The DOI matches its Crossref record; 106 of the 106 references it cites were found in a registry or an index.
Essential role for autophagy in life span extension
Open accessAbstract
Life and health span can be prolonged by calorie limitation or by pharmacologic agents that mimic the effects of caloric restriction. Both starvation and the genetic inactivation of nutrient signaling converge on the induction of autophagy, a cytoplasmic recycling process that counteracts the age-associated accumulation of damaged organelles and proteins as it improves the metabolic fitness of cells. Here we review experimental findings indicating that inhibition of the major nutrient and growth-related signaling pathways as well as the upregulation of anti-aging pathways mediate life span extension via the induction of autophagy. Furthermore, we discuss mounting evidence suggesting that autophagy is not only necessary but, at least in some cases, also sufficient for increasing longevity.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Because resveratrol activates mitochondrial biogenesis through the AMPK-SIRT1-PGC1α axis, it prompts mitochondrial biogenesis, the unfolded protein response, and autophagy machinery that are known to extend longevity in animals (37, 249).”
From Metabolic Flexibility as an Adaptation to Energy Resources and Requirements in Health and Disease (2018) · cites this paper as [37]
In the citing paper
“It has been shown in model organisms (yeast, Drosophila, Caenorhabditis elegans and mice) that many paradigms of life extension depend on autophagy [34,130,135,136].”
From The mitochondrial permeability transition: Nexus of aging, disease and longevity (2021) · cites this paper as [135]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2013) · Cell · doi:10.1016/j.cell.2013.05.039 · Cited by 14,982
Self-citationResveratrol improves health and survival of mice on a high-calorie diet
Baur, J. A., Pearson, K. J., Price, N. L., Jamieson, H. A., Lerin, C., Kalra, A., Prabhu, V. V., Allard, J. S., Lopez-Lluch, G., Lewis, K., et al. (2006) · Nature · doi:10.1038/nature05354 · Cited by 4,290
Autophagy regulates lipid metabolism
Singh, R., Kaushik, S., Wang, Y., Xiang, Y., Novak, I., Komatsu, M., Tanaka, K., Cuervo, A. M., & Czaja, M. J. (2009) · Nature · doi:10.1038/nature07976 · Cited by 3,975
Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan
Howitz, K. T., Bitterman, K. J., Cohen, H. Y., Lamming, D. W., Lavu, S., Wood, J. G., Zipkin, R. E., Chung, P., Kisielewski, A., Zhang, L.-L., et al. (2003) · Nature · doi:10.1038/nature01960 · Cited by 3,796
Rapamycin fed late in life extends lifespan in genetically heterogeneous mice
Harrison, D. E., Strong, R., Sharp, Z. D., Nelson, J. F., Astle, C. M., Flurkey, K., Nadon, N. L., Wilkinson, J. E., Frenkel, K., Carter, C. S., et al. (2009) · Nature · doi:10.1038/nature08221 · Cited by 3,766
Bcl-2 Antiapoptotic Proteins Inhibit Beclin 1-Dependent Autophagy
Pattingre, S., Tassa, A., Qu, X., Garuti, R., Liang, X. H., Mizushima, N., Packer, M., Schneider, M. D., & Levine, B. (2005) · Cell · doi:10.1016/j.cell.2005.07.002 · Cited by 3,536
The Beclin 1 network regulates autophagy and apoptosis
Kang, R., Zeh, H. J., Lotze, M. T., & Tang, D. (2011) · Cell Death & Differentiation · doi:10.1038/cdd.2010.191 · Cited by 2,485
Caloric Restriction Delays Disease Onset and Mortality in Rhesus Monkeys
Colman, R. J., Anderson, R. M., Johnson, S. C., Kastman, E. K., Kosmatka, K. J., Beasley, T. M., Allison, D. B., Cruzen, C., Simmons, H. A., Kemnitz, J. W., et al. (2009) · Science · doi:10.1126/science.1173635 · Cited by 2,277
Autophagosome formation: core machinery and adaptations
Xie, Z., & Klionsky, D. J. (2007) · Nature Cell Biology · doi:10.1038/ncb1007-1102 · Cited by 2,237
Rubinsztein, D. C., Mariño, G., & Kroemer, G. (2011) · Cell · doi:10.1016/j.cell.2011.07.030 · Cited by 2,107
Self-citation
Research works printed but not linked: 3
- Willcox, 2014, Curr Opin Clin Nutr Metab Care., 17, 51
- Nicoli, 2014, Rom J Morphol Embryol., 55, 57
- Zhang, 2014, Autophagy., 10, 22
Cited by
Sorted by citations
Sarcopenia: Aging-Related Loss of Muscle Mass and Function
Larsson, L., Degens, H., Li, M., Salviati, L., Lee, Y. I., Thompson, W., Kirkland, J. L., & Sandri, M. (2019) · Physiological Reviews · doi:10.1152/physrev.00061.2017 · Cited by 1,797
Autophagy in major human diseases
Klionsky, D. J., Petroni, G., Amaravadi, R. K., Baehrecke, E. H., Ballabio, A., Boya, P., Bravo‐San Pedro, J. M., Cadwell, K., Cecconi, F., Choi, A. M. K., et al. (2021) · The EMBO Journal · doi:10.15252/embj.2021108863 · Cited by 1,585
Self-citationHallmarks of Brain Aging: Adaptive and Pathological Modification by Metabolic States
Mattson, M. P., & Arumugam, T. V. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.05.011 · Cited by 1,242
Cardioprotection and lifespan extension by the natural polyamine spermidine
Eisenberg, T., Abdellatif, M., Schroeder, S., Primessnig, U., Stekovic, S., Pendl, T., Harger, A., Schipke, J., Zimmermann, A., Schmidt, A., et al. (2016) · Nature Medicine · doi:10.1038/nm.4222 · Cited by 1,168
Self-citationKaushik, S., & Cuervo, A. M. (2015) · Nature Medicine · doi:10.1038/nm.4001 · Cited by 899
Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles
Galluzzi, L., Bravo-San Pedro, J. M., Levine, B., Green, D. R., & Kroemer, G. (2017) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2017.22 · Cited by 842
Self-citationMetabolic Control of Longevity
López-Otín, C., Galluzzi, L., Freije, J. M. P., Madeo, F., & Kroemer, G. (2016) · Cell · doi:10.1016/j.cell.2016.07.031 · Cited by 753
Self-citationMetabolic Flexibility as an Adaptation to Energy Resources and Requirements in Health and Disease
Smith, R. L., Soeters, M. R., Wüst, R. C. I., & Houtkooper, R. H. (2018) · Endocrine Reviews · doi:10.1210/er.2017-00211 · Cited by 787
Chronic obstructive pulmonary disease
Barnes, P. J., Burney, P., Silverman, E. K., Celli, B. R., Vestbo, J., Wedzicha, J. A., & Wouters, E. F. �. (2015) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2015.76 · Cited by 761
Sun, N., Yun, J., Liu, J., Malide, D. A., Liu, C., Rovira, I. I., Holmström, K. M., Fergusson, M. M., Yoo, Y. H., Combs, C. A., et al. (2015) · Molecular Cell · doi:10.1016/j.molcel.2015.10.009 · Cited by 718
Disruption of the beclin 1–BCL2 autophagy regulatory complex promotes longevity in mice
Fernández, Á. F., Sebti, S., Wei, Y., Zou, Z., Shi, M., McMillan, K. L., He, C., Ting, T., Liu, Y., Chiang, W.-C., et al. (2018) · Nature · doi:10.1038/s41586-018-0162-7 · Cited by 630
Molecular mechanisms and consequences of mitochondrial permeability transition
Bonora, M., Giorgi, C., & Pinton, P. (2021) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-021-00433-y · Cited by 578
Aging and Autophagy in the Heart
Shirakabe, A., Ikeda, Y., Sciarretta, S., Zablocki, D., & Sadoshima, J. (2016) · Circulation Research · doi:10.1161/circresaha.116.307474 · Cited by 448
The Mitochondrial Basis of Aging and Age-Related Disorders
Srivastava, S. (2017) · Genes · doi:10.3390/genes8120398 · Cited by 446
Stekovic, S., Hofer, S. J., Tripolt, N., Aon, M. A., Royer, P., Pein, L., Stadler, J. T., Pendl, T., Prietl, B., Url, J., et al. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.07.016 · Cited by 412
Self-citationThe Biology of Aging and Cancer: A Brief Overview of Shared and Divergent Molecular Hallmarks
Aunan, J. R., Cho, W. C. S., & Søreide, K. (2017) · Aging and Disease · doi:10.14336/ad.2017.0103 · Cited by 389
Cancer as a disease of old age: changing mutational and microenvironmental landscapes
Laconi, E., Marongiu, F., & DeGregori, J. (2020) · British Journal of Cancer · doi:10.1038/s41416-019-0721-1 · Cited by 348
The metabolic regulation of aging
Finkel, T. (2015) · Nature Medicine · doi:10.1038/nm.3998 · Cited by 325
Autophagy and Microglia: Novel Partners in Neurodegeneration and Aging
Plaza-Zabala, A., Sierra-Torre, V., & Sierra, A. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18030598 · Cited by 323
Molecular and biological hallmarks of ageing
Aunan, J. R., Watson, M. M., Hagland, H. R., & Søreide, K. (2016) · British journal of surgery · doi:10.1002/bjs.10053 · Cited by 341
Autophagy: a druggable process that is deregulated in aging and human disease
Kroemer, G. (2015) · Journal of Clinical Investigation · doi:10.1172/jci78652 · Cited by 318
Self-citationKhandia, R., Dadar, M., Munjal, A. K., Dhama, K., Karthik, K., Tiwari, R., Yatoo, M. I., Iqbal, H. M. N., Singh, K. P., Joshi, S. K., et al. (2019) · Cells · doi:10.3390/cells8070674 · Cited by 337
Autophagy and the hallmarks of aging
Kaushik, S., Tasset, I., Arias, E., Pampliega, O., Wong, E., Martinez-Vicente, M., & Cuervo, A. M. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101468 · Cited by 285
Proteostasis, oxidative stress and aging
Korovila, I., Hugo, M., Castro, J. P., Weber, D., Höhn, A., Grune, T., & Jung, T. (2017) · Redox Biology · doi:10.1016/j.redox.2017.07.008 · Cited by 285
Mitochondrial Dynamics and Mitophagy in Skeletal Muscle Health and Aging
Leduc-Gaudet, J.-P., Hussain, S. N. A., Barreiro, E., & Gouspillou, G. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22158179 · Cited by 268
Aging Hallmarks and Progression and Age-Related Diseases: A Landscape View of Research Advancement
Tenchov, R., Sasso, J. M., Wang, X., & Zhou, Q. A. (2024) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.3c00531 · Cited by 276
The crucial impact of lysosomes in aging and longevity
Carmona‐Gutiérrez, D., Hughes, A. L., Madeo, F., & Ruckenstuhl, C. (2016) · Ageing Research Reviews · doi:10.1016/j.arr.2016.04.009 · Cited by 254
Self-citationAutophagy in Cardiovascular Aging
Abdellatif, M., Sedej, S., Carmona-Gutierrez, D., Madeo, F., & Kroemer, G. (2018) · Circulation Research · doi:10.1161/circresaha.118.312208 · Cited by 239
Self-citationAutophagy in the eye: Development, degeneration, and aging
Boya, P., Esteban‐Martínez, L., Serrano‐Puebla, A., Gómez‐Sintes, R., & Villarejo‐Zori, B. (2016) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2016.08.001 · Cited by 236
Autophagy and aging: Maintaining the proteome through exercise and caloric restriction
Escobar, K. A., Cole, N. H., Mermier, C. M., & VanDusseldorp, T. A. (2018) · Aging Cell · doi:10.1111/acel.12876 · Cited by 228
Byun, S., Seok, S., Kim, Y., Zhang, Y., Yau, P. M., Iwamori, N., Xu, H. E., Ma, J., KEMPER, B. W., & Kemper, J. K. (2020) · Nature Communications · doi:10.1038/s41467-020-14384-z · Cited by 218
Mitochondrial Permeability Uncouples Elevated Autophagy and Lifespan Extension
Zhou, B., Kreuzer, J., Kumsta, C., Wu, L., Kamer, K. J., Cedillo, L., Zhang, Y., Li, S., Kacergis, M. C., Webster, C. M., et al. (2019) · Cell · doi:10.1016/j.cell.2019.02.013 · Cited by 220
Suppression of autophagic activity by Rubicon is a signature of aging
Nakamura, S., Oba, M., Suzuki, M., Takahashi, A., Yamamuro, T., Fujiwara, M., Ikenaka, K., Minami, S., Tabata, N., Yamamoto, K., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-08729-6 · Cited by 205
Autophagy in stem cells: repair, remodelling and metabolic reprogramming
Boya, P., Codogno, P., & Rodriguez-Muela, N. (2018) · Development · doi:10.1242/dev.146506 · Cited by 197
Methionine Restriction Extends Lifespan in Progeroid Mice and Alters Lipid and Bile Acid Metabolism
Bárcena, C., Quirós, P. M., Durand, S., Mayoral, P., Rodríguez, F., Caravia, X. M., Mariño, G., Garabaya, C., Fernández-García, M. T., Kroemer, G., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.07.089 · Cited by 185
Self-citationGuidelines and recommendations on yeast cell death nomenclature
Carmona‐Gutiérrez, D., Bauer, M. A., Zimmermann, A., Aguilera, A., Austriaco, N. P. G., Ayscough, K. R., Balzan, R., Bar‐Nun, S., Barrientos, A., Belenky, P. A., et al. (2017) · Microbial Cell · doi:10.15698/mic2018.01.607 · Cited by 193
Self-citationAxonal Degeneration during Aging and Its Functional Role in Neurodegenerative Disorders
Salvadores, N., Sanhueza, M., Manque, P., & Court, F. A. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2017.00451 · Cited by 182
Spermidine is essential for fasting-mediated autophagy and longevity
Hofer, S. J., Daskalaki, I., Bergmann, M., Friščić, J., Zimmermann, A., Mueller, M. I., Abdellatif, M., Nicastro, R., Masser, S., Durand, S., et al. (2024) · Nature Cell Biology · doi:10.1038/s41556-024-01468-x · Cited by 186
Self-citationKadota, T., Fujita, Y., Yoshioka, Y., Araya, J., Kuwano, K., & Ochiya, T. (2017) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2017.11.005 · Cited by 179
Dysregulation of autophagy as a common mechanism in lysosomal storage diseases
Seranova, E., Connolly, K. J., Zatyka, M., Rosenstock, T. R., Barrett, T. G., Tuxworth, R. I., & Sarkar, S. (2017) · Essays in Biochemistry · doi:10.1042/ebc20170055 · Cited by 183
Portal‐Núñez, S., Esbrit, P., Alcaraz, M. J., & Largo, R. (2015) · Biochemical Pharmacology · doi:10.1016/j.bcp.2015.12.012 · Cited by 170
Autophagy induction by trehalose: Molecular mechanisms and therapeutic impacts
Moghaddam, K. H., Caraglia, M., & Sahebkar, A. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.26583 · Cited by 173
Long-Term Calorie Restriction Enhances Cellular Quality-Control Processes in Human Skeletal Muscle
Yang, L., Licastro, D., Cava, E., Veronese, N., Spelta, F., Rizza, W., Bertozzi, B., Villareal, D. T., Hotamışlıgil, G. S., Holloszy, J. O., et al. (2016) · Cell Reports · doi:10.1016/j.celrep.2015.12.042 · Cited by 174
Cellular Senescence: From Mechanisms to Current Biomarkers and Senotherapies
Lucas, V., Cavadas, C., & Aveleira, C. A. (2023) · Pharmacological Reviews · doi:10.1124/pharmrev.122.000622 · Cited by 172
The role of autophagy in hepatocellular carcinoma: friend or foe
Liu, L., Liao, J., He, X., & Li, P. (2017) · Oncotarget · doi:10.18632/oncotarget.17202 · Cited by 158
Revuelta, M., & Matheu, A. (2017) · Aging Cell · doi:10.1111/acel.12655 · Cited by 149
Emerging Anti-Aging Strategies - Scientific Basis and Efficacy
Shetty, A. K., Kodali, M., Upadhya, R., & Madhu, L. N. (2018) · Aging and Disease · doi:10.14336/ad.2018.1026 · Cited by 149
Wahl, D., Solon‐Biet, S. M., Cogger, V. C., Fontana, L., Simpson, S. J., Couteur, D. G. L., & Ribeiro, R. V. (2019) · Neurobiology of Disease · doi:10.1016/j.nbd.2019.104481 · Cited by 155
Kuwano, K., Araya, J., Hara, H., Minagawa, S., Takasaka, N., Ito, S., Kobayashi, K., & Nakayama, K. (2016) · Respiratory Investigation · doi:10.1016/j.resinv.2016.03.010 · Cited by 150
Anti-aging pharmacology: Promises and pitfalls
Vaiserman, A. M., Lushchak, O. V., & Koliada, A. K. (2016) · Ageing Research Reviews · doi:10.1016/j.arr.2016.08.004 · Cited by 148
Hepatic lipid metabolism and non-alcoholic fatty liver disease in aging
Gong, Z., Tas, E., Yakar, S., & Muzumdar, R. H. (2016) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2016.12.022 · Cited by 153
Vitamin D deficiency accelerates ageing and age‐related diseases: a novel hypothesis
Berridge, M. J. (2017) · The Journal of Physiology · doi:10.1113/jp274887 · Cited by 145
Advances in Autophagy Regulatory Mechanisms
Gallagher, L. E., Williamson, L. E., & Chan, E. Y. W. (2016) · Cells · doi:10.3390/cells5020024 · Cited by 140
The regulation of autophagy during exercise in skeletal muscle
Vainshtein, A., & Hood, D. A. (2015) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00550.2015 · Cited by 137
Cortical neurons develop a senescence-like phenotype promoted by dysfunctional autophagy
Moreno-Blas, D., Gorostieta-Salas, E., Pommer-Alba, A., Muciño-Hernández, G., Gerónimo-Olvera, C., Maciel-Barón, L. A., Konigsberg, M., Massieu, L., & Castro-Obregón, S. (2019) · Aging · doi:10.18632/aging.102181 · Cited by 128
Yeast as a tool to identify anti-aging compounds
Zimmermann, A., Hofer, S. J., Pendl, T., Kainz, K., Madeo, F., & Carmona‐Gutiérrez, D. (2018) · FEMS Yeast Research · doi:10.1093/femsyr/foy020 · Cited by 126
Self-citationMouse Models to Disentangle the Hallmarks of Human Aging
Folgueras, A. R., Freitas-Rodríguez, S., Velasco, G., & López-Otín, C. (2018) · Circulation Research · doi:10.1161/circresaha.118.312204 · Cited by 113
Mulugeta, S., Nureki, S., & Beers, M. F. (2015) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00139.2015 · Cited by 124
The Effects of Calorie Restriction on Autophagy: Role on Aging Intervention
Chung, K. W., & Chung, H. Y. (2019) · Nutrients · doi:10.3390/nu11122923 · Cited by 125
Diverse Functions of Autophagy in Liver Physiology and Liver Diseases
Ke, P. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20020300 · Cited by 117
Autophagy and Rheumatoid Arthritis: Current Knowledges and Future Perspectives
Vomero, M., Barbati, C., Colasanti, T., Perricone, C., Novelli, L., Ceccarelli, F., Spinelli, F. R., Franco, M. D., Conti, F., Valesini, G., et al. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01577 · Cited by 116
Metabolic features and regulation in cell senescence
Kwon, S. M., Hong, S. M., Lee, Y.-K., Min, S., & Yoon, G. (2019) · BMB Reports · doi:10.5483/bmbrep.2019.52.1.291 · Cited by 111
“Protein synthesis and dysregulated proteostasis One of the most important alterations during normal aging is impaired proteasis (protein homeostasis) (81, 82).”
BackgroundMetformin as a geroprotector: experimental and clinical evidence
Piskovatska, V., Stefanyshyn, N., Storey, K. B., Vaiserman, A. M., & Lushchak, O. V. (2018) · Biogerontology · doi:10.1007/s10522-018-9773-5 · Cited by 111
Caloric Restriction Mimetics in Nutrition and Clinical Trials
Hofer, S. J., Davinelli, S., Bergmann, M., Scapagnini, G., & Madeo, F. (2021) · Frontiers in Nutrition · doi:10.3389/fnut.2021.717343 · Cited by 109
Self-citationCellular Regulation of Amyloid Formation in Aging and Disease
Stroo, E., Koopman, M., Nollen, E. A. A., & Mata‐Cabana, A. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2017.00064 · Cited by 119
D'Arcy, M. (2024) · APOPTOSIS · doi:10.1007/s10495-024-01977-y · Cited by 118
Metabolic effects of fasting on human and mouse blood in vivo
Pietrocola, F., Demont, Y., Castoldi, F., Enot, D. P., Durand, S., Semeraro, M., Baracco, E. E., Pol, J. G., Pedro, J. M. B., Bordenave, C., et al. (2017) · Autophagy · doi:10.1080/15548627.2016.1271513 · Cited by 107
Self-citationAutophagy: Supporting cellular and organismal homeostasis by self-eating
Eskelinen, E. (2019) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2019.03.010 · Cited by 110
Oxidative stress, aging, antioxidant supplementation and their impact on human health: An overview
Martemucci, G., Portincasa, P., Ciaula, A. D., Mariano, M., Centonze, V., & D‘Alessandro, A. G. (2022) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2022.111707 · Cited by 112
Antiaging agents: safe interventions to slow aging and healthy life span extension
Liu, J. (2022) · Natural Products and Bioprospecting · doi:10.1007/s13659-022-00339-y · Cited by 112
Ant phylogenomics reveals a natural selection hotspot preceding the origin of complex eusociality
Romiguier, J., Borowiec, M. L., Weyna, A., Helleu, Q., Loire, É., Mendola, C. L., Rabeling, C., Fisher, B. L., Ward, P. S., & Keller, L. (2022) · Current Biology · doi:10.1016/j.cub.2022.05.001 · Cited by 102
Gheller, B. J. F., Riddle, E. S., Lem, M. R., & Thalacker-Mercer, A. E. (2016) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-071715-050901 · Cited by 98
The effect of fasting or calorie restriction on mitophagy induction: A literature review
Mehrabani, S., Bagherniya, M., Askari, G., Read, M. I., & Sahebkar, A. (2020) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.12611 · Cited by 103
Age-dependent loss of adipose Rubicon promotes metabolic disorders via excess autophagy
Yamamuro, T., Kawabata, T., Fukuhara, A., Saita, S., Nakamura, S., Takeshita, H., Fujiwara, M., Enokidani, Y., Yoshida, G., Tabata, K., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-17985-w · Cited by 97
Spermidine delays aging in humans
Madeo, F., Carmona‐Gutiérrez, D., Kepp, O., & Kroemer, G. (2018) · Aging · doi:10.18632/aging.101517 · Cited by 95
Self-citationThe mitochondrial permeability transition: Nexus of aging, disease and longevity
Rottenberg, H., & Hoek, J. B. (2021) · Cells · doi:10.3390/cells10010079 · Cited by 94
“elegans and mice) that many paradigms of life extension depend on autophagy (34, 129, 134, 135).”
BackgroundMetformin prevents against oxidative stress-induced senescence in human periodontal ligament cells
Kuang, Y., Hu, B., Ge, F., Xiang, M., Deng, Y., Tan, M., Li, J., & Song, J. (2019) · Biogerontology · doi:10.1007/s10522-019-09838-x · Cited by 94
The Role of Rapamycin in Healthspan Extension via the Delay of Organ Aging
Zhang, Y., Zhang, J., & Wang, S. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101376 · Cited by 92
Bloemberg, D., & Quadrilatero, J. (2019) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00261.2018 · Cited by 100
Mitophagy in the Pathogenesis of Liver Diseases
Ke, P. (2020) · Cells · doi:10.3390/cells9040831 · Cited by 91
Nutrition and longevity—From mechanisms to uncertainties
Ekmekcioglu, C. (2020) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2019.1676698 · Cited by 87
Mitochondrial remodeling: Rearranging, recycling, and reprogramming
Gottlieb, R. A., & Bernstein, D. (2016) · Cell Calcium · doi:10.1016/j.ceca.2016.04.006 · Cited by 91
Salminen, A., Kaarniranta, K., & Kauppinen, A. (2016) · Biogerontology · doi:10.1007/s10522-016-9655-7 · Cited by 89
Reprogramming of energy metabolism as a driver of aging
Feng, Z., Hanson, R. W., Berger, N. A., & Trubitsyn, A. G. (2016) · Oncotarget · doi:10.18632/oncotarget.7645 · Cited by 84
Phosphorylation of eukaryotic initiation factor-2α (eIF2α) in autophagy
Humeau, J., Leduc, M., Cerrato, G., Loos, F., Kepp, O., & Kroemer, G. (2020) · Cell Death and Disease · doi:10.1038/s41419-020-2642-6 · Cited by 91
Self-citationAutophagy at the intersection of aging, senescence, and cancer
Cassidy, L. D., & Narita, M. (2022) · Molecular Oncology · doi:10.1002/1878-0261.13269 · Cited by 93
Influence of the Mediterranean Diet on Healthy Aging
Andreo-López, M. C., Contreras-Bolívar, V., Muñoz‐Torres, M., García-Fontana, B., & García‐Fontana, C. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24054491 · Cited by 94
Frailty biomarkers under the perspective of geroscience: A narrative review
Gonçalves, R. S. D. S. A., Maciel, Á. C. C., Rolland, Y., Vellas, B. J., & Barreto, P. D. S. (2022) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101737 · Cited by 89
Chen, Y., Tao, J., Zhao, P., Tang, W., Xu, J., Zhang, K., & Zou, C. (2019) · Nature Communications · doi:10.1038/s41467-019-10475-8 · Cited by 80
Autophagy regulation in preeclampsia: Pros and cons
Nakashima, A., Aoki, A., Kusabiraki, T., Cheng, S., Sharma, S., & Saito, S. (2017) · Journal of Reproductive Immunology · doi:10.1016/j.jri.2017.08.006 · Cited by 83
Autophagy modulation: a potential therapeutic approach in cardiac hypertrophy
Wang, X., & Cui, T. (2017) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00145.2017 · Cited by 79
Sarcosine Is Uniquely Modulated by Aging and Dietary Restriction in Rodents and Humans
Walters, R. O., Arias, E., Díaz, A., Burgos, E. S., Guan, F., Tiano, S., Mao, K., Green, C. L., Qiu, Y., Shah, H., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.09.065 · Cited by 77
Target acquired: Selective autophagy in cardiometabolic disease
Evans, T. D., Sergin, I., Zhang, X., & Razani, B. (2017) · Science Signaling · doi:10.1126/scisignal.aag2298 · Cited by 74
Autophagy and proteostasis in the control of synapse aging and disease
Liang, Y., & Sigrist, S. J. (2017) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2017.12.006 · Cited by 74
The Multifaceted Roles of Autophagy in Flavivirus-Host Interactions
Ke, P. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19123940 · Cited by 78
Vaiserman, A. M., & Lushchak, O. V. (2017) · Journal of Translational Medicine · doi:10.1186/s12967-017-1259-8 · Cited by 72
Exercise-mediated regulation of autophagy in the cardiovascular system
Wang, L., Wang, J., Crețoiu, D., Li, G., & Xiao, J. (2019) · Journal of sport and health science/Journal of Sport and Health Science · doi:10.1016/j.jshs.2019.10.001 · Cited by 71
Bjedov, I., Cochemé, H. M., Foley, A., Wieser, D., Woodling, N. S., Castillo-Quan, J. I., Norvaišas, P., Lujan, C., Regan, J. C., Toivonen, J. M., et al. (2020) · PLoS Genetics · doi:10.1371/journal.pgen.1009083 · Cited by 69
Inhibition of autophagy inhibits the conversion of cardiac fibroblasts to cardiac myofibroblasts
Gupta, S., Zeglinski, M. R., Rattan, S. G., Landry, N. M., Ghavami, S., Wigle, J. T., Klonisch, T. C., Halayko, A. J., & Dixon, I. (2016) · Oncotarget · doi:10.18632/oncotarget.12392 · Cited by 69
The Role of Free Radicals in Autophagy Regulation: Implications for Ageing
Pajares, M. A., Cuadrado, A., Engedal, N., Jirsova, Z., & Cahová, M. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/2450748 · Cited by 69
Metadata
- Authors
- Madeo, F., Zimmermann, A., Maiuri, M. C., & Kroemer, G.
- Affiliations
- University of Graz (AT)
- Inserm (FR)
- Corresponding author
- Madeo, Frank
- Zimmermann, Andreas
- Kroemer, Guido
- Venue
- Journal of Clinical Investigation
- Published
- 2015-01-02
- Volume
- 125
- Issue
- 1
- Pages
- 85-93
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC4382258
- OpenAlex
- W2021632384
- Cited by
- 464
- References
- 106
- Citations by year
- 2026: 27 · 2025: 31 · 2024: 18 · 2023: 27 · 2022: 31 · 2021: 54 · 2020: 45 · 2019: 53 · 2018: 60 · 2017: 55 · 2016: 44 · 2015: 18
- FWCI
- 5.17
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Association pour la Recherche sur le Cancer
- European Commission
- Agence Nationale de la Recherche
- Institut National de la Santé et de la Recherche Médicale
- Austrian Science Fund (P 24381, I1000, P 23490)
- Fondation pour la Recherche Médicale
- Ligue Contre le Cancer
- Fondation de France
- Institut National Du Cancer
- Institut Gustave-Roussy
- Karl-Franzens-Universität Graz
- Labex Immuno-Oncology
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Keywords
- autophagy, lifespan extension, longevity, caloric restriction, nutrient signaling, starvation, protein quality control, organelle recycling, growth factor signaling
- MeSH terms
- Acetylation, Animals, Autophagy, Humans, Longevity, Phagosomes, Protein Processing, Post-Translational, Paracrine Communication
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
