu, D., Xu, Z., Du, J., et al. (2026) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-026-02662-z · Cited by 12
Dietary Impact on Neuronal Autophagy Control and Brain Health
Ntsapi, C., du Toit, A., & Loos, B. (2019) · IntechOpen eBooks · doi:10.5772/intechopen.85228 · Cited by 8
Maiuri, L., & Kroemer, G. (2018) · Aging · doi:10.18632/aging.101736 · Cited by 8
Self-citationShang, X., Cao, G., Gao, H. J., Li, M. M., Peng, G., Ji, Y., Zhang, Y., Zhang, W., Li, W., & Dou, F. (2020) · Journal of Molecular Biology · doi:10.1016/j.jmb.2020.09.003 · Cited by 9
Hołowko, J., Cięszczyk, P., Biliński, J., Basak, G. W., & Stachowska, E. (2020) · Nutrients · doi:10.3390/nu12123604 · Cited by 9
Yang, Y., Cai, Q., Zhu, M., Rong, J., Feng, X., & Wang, K. (2025) · Life Sciences · doi:10.1016/j.lfs.2025.123678 · Cited by 9
Schädel, P., Wichmann-Costaganna, M., Czapka, A., Gebert, N., Ori, A., & Werz, O. (2023) · Nutrients · doi:10.3390/nu15163660 · Cited by 7
12 days of in vivo caloric reduction can improve important parameters of aging in humans
Schöller-Mann, A., Matt, K., Schniertshauer, D., Hochecker, B., & Bergemann, J. (2020) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2020.111238 · Cited by 8
Dec2 attenuates autophagy in inflamed periodontal tissues
Oka, S., Li, X., Sato, F., Zhang, F., Tewari, N., Chen, C., Zhong, L., Makishima, M., Liu, Y. F., & BHAWAL, U. K. (2020) · Immunity Inflammation and Disease · doi:10.1002/iid3.389 · Cited by 7
Mohammad, K., & Titorenko, V. I. (2021) · Oncotarget · doi:10.18632/oncotarget.27926 · Cited by 8
Machihara, K., Kageyama, S., Oki, S., Makino, H., Sasaki, M., Iwahashi, H., & Namba, T. (2022) · Aging · doi:10.18632/aging.204303 · Cited by 7
Metadata
- Authors
- Madeo, F., Zimmermann, A., Maiuri, M. C., & Kroemer, G.
- Affiliations
- University of Graz (AT)
- Inserm (FR)
- Corresponding author
- Madeo, Frank
- Zimmermann, Andreas
- Kroemer, Guido
- Venue
- Journal of Clinical Investigation
- Published
- 2015-01-02
- Volume
- 125
- Issue
- 1
- Pages
- 85-93
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC4382258
- OpenAlex
- W2021632384
- Cited by
- 464
- References
- 106
- Citations by year
- 2026: 27 · 2025: 31 · 2024: 18 · 2023: 27 · 2022: 31 · 2021: 54 · 2020: 45 · 2019: 53 · 2018: 60 · 2017: 55 · 2016: 44 · 2015: 18
- FWCI
- 5.17
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Association pour la Recherche sur le Cancer
- European Commission
- Agence Nationale de la Recherche
- Institut National de la Santé et de la Recherche Médicale
- Austrian Science Fund (P 24381, I1000, P 23490)
- Fondation pour la Recherche Médicale
- Ligue Contre le Cancer
- Fondation de France
- Institut National Du Cancer
- Institut Gustave-Roussy
- Karl-Franzens-Universität Graz
- Labex Immuno-Oncology
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Keywords
- autophagy, lifespan extension, longevity, caloric restriction, nutrient signaling, starvation, protein quality control, organelle recycling, growth factor signaling
- MeSH terms
- Acetylation, Animals, Autophagy, Humans, Longevity, Phagosomes, Protein Processing, Post-Translational, Paracrine Communication
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review