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Reactive Oxygen Species as a Signal in Glucose-Stimulated Insulin Secretion

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Nkx6.1 Is Essential for Maintaining the Functional State of Pancreatic Beta Cells

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Members of the Large Maf Transcription Family Regulate Insulin Gene Transcription in Islet β Cells

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MafA and MafB Regulate Genes Critical to β-Cells in a Unique Temporal Manner

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Intraislet Endothelial Cells Contribute to Revascularization of Transplanted Pancreatic Islets

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MafB is required for islet β cell maturation

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Human β-Cell Proliferation and Intracellular Signaling

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Palmitate Inhibition of Insulin Gene Expression Is Mediated at the Transcriptional Level via Ceramide Synthesis

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Oxidative Stress-mediated, Post-translational Loss of MafA Protein as a Contributing Mechanism to Loss of Insulin Gene Expression in Glucotoxic Beta Cells

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Peroxisome-generated hydrogen peroxide as important mediator of lipotoxicity in insulin-producing cells

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Autophagy defends pancreatic β cells from human islet amyloid polypeptide-induced toxicity

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Transcriptomes of the major human pancreatic cell types

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Insulin Resistance Alters Islet Morphology in Nondiabetic Humans

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Insulin demand regulates β cell number via the unfolded protein response

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Islet Microenvironment, Modulated by Vascular Endothelial Growth Factor-A Signaling, Promotes β Cell Regeneration

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Differences in the Expression of Heat-Shock Proteins and Antioxidant Enzymes between Human and Rodent Pancreatic Islets: Implications for the Pathogenesis of Insulin-Dependent Diabetes Mellitus

Welsh, N., Margulis, B. A., Borg, L., Jernberg‐Wiklund, H., Saldeen, J., Flodström‐Tullberg, M., Mello, M. A., Andersson, A., PIPELEERS, D. G., Hellerström, C., et al. (1995) · Molecular Medicine · doi:10.1007/bf03401895 · Cited by 203

Islet-enriched gene expression and glucose-induced insulin secretion in human and mouse islets

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Endoplasmic Reticulum Stress, Pancreatic -Cell Degeneration, and DiabetesPreprint

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Islet amyloid: From fundamental biophysics to mechanisms of cytotoxicity

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Human IAPP–induced pancreatic β cell toxicity and its regulation by autophagy

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Role of metabolically generated reactive oxygen species for lipotoxicity in pancreatic β ‐cells

Gehrmann, W., Elsner, M., & Lenzen, S. (2010) · Diabetes Obesity and Metabolism · doi:10.1111/j.1463-1326.2010.01265.x · Cited by 176

Islet amyloid deposition limits the viability of human islet grafts but not porcine islet grafts

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A novel high-affinity peptide antagonist to the insulin receptor

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The Nkx6.1 homeodomain transcription factor suppresses glucagon expression and regulates glucose-stimulated insulin secretion in islet beta cells

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Human β-Cell Proliferation and Intracellular Signaling: Part 3

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Generation of improved humanized mouse models for human infectious diseases

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Analysis of Beta-Cell Gene Expression Reveals Inflammatory Signaling and Evidence of Dedifferentiation following Human Islet Isolation and Culture

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Differentiation of glucose toxicity from beta cell exhaustion during the evolution of defective insulin gene expression in the pancreatic islet cell line, HIT-T15.

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Failure of the Adaptive Unfolded Protein Response in Islets of Obese Mice Is Linked With Abnormalities in β-Cell Gene Expression and Progression to Diabetes

Chan, J. Y., Luzuriaga, J., Bensellam, M., Biden, T. J., & Laybutt, D. R. (2012) · Diabetes · doi:10.2337/db12-0701 · Cited by 123

Elevated Mouse Hepatic Betatrophin Expression Does Not Increase Human β-Cell Replication in the Transplant Setting

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Pancreatic Islet Vasculature Adapts to Insulin Resistance Through Dilation and Not Angiogenesis

Dai, C., Briššová, M., Reinert, R. B., Nyman, L. R., Liu, E. H., Thompson, C. S., Shostak, A., Shiota, M., Takahashi, T., & Powers, A. C. (2013) · Diabetes · doi:10.2337/db12-1657 · Cited by 117

Ceramide synthase 4 and de novo production of ceramides with specific N-acyl chain lengths are involved in glucolipotoxicity-induced apoptosis of INS-1 β-cells

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Glucose stimulates human beta cell replication in vivo in islets transplanted into NOD–severe combined immunodeficiency (SCID) mice

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Increased Dietary Fat Promotes Islet Amyloid Formation and β-Cell Secretory Dysfunction in a Transgenic Mouse Model of Islet Amyloid

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Islet formation in mice and men: Lessons for the generation of functional insulin-producing β cells from human pluripotent stem cells

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Determinants of glucose toxicity and its reversibility in the pancreatic islet β-cell line, HIT-T15

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Vascular Endothelial Growth Factor-A and Islet Vascularization Are Necessary in Developing, but Not Adult, Pancreatic Islets

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S961, an insulin receptor antagonist causes hyperinsulinemia, insulin-resistance and depletion of energy stores in rats

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Enhanced expression of VEGF-A in β cells increases endothelial cell number but impairs islet morphogenesis and β cell proliferation

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Interaction between cytokines and inflammatory cells in islet dysfunction, insulin resistance and vascular disease

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Long-Term Exposure to Glucose and Lipids Inhibits Glucose-Induced Insulin Secretion Downstream of Granule Fusion With Plasma Membrane

Olofsson, C. S., Collins, S., Bengtsson, M., Eliasson, L., Salehi, A., Shimomura, K., Tarasov, A., Holm, C., Ashcroft, F., & Rorsman, P. (2007) · Diabetes · doi:10.2337/db06-1150 · Cited by 87

Glucotoxicity Inhibits Late Steps of Insulin Exocytosis

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Human islet preparations distributed for research exhibit a variety of insulin-secretory profiles

Kayton, N. S., Poffenberger, G., Henske, J. A., Dai, C., Thompson, C. S., Aramandla, R., Shostak, A., Nicholson, W. E., Briššová, M., Bush, W. S., et al. (2015) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00437.2014 · Cited by 83

β-Cell Function, Insulin Sensitivity, and Glucose Tolerance in Obese Diabetic and Nondiabetic Adolescents and Young Adults

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Human Immune System Development and Rejection of Human Islet Allografts in Spontaneously Diabetic NOD-Rag1null IL2rγnull Ins2Akita Mice

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Combination of the Dipeptidyl Peptidase IV Inhibitor LAF237 [(S)-1-[(3-Hydroxy-1-adamantyl)ammo]acetyl-2-cyanopyrrolidine] with the Angiotensin II Type 1 Receptor Antagonist Valsartan [N-(1-Oxopentyl)-N-[[2′-(1 H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl]methyl]-l-valine] Enhances Pancreatic Islet Morphology and Function in a Mouse Model of Type 2 Diabetes

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