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Targeted inhibition of tumor-specific glutaminase diminishes cell-autonomous tumorigenesis
Open accessAbstract
Glutaminase (GLS), which converts glutamine to glutamate, plays a key role in cancer cell metabolism, growth, and proliferation. GLS is being explored as a cancer therapeutic target, but whether GLS inhibitors affect cancer cell-autonomous growth or the host microenvironment or have off-target effects is unknown. Here, we report that loss of one copy of Gls blunted tumor progression in an immune-competent MYC-mediated mouse model of hepatocellular carcinoma. Compared with results in untreated animals with MYC-induced hepatocellular carcinoma, administration of the GLS-specific inhibitor bis-2-(5-phenylacetamido-1,3,4-thiadiazol-2-yl)ethyl sulfide (BPTES) prolonged survival without any apparent toxicities. BPTES also inhibited growth of a MYC-dependent human B cell lymphoma cell line (P493) by blocking DNA replication, leading to cell death and fragmentation. In mice harboring P493 tumor xenografts, BPTES treatment inhibited tumor cell growth; however, P493 xenografts expressing a BPTES-resistant GLS mutant (GLS-K325A) or overexpressing GLS were not affected by BPTES treatment. Moreover, a customized Vivo-Morpholino that targets human GLS mRNA markedly inhibited P493 xenograft growth without affecting mouse Gls expression. Conversely, a Vivo-Morpholino directed at mouse Gls had no antitumor activity in vivo. Collectively, our studies demonstrate that GLS is required for tumorigenesis and support small molecule and genetic inhibition of GLS as potential approaches for targeting the tumor cell-autonomous dependence on GLS for cancer therapy.
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“Importantly, inhibiting glutamine entry into the TCA cycle can blunt tumor progression in a MYC-driven cancer model of liver cancer (Xiang et al., 2015; Yuneva et al., 2012) and a MYC-inducible Burkitt lymphoma model (Le et al., 2012; Xiang et al., 2015).”
From Targeting Metabolism for Cancer Therapy (2017) · cites this paper as Xiang et al., 2015
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“Nevertheless, the specific metabolic importance of glutamine in tumorigenesis and tumor growth has also been reported194–196”
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Metadata
- Authors
- Xiang, Y., Stine, Z. E., Xia, J., Lu, Y., O’Connor, R. S., Altman, B. J., Hsieh, A. L., Gouw, A. M., Thomas, A. G., Gao, P., Sun, L., Song, L., Yan, B., Slusher, B. S., Zhuo, J., Ooi, L. L., Lee, C. G. L., Mancuso, A., McCallion, A. S., Le, A., Milone, M. C., Rayport, S., Felsher, D. W., & Dang, C. V.
- Affiliations
- Abramson Cancer Center (US)
- University of Pennsylvania (US)
- Johns Hopkins University (US)
- University of Science and Technology of China (CN)
- Sun Yat-sen University Cancer Center (CN)
- KK Women's and Children's Hospital (SG)
- National Cancer Centre Singapore (SG)
- Singapore General Hospital (SG)
- National University of Singapore (SG)
- New York State Psychiatric Institute (US)
- Stanford Medicine (US)
- Corresponding author
- Xiang, Yan
- Stine, Zachary E.
- Dang, Chi V.
- ORCID
- Venue
- Journal of Clinical Investigation
- Published
- 2015-04-27
- Volume
- 125
- Issue
- 6
- Pages
- 2293-2306
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC4497742
- OpenAlex
- W2004574994
- Cited by
- 409
- References
- 61
- Citations by year
- 2026: 19 · 2025: 22 · 2024: 31 · 2023: 33 · 2022: 43 · 2021: 49 · 2020: 48 · 2019: 39 · 2018: 30 · 2017: 50 · 2016: 29 · 2015: 16
- FWCI
- 13.88
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Cancer Research Institute
- National Natural Science Foundation of China (81372148)
- National Institute of Mental Health (R01MH117128)
- National Cancer Institute (R01CA057341, F32CA174148, P30 CA16620, R01CA051497, P30CA016520)
- Abramson Family Cancer Research Institute
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Amino Acid Enzymes and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Bacterial Cancer Therapy
- Keywords
- glutaminase, BPTES, hepatocellular carcinoma, B-cell lymphoma, cancer metabolism, glutamine metabolism, cancer therapy, morpholino antisense, DNA replication inhibition
- MeSH terms
- Animals, Cell Transformation, Neoplastic, Glutaminase, Carcinoma, Hepatocellular, Humans, Liver Neoplasms, Experimental, Mice, Inbred BALB C, Mice, Transgenic, Neoplasm Transplantation, Sulfides, Thiadiazoles, Gene Expression Regulation, Enzymologic, Gene Expression Regulation, Neoplastic, Amino Acid Substitution, Mutation, Missense, Mice, Heterografts
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