Redistribution of substrates to adipose tissue promotes obesity in mice with selective insulin resistance in muscle

The metabolic phenotype in obesity: Fat mass, body fat distribution, and adipose tissue function

Goossens, G. H. (2017) · Obesity Facts · doi:10.1159/000471488 · Cited by 8,481

The Effect of Insulin on the Disposal of Intravenous Glucose: Results from Indirect Calorimetry and Hepatic and Femoral Venous Catheterization

DeFronzo, R. A., Jacot, E., Jequier, E., Maeder, E., Wahren, J., & Felber, J. P. (1981) · Diabetes · doi:10.2337/diab.30.12.1000 · Cited by 1,770

Quantitation of Muscle Glycogen Synthesis in Normal Subjects and Subjects with Non-Insulin-Dependent Diabetes by13C Nuclear Magnetic Resonance Spectroscopy

Shulman, G. I., Rothman, D. L., Jue, T., Stein, P., DeFronzo, R. A., & Shulman, R. G. (1990) · New England Journal of Medicine · doi:10.1056/nejm199001253220403 · Cited by 1,248

A Muscle-Specific Insulin Receptor Knockout Exhibits Features of the Metabolic Syndrome of NIDDM without Altering Glucose Tolerance

Brüning, J. C., Michael, M. D., Winnay, J. N., Hayashi, T., Hörsch, D., Accili, D., Goodyear, L. J., & Kahn, C. R. (1998) · Molecular Cell · doi:10.1016/s1097-2765(00)80155-0 · Cited by 1,173

Insulin Action, Diabetogenes, and the Cause of Type II Diabetes

Kahn, C. R. (1994) · Diabetes · doi:10.2337/diab.43.8.1066 · Cited by 916

Impaired Glucose Transport as a Cause of Decreased Insulin-Stimulated Muscle Glycogen Synthesis in Type 2 Diabetes

Cline, G. W., Petersen, K. F., Krssak, M., Shen, J., Hundal, R. S., Trajanoski, Z., Inzucchi, S., Dresner, A., Rothman, D. L., & Shulman, G. I. (1999) · New England Journal of Medicine · doi:10.1056/nejm199907223410404 · Cited by 675

Early neonatal death in mice homozygous for a null allele of the insulin receptor gene

Accili, D., Drago, J., Lee, E. J., Johnson, M. D., Cool, M. H., Salvatore, P., Asico, L. D., José, P. A., Taylor, S. I., & Westphal, H. (1996) · Nature Genetics · doi:10.1038/ng0196-106 · Cited by 594

Hepatic and peripheral insulin resistance: A common feature of Type 2 (non-insulin-dependent) and Type 1 (insulin-dependent) diabetes mellitus

DeFronzo, R. A., Simonson, D. C., & Ferrannini, E. (1982) · Diabetologia · doi:10.1007/bf00253736 · Cited by 539

Muscle Glucose Metabolism following Exercise in the Rat

Richter, E. A., Garetto, L. P., Goodman, M. N., & Ruderman, N. B. (1982) · Journal of Clinical Investigation · doi:10.1172/jci110517 · Cited by 510

Mechanism of Insulin Resistance in A-ZIP/F-1 Fatless Mice

Kim, J. K., Gavrilova, O., Chen, Y., Reitman, M. L., & Shulman, G. I. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.12.8456 · Cited by 443

PTG gene deletion causes impaired glycogen synthesis and developmental insulin resistance

Crosson, S. M., Khan, A. H., Printen, J. A., Pessin, J. E., & Saltiel, A. R. (2003) · Journal of Clinical Investigation · doi:10.1172/jci17975 · Cited by 95

AS160 deficiency causes whole-body insulin resistance via composite effects in multiple tissues

Wang, H. Y., Ducommun, S., Quan, C., Xie, B., Li, M., Wasserman, D. H., Sakamoto, K., MacKintosh, C., & Chen, S. (2012) · Biochemical Journal · doi:10.1042/bj20120702 · Cited by 92

Rodent Models of Nonalcoholic Fatty Liver Disease/Nonalcoholic Steatohepatitis

Imajo, K., Yoneda, M., Kessoku, T., Ogawa, Y., Maeda, S., Sumida, Y., Hyogo, H., Eguchi, Y., Wada, K., & Nakajima, A. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms141121833 · Cited by 93

Regulation of Metabolic Responses by Adipocyte/ Macrophage Fatty Acid–Binding Proteins in Leptin-Deficient Mice

Cao, H., Maeda, K., Görgün, C. Z., Kim, H., Park, S., Shulman, G. I., Kim, J. K., & Hotamışlıgil, G. S. (2006) · Diabetes · doi:10.2337/db05-1496 · Cited by 91

Differential Effects of Rosiglitazone on Skeletal Muscle and Liver Insulin Resistance in A-ZIP/F-1 Fatless Mice

Kim, J. K., Fillmore, J. J., Gavrilova, O., Chao, L. C., Higashimori, T., Choi, H., Kim, H., Yu, C., Chen, Y., Qu, X., et al. (2003) · Diabetes · doi:10.2337/diabetes.52.6.1311 · Cited by 88

Pathways and mechanisms linking dietary components to cardiometabolic disease: thinking beyond calories

Stanhope, K. L., Goran, M. I., Bosy‐Westphal, A., King, J. C., Schmidt, L. A., Schwarz, J., Stice, E. M., Sylvetsky, A. C., Turnbaugh, P. J., Bray, G. A., et al. (2018) · Obesity Reviews · doi:10.1111/obr.12699 · Cited by 90

Potential role of skeletal muscle glucose metabolism on the regulation of insulin secretion

Mizgier, M. L., Casas, M., Contreras‐Ferrat, A. E., Llanos, P., & Galgani, J. E. (2014) · Obesity Reviews · doi:10.1111/obr.12166 · Cited by 88

Fat Mass Accumulation during Childhood Determines Insulin Sensitivity in Early Adulthood

Leunissen, R. W. J., Oosterbeek, P., Hol, L. K. M., Hellingman, A. A., Stijnen, T., & Hokken‐Koelega, A. C. S. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-1543 · Cited by 84

Knockout models are useful tools to dissect the pathophysiology and genetics of insulin resistance

Mauvais‐Jarvis, F., Kulkarni, R., & Kahn, C. R. (2002) · Clinical Endocrinology · doi:10.1046/j.1365-2265.2002.01563.x · Cited by 82

Reduced expression of the NADPH oxidase NOX4 is a hallmark of adipocyte differentiation

Mouche, S., Mkaddem, S. B., Wang, W., Katić, M., Tseng, Y., Carnésecchi, S., Steger, K., Foti, M., Meier, C. A., Muzzin, P., et al. (2007) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2007.03.003 · Cited by 84

A model to explore the interaction between muscle insulin resistance and beta-cell dysfunction in the development of type 2 diabetes.

Mauvais‐Jarvis, F., Virkamäki, A., Michael, M. D., Winnay, J. N., Zisman, A., Kulkarni, R. N., & Kahn, C. R. (2000) · Diabetes · doi:10.2337/diabetes.49.12.2126 · Cited by 82

Metabolic, anabolic, and mitogenic insulin responses: A tissue-specific perspective for insulin receptor activators

Bedinger, D., & Adams, S. H. (2015) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2015.08.013 · Cited by 85

TRIENNIAL GROWTH SYMPOSIUM: Effects of polymeric carbohydrates on growth and development in pigs1

Bach Knudsen, K. E. (2011) · Journal of Animal Science · doi:10.2527/jas.2010-3602 · Cited by 75

Insulin hypersensitivity in mice lacking the V1b vasopressin receptor

Fujiwara, Y., Hiroyama, M., Sanbe, A., Aoyagi, T., Birumachi, J., Yamauchi, J., Tsujimoto, G., & Tanoue, A. (2007) · The Journal of Physiology · doi:10.1113/jphysiol.2007.136481 · Cited by 75

Insulin resistance causes increased beta-cell mass but defective glucose-stimulated insulin secretion in a murine model of type 2 diabetes

Asghar, Z., Yau, D., Chan, F., LeRoith, D., Chan, C. B., & Wheeler, M. B. (2005) · Diabetologia · doi:10.1007/s00125-005-0045-y · Cited by 77

Changes in Cells Associated with Insulin Resistance

Szablewski, L. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25042397 · Cited by 78

Adipose tissue inflammation contributes to short-term high-fat diet-induced hepatic insulin resistance

Wiedemann, M. S. F., Wueest, S., Item, F., Schoenle, E. J., & Konrad, D. (2013) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00179.2013 · Cited by 74

Pancreatic-Specific Inactivation of IGF-I Gene Causes Enlarged Pancreatic Islets and Significant Resistance to Diabetes

Lu, Y., Herrera, P. L., Guo, Y., Sun, D. F., Tang, Z., LeRoith, D., & Liu, J. (2004) · Diabetes · doi:10.2337/diabetes.53.12.3131 · Cited by 73

Improved Insulin Sensitivity by GLUT12 Overexpression in Mice

Purcell, S. H., Aerni-Flessner, L. B., Willcockson, A. R., Diggs‐Andrews, K. A., Fisher, S. J., & Moley, K. H. (2011) · Diabetes · doi:10.2337/db11-0033 · Cited by 72

SWELL1 regulates skeletal muscle cell size, intracellular signaling, adiposity and glucose metabolism

Kumar, A., Xie, L., Ta, C. M., Hinton, A. O., Jr., Gunasekar, S. K., Minerath, R. A., Shen, K. C., Maurer, J. M., Grueter, C. E., Abel, E. D., et al. (2020) · eLife · doi:10.7554/elife.58941 · Cited by 69

Understanding adipose tissue development from transgenic animal models

Valet, P., Tavernier, G., Castan‐Laurell, I., Saulnier‐Blache, J. S., & Langin, D. (2002) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)30458-2 · Cited by 70

Longitudinal Changes in Body Fat in African American and Caucasian Children: Influence of Fasting Insulin and Insulin Sensitivity

Johnson, M. S., Figueroa‐Colón, R., Huang, T.-P., Dwyer, J., & Goran, M. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.7.7665 · Cited by 69

Carotid body denervation prevents fasting hyperglycemia during chronic intermittent hypoxia

Shin, M., Yao, Q., Jun, J. C., Bevans‐Fonti, S., Yoo, D.-Y., Han, W., Mesarwi, O. A., Richardson, R., Fu, Y., Pasricha, P. J., et al. (2014) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01133.2013 · Cited by 71

The human longevity gene homolog INDY and interleukin‐6 interact in hepatic lipid metabolism

von Loeffelholz, C., Lieske, S., Neuschäfer‐Rube, F., Willmes, D. M., Raschzok, N., Sauer, I. M., König, J., Fromm, M. F., Horn, P., Chatzigeorgiou, A., et al. (2017) · Hepatology · doi:10.1002/hep.29089 · Cited by 70

Foetal and neonatal energy metabolism in pigs and humans: a review

Mota‐Rojas, D., Orozco-Gregorio, H., Villanueva‐García, D., Bonilla‐Jaime, H., Suarez-Bonilla, X., González, R. H., Roldán-Santiago, P., & Ortega, M. E. T. (2011) · Veterinární Medicína · doi:10.17221/1565-vetmed · Cited by 68

Restoration of muscle functionality by genetic suppression of glycogen synthesis in a murine model of Pompe disease

Douillard‐Guilloux, G., Raben, N., Takikita, S., Ferry, A., Vignaud, A., Guillet-Deniau, I., Favier, M., Thurberg, B. L., Roach, P. J., Caillaud, C., et al. (2009) · Human Molecular Genetics · doi:10.1093/hmg/ddp535 · Cited by 66

Normal Insulin-Stimulated Endothelial Function and Impaired Insulin-Stimulated Muscle Glucose Uptake in Young Adults with Low Birth Weight

Hermann, T. S., Rask‐Madsen, C., Ihlemann, N., Domínguez, H., Jensen, C. B., Storgaard, H., Vaag, A. A., Køber, L., & Torp-Pedersen, C. T. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-021550 · Cited by 65

Induction of Cytosolic Phospholipase A2α Is Required for Adipose Neutrophil Infiltration and Hepatic Insulin Resistance Early in the Course of High-Fat Feeding

Hadad, N., Burgazliev, O., Elgazar-Carmon, V., Solomonov, Y., Wueest, S., Item, F., Konrad, D., Rudich, A., & Lévy, R. (2013) · Diabetes · doi:10.2337/db12-1300 · Cited by 66

High Circulating Leptin Receptors with Normal Leptin Sensitivity in Liver-specific Insulin Receptor Knock-out (LIRKO) Mice

Cohen, S. E., Kokkotou, E. G., Biddinger, S. B., Kondo, T., Gebhardt, R., Kratzsch, J., Mantzoros, C. S., & Kahn, C. R. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m704053200 · Cited by 67

Phloridzin Improves Hyperglycemia But Not Hepatic Insulin Resistance in a Transgenic Mouse Model of Type 2 Diabetes

Zhao, H., Yakar, S., Gavrilova, O., Sun, H., Zhang, Y., Kim, H., Setser, J., Jou, W., & LeRoith, D. (2004) · Diabetes · doi:10.2337/diabetes.53.11.2901 · Cited by 64

Visceral adiposity, inflammation, and hippocampal function in obesity

Stranahan, A. M. (2021) · Neuropharmacology · doi:10.1016/j.neuropharm.2021.108920 · Cited by 63

Glucose-Fatty Acid Interaction in Skeletal Muscle and Adipose Tissue in Insulin Resistance

Cahová, M., Vavřínková, H., & Kazdová, L. (2007) · Physiological Research · doi:10.33549/physiolres.930882 · Cited by 64

Metabolic Consequences of High-Fat Diet Are Attenuated by Suppression of HIF-1α

Shin, M., Drager, L. F., Yao, Q., Bevans‐Fonti, S., Yoo, D. Y., Jun, J. C., Aja, S. M., Bhanot, S., & Polotsky, V. Y. (2012) · PLoS ONE · doi:10.1371/journal.pone.0046562 · Cited by 65

Dietary Polysaccharides in the Amelioration of Gut Microbiome Dysbiosis and Metabolic Diseases.

Ahmadi, S., Mainali, R., Nagpal, R., Sheikh‐Zeinoddin, M., Soleimanian‐Zad, S., Wang, S., Deep, G., Mishra, S. K., & Yadav, H. (2017) · PubMed · doi:10.15226/2374-8354/4/2/00140 · Cited by 62

Transgenic mice with dominant negative PKC‐theta in skeletal muscle: A new model of insulin resistance and obesity

Serra, C., Federici, M., Buongiorno, A. M., Senni, M., Morelli, S., Segratella, E., Pascuccio, M., Tiveron, C., Mattei, E., Tatangelo, L., et al. (2003) · Journal of Cellular Physiology · doi:10.1002/jcp.10278 · Cited by 62

Improvement of Insulin Sensitivity after Peroxisome Proliferator-Activated Receptor-α Agonist Treatment Is Accompanied by Paradoxical Increase of Circulating Resistin Levels

Haluzı́k, M., Lacinová, Z., Dolinkova, M., Haluzíková, D., Housa, D., Hořínek, A., Vernerová, Z., Kumstyrova, T., & Haluzı́k, M. (2006) · Endocrinology · doi:10.1210/en.2005-1624 · Cited by 62

Muscle-Specific Overexpression of CD36 Reverses the Insulin Resistance and Diabetes of MKR Mice

Héron‐Milhavet, L., Haluzı́k, M., Yakar, S., Gavrilova, O., Pack, S., Jou, W., Ibrahimi, A., Kim, H., Hunt, D. G., Yau, D., et al. (2004) · Endocrinology · doi:10.1210/en.2003-1543 · Cited by 61

The Adipocyte-Expressed Forkhead Transcription Factor Foxc2 Regulates Metabolism Through Altered Mitochondrial Function

Lidell, M. E., Seifert, E. L., Westergren, R., Heglind, M., Gowing, A., Sukonina, V., Arani, Z., Itkonen, P., Wallin, S., Westberg, F., et al. (2011) · Diabetes · doi:10.2337/db10-0409 · Cited by 64

Cardiac-Specific Overexpression of CYP2J2 Attenuates Diabetic Cardiomyopathy in Male Streptozotocin-Induced Diabetic Mice

Ma, B., Xiong, X., Chen, C., Li, H., Xu, X., Li, X., Li, R., Chen, G., Dackor, R. T., Zeldin, D. C., et al. (2013) · Endocrinology · doi:10.1210/en.2012-2166 · Cited by 59

Diabetes in Mice With Selective Impairment of Insulin Action in Glut4-Expressing Tissues

Lin, H. V., Ren, H., Samuel, V. T., Lee, H., Lu, T. Y., Shulman, G. I., & Accili, D. (2011) · Diabetes · doi:10.2337/db10-1056 · Cited by 59

Skeletal Muscle Stem Cells from Animals I. Basic Cell Biology

Dodson, M. V., Hausman, G. J., Guan, L. L., Du, ‬., Rasmussen, T. P., Poulos, S. P., Mir, P. S., Bergen, W. G., Fernyhough, M. E., McFarland, D. C., et al. (2010) · International Journal of Biological Sciences · doi:10.7150/ijbs.6.465 · Cited by 59

Normal Akt/PKB with reduced PI3K activation in insulin-resistant mice

Nadler, S. T., Stoehr, J. P., Rabaglia, M. E., Schueler, K. L., Birnbaum, M. J., & Attie, A. (2001) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2001.281.6.e1249 · Cited by 58

Inhibitory G proteins and their receptors: emerging therapeutic targets for obesity and diabetes

Kimple, M. E., Neuman, J. C., Linnemann, A. K., & Casey, P. J. (2014) · Experimental & Molecular Medicine · doi:10.1038/emm.2014.40 · Cited by 54

Effect of adipocyte β3-adrenergic receptor activation on the type 2 diabetic MKR mice

Kim, H., Pennisi, P. A., Gavrilova, O., Pack, S., Jou, W., Setser, J., East-Palmer, J., Tang, Y., Manganiello, V. C., & LeRoith, D. (2006) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00344.2005 · Cited by 55

Fas cell surface death receptor controls hepatic lipid metabolism by regulating mitochondrial function

Item, F., Wueest, S., Lemos, V., Stein, S., Lucchini, F. C., Denzler, R., Fisser, M. C., Challa, T. D., Pirinen, E., Kim, Y., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-00566-9 · Cited by 54

C-Reactive Protein Causes Insulin Resistance in Mice Through Fcγ Receptor IIB–Mediated Inhibition of Skeletal Muscle Glucose Delivery

Tanigaki, K., Vongpatanasin, W., Barrera, J. A., Atochin, D. N., Huang, P. L., Bonvini, E., Shaul, P. W., & Mineo, C. (2012) · Diabetes · doi:10.2337/db12-0133 · Cited by 54

Mechanism of glucose intolerance in mice with dominant negative mutation of CEACAM1

Park, S.-Y., Cho, Y.-R., Kim, H.-J., Hong, E.-G., Higashimori, T., Lee, S. J., Goldberg, I. J., Shulman, G. I., Najjar, S. M., & Kim, J. K. (2006) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00077.2006 · Cited by 51

Lipodystrophy and severe metabolic dysfunction in mice with adipose tissue-specific insulin receptor ablation

Qiang, G., Kong, H. W., Xu, S., Pham, H. A., Parlee, S. D., Burr, A. A., Gil, V., Pang, J., Hughes, A., Gu, X., et al. (2016) · Molecular Metabolism · doi:10.1016/j.molmet.2016.05.005 · Cited by 54

Rac1 muscle knockout exacerbates the detrimental effect of high‐fat diet on insulin‐stimulated muscle glucose uptake independently of Akt

Raun, S. H., Ali, M. S., Kjøbsted, R., Møller, L. L. V., Federspiel, M. A., Richter, E. A., Jensen, T. E., & Sylow, L. (2018) · The Journal of Physiology · doi:10.1113/jp275602 · Cited by 51

Opposite Effects of Background Genotype on Muscle and Liver Insulin Sensitivity of Lipoatrophic Mice

Colombo, C., Haluzı́k, M., Cutson, J. J., Dietz, K. R., Marcus‐Samuels, B., Vinson, C., Gavrilova, O., & Reitman, M. L. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m207665200 · Cited by 51

Small molecule SWELL1 complex induction improves glycemic control and nonalcoholic fatty liver disease in murine Type 2 diabetes

Gunasekar, S. K., Xie, L., Kumar, A., Hong, J., Chheda, P. R., Chen, K., Kern, D. M., My-Ta, C., Maurer, J. M., Heebink, J., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-28435-0 · Cited by 51

Overexpression of APOC1 in obob mice leads to hepatic steatosis and severe hepatic insulin resistance

Muurling, M., van den Hoek, A. M., Mensink, R. P., Pijl, H., Romijn, J. A., Havekes, L. M., & Voshol, P. J. (2004) · Journal of Lipid Research · doi:10.1194/jlr.m300240-jlr200 · Cited by 49

From a glucocentric to a lipocentric approach towards metabolic syndrome

Mittra, S., Bansal, V. S., & Bhatnagar, P. K. (2008) · Drug Discovery Today · doi:10.1016/j.drudis.2008.01.006 · Cited by 48

Impaired insulin-receptor autophosphorylation is an early defect in fat-fed, insulin-resistant rats

YOUNGREN, J. F., Paik, J., & Barnard, R. J. (2001) · Journal of Applied Physiology · doi:10.1152/jappl.2001.91.5.2240 · Cited by 51

Understanding the pathogenesis and treatment of insulin resistance and type 2 diabetes mellitus: what can we learn from transgenic and knockout mice?

Mauvais‐Jarvis, F., & Kahn, C. R. (2000) · PubMed · Cited by 48

A role for suppressed skeletal muscle thermogenesis in pathways from weight fluctuations to the insulin resistance syndrome

Dulloo, A. G. (2005) · Acta Physiologica Scandinavica · doi:10.1111/j.1365-201x.2005.01466.x · Cited by 47

Liver steatosis is associated with insulin resistance in skeletal muscle rather than in the liver in J apanese patients with non‐alcoholic fatty liver disease

Kato, K., Takeshita, Y., Misu, H., Zen, Y., Kaneko, S., & Takamura, T. (2014) · Journal of Diabetes Investigation · doi:10.1111/jdi.12271 · Cited by 49

Effects of a high‐fat, low‐ versus high‐glycemic index diet: retardation of insulin resistance involves adipose tissue modulation

van Schothorst, E. M., Bunschoten, A., Schrauwen, P., Mensink, R. P., & Keijer, J. (2008) · The FASEB Journal · doi:10.1096/fj.08-117119 · Cited by 47

Ectopic Fat Accumulation and Distant Organ-Specific Insulin Resistance in Japanese People with Nonalcoholic Fatty Liver Disease

Kato, K., Takamura, T., Takeshita, Y., Ryu, Y., Misu, H., Ota, T., Tokuyama, K., Nagasaka, S., Matsuhisa, M., Matsui, O., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0092170 · Cited by 47

Disruption of Gpr45 causes reduced hypothalamic POMC expression and obesity

Cui, J., Ding, Y., Chen, S., Zhu, X., Wu, Y., Zhang, M., Zhao, Y., Li, T.-R. R., Sun, L. V., Zhao, S., et al. (2016) · Journal of Clinical Investigation · doi:10.1172/jci85676 · Cited by 47

The role of mitochondrial reactive oxygen species in insulin resistance

Ayer, A., Fazakerley, D. J., James, D. E., & Stocker, R. (2021) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2021.11.007 · Cited by 50

Insulin‐Like Growth Factor I Regulation and Its Actions in Skeletal Muscle

Vassilakos, G., & Barton, E. R. (2018) · Comprehensive physiology · doi:10.1002/cphy.c180010 · Cited by 48

Short-Termin VivoInhibition of Insulin Receptor Substrate-1 Expression Leads to Insulin Resistance, Hyperinsulinemia, and Increased Adiposity

ARAUJO, E. P. D., de Souza, C. T., Gasparetti, A. L., Ueno, M., Boschero, A. C., Saad, M. J. A., & Velloso, L. A. (2004) · Endocrinology · doi:10.1210/en.2004-0778 · Cited by 46

Thiazolidinediones improve insulin sensitivity in adipose tissue and reduce the hyperlipidaemia without affecting the hyperglycaemia in a transgenic model of type 2 diabetes

Kim, H., Haluzı́k, M., Gavrilova, O., Yakar, S., Portas, J., Sun, H., Pajvani, U. B., Scherer, P. E., & LeRoith, D. (2004) · Diabetologia · doi:10.1007/s00125-004-1581-6 · Cited by 47

Cellular and Molecular Mechanisms of Adipose Tissue Plasticity in Muscle Insulin Receptor Knockout Mice

Cariou, B., Postic, C., Boudou, P., Burcelin, R., Kahn, C. R., Girard, J. R., Burnol, A., & Mauvais‐Jarvis, F. (2003) · Endocrinology · doi:10.1210/en.2003-0882 · Cited by 46

Regression of Liver Steatosis Following Phosphatidylcholine Administration: A Review of Molecular and Metabolic Pathways Involved

Osipova, D., Kokoreva, K., Лазебник, Л. Б., Голованова, Е. В., Pavlov, C. S., Духанин, А. С., Orlova, S., & Starostin, K. M. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.797923 · Cited by 45

Trapped fat: Obesity pathogenesis as an intrinsic disorder in metabolic fuel partitioning

Friedman, M. I., Sørensen, T. I. A., Taubes, G., Lund, J. T., & Ludwig, D. S. (2024) · Obesity Reviews · doi:10.1111/obr.13795 · Cited by 47

4-Quinolone-3-carboxylic acids as cell-permeable inhibitors of protein tyrosine phosphatase 1B

Zhi, Y., Gao, L., Jin, Y., Tang, C., Li, J.-Y., Li, J., & Long, Y. (2014) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2014.05.028 · Cited by 45

Insulin resistance is not related to plasma homocysteine concentration in healthy premenopausal women

Tanrıkulu-Kılıç, F., Bekpınar, S., Ünlüçerçi, Y., & Orhan, Y. (2006) · Physiological Research · doi:10.33549/physiolres.930745 · Cited by 45

Adrenalectomy Improves Diabetes in A-ZIP/F-1 Lipoatrophic Mice by Increasing Both Liver and Muscle Insulin Sensitivity

Haluzı́k, M., Dietz, K. R., Kim, J. K., Marcus‐Samuels, B., Shulman, G. I., Gavrilova, O., & Reitman, M. L. (2002) · Diabetes · doi:10.2337/diabetes.51.7.2113 · Cited by 45

Taurine Alters Respiratory Gas Exchange and Nutrient Metabolism in Type 2 Diabetic Rats

Harada, N., Ninomiya, C., Osako, Y., Morishima, M., Mawatari, K., Takahashi, A., & Nakaya, Y. (2004) · Obesity Research · doi:10.1038/oby.2004.135 · Cited by 44

Epigenomic and transcriptional control of insulin resistance

Rosen, E. D. (2016) · Journal of Internal Medicine · doi:10.1111/joim.12547 · Cited by 43

Absence of insulin signalling in skeletal muscle is associated with reduced muscle mass and function: evidence for decreased protein synthesis and not increased degradation

O'Neill, E. D., Wilding, J. P. H., Kahn, C. R., Remmen, H. V., McArdle, A., Jackson, M. J., & Close, G. L. (2010) · AGE · doi:10.1007/s11357-009-9125-0 · Cited by 42

Mosaic analysis of insulin receptor function

Kitamura, T., Kitamura, Y., Nakae, J., Giordano, A., Cinti, S., Kahn, C. R., Efstratiadis, A., & Accili, D. (2004) · Journal of Clinical Investigation · doi:10.1172/jci17810 · Cited by 42

Using isotope tracers to study metabolism: application in mouse models

McCabe, B. J., & Previs, S. F. (2003) · Metabolic Engineering · doi:10.1016/j.ymben.2003.09.003 · Cited by 41

Role of PKCδ in Insulin Sensitivity and Skeletal Muscle Metabolism

Li, M., Vienberg, S. G., Bézy, O., O'Neill, B. T., & Kahn, C. R. (2015) · Diabetes · doi:10.2337/db14-1891 · Cited by 40

Insulin Stimulation of Hepatic Triacylglycerol Secretion in the Insulin‐Replete State

Zammit, V. A. (2002) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2002.tb04263.x · Cited by 40

Genetic manipulation of insulin signaling, action and secretion in mice

Baudry, A., Leroux, L., Jackerott, M., & Joshi, R. L. (2002) · EMBO Reports · doi:10.1093/embo-reports/kvf078 · Cited by 40

New methodologies for studying lipid synthesis and turnover: Looking backwards to enable moving forwards

Previs, S. F., McLaren, D. G., Wang, S.-P., Stout, S. J., Zhou, H., Herath, K. B., Shah, V., Miller, P. L., Wilsie, L. C., Castro‐Perez, J. M., et al. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2013.05.019 · Cited by 40

The ERα-PI3K Cascade in Proopiomelanocortin Progenitor Neurons Regulates Feeding and Glucose Balance in Female Mice

Zhu, L., Xu, P., Cao, X., Yang, Y., Hinton, A. O., Jr., Xia, Y., Saito, K., Yan, X., Zou, F., Ding, H., et al. (2015) · Endocrinology · doi:10.1210/en.2015-1660 · Cited by 39

Peroxisome Proliferator-Activated Receptor-α Deficiency Does Not Alter Insulin Sensitivity in Mice Maintained on Regular or High-Fat Diet: Hyperinsulinemic-Euglycemic Clamp Studies

Haluzı́k, M., Gavrilova, O., & LeRoith, D. (2003) · Endocrinology · doi:10.1210/en.2003-1015 · Cited by 39

The reduced insulin-mediated glucose oxidation in skeletal muscle from type 2 diabetic subjects may be of genetic origin—evidence from cultured myotubes

Gaster, M., & Beck-Nielsen, H. (2004) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2004.05.006 · Cited by 38

Novel application of the “doubly labeled” water method: measuring CO2production and the tissue-specific dynamics of lipid and protein in vivo

Bederman, I. R., Dufner, D. A., Alexander, J. C., & Previs, S. F. (2005) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00340.2005 · Cited by 38

Metabolic insights from extreme human insulin resistance phenotypes

Stears, A. J., O’Rahilly, S., Semple, R. K., & Savage, D. B. (2012) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2011.09.003 · Cited by 38

Use of mouse models in studying type 2 diabetes mellitus

Lee, A., & Cox, R. (2010) · Expert Reviews in Molecular Medicine · doi:10.1017/s1462399410001729 · Cited by 37

Decreased mitochondrial carnitine translocase in skeletal muscles impairs utilization of fatty acids in insulin-resistant patients

Peluso, G. (2002) · Frontiers in bioscience · doi:10.2741/a745 · Cited by 36

New Insights into the Integrated Physiology of Insulin Action

Kitamura, Y., & Accili, D. (2004) · Reviews in Endocrine and Metabolic Disorders · doi:10.1023/b:remd.0000021436.91347.93 · Cited by 35

A Life without Hunger: The Ups (and Downs) to Modulating Melanocortin-3 Receptor Signaling

Butler, A. A., Clemence, G., Mavrikaki, M., Trevaskis, J. L., Macarthur, H., Marks, D. L., & Farr, S. A. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2017.00128 · Cited by 36

Lipoxins, resolvins, protectins, maresins and nitrolipids, and their clinical implications with specific reference to diabetes mellitus and other diseases: part II

Das, U. N. (2013) · Clinical Lipidology · doi:10.2217/clp.13.32 · Cited by 35

Muscle-specific Pikfyve gene disruption causes glucose intolerance, insulin resistance, adiposity, and hyperinsulinemia but not muscle fiber-type switching

Ikonomov, O. C., Sbrissa, D., Delvecchio, K., Feng, H., Cartee, G. D., Jin, J., & Shisheva, A. (2013) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00030.2013 · Cited by 35

Impact of Physical Inactivity on Subcutaneous Adipose Tissue Metabolism in Healthy Young Male Offspring of Patients With Type 2 Diabetes

Højbjerre, L., Sonne, M. P., Alibegovic, A. C., Dela, F., Vaag, A. A., Meldgaard, J. B., Christensen, K. B., & Stallknecht, B. M. (2010) · Diabetes · doi:10.2337/db10-0320 · Cited by 40

Role of Circadian Transcription Factor Rev-Erb in Metabolism and Tissue Fibrosis

Raza, G. S., Sodum, N., Kaya, Y., & Herzig, K. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232112954 · Cited by 35

Mice with deletion of the mitochondrial glycerol-3-phosphate dehydrogenase gene exhibit a thrifty phenotype: effect of gender

Alfadda, A. A., Eichler, R. A. D. S., Stepanyan, Z., Marrif, H. I., & Silva, J. E. (2004) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00103.2004 · Cited by 34

Gα13 ablation reprograms myofibers to oxidative phenotype and enhances whole-body metabolism

Koo, J. H., Kim, T. H., Park, S., Joo, M. S., Han, C. Y., Choi, C. S., & Kim, S. G. (2017) · Journal of Clinical Investigation · doi:10.1172/jci92067 · Cited by 33

Vav2 catalysis-dependent pathways contribute to skeletal muscle growth and metabolic homeostasis

Rodríguez‐Fdez, S., Lorenzo‐Martín, L. F., Fernández‐Pisonero, I., Porteiro, B., Veyrat‐Durebex, C., Beiroa, D., Al–Massadi, O., Abad, A., Diéguez, C., Coppari, R., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-19489-z · Cited by 33

Role of Insulin-Stimulated Adipose Tissue Perfusion in the Development of Whole-Body Insulin Resistance

Emanuel, A. L., Meijer, R. I., Muskiet, M. H. A., van Raalte, D. H., Eringa, E. C., & Serné, E. H. (2017) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.116.308670 · Cited by 32

Weight loss in obese men by caloric restriction and high‐dose diazoxide–mediated insulin suppression

van Boekel, G., Loves, S., van Sorge, A., Ruinemans‐Koerts, J., Rijnders, T., & de Boer, H. (2008) · Diabetes Obesity and Metabolism · doi:10.1111/j.1463-1326.2008.00878.x · Cited by 31

Increased Hepatic Insulin Action in Diet-Induced Obese Mice Following Inhibition of Glucosylceramide Synthase

Yew, N. S., Zhao, H., Hong, E., Wu, I., Przybylska, M., Siegel, C., Shayman, J. A., ARBEENY, C. M., Kim, J. K., Jiang, C., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0011239 · Cited by 31

Increased Lactate Release per Fat Cell in Normoglycemic First-Degree Relatives of Individuals With Type 2 Diabetes

Sandqvist, M., Eriksson, J. W., & Jansson, P. (2001) · Diabetes · doi:10.2337/diabetes.50.10.2344 · Cited by 31

Abdominal obesity in BTBR male mice is associated with peripheral but not hepatic insulin resistance

Flowers, J. B., Oler, A. T., Nadler, S. T., Choi, Y., Schueler, K. L., Yandell, B. S., Kendziorski, C. M., & Attie, A. (2006) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00370.2006 · Cited by 33

Cellular and Molecular Mechanisms of Adipose Tissue Plasticity in Muscle Insulin Receptor Knockout Mice

Cariou, B., Postic, C., Boudou, P., Burcelin, R., Kahn, C. R., Girard, J. R., Burnol, A., & Mauvais‐Jarvis, F. (2003) · Endocrinology · doi:10.1210/en.2003-0882 · Cited by 46

Adipose-selective targeting of the GLUT4 gene impairs insulin action in muscle and liver

Abel, E. D., Peroni, O. D., Kim, J. K., Kim, Y., Boss, O., Hadro, E., Minnemann, T., Shulman, G. I., & Kahn, B. B. (2001) · Nature · doi:10.1038/35055575 · Cited by 1,276

A model to explore the interaction between muscle insulin resistance and beta-cell dysfunction in the development of type 2 diabetes.

Mauvais‐Jarvis, F., Virkamäki, A., Michael, M. D., Winnay, J. N., Zisman, A., Kulkarni, R. N., & Kahn, C. R. (2000) · Diabetes · doi:10.2337/diabetes.49.12.2126 · Cited by 82

Transgenic mice with muscle-specific insulin resistance develop increased adiposity, impaired glucose tolerance, and dyslipidemia

Moller, D. E., Chang, P.-Y., Yaspelkis, B. B., Flier, J. S., Wallberg‐Henriksson, H., & Ivy, J. L. (1996) · Endocrinology · doi:10.1210/endo.137.6.8641192 · Cited by 56

Adipose-specific overexpression of GLUT4 reverses insulin resistance and diabetes in mice lacking GLUT4 selectively in muscle

Carvalho, E., Kotani, K., Peroni, O. D., & Kahn, B. B. (2005) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00116.2005 · Cited by 247