The DOI matches its Crossref record; 141 of the 141 references it cites were found in a registry or an index.
Gut/brain axis and the microbiota
Open accessAbstract
Tremendous progress has been made in characterizing the bidirectional interactions between the central nervous system, the enteric nervous system, and the gastrointestinal tract. A series of provocative preclinical studies have suggested a prominent role for the gut microbiota in these gut-brain interactions. Based on studies using rodents raised in a germ-free environment, the gut microbiota appears to influence the development of emotional behavior, stress- and pain-modulation systems, and brain neurotransmitter systems. Additionally, microbiota perturbations by probiotics and antibiotics exert modulatory effects on some of these measures in adult animals. Current evidence suggests that multiple mechanisms, including endocrine and neurocrine pathways, may be involved in gut microbiota-to-brain signaling and that the brain can in turn alter microbial composition and behavior via the autonomic nervous system. Limited information is available on how these findings may translate to healthy humans or to disease states involving the brain or the gut/brain axis. Future research needs to focus on confirming that the rodent findings are translatable to human physiology and to diseases such as irritable bowel syndrome, autism, anxiety, depression, and Parkinson's disease.
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“Sophisticated crosstalk between the CNS and the gut microbiome (known as the gut–brain axis) is critical for several facets of CNS physiology, including microglial development and function (Mayer et al., 2015; Fung et al., 2017).”
From Microbiome–microglia connections via the gut–brain axis (2019) · cites this paper as Mayer et al., 2015
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“microglial activity is now known to be influenced by factors originating outside the CNS, including the gut.”
From Microbiome–microglia connections via the gut–brain axis (2019) · cites this paper as Mayer et al., 2015
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Cites
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Sorted by citations
Cryan, J. F., O'Riordan, K. J., Cowan, C. S. M., Sandhu, K. V., Bastiaanssen, T. F. S., Boehme, M., Codagnone, M. G., Cussotto, S., Fulling, C., Golubeva, A. V., et al. (2019) · Physiological Reviews · doi:10.1152/physrev.00018.2018 · Cited by 5,286
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Immunopathogenesis of IBD: current state of the art
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The vagus nerve at the interface of the microbiota-gut-brain axis
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Metadata
- Authors
- Mayer, E. A., Tillisch, K., & Gupta, A.
- Affiliations
- University of California, Los Angeles (US)
- VA Greater Los Angeles Healthcare System (US)
- Corresponding author
- Mayer, Emeran A.
- Venue
- Journal of Clinical Investigation
- Published
- 2015-02-17
- Volume
- 125
- Issue
- 3
- Pages
- 926-938
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC4362231
- OpenAlex
- W2001339909
- Cited by
- 1,503
- References
- 141
- Citations by year
- 2026: 144 · 2025: 143 · 2024: 133 · 2023: 128 · 2022: 169 · 2021: 165 · 2020: 160 · 2019: 126 · 2018: 122 · 2017: 90 · 2016: 81 · 2015: 41
- FWCI
- 10.79
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Institutes of Health (DK 48351)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK-48351, DK 64539, R01DK048351, P50DK064539)
- National Center for Complementary and Integrative Health (AT007137, R01AT007137)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Keywords
- gut-brain axis, gut microbiota, enteric nervous system, emotional behavior, stress response, pain modulation, neurotransmitter systems, probiotics, antibiotics, hormone signaling, autonomic nervous system, irritable bowel syndrome, autism spectrum disorder, anxiety, depression, Parkinson's disease
- MeSH terms
- Animals, Behavior, Brain, Cell Membrane Permeability, Diet, Emotions, Humans, Hypothalamo-Hypophyseal System, Intestinal Mucosa, Pituitary-Adrenal System, Gastrointestinal Tract, Microbiota
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