Cited by 210Gut microbiota and healthProbiotics and Fermented FoodsGastrointestinal motility and disorders

Mind-altering with the gut: Modulation of the gut-brain axis with probiotics

Kim, Namhee, Yun, Misun, Oh, Young Joon, Choi, Hak-Jong·2018·Journal of Microbiology

Abstract

It is increasingly evident that bidirectional interactions exist among the gastrointestinal tract, the enteric nervous system, and the central nervous system. Recent preclinical and clinical trials have shown that gut microbiota plays an important role in these gut-brain interactions. Furthermore, alterations in gut microbiota composition may be associated with pathogenesis of various neurological disorders, including stress, autism, depression, Parkinson's disease, and Alzheimer's disease. Therefore, the concepts of the microbiota-gut-brain axis is emerging. Here, we review the role of gut microbiota in bidirectional interactions between the gut and the brain, including neural, immune-mediated, and metabolic mechanisms. We highlight recent advances in the understanding of probiotic modulation of neurological and neuropsychiatric disorders via the gut-brain axis.

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Crossref · 10.1007/s12275-018-8032-4

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122 of 122 references verified0 citation errors · 0 not checkable

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  • Probiotics can affect the CNS by regulating the intestinal flora and preventing mental diseases through the gut-brain axis.

    “several research findings have shown that probiotics can affect the CNS by regulating the intestinal flora and preventing mental diseases through the gut–brain axis [71,72,73].”

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Authors
Kim, N., Yun, M., Oh, Y. J., & Choi, H.-J.
Affiliations
World Institute of Kimchi (KR)
Corresponding author
Choi, Hak-Jong
Venue
Journal of Microbiology
Published
2018-02-28
Volume
56
Issue
3
Pages
172-182
ISSN
  • 1225-8873 (ISSN-L)
  • 1976-3794
OpenAlex
W2793180020
Cited by
210
References
122
Citations by year
2026: 9 · 2025: 20 · 2024: 32 · 2023: 26 · 2022: 33 · 2021: 29 · 2020: 30 · 2019: 21 · 2018: 10
FWCI
2.21
Type
journal article
Language
en
Open access
closed
Locations
  • The Journal of Microbiology (publishedVersion)
  • PubMed (publishedVersion)
Funders
World Institute of Kimchi
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Keywords
gut-brain axis, gut microbiota, probiotics, enteric nervous system, neurological disorders, neuropsychiatric disorders, depression, autism spectrum disorder, Parkinson's disease, Alzheimer's disease, stress, immune-mediated mechanisms, metabolic mechanisms
MeSH terms
Gastrointestinal Microbiome, Animals, Brain, Central Nervous System, Humans, Nervous System Diseases, Enteric Nervous System, Probiotics, Gastrointestinal Tract, Mice, Dysbiosis

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