Inflammation in obesity and diabetes: islet dysfunction and therapeutic opportunity

Donath, Marc Y.; Dalmas, Élise; Sauter, Nadine S.; Böni-Schnetzler, Marianne

doi:10.1016/j.cmet.2013.05.001

Cited by 339Pancreatic function and diabetesAdipokines, Inflammation, and Metabolic DiseasesDiabetes and associated disorders

Inflammation in obesity and diabetes: islet dysfunction and therapeutic opportunity

Open access

Donath, Marc Y., Dalmas, Élise, Sauter, Nadine S., Böni-Schnetzler, Marianne·2013·Cell Metabolism

DOI 10.1016/j.cmet.2013.05.001

Open this paper in CoChat — free account Open PDF

Abstract

The role of the immune system is to restore functionality in response to stress. Increasing evidence shows that this function is not limited to insults by infection or injury and plays a role in response to overnutrition. Initially, this metabolic activation of the immune system is a physiological response, but it may become deleterious with time. Therefore, therapeutic interventions should aim at modulating the immune system rather than simply damping it. In this article, we describe the physiology and pathology of the immune system during obesity and diabetes with a focus on islet inflammation, the IL-1β pathway, and clinical translation.

Integrity signals

Registry

Crossref · 10.1016/j.cmet.2013.05.001

Cites

146 of 146 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

T2D is associated with inflammation of insulin-producing β cells and white adipose tissue, resulting in decreased insulin production and increased insulin resistance.
“T2D is associated with inflammation of the insulin-producing β cells of the pancreatic islets and the white adipose tissue itself, which results in decreased insulin production and increased insulin resistance, respectively (comprehensively reviewed by (Donath et al., 2013)).”
From Understanding the Holobiont: How Microbial Metabolites Affect Human Health and Shape the Immune System (2017) · cites this paper as Donath et al., 2013

1 retracted

Low Concentration of Interleukin-1β Induces FLICE-Inhibitory Protein–Mediated β-Cell Proliferation in Human Pancreatic Islets
Maedler, K., Schumann, D., Sauter, N. S., Ellingsgaard, H., Bosco, D., Baertschiger, R. M., Iwakura, Y., Oberholzer, J., Wollheim, C. B., Gauthier, B. R., et al. (2006) · Diabetes · doi:10.2337/db05-1430 · Cited by 156 · see citing works
Retracted
An obesity-associated gut microbiome with increased capacity for energy harvest
Turnbaugh, P. J., Ley, R. E., Mahowald, M. A., Magrini, V., Mardis, E. R., & Gordon, J. I. (2006) · Nature · doi:10.1038/nature05414 · Cited by 12,444 · see citing works
Obesity is associated with macrophage accumulation in adipose tissue
Weisberg, S. P., McCann, D., Desai, M., Rosenbaum, M., Leibel, R. L., & Ferrante, A. W. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319246 · Cited by 10,041 · see citing works
Human gut microbes associated with obesity
Ley, R. E., Turnbaugh, P. J., Klein, S., & Gordon, J. I. (2006) · Nature · doi:10.1038/4441022a · Cited by 8,785 · see citing works
Adipose Expression of Tumor Necrosis Factor-α: Direct Role in Obesity-Linked Insulin Resistance
Hotamisligil, G. S., Shargill, N. S., & Spiegelman, B. M. (1993) · Science · doi:10.1126/science.7678183 · Cited by 7,518 · see citing works
Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance
Xu, H., Barnes, G. T., Yang, Q., Tan, G., Yang, D., Chou, C. J., Sole, J., Nichols, A., Ross, J. S., Tartaglia, L. A., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319451 · Cited by 6,760 · see citing works
Rosuvastatin to Prevent Vascular Events in Men and Women with Elevated C-Reactive Protein
Ridker, P. M., Danielson, E., Fonseca, F. A. H., Genest, J., Gotto, A. M., Kastelein, J. J. P., Koenig, W., Libby, P., Lorenzatti, A. J., MacFadyen, J. G., et al. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa0807646 · Cited by 6,674 · see citing works
Metabolic Endotoxemia Initiates Obesity and Insulin Resistance
Cani, P. D., Amar, J., Iglesias, M. A., Poggi, M., Knauf, C., Bastelica, D., Neyrinck, A. M., Fava, F., Tuohy, K. M., Chabo, C., et al. (2007) · Diabetes · doi:10.2337/db06-1491 · Cited by 6,638 · see citing works
The gut microbiota as an environmental factor that regulates fat storage
Bäckhed, F., Ding, H., Wang, T., Hooper, L. V., Koh, G. Y., Nagy, A., Semenkovich, C. F., & Gordon, J. I. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407076101 · Cited by 6,245 · see citing works
Obesity alters gut microbial ecology
Ley, R. E., Bäckhed, F., Turnbaugh, P., Lozupone, C. A., Knight, R. D., & Gordon, J. I. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504978102 · Cited by 6,176 · see citing works
Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men
Ridker, P. M., Cushman, M., Stampfer, M. J., Tracy, R. P., & Hennekens, C. H. (1997) · New England Journal of Medicine · doi:10.1056/nejm199704033361401 · Cited by 5,504 · see citing works
Gout-associated uric acid crystals activate the NALP3 inflammasome
Martinon, F., Pétrilli, V., Mayor, A., Tardivel, A., & Tschopp, J. (2006) · Nature · doi:10.1038/nature04516 · Cited by 5,326 · see citing works
Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice
Cani, P. D., Bibiloni, R., Knauf, C., Waget, A., Neyrinck, A. M., Delzenne, N. M., & Burcelin, R. (2008) · Diabetes · doi:10.2337/db07-1403 · Cited by 4,819 · see citing works
C-Reactive Protein, Interleukin 6, and Risk of Developing Type 2 Diabetes Mellitus
Pradhan, A. D. (2001) · JAMA · doi:10.1001/jama.286.3.327 · Cited by 4,433 · see citing works
Inflammation, stress, and diabetes
Wellen, K. E., & Hotamisligil, G. S. (2005) · Journal of Clinical Investigation · doi:10.1172/jci25102 · Cited by 4,143 · see citing works
NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals
Duewell, P., Kono, H., Rayner, K. J., Sirois, C. M., Vladimer, G., Bauernfeind, F. G., Abela, G. S., Franchi, L., Nuñez, G., Schnurr, M., et al. (2010) · Nature · doi:10.1038/nature08938 · Cited by 4,026 · cited 3× · see citing works
“In human macrophages, cholesterol crystals have comparable effects (Duewell et al., 2010; Rajamäki et al., 2010).”
Background
Inflammation in Atherosclerosis
Libby, P. (2012) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.108.179705 · Cited by 3,748 · see citing works
Type 2 diabetes as an inflammatory disease
Donath, M. Y., & Shoelson, S. E. (2011) · Nature Reviews Immunology · doi:10.1038/nri2925 · Cited by 3,737 · see citing works
Self-citation
TLR4 links innate immunity and fatty acid-induced insulin resistance
Shi, H., Kokoeva, M. V., Inouye, K., Tzameli, I., Yin, H., & Flier, J. S. (2006) · Journal of Clinical Investigation · doi:10.1172/jci28898 · Cited by 3,690 · see citing works
Rosuvastatin to Prevent Vascular Events in Men and Women With Elevated C-Reactive Protein
Ridker, P. M., Danielson, E., Fonseca, F. A. H., Genest, J. J., Gotto, A. M., Kastelein, J. J. P., Köenig, W., Libby, P., Lorenzatti, A. J., MacFadyen, J. G., et al. (2009) · Obstetrical & Gynecological Survey · doi:10.1097/01.ogx.0000344393.60303.0a · Cited by 3,641 · see citing works
Immunological and inflammatory functions of the interleukin-1 family
Dinarello, C. A. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132612 · Cited by 3,466 · see citing works
Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization
Hornung, V., Bauernfeind, F., Halle, A., Samstad, E. O., Kono, H., Rock, K. L., Fitzgerald, K. A., & Latz, E. (2008) · Nature Immunology · doi:10.1038/ni.1631 · Cited by 3,065 · see citing works
Transfer of intestinal microbiota from lean donors increases insulin sensitivity in individuals with metabolic syndrome
Vrieze, A., Van Nood, E., Holleman, F., Salojärvi, J., Kootte, R. S., Bartelsman, J. F. W. M., Dallinga–Thie, G. M., Ackermans, M. T., Serlie, M. J., Oozeer, R., et al. (2012) · Gastroenterology · doi:10.1053/j.gastro.2012.06.031 · Cited by 2,913 · see citing works
Endoplasmic reticulum stress and the inflammatory basis of metabolic disease
Hotamisligil, G. S. (2010) · Cell · doi:10.1016/j.cell.2010.02.034 · Cited by 2,802 · see citing works
Thioredoxin-interacting protein links oxidative stress to inflammasome activation
Zhou, R., Tardivel, A., Thorens, B., Choi, I., & Tschopp, J. (2010) · Nature Immunology · doi:10.1038/ni.1831 · Cited by 2,708 · see citing works
The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance
Vandanmagsar, B., Youm, Y.-H., Ravussin, A., Galgani, J. E., Stadler, K., Mynatt, R. L., Ravussin, E., Stephens, J. M., & Dixit, V. D. (2011) · Nature Medicine · doi:10.1038/nm.2279 · Cited by 2,655 · see citing works
Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans
Cinti, S., Mitchell, G., Barbatelli, G., Murano, I., Ceresi, E., Faloia, E., Wang, S., Fortier, M., Greenberg, A. S., & Obin, M. S. (2005) · Journal of Lipid Research · doi:10.1194/jlr.m500294-jlr200 · Cited by 2,529 · see citing works
CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity
Nishimura, S., Manabe, I., Nagasaki, M., Eto, K., Yamashita, H., Ohsugi, M., Otsu, M., Hara, K., Ueki, K., Sugiura, S., et al. (2009) · Nature Medicine · doi:10.1038/nm.1964 · Cited by 2,230 · see citing works
Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters
Feuerer, M., Herrero, L., Cipolletta, D., Naaz, A., Wong, J., Nayer, A., Lee, J., Goldfine, A. B., Benoist, C., Shoelson, S., et al. (2009) · Nature Medicine · doi:10.1038/nm.2002 · Cited by 2,145 · see citing works
Fatty acid–induced NLRP3-ASC inflammasome activation interferes with insulin signaling
Wen, H., Gris, D., Lei, Y. L., Jha, S., Zhang, L., Huang, M. T.-H., Brickey, W. J., & Ting, J. P. ‐. (2011) · Nature Immunology · doi:10.1038/ni.2022 · Cited by 1,811 · see citing works
Interleukin-1-receptor antagonist in type 2 diabetes mellitus
Larsen, C. M., Faulenbach, M., Vaag, A., Vølund, A., Ehses, J. A., Seifert, B., Mandrup-Poulsen, T., & Donath, M. Y. (2007) · New England Journal of Medicine · doi:10.1056/nejmoa065213 · Cited by 1,798 · see citing works
Role of Fatty Acids in the Pathogenesis of Insulin Resistance and NIDDM
Boden, G. (1997) · Diabetes · doi:10.2337/diab.46.1.3 · Cited by 1,728 · see citing works
Involvement of Toll-like Receptors 2 and 4 in Cellular Activation by High Mobility Group Box 1 Protein
Park, J. S., Svetkauskaite, D., He, Q., Kim, J., Strassheim, D., Ishizaka, A., & Abraham, E. H. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m306793200 · Cited by 1,560 · see citing works
Inflammatory Cytokines and the Risk to Develop Type 2 Diabetes
Spranger, J., Kroke, A., Möhlig, M., Hoffmann, K., Bergmann, M. M., Ristow, M., Boeing, H., & Pfeiffer, A. F. H. (2003) · Diabetes · doi:10.2337/diabetes.52.3.812 · Cited by 1,493 · see citing works
Immune and Inflammatory Mechanisms of Atherosclerosis
Galkina, E., & Ley, K. F. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132620 · Cited by 1,446 · see citing works
Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes
Masters, S. L., Dunne, A., Subramanian, S. L., Hull, R. L., Tannahill, G. M., Sharp, F. A., Becker, C., Franchi, L., Yoshihara, E., Chen, Z., et al. (2010) · Nature Immunology · doi:10.1038/ni.1935 · Cited by 1,330 · cited 3× · see citing works
“, 2006), and human IAPP was added to the list recently (Masters et al., 2010).”
Background
Saturated Fatty Acids, but Not Unsaturated Fatty Acids, Induce the Expression of Cyclooxygenase-2 Mediated through Toll-like Receptor 4
Lee, J. Y., Sohn, K. H., Rhee, S. H., & Hwang, D. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m011695200 · Cited by 1,299 · see citing works
Relationship between Adipocyte Size and Adipokine Expression and Secretion
Skurk, T., Alberti-Huber, C., Herder, C., & Hauner, H. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-1055 · Cited by 1,288 · see citing works
NIDDM as a disease of the innate immune system: association of acute-phase reactants and interleukin-6 with metabolic syndrome X
Pickup, J. C., Mattock, M. B., Chusney, G. D., & Burt, D. J. (1997) · Diabetologia · doi:10.1007/s001250050822 · Cited by 1,241 · see citing works
Glucose-induced β cell production of IL-1β contributes to glucotoxicity in human pancreatic islets
Maedler, K., Sergeev, P., Ris, F., Oberholzer, J., Joller‐Jemelka, H. I., Spinas, G. A., Kaiser, N., Halban, P. A., & Donath, M. Y. (2017) · Journal of Clinical Investigation · doi:10.1172/jci92172 · Cited by 1,114 · see citing works
B cells promote insulin resistance through modulation of T cells and production of pathogenic IgG antibodies
Winer, D. A., Winer, S., Shen, L., Wadia, P. P., Yantha, J., Paltser, G., Tsui, H., Wu, P., Davidson, M. G., Alonso, M. N., et al. (2011) · Nature Medicine · doi:10.1038/nm.2353 · Cited by 1,050 · see citing works
Islet Amyloid Polypeptide, Islet Amyloid, and Diabetes Mellitus
Westermark, P., Andersson, A., & Westermark, G. T. (2011) · Physiological Reviews · doi:10.1152/physrev.00042.2009 · Cited by 1,044 · see citing works
Is Type II diabetes mellitus a disease of the innate immune system?
Pickup, J. C., & Crook, M. A. (1998) · Diabetologia · doi:10.1007/s001250051058 · Cited by 1,040 · see citing works
IL-6 Trans-Signaling via the Soluble IL-6 Receptor: Importance for the Pro-Inflammatory Activities of IL-6
Rose-John, S. (2012) · International Journal of Biological Sciences · doi:10.7150/ijbs.4989 · Cited by 1,040 · cited 1× · see citing works
“However, this remains speculative, and due to the complex effects of IL-6, clinical translation should await the outcome of further studies clarifying the precise role of IL-6 in metabolism and the development of drugs, allowing IL-6 effects to be targeted to a specific tissue (Rose-John, 2012).”
Background
Cholesterol Crystals Activate the NLRP3 Inflammasome in Human Macrophages: A Novel Link between Cholesterol Metabolism and Inflammation
Rajamäki, K., Lappalainen, J., Öörni, K., Välimäki, E., Matikainen, S., Kovanen, P. T., & Eklund, K. K. (2010) · PLoS ONE · doi:10.1371/journal.pone.0011765 · Cited by 1,039 · see citing works
A Subpopulation of Macrophages Infiltrates Hypertrophic Adipose Tissue and Is Activated by Free Fatty Acids via Toll-like Receptors 2 and 4 and JNK-dependent Pathways
Nguyen, M. T. A., Favelyukis, S., Nguyen, A.-K., Reichart, D., Scott, P. A., Jenn, A., Liu-Bryan, R., Glass, C. K., Neels, J. G., & Olefsky, J. M. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m706762200 · Cited by 1,035 · see citing works
Glucose-induced β cell production of IL-1β contributes to glucotoxicity in human pancreatic islets
Maedler, K., Sergeev, P., Ris, F., Oberholzer, J., Joller‐Jemelka, H. I., Spinas, G. A., Kaiser, N., Halban, P. A., & Donath, M. Y. (2002) · Journal of Clinical Investigation · doi:10.1172/jci200215318 · Cited by 1,006 · see citing works
The Role of Inflammatory Cytokines in Diabetic Nephropathy
Navarro‐González, J. F., & Fernández, C. M. (2008) · Journal of the American Society of Nephrology · doi:10.1681/asn.2007091048 · Cited by 936 · see citing works
Fetuin-A acts as an endogenous ligand of TLR4 to promote lipid-induced insulin resistance
Pal, D., Dasgupta, S., Kundu, R., Maitra, S., Das, G., Mukhopadhyay, S., Ray, S., Majumdar, S. S., & Bhattacharya, S. (2012) · Nature Medicine · doi:10.1038/nm.2851 · Cited by 922 · see citing works
Interleukin-6 enhances insulin secretion by increasing glucagon-like peptide-1 secretion from L cells and alpha cells
Ellingsgaard, H., Hauselmann, I., Schuler, B., Habib, A. M., Baggio, L. L., Meier, D. T., Eppler, E., Bouzakri, K., Wueest, S., Muller, Y. D., et al. (2011) · Nature Medicine · doi:10.1038/nm.2513 · Cited by 922 · see citing works
Interleukin-6 Increases Insulin-Stimulated Glucose Disposal in Humans and Glucose Uptake and Fatty Acid Oxidation In Vitro via AMP-Activated Protein Kinase
Carey, A. L., Steinberg, G. R., Macaulay, S. L., Thomas, W. G., Holmes, A. G., Ramm, G., Prelovsek, O., Hohnen-Behrens, C., Watt, M. J., James, D. E., et al. (2006) · Diabetes · doi:10.2337/db05-1404 · Cited by 898 · see citing works
Muscle‐derived interleukin‐6: mechanisms for activation and possible biological roles
FEBBRAIO, M. A., & PEDERSEN, B. K. (2002) · The FASEB Journal · doi:10.1096/fj.01-0876rev · Cited by 875 · see citing works
Microtubule-driven spatial arrangement of mitochondria promotes activation of the NLRP3 inflammasome
Misawa, T., Takahama, M., Kozaki, T., Lee, H., Zou, J., Saitoh, T., & Akira, S. (2013) · Nature Immunology · doi:10.1038/ni.2550 · Cited by 863 · see citing works
Increased Number of Islet-Associated Macrophages in Type 2 Diabetes
Ehses, J. A., Perren, A. A., Eppler, E., Ribaux, P., Pospisilik, J. A., Maor-Cahn, R., Guéripel, X., Ellingsgaard, H., Schneider, M. K. J., Biollaz, G., et al. (2007) · Diabetes · doi:10.2337/db06-1650 · Cited by 783 · see citing works
Lack of Interleukin-1β Decreases the Severity of Atherosclerosis in ApoE-Deficient Mice
Kirii, H., Niwa, T., Yamada, Y., Wada, H., Saito, K., Iwakura, Y., Asano, M., Moriwaki, H., & Seishima, M. (2003) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000064374.15232.c3 · Cited by 748 · see citing works
T-Cell Accumulation and Regulated on Activation, Normal T Cell Expressed and Secreted Upregulation in Adipose Tissue in Obesity
Wu, H., Ghosh, S., Perrard, X. D., Feng, L., García, G., Perrard, J. L., Sweeney, J. F., Peterson, L. E., Chan, L., Smith, C. W., et al. (2007) · Circulation · doi:10.1161/circulationaha.106.638379 · Cited by 682 · see citing works
Thioredoxin-Interacting Protein Mediates ER Stress-Induced β Cell Death through Initiation of the Inflammasome
Oslowski, C. M., Hara, T., O’Sullivan-Murphy, B., Kanekura, K., Lu, S., Hara, M., Ishigaki, S., Zhu, L. J., Hayashi, E., Hui, S. T. Y., et al. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.07.005 · Cited by 678 · see citing works
Evidence for apoptosis in advanced human atheroma. Colocalization with interleukin-1 beta-converting enzyme.
Geng, Y., & Libby, P. (1995) · PubMed · Cited by 641 · see citing works
A Stress Signaling Pathway in Adipose Tissue Regulates Hepatic Insulin Resistance
Sabio, G., Das, M., Mora, A., Zhang, Z., Jun, J. Y., Ko, H. J., Barrett, T., Kim, J. K., & Davis, R. J. (2008) · Science · doi:10.1126/science.1160794 · Cited by 604 · see citing works
Elevation of C-reactive protein in “active” coronary artery disease
Berk, B. C., Weintraub, W. S., & Alexander, R. W. (1990) · The American Journal of Cardiology · doi:10.1016/0002-9149(90)90079-g · Cited by 593 · see citing works
How Obesity Causes Diabetes: Not a Tall Tale
Lazar, M. A. (2005) · Science · doi:10.1126/science.1104342 · Cited by 570 · see citing works
Fatty Acids Modulate Toll-like Receptor 4 Activation through Regulation of Receptor Dimerization and Recruitment into Lipid Rafts in a Reactive Oxygen Species-dependent Manner
Wong, S. W., Kwon, M.-J., Choi, A. M. K., Kim, H.-P., Nakahira, K., & Hwang, D. H. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.044065 · Cited by 562 · see citing works
Emerging role of adipose tissue hypoxia in obesity and insulin resistance
Ye, J. (2008) · International Journal of Obesity · doi:10.1038/ijo.2008.229 · Cited by 539 · see citing works
Effects of Interleukin-1β Inhibition With Canakinumab on Hemoglobin A1c, Lipids, C-Reactive Protein, Interleukin-6, and Fibrinogen: A Phase IIb Randomized, Placebo-Controlled Trial
Ridker, P. M., Howard, C. P., Walter, V., Everett, B., Libby, P., Hensen, J., & Thuren, T. (2012) · Circulation · doi:10.1161/circulationaha.112.122556 · Cited by 530 · see citing works
Interferon-γ, a Th1 Cytokine, Regulates Fat Inflammation
Rocha, V. Z., Folco, E. J. E., Sukhova, G. K., Shimizu, K., Gotsman, I., Vernon, A. H., & Libby, P. (2008) · Circulation Research · doi:10.1161/circresaha.108.177105 · Cited by 524 · see citing works
Saturated Fatty Acid and TLR Signaling Link β Cell Dysfunction and Islet Inflammation
Eguchi, K., Manabe, I., Tanaka, Y., Ohsugi, M., Kono, N., Ogata, F., Yagi, N., Ohto, U., Kimoto, M., Miyake, K., et al. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.01.023 · Cited by 519 · see citing works
Effects of an Engineered Human Anti–TNF-α Antibody (CDP571) on Insulin Sensitivity and Glycemic Control in Patients With NIDDM
Ofei, F., Hurel, S. J., Newkirk, J., Sopwith, M., & Taylor, R. (1996) · Diabetes · doi:10.2337/diab.45.7.881 · Cited by 510 · see citing works
Saturated Fatty Acid Activates but Polyunsaturated Fatty Acid Inhibits Toll-like Receptor 2 Dimerized with Toll-like Receptor 6 or 1
Lee, J. Y., Zhao, L., Youn, H. S., Weatherill, A. R., Tapping, R. I., Feng, L., Lee, W. H., Fitzgerald, K. A., & Hwang, D. H. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m312990200 · Cited by 493 · see citing works
Atherogenic Lipids and Lipoproteins Trigger CD36-TLR2-Dependent Apoptosis in Macrophages Undergoing Endoplasmic Reticulum Stress
Seimon, T. A., Nadolski, M. J., Liao, X., Magallon, J., Nguyen, M. T., Feric, N. T., Koschinsky, M. L., Harkewicz, R., Witztum, J. L., Tsimikas, S., et al. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.09.010 · Cited by 478 · see citing works
Endoplasmic Reticulum Stress and the Development of Diabetes
Harding, H. P., & Ron, D. (2002) · Diabetes · doi:10.2337/diabetes.51.2007.s455 · Cited by 465 · see citing works
Activation of Toll-like receptor 4 is associated with insulin resistance in adipocytes
Song, M. J., Kim, K. H., Yoon, J. M., & Kim, J. B. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.05.170 · Cited by 454 · see citing works
An inhibitor of the protein kinases TBK1 and IKK-ɛ improves obesity-related metabolic dysfunctions in mice
Reilly, S. M., Chiang, S.-H., Decker, S. J., Chang, L. C., Uhm, M., Larsen, M. J., Rubin, J. R., Mowers, J. C., White, N. M. A., Hochberg, I., et al. (2013) · Nature Medicine · doi:10.1038/nm.3082 · Cited by 431 · see citing works
Elevated Proinflammatory Cytokine Production by a Skewed T Cell Compartment Requires Monocytes and Promotes Inflammation in Type 2 Diabetes
Jagannathan‐Bogdan, M., McDonnell, M. E., Shin, H., Rehman, Q., Hastürk, H., Apovian, C. M., & Nikolajczyk, B. S. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1002615 · Cited by 418 · see citing works
Antiinflammatory Effects of Angiotensin II Subtype 1 Receptor Blockade in Hypertensive Patients With Microinflammation
Fliser, D., Buchholz, K., & Haller, H. G. (2004) · Circulation · doi:10.1161/01.cir.0000140265.21608.8e · Cited by 405 · see citing works
Hyperglycemia-induced beta-cell apoptosis in pancreatic islets of Psammomys obesus during development of diabetes
Donath, M. Y., Gross, D. J., Cerasi, E., & Kaiser, N. (1999) · Diabetes · doi:10.2337/diabetes.48.4.738 · Cited by 405 · see citing works
Identification of Adipose Tissue Dendritic Cells Correlated With Obesity-Associated Insulin-Resistance and Inducing Th17 Responses in Mice and Patients
Bertola, A., Ciucci, T., Rousseau, D., Bourlier, V., Duffaut, C., Bonnafous, S., Blin‐Wakkach, C., Anty, R., Iannelli, A., Gugenheim, J., et al. (2012) · Diabetes · doi:10.2337/db11-1274 · Cited by 403 · see citing works
Sustained effects of interleukin-1 receptor antagonist treatment in type 2 diabetes
Larsen, C. M., Faulenbach, M., Vaag, A., Ehses, J. A., Donath, M. Y., & Mandrup-Poulsen, T. (2009) · Diabetes Care · doi:10.2337/dc09-0533 · Cited by 401 · see citing works
IL-17 regulates adipogenesis, glucose homeostasis, and obesity
Zúñiga, L. A., Shen, W.-J., Joyce-Shaikh, B., Pyatnova, E. A., Richards, A. G., Thom, C., Andrade, S. M., Cua, D. J., Kraemer, F. B., & Butcher, E. C. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1001269 · Cited by 394 · see citing works
Differential Lipid Partitioning Between Adipocytes and Tissue Macrophages Modulates Macrophage Lipotoxicity and M2/M1 Polarization in Obese Mice
Prieur, X., Mok, C. Y. L., Velagapudi, V. R., Núñez, V., Fuentes, L., Montaner, D., Ishikawa, K., Camacho, A., Barbarroja, N., O’Rahilly, S., et al. (2011) · Diabetes · doi:10.2337/db10-0705 · Cited by 381 · see citing works
Beneficial health effects of exercise – the role of IL-6 as a myokine
Pedersen, B. K., & Fischer, C. P. (2007) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2007.02.002 · Cited by 371 · see citing works
Glucose Induces β-Cell Apoptosis Via Upregulation of the Fas Receptor in Human Islets
Maedler, K., Spinas, G. A., Lehmann, R., Sergeev, P., Weber, M., Fontana, A., Kaiser, N., & Donath, M. Y. (2001) · Diabetes · doi:10.2337/diabetes.50.8.1683 · Cited by 367 · see citing works
Fatty acid‐induced induction of Toll‐like receptor‐4/nuclear factor‐κB pathway in adipocytes links nutritional signalling with innate immunity
Schaeffler, A., Gross, P., Buettner, R., Bollheimer, C., Buechler, C., Neumeier, M., Kopp, A., Schoelmerich, J., & Falk, W. (2009) · Immunology · doi:10.1111/j.1365-2567.2008.02892.x · Cited by 360 · see citing works
Salsalate Improves Glycemia and Inflammatory Parameters in Obese Young Adults
Fleischman, A., Shoelson, S. E., Bernier, R., & Goldfine, A. B. (2008) · Diabetes Care · doi:10.2337/dc07-1338 · Cited by 352 · see citing works
IL-1 antagonism reduces hyperglycemia and tissue inflammation in the type 2 diabetic GK rat
Ehses, J. A., Lacraz, G., Giroix, M.-H., Schmidlin, F., Coulaud, J., Kassis, N., Irminger, J.-C., Kergoat, M., Portha, B., Homo-Delarche, F., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0810087106 · Cited by 346 · see citing works
Free Fatty Acids Induce a Proinflammatory Response in Islets via the Abundantly Expressed Interleukin-1 Receptor I
Böni‐Schnetzler, M., Boller, S., Debray, S., Bouzakri, K., Meier, D. T., Prazak, R., Kerr-Conte, J. A., Pattou, F. N., Ehses, J. A., Schuit, F. C., et al. (2009) · Endocrinology · doi:10.1210/en.2009-0543 · Cited by 344 · see citing works
Gut-derived lipopolysaccharide augments adipose macrophage accumulation but is not essential for impaired glucose or insulin tolerance in mice
Caesar, R., Reigstad, C. S., Bäckhed, H. K., Reinhardt, C., Ketonen, M., Östergren‐Lundén, G., Cani, P. D., & Bäckhed, F. (2012) · Gut · doi:10.1136/gutjnl-2011-301689 · Cited by 330 · see citing works
Increased Adipose Tissue Oxygen Tension in Obese Compared With Lean Men Is Accompanied by Insulin Resistance, Impaired Adipose Tissue Capillarization, and Inflammation
Goossens, G. H., Bizzarri, A., Venteclef, N., Essers, Y., Cleutjens, J. P., Konings, E., Jocken, J. W. E., Čajlaković, M., Ribitsch, V., Clément, K., et al. (2011) · Circulation · doi:10.1161/circulationaha.111.027813 · Cited by 324 · see citing works
TNF-α Antagonism with Etanercept Decreases Glucose and Increases the Proportion of High Molecular Weight Adiponectin in Obese Subjects with Features of the Metabolic Syndrome
Stanley, T. L., Zanni, M. V., Johnsen, S., Rasheed, S., Makimura, H., Lee, H., Khor, V. K., Ahima, R. S., & Grinspoon, S. K. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2010-1170 · Cited by 321 · see citing works
Increased Interleukin (IL)-1β Messenger Ribonucleic Acid Expression in β-Cells of Individuals with Type 2 Diabetes and Regulation of IL-1β in Human Islets by Glucose and Autostimulation
Böni‐Schnetzler, M., Thorne, J. T., Parnaud, G., Marselli, L., Ehses, J. A., Kerr-Conte, J. A., Pattou, F. N., Halban, P. A., Weir, G. C., & Donath, M. Y. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-0396 · Cited by 319 · see citing works
Multiple levels of regulation determine the role of the receptor for AGE (RAGE) as common soil in inflammation, immune responses and diabetes mellitus and its complications
Bierhaus, A., & Nawroth, P. P. (2009) · Diabetologia · doi:10.1007/s00125-009-1458-9 · Cited by 315 · see citing works
Interleukin-1β in Coronary Arteries of Patients With Ischemic Heart Disease
Galea, J., Armstrong, J., Gadsdon, P., Holden, H. M., Francis, S., & Holt, C. M. (1996) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.16.8.1000 · Cited by 310 · see citing works
Nrf2 is essential for cholesterol crystal-induced inflammasome activation and exacerbation of atherosclerosis
Freigang, S., Ampenberger, F., Spohn, G., Heer, S., Shamshiev, A. T., Kisielow, J., Hersberger, M., Yamamoto, M., Bachmann, M. F., & Kopf, M. (2011) · European Journal of Immunology · doi:10.1002/eji.201041316 · Cited by 300 · see citing works
Unexpected trafficking of immune cells within the adipose tissue during the onset of obesity
Duffaut, C., Galitzky, J., Lafontan, M., & Bouloumié, A. (2009) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2009.05.002 · Cited by 296 · see citing works
Effects of Gevokizumab on Glycemia and Inflammatory Markers in Type 2 Diabetes
Cavelti‐Weder, C., Babians-Brunner, A., Keller, C., Stahel, M., Kurz-Levin, M. M., Zayed, H., Solinger, A. M., Mandrup-Poulsen, T. R., Dinarello, C. A., & Donath, M. Y. (2012) · Diabetes Care · doi:10.2337/dc11-2219 · Cited by 294 · see citing works
Why blockade of the renin–angiotensin system reduces the incidence of new-onset diabetes
Jandeleit-Dahm, K. A., Tikellis, C., Reid, C. M., Johnston, C. I., & Cooper, M. E. (2005) · Journal of Hypertension · doi:10.1097/01.hjh.0000160198.05416.72 · Cited by 293 · see citing works
Use of Salsalate to Target Inflammation in the Treatment of Insulin Resistance and Type 2 Diabetes
Goldfine, A. B., Silver, R., Aldhahi, W., Cai, D., Tatro, E., Lee, J., & Shoelson, S. E. (2008) · Clinical and Translational Science · doi:10.1111/j.1752-8062.2008.00026.x · Cited by 289 · see citing works
The type III histone deacetylase Sirt1 is essential for maintenance of T cell tolerance in mice
Zhang, J., Lee, S., Shannon, S., Gao, B., Chen, W., Chen, A., Divekar, R. D., McBurney, M. W., Braley‐Mullen, H., Zaghouani, H., et al. (2009) · Journal of Clinical Investigation · doi:10.1172/jci38902 · Cited by 289 · see citing works
Metabolic and Vascular Effects of Tumor Necrosis Factor-α Blockade with Etanercept in Obese Patients with Type 2 Diabetes
Dominguez, H., Storgaard, H., Rask-Madsen, C., Steffen Hermann, T., Ihlemann, N., Baunbjerg Nielsen, D., Spohr, C., Kober, L., Vaag, A., & Torp-Pedersen, C. (2005) · Journal of Vascular Research · doi:10.1159/000088261 · Cited by 286 · see citing works
Saturated Fatty Acids Induce c-Src Clustering within Membrane Subdomains, Leading to JNK Activation
Holzer, R. G., Park, E., Li, N., Tran, H., Chen, M. F., Choi, C., Solinas, G., & Karin, M. (2011) · Cell · doi:10.1016/j.cell.2011.08.034 · Cited by 283 · see citing works
Interleukin-6 regulates pancreatic α-cell mass expansion
Ellingsgaard, H., Ehses, J. A., Hammar, E. B., Van Lommel, L., Quintens, R., Martens, G., Kerr-Conte, J., Pattou, F., Berney, T., Pipeleers, D., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0801059105 · Cited by 269 · see citing works
Pathways in Microbe-Induced Obesity
Cox, L. M., & Blaser, M. J. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.05.004 · Cited by 266 · see citing works
Effects of Etanercept in Patients With the Metabolic Syndrome
Bernstein, L. E., Berry, J., Kim, S. S. Y., Hron, B. M., & Grinspoon, S. K. (2006) · Archives of Internal Medicine · doi:10.1001/archinte.166.8.902 · Cited by 258 · see citing works
Effects of infliximab treatment on insulin resistance in patients with rheumatoid arthritis and ankylosing spondylitis
Kiortsis, D. N., Mavridis, A. K., Vasakos, S., Nikas, S. N., & Drosos, A. A. (2004) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2004.026534 · Cited by 254 · see citing works
Differential Effects of Cream, Glucose, and Orange Juice on Inflammation, Endotoxin, and the Expression of Toll-Like Receptor-4 and Suppressor of Cytokine Signaling-3
Deopurkar, R., Ghanim, H., Friedman, J., Abuaysheh, S., Sia, C. L., Mohanty, P., Viswanathan, P., Chaudhuri, A., & Dandona, P. (2010) · Diabetes Care · doi:10.2337/dc09-1630 · Cited by 246 · see citing works
Islet-associated macrophages in type 2 diabetes
Richardson, S. J., Willcox, A., Bone, A. J., Foulis, A. K., & Morgan, N. G. (2009) · Diabetologia · doi:10.1007/s00125-009-1410-z · Cited by 240 · see citing works
Receptor for AGE (RAGE) and its ligands—cast into leading roles in diabetes and the inflammatory response
Yan, S. F., Ramasamy, R., & Schmidt, A. M. (2009) · Journal of Molecular Medicine · doi:10.1007/s00109-009-0439-2 · Cited by 236 · see citing works
Interleukin-6 signaling in liver-parenchymal cells suppresses hepatic inflammation and improves systemic insulin action
Wunderlich, F. T., Ströhle, P., Könner, A. C., Gruber, S., Tovar, S., Brönneke, H. S., Juntti-Berggren, L., Li, L.-S., van Rooijen, N., Libert, C., et al. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.06.011 · Cited by 229 · cited 3× · see citing works
“Progressive lipid accumulation also contributes to the alternative anti-inflammatory M2-to-proinflammatory M1 phenotypic switch in macrophages that occurs in adipose tissue of obese mice (Prieur et al., 2011; Weisberg et al., 2003; Xu et al., 2003).”
Background
Meal modulation of circulating interleukin 18 and adiponectin concentrations in healthy subjects and in patients with type 2 diabetes mellitus
Esposito, K., Nappo, F., Giugliano, F., Palo, C. D., Ciotola, M., Barbieri, M., Paolisso, G., & Giugliano, D. (2003) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/78.6.1135 · Cited by 225 · see citing works
No Increased Insulin Sensitivity after a Single Intravenous Administration of a Recombinant Human Tumor Necrosis Factor Receptor: Fc Fusion Protein in Obese Insulin-Resistant Patients
Paquot, N., Castillo, M. J., Lefèbvre, P. J., & Scheen, A. J. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.3.6417 · Cited by 213 · see citing works
Free fatty acids in the presence of high glucose amplify monocyte inflammation via Toll-like receptors
Dasu, M. R. K., & Jialal, I. (2010) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00490.2010 · Cited by 211 · see citing works
Differential Effects of Interleukin-1 Receptor Antagonist and Tumor Necrosis Factor Binding Protein on Fatty-Streak Formation in Apolipoprotein E–Deficient Mice
Elhage, R., Maret, A., Pieraggi, M. T., Thiers, J., Arnal, J., & Bayard, F. (1998) · Circulation · doi:10.1161/01.cir.97.3.242 · Cited by 209 · see citing works
Secreted Frizzled-Related Protein 4 Reduces Insulin Secretion and Is Overexpressed in Type 2 Diabetes
Mahdi, T., Hänzelmann, S., Salehi, A. A., Muhammed, S. J., Reinbothe, T. M., Tang, Y., Axelsson, A. S., Zhou, Y., Jing, X., Almgren, P., et al. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.10.009 · Cited by 194 · see citing works
IL-1 Blockade Attenuates Islet Amyloid Polypeptide-Induced Proinflammatory Cytokine Release and Pancreatic Islet Graft Dysfunction
Westwell-Roper, C. Y., Dai, D. L., Soukhatcheva, G., Potter, K. J., van Rooijen, N., Ehses, J. A., & Verchere, C. B. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1002854 · Cited by 190 · see citing works
Double-Blind, Randomized Study Evaluating the Glycemic and Anti-inflammatory Effects of Subcutaneous LY2189102, a Neutralizing IL-1β Antibody, in Patients With Type 2 Diabetes
Sloan‐Lancaster, J., Abu-Raddad, E., Polzer, J. P., Miller, J. W., Scherer, J. C., Gaetano, A. D., Berg, J. K., & Landschulz, W. H. (2013) · Diabetes Care · doi:10.2337/dc12-1835 · Cited by 185 · see citing works
Interleukin-6 does/does not have a beneficial role in insulin sensitivity and glucose homeostasis
Pedersen, B. K., & Febbraio, M. A. (2006) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01208.2006 · Cited by 177 · see citing works
Treatment with Anakinra Improves Disposition Index But Not Insulin Sensitivity in Nondiabetic Subjects with the Metabolic Syndrome: A Randomized, Double-Blind, Placebo-Controlled Study
van Asseldonk, E. J. P., Stienstra, R., Koenen, T. B., Joosten, L. A. B., Netea, M. G., & Tack, C. J. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2010-2992 · Cited by 155 · see citing works
Effect of anti‐ IL ‐1β antibody (canakinumab) on insulin secretion rates in impaired glucose tolerance or type 2 diabetes: results of a randomized, placebo‐controlled trial
Rissanen, A., Howard, C. P., Botha, J., Thuren, T. Y., & for the Global Investigators (2012) · Diabetes Obesity and Metabolism · doi:10.1111/j.1463-1326.2012.01637.x · Cited by 140 · see citing works
FLIP switches Fas-mediated glucose signaling in human pancreatic β cells from apoptosis to cell replication
Maedler, K., Fontana, A., Ris, F., Sergeev, P., Toso, C., Oberholzer, J., Lehmann, R., Bachmann, F., Tasinato, A., Spinas, G. A., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.122686299 · Cited by 136 · see citing works
Improvement of insulin sensitivity in insulin resistant subjects during prolonged treatment with the anti‐TNF‐α antibody infliximab
Yazdani‐Biuki, B., Stelzl, H., Brezinschek, H. P., Hermann, J., Mueller, T., Krippl, P., Graninger, W. B., & Wascher, T. C. (2004) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.2004.01390.x · Cited by 135 · see citing works
A randomised trial of salsalate for insulin resistance and cardiovascular risk factors in persons with abnormal glucose tolerance
Goldfine, A. B., Conlin, P. R., Halperin, F., Koška, J., Permana, P. A., Schwenke, D. C., Shoelson, S. E., & Reaven, P. D. (2013) · Diabetologia · doi:10.1007/s00125-012-2819-3 · Cited by 128 · see citing works
The effect of salsalate on insulin action and glucose tolerance in obese non-diabetic patients: results of a randomised double-blind placebo-controlled study
Koška, J., Ortega, E., Bunt, J. C., Gasser, A., Impson, J., Hanson, R. L., Forbes, J. M., de Courten, B. V., & Krakoff, J. A. (2008) · Diabetologia · doi:10.1007/s00125-008-1239-x · Cited by 119 · see citing works
The Discovery of Cellular Immunity in the Atherosclerotic Plaque
Hansson, G. K., & Jonasson, L. (2009) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.108.179713 · Cited by 118 · see citing works
Identification of a SIRT1 Mutation in a Family with Type 1 Diabetes
Biason‐Lauber, A., Böni‐Schnetzler, M., Hubbard, B. P., Bouzakri, K., Brunner, A., Cavelti‐Weder, C., Keller, C., Meyer‐Böni, M., Meier, D. T., Brorsson, C., et al. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.02.001 · Cited by 116 · see citing works
Insulin resistance in patients with rheumatoid arthritis: effect of anti‐TNFα therapy
Rosenvinge, A., Krogh‐Madsen, R., Baslund, B., & Pedersen, B. K. (2007) · Scandinavian Journal of Rheumatology · doi:10.1080/03009740601179605 · Cited by 112 · see citing works
Effects of TNF-α neutralization on adipocytokines and skeletal muscle adiposity in the metabolic syndrome
Lo, J., Bernstein, L. E., Hron, B. M., Torriani, M., Jackson, M. B., Ahima, R. S., & Grinspoon, S. K. (2007) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00089.2007 · Cited by 106 · see citing works
Telmisartan Improves Insulin Resistance and Modulates Adipose Tissue Macrophage Polarization in High-Fat-Fed Mice
Fujisaka, S., Usui, I., Kanatani, Y., Ikutani, M., Takasaki, I., Tsuneyama, K., Tabuchi, Y., Bukhari, A., Yamazaki, Y., Suzuki, H., et al. (2011) · Endocrinology · doi:10.1210/en.2010-1312 · Cited by 105 · see citing works
Effects of Angiotensin II Receptor Blockade with Valsartan on Pro-Inflammatory Cytokines in Patients with Essential Hypertension
Manabe, S., Okura, T., Watanabe, S., Fukuoka, T., & Higaki, J. (2005) · Journal of Cardiovascular Pharmacology · doi:10.1097/01.fjc.0000185783.00391.60 · Cited by 103 · see citing works
Pancreatic islet inflammation in type 2 diabetes: From α and β cell compensation to dysfunction
Ehses, J. A., Ellingsgaard, H., Böni-Schnetzler, M., & Donath, M. Y. (2009) · Archives of Physiology and Biochemistry · doi:10.1080/13813450903025879 · Cited by 97 · see citing works
Glucose-dependent insulinotropic polypeptide induces cytokine expression, lipolysis, and insulin resistance in human adipocytes
Timper, K., Grisouard, J., Sauter, N. S., Herzog-Radimerski, T., Dembinski, K., Peterli, R., Frey, D. M., Zulewski, H., Keller, U., Müller, B., et al. (2013) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00100.2012 · Cited by 88 · see citing works
The Fas pathway is involved in pancreatic β cell secretory function
Schumann, D., Maedler, K., Franklin, I., Konrad, D., Størling, J., Böni‐Schnetzler, M., Gjinovci, A., Kurrer, M. O., Gauthier, B. R., Bosco, D., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0611487104 · Cited by 76 · see citing works
COUNTERPOINT: INTERLEUKIN-6 DOES NOT HAVE A BENEFICIAL ROLE IN INSULIN SENSITIVITY AND GLUCOSE HOMEOSTASIS
Mooney, R. A. (2007) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01208a.2006 · Cited by 71 · see citing works
Differential Effects of Cream, Glucose, and Orange Juice on Inflammation, Endotoxin, and the Expression of Toll-Like Receptor-4 and Suppressor of Cytokine Signaling-3.
Deopurkar, R., Ghanim, G., Friedman, & Abuaysheh (2010) · Diabetes Care · Cited by 71 · see citing works
Effect of Diacerein on Insulin Secretion and Metabolic Control in Drug-Naïve Patients With Type 2 Diabetes
Ramos-Zavala, M. G., González-Ortı́z, M., Martínez‐Abundis, E., Robles-Cervantes, J. A., González-López, R., & Santiago-Hernández, N. J. (2011) · Diabetes Care · doi:10.2337/dc11-0357 · Cited by 68 · see citing works
The Relationship between Metabolism and the Autophagy Machinery during the Innate Immune Response
Martinez, J., Verbist, K., Wang, R., & Green, D. R. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.05.012 · Cited by 67 · see citing works
Salsalate improves glycemic control in patients with newly diagnosed type 2 diabetes
Faghihimani, E., Aminorroaya, A., Rezvanian, H., Adibi, P., Ismail‐Beigi, F., & Amini, M. (2011) · Acta Diabetologica · doi:10.1007/s00592-011-0329-2 · Cited by 66 · see citing works
Glucose‐dependent insulinotropic peptide impairs insulin signaling <i>via</i> inducing adipocyte inflammation in glucose‐dependent insulinotropic peptide receptor‐overexpressing adipocytes
Nie, Y., Ma, R. C., Chan, J. C. N., Xu, H., & Xu, G. (2012) · The FASEB Journal · doi:10.1096/fj.11-196782 · Cited by 53 · see citing works
Reappraising the stereotypes of diabetes in the modern diabetogenic environment
Wentworth, J. M., Fourlanos, S., & Harrison, L. C. (2009) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2009.149 · Cited by 52 · see citing works
Relapse of Diabetes After Interruption of Chronic Administration of Anti–Tumor Necrosis Factor-α Antibody Infliximab
Yazdani‐Biuki, B., Mueller, T., Brezinschek, H. P., Hermann, J., Graninger, W. B., & Wascher, T. C. (2006) · Diabetes Care · doi:10.2337/dc06-0636 · Cited by 41 · see citing works
Interleukin-6 does/does not have a beneficial role in insulin sensitivity and glucose homeostasis
Spangenburg, E. E. (2007) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01353.2006 · Cited by 41 · see citing works
Susceptibility to Fatty Acid-Induced β-Cell Dysfunction Is Enhanced in Prediabetic Diabetes-Prone BioBreeding Rats: A Potential Link Between β-Cell Lipotoxicity and Islet Inflammation
Tang, C., Naassan, A. E., Chamson-Reig, A., Koulajian, K., Goh, T. T., Yoon, F. H., Oprescu, A. I., Ghanim, H., Lewis, G. F., Dandona, P., et al. (2012) · Endocrinology · doi:10.1210/en.2012-1720 · Cited by 38 · see citing works
Does interference with the renin–angiotensin system protect against diabetes? Evidence and mechanisms
van der Zijl, N. J., Moors, C. C. M., Goossens, G. H., Blaak, E. E., & Diamant, M. (2012) · Diabetes Obesity and Metabolism · doi:10.1111/j.1463-1326.2012.01559.x · Cited by 35 · see citing works
Comparison of cryopreservation methods on T‐cell responses to islet and control antigens from type 1 diabetic patients and controls
Brooks‐Worrell, B., Tree, T. I. M., Mannering, S. I., Durinovic‐Belló, I., James, E. A., Gottlieb, P. A., Wong, F. S., Zhou, Z., Yang, L., Cilio, C., et al. (2011) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.1245 · Cited by 24 · see citing works
Angiotensin blockade in diabetic patients decreases insulin resistance‐associated low‐grade inflammation
Pavlatou, M. G., Mastorakos, G. P., Margeli, A., Kouskouni, E. E., Tentolouris, N., Katsilambros, N., Chrousos, G. P., & Papassotiriou, I. (2010) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.2010.02453.x · Cited by 19 · see citing works
The Effects of Salsalate on Glycemic Control in Patients With Type 2 Diabetes
Goldfine, A. B., Fonseca, V. A., Jablonski, K. A., Pyle, L. L., Staten, M. A., Shoelson, S. E., & for the TINSAL-T2D (Targeting Inflammation Using Salsalate in Type 2 Diabetes) Study Team* (2010) · Annals of Internal Medicine · doi:10.7326/0003-4819-152-6-201003160-00004 · Cited by 18 · see citing works
ANG II receptor antagonists as modulators of macrophages polarization
Garcia, G. E. (2010) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00041.2010 · Cited by 13 · see citing works
Toll-like receptor-2 is essential for the development of palmitate-induced insulin resistance in myotubes
Senn, J. J. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.a109.513304 · Cited by 8 · see citing works

Flagged first, then by citations

1 of the 147 references couldn’t be matched to a known paper.

Sorted by citations

Cellular senescence: from physiology to pathology
Muñoz-Espín, D., & Serrano, M. (2014) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3823 · Cited by 2,818 · see citing works
Understanding the Holobiont: How Microbial Metabolites Affect Human Health and Shape the Immune System
Postler, T. S., & Ghosh, S. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.05.008 · Cited by 876 · see citing works
“Arpaia et al., 2013; Brown et al., 2003; Chang et al., 2014; Donohoe et al., 2012; Kalina et al., 2002; Kim et al., 2016; Le Poul et al., 2003; Macia et al., 2015; Maslowski et al., 2009; Millard et al., 2002; Nilsson et al., 2003; Singh et al., 2010; Smith et al., 2013; Thangaraju et al., 2009a,…”
Background
Type 2 diabetes mellitus, oxidative stress and inflammation: examining the links.
Oguntibeju, O. O. (2019) · Europe PMC (PubMed Central) · Cited by 758 · see citing works
The crucial role and mechanism of insulin resistance in metabolic disease
Zhao, X., An, X., Yang, C., Sun, W., Ji, H., & Lian, F. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1149239 · Cited by 630 · see citing works
Type 2 diabetes mellitus: From a metabolic disorder to an inflammatory condition
Hameed, I., Masoodi, S. R., Mir, S. A., Nabi, M., Ghazanfar, K., & Ganai, B. A. (2015) · World Journal of Diabetes · doi:10.4239/wjd.v6.i4.598 · Cited by 513 · see citing works
Postprandial macrophage-derived IL-1β stimulates insulin, and both synergistically promote glucose disposal and inflammation
Dror, E., Dalmas, É., Meier, D. T., Wueest, S., Thévenet, J., Thienel, C., Timper, K., Nordmann, T. M., Traub, S., Schulze, F., et al. (2017) · Nature Immunology · doi:10.1038/ni.3659 · Cited by 396 · see citing works
The role of macrophages in obesity-associated islet inflammation and β-cell abnormalities
Ying, W., Fu, W., Lee, Y. S., & Olefsky, J. M. (2019) · Nature Reviews Endocrinology · doi:10.1038/s41574-019-0286-3 · Cited by 395 · see citing works
Inflammation and the Metabolic Syndrome: The Tissue-Specific Functions of NF-κB
Catrysse, L., & van Loo, G. (2017) · Trends in Cell Biology · doi:10.1016/j.tcb.2017.01.006 · Cited by 329 · see citing works
LTB4 promotes insulin resistance in obese mice by acting on macrophages, hepatocytes and myocytes
Li, P., Oh, D. Y., Bandyopadhyay, G. K., Lagakos, W., Talukdar, S., Osborn, O., Johnson, A., Chung, H., Mayoral, R., Maris, M., et al. (2015) · Nature Medicine · doi:10.1038/nm.3800 · Cited by 318 · see citing works
The transcriptional landscape of mouse beta cells compared to human beta cells reveals notable species differences in long non-coding RNA and protein-coding gene expression
Benner, C., van der Meulen, T., Cacéres, E., Tigyi, K., Donaldson, C. J., & Huising, M. O. (2014) · BMC Genomics · doi:10.1186/1471-2164-15-620 · Cited by 302 · see citing works
Hematopoietic-Derived Galectin-3 Causes Cellular and Systemic Insulin Resistance
Li, P., Liu, S., Lu, M. M., Bandyopadhyay, G. K., Oh, D., Imamura, T., Johnson, A. M. F., Sears, D. D., Shen, Z., Cui, B., et al. (2016) · Cell · doi:10.1016/j.cell.2016.10.025 · Cited by 297 · see citing works
Inflammasomes on the Crossroads of Innate Immune Recognition and Metabolic Control
Próchnicki, T., & Latz, E. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.06.018 · Cited by 297 · see citing works
Expansion of Islet-Resident Macrophages Leads to Inflammation Affecting β Cell Proliferation and Function in Obesity
Ying, W., Lee, Y. S., Dong, Y. W., Seidman, J. S., Yang, M., Isaac, R., Seo, J. B., Yang, B.-H., Wollam, J., Riopel, M., et al. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.12.003 · Cited by 268 · see citing works
Obesity in Type 1 Diabetes: Pathophysiology, Clinical Impact, and Mechanisms
Corbin, K. D., Driscoll, K. A., Pratley, R. E., Smith, S. R., Maahs, D. M., Mayer-Davis, E. J., & Advancing Care for Type 1 Diabetes and Obesity Network (ACT1ON) (2018) · Endocrine Reviews · doi:10.1210/er.2017-00191 · Cited by 262 · see citing works
Anti-inflammatory Agents in the Treatment of Diabetes and Its Vascular Complications
Pollack, R. M., Donath, M. Y., LeRoith, D., & Leibowitz, G. (2016) · Diabetes Care · doi:10.2337/dcs15-3015 · Cited by 261 · see citing works
IL-1 family members in the pathogenesis and treatment of metabolic disease: Focus on adipose tissue inflammation and insulin resistance
Ballak, D. B., Stienstra, R., Tack, C. J., Dinarello, C. A., & van Diepen, J. A. (2015) · Cytokine · doi:10.1016/j.cyto.2015.05.005 · Cited by 256 · see citing works
Oxidative and endoplasmic reticulum stress in β-cell dysfunction in diabetes
Hasnain, S. Z., Prins, J. B., & McGuckin, M. A. (2015) · Journal of Molecular Endocrinology · doi:10.1530/jme-15-0232 · Cited by 254 · see citing works
Anti-inflammatory agents to treat or prevent type 2 diabetes, metabolic syndrome and cardiovascular disease
Esser, N., Paquot, N., & Scheen, A. J. (2014) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.2015.974804 · Cited by 252 · see citing works
An overview of the inflammatory signalling mechanisms in the myocardium underlying the development of diabetic cardiomyopathy
Frati, G., Schirone, L., Chimenti, I., Yee, D., Biondi‐Zoccai, G., Volpe, M., & Sciarretta, S. (2017) · Cardiovascular Research · doi:10.1093/cvr/cvx011 · Cited by 245 · see citing works
T Cell–Derived IL-22 Amplifies IL-1β–Driven Inflammation in Human Adipose Tissue: Relevance to Obesity and Type 2 Diabetes
Dalmas, É., Venteclef, N., Caer, C., Poitou, C., Cremer, I., Aron‐Wisnewsky, J., Lacroix‐Desmazes, S., Bayry, J., Kaveri, S. V., Clément, K., et al. (2014) · Diabetes · doi:10.2337/db13-1511 · Cited by 240 · see citing works
Natural history of β-cell adaptation and failure in type 2 diabetes
Alejandro, E. U., Gregg, B. E., Blandino-Rosano, M., CRAS-MÉNEUR, C. M. H., & Bernal‐Mizrachi, E. (2014) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2014.12.002 · Cited by 235 · see citing works
Resident Macrophages Mediate Islet Amyloid Polypeptide–Induced Islet IL-1β Production and β-Cell Dysfunction
Westwell-Roper, C. Y., Ehses, J. A., & Verchere, C. B. (2013) · Diabetes · doi:10.2337/db13-0863 · Cited by 225 · see citing works
Lipoxin A4 Attenuates Obesity-Induced Adipose Inflammation and Associated Liver and Kidney Disease
Börgeson, E., Johnson, A. M. F., Lee, Y. S., Till, A., Syed, G. H., Shah, S. T. A., Guiry, P. J., Dalli, J., Colas, R. A., Serhan, C. N., et al. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.05.003 · Cited by 225 · see citing works
Islet inflammation in type 2 diabetes
Böni‐Schnetzler, M., & Meier, D. T. (2019) · Seminars in Immunopathology · doi:10.1007/s00281-019-00745-4 · Cited by 215 · see citing works
Vitamin D Switches BAF Complexes to Protect β Cells
Wei, Z., Yoshihara, E., He, N., Hah, N., Fan, W., Pinto, A. F. M., Huddy, T. F., Wang, Y., Ross, B., Estepa, G., et al. (2018) · Cell · doi:10.1016/j.cell.2018.04.013 · Cited by 206 · see citing works
mTORC1 Signaling: A Double-Edged Sword in Diabetic β Cells
Ardestani, A. D., Lupše, B., Kido, Y., Leibowitz, G., & Maedler, K. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.11.004 · Cited by 194 · see citing works
Generation of tissue-engineered small intestine using embryonic stem cell-derived human intestinal organoids
Finkbeiner, S. R., Freeman, J. J., Wieck, M. M., El-Nachef, W., Altheim, C. H., Tsai, Y.-H., Huang, S., Dyal, R., White, E. S., Grikscheit, T. C., et al. (2015) · Biology Open · doi:10.1242/bio.013235 · Cited by 174 · see citing works
Free fatty acids as modulators of the NLRP3 inflammasome in obesity/type 2 diabetes
Legrand-Poels, S., Esser, N., L’homme, L., Scheen, A., Paquot, N., & Piette, J. (2014) · Biochemical Pharmacology · doi:10.1016/j.bcp.2014.08.013 · Cited by 194 · see citing works
The IL-1 Pathway in Type 2 Diabetes and Cardiovascular Complications
Herder, C., Dalmas, É., Böni‐Schnetzler, M., & Donath, M. Y. (2015) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2015.08.001 · Cited by 169 · see citing works
Interleukin-33-Activated Islet-Resident Innate Lymphoid Cells Promote Insulin Secretion through Myeloid Cell Retinoic Acid Production
Dalmas, É., Lehmann, F., Dror, E., Wueest, S., Thienel, C., Borsigova, M., Stawiski, M., Traunecker, E., Lucchini, F. C., Dapito, D. H., et al. (2017) · Immunity · doi:10.1016/j.immuni.2017.10.015 · Cited by 170 · see citing works
Association of proinflammatory cytokines and islet resident leucocytes with islet dysfunction in type 2 diabetes
Butcher, M. J., Hallinger, D. R., Garcia, E., Machida, Y., Chakrabarti, S., Nadler, J. L., Galkina, E., & Imai, Y. (2014) · Diabetologia · doi:10.1007/s00125-013-3116-5 · Cited by 161 · see citing works
Flavonoids for preserving pancreatic beta cell survival and function: A mechanistic review
Ghorbani, A., Rashidi, R., & Shafiee-Nick, R. (2019) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.12.127 · Cited by 158 · see citing works
Treatment with adipose tissue-derived mesenchymal stem cells exerts anti-diabetic effects, improves long-term complications, and attenuates inflammation in type 2 diabetic rats
Yu, S., Cheng, Y., Zhang, L., Yin, Y., Xue, J., Li, B., Gong, Z., Gao, J., & Mu, Y. (2019) · Stem Cell Research & Therapy · doi:10.1186/s13287-019-1474-8 · Cited by 158 · see citing works
Visceral Adipose Tissue Immune Homeostasis Is Regulated by the Crosstalk between Adipocytes and Dendritic Cell Subsets
Macdougall, C. E., Wood, E. G., Loschko, J., Scagliotti, V., Cassidy, F. C., Robinson, M. E., Feldhahn, N., Castellano, L., Voisin, M.-B., Marelli‐Berg, F. M., et al. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.02.007 · Cited by 155 · see citing works
Role of Thioredoxin-Interacting Protein in Diseases and Its Therapeutic Outlook
Qayyum, N., Haseeb, M., Kim, M. S., & Choi, S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22052754 · Cited by 151 · see citing works
Differential Effects of Alternate-Day Fasting Versus Daily Calorie Restriction on Insulin Resistance
Gabel, K., Kroeger, C. M., Trepanowski, J. F., Hoddy, K. K., Cienfuegos, S., Kalam, F., & Varady, K. A. (2019) · Obesity · doi:10.1002/oby.22564 · Cited by 144 · see citing works
NLRP3 Inflammasome at the Interface of Inflammation, Endothelial Dysfunction, and Type 2 Diabetes
Góra, I. M., Ciechanowska, A., & Ładyżyński, P. (2021) · Cells · doi:10.3390/cells10020314 · Cited by 150 · see citing works
Current and emerging avenues for Alzheimer's disease drug targets
Loera‐Valencia, R., Cedazo-Mı́nguez, Á., Kenigsberg, P.-A., Page, G., Duarte, A. I., Giusti, P., Zusso, M., Robert, P. H., Frisoni, G. B., Cattaneo, A., et al. (2019) · Journal of Internal Medicine · doi:10.1111/joim.12959 · Cited by 139 · see citing works
Lipotoxicity in the Pancreatic Beta Cell: Not Just Survival and Function, but Proliferation as Well?
Sharma, R. B., & Alonso, L. C. (2014) · Current Diabetes Reports · doi:10.1007/s11892-014-0492-2 · Cited by 136 · see citing works
Tissue resident macrophages: Key players in the pathogenesis of type 2 diabetes and its complications
Meshkani, R., & Vakili, S. (2016) · Clinica Chimica Acta · doi:10.1016/j.cca.2016.08.015 · Cited by 132 · see citing works
Diabetes and Sepsis: Risk, Recurrence, and Ruination
Frydrych, L. M., Fattahi, F., He, K., Ward, P. A., & Delano, M. J. (2017) · Frontiers in Endocrinology · doi:10.3389/fendo.2017.00271 · Cited by 133 · see citing works
Management of Type 2 Diabetes: Current Strategies, Unfocussed Aspects, Challenges, and Alternatives
Borse, S., Chhipa, A. S., Sharma, V., Singh, D. P., & Nivsarkar, M. (2020) · Medical Principles and Practice · doi:10.1159/000511002 · Cited by 134 · see citing works
Improvement of obesity-associated disorders by a small-molecule drug targeting mitochondria of adipose tissue macrophages
Wang, Y., Tang, B., Long, L., Luo, P., Xiang, W., Li, X., Wang, H., Jiang, Q., Tan, X., Luo, S., et al. (2021) · Nature Communications · doi:10.1038/s41467-020-20315-9 · Cited by 113 · see citing works
Phosphoproteomics Reveals the GSK3-PDX1 Axis as a Key Pathogenic Signaling Node in Diabetic Islets
Sacco, F., Seelig, A., Humphrey, S. J., Krahmer, N., Volta, F., Reggio, A., Marchetti, P., Gerdes, J. M., & Mann, M. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.02.012 · Cited by 112 · see citing works
Persistent or Transient Human β Cell Dysfunction Induced by Metabolic Stress: Specific Signatures and Shared Gene Expression with Type 2 Diabetes
Marselli, L., Piron, A., Suleiman, M., Colli, M. L., Yi, X., Khamis, A., Carrat, G., Rutter, G. A., Bugliani, M., Giusti, L., et al. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.108466 · Cited by 115 · see citing works
G protein-coupled receptors as targets for anti-diabetic therapeutics
Oh, D. Y., & Olefsky, J. M. (2016) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2015.4 · Cited by 110 · see citing works
Mouse pancreatic islet macrophages use locally released ATP to monitor beta cell activity
Weitz, J., Makhmutova, M., Almaça, J., Stertmann, J., Aamodt, K. I., Briššová, M., Speier, S., Rodriguez‐Diaz, R., & Caicedo, A. (2017) · Diabetologia · doi:10.1007/s00125-017-4416-y · Cited by 111 · see citing works
Stress-impaired transcription factor expression and insulin secretion in transplanted human islets
Dai, C., Kayton, N. S., Shostak, A., Poffenberger, G., Cyphert, H. A., Aramandla, R., Thompson, C., Papagiannis, I. G., Emfinger, C., Shiota, M., et al. (2016) · Journal of Clinical Investigation · doi:10.1172/jci83657 · Cited by 109 · see citing works
Marine natural products with anti-inflammatory activity
Cheung, R. C. F., Ng, T. B., Wong, J. H., Chen, Y., & Chan, W. (2015) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-015-7244-3 · Cited by 110 · see citing works
Role of Caspase-1 in the Pathogenesis of Inflammatory-Associated Chronic Noncommunicable Diseases
Molla, M. D., Akalu, Y., Geto, Z., Dagnew, B., Ayelign, B., & Shibabaw, T. (2020) · Journal of Inflammation Research · doi:10.2147/jir.s277457 · Cited by 110 · see citing works
Altered Peripheral B-Lymphocyte Subsets in Type 1 Diabetes and Latent Autoimmune Diabetes in Adults
Deng, C., Xiang, Y., Tan, T., Ren, Z., Cao, C., Huang, G., Li, W., & Zhou, Z. (2015) · Diabetes Care · doi:10.2337/dc15-1765 · Cited by 105 · see citing works
Hyperglycaemia, oxidative stress and inflammatory markers
Butkowski, E., & Jelinek, H. F. (2016) · Redox Report · doi:10.1080/13510002.2016.1215643 · Cited by 100 · see citing works
Amylin at the interface between metabolic and neurodegenerative disorders
Lutz, T. A., & Meyer, U. (2015) · Frontiers in Neuroscience · doi:10.3389/fnins.2015.00216 · Cited by 100 · see citing works
Diet components can suppress inflammation and reduce cancer risk
Hardman, W. E. (2014) · Nutrition Research and Practice · doi:10.4162/nrp.2014.8.3.233 · Cited by 100 · see citing works
Antidiabetic Potential of Monoterpenes: A Case of Small Molecules Punching above Their Weight
Habtemariam, S. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms19010004 · Cited by 100 · see citing works
M1 macrophage-derived exosomes impair beta cell insulin secretion via miR-212-5p by targeting SIRT2 and inhibiting Akt/GSK-3β/β-catenin pathway in mice
Qian, B., Yang, Y., Tang, N., Wang, J., Sun, P. G., Yang, N., Chen, F., Wu, T., Sun, T., Li, Y., et al. (2021) · Diabetologia · doi:10.1007/s00125-021-05489-1 · Cited by 99 · see citing works
Type 2 diabetes – An autoinflammatory disease driven by metabolic stress
Gonzalez, L. L., Garrie, K., & Turner, M. D. (2018) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2018.08.034 · Cited by 98 · see citing works
Antidiabetic Effects of Yam (Dioscorea batatas) and Its Active Constituent, Allantoin, in a Rat Model of Streptozotocin-Induced Diabetes
Go, H.-K., Rahman, M. M., Kim, G.-B., Na, C.-S., Song, C.-H., Kim, J.-S., Kim, S., & Kang, H. (2015) · Nutrients · doi:10.3390/nu7105411 · Cited by 97 · see citing works
Targeting Imbalance between IL-1β and IL-1 Receptor Antagonist Ameliorates Delayed Epithelium Wound Healing in Diabetic Mouse Corneas
Yan, C., Gao, N., Sun, H., Yin, J., Lee, P. S. Y., Zhou, L., Fan, X., & Yu, F. X. (2016) · American Journal Of Pathology · doi:10.1016/j.ajpath.2016.01.019 · Cited by 96 · see citing works
Connecting pancreatic islet lipid metabolism with insulin secretion and the development of type 2 diabetes
Imai, Y., Cousins, R. S., Liu, S., Phelps, B. M., & Promes, J. A. (2019) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.14037 · Cited by 95 · see citing works
Arachidonic acid sex-dependently affects obesity through linking gut microbiota-driven inflammation to hypothalamus-adipose-liver axis
Zhuang, P., Shou, Q., Lu, Y., Wang, G., Qiu, J., Wang, J., He, L., Chen, J., Jiao, J., & Zhang, Y. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2017.07.003 · Cited by 94 · see citing works
Saturated fatty acids induce NLRP3 activation in human macrophages through K+ efflux resulting from phospholipid saturation and Na, K-ATPase disruption
Gianfrancesco, M. A., Dehairs, J., L’homme, L., Herinckx, G., Esser, N., Jansen, O., Habraken, Y., Lassence, C., Swinnen, J. V., Rider, M. H., et al. (2019) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2019.04.001 · Cited by 90 · see citing works
Nutrition Regulates Innate Immunity in Health and Disease
Nobs, S. P., Zmora, N., & Elinav, E. (2020) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-120919-094440 · Cited by 89 · see citing works
Molecular Integration of Incretin and Glucocorticoid Action Reverses Immunometabolic Dysfunction and Obesity
Quarta, C., Clemmensen, C., Zhu, Z., Yang, B. S., Joseph, S. S., Lutter, D., Yi, C., Graf, E., García‐Cáceres, C., Legutko, B., et al. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.08.023 · Cited by 88 · see citing works
The relationship between rheumatoid arthritis and diabetes mellitus: a systematic review and meta-analysis
Tian, Z., McLaughlin, J. T., Verma, A., Chinoy, H., & Heald, A. H. (2021) · Cardiovascular Endocrinology & Metabolism · doi:10.1097/xce.0000000000000244 · Cited by 80 · see citing works
Inflammatory markers and cardiometabolic diseases
Esser, N., Paquot, N., & Scheen, A. J. (2015) · Acta Clinica Belgica · doi:10.1179/2295333715y.0000000004 · Cited by 79 · see citing works
METTL3 is required for maintaining β-cell function
Li, X., Jiang, Y., Sun, X., Wu, Y., & Chen, Z. (2021) · Metabolism · doi:10.1016/j.metabol.2021.154702 · Cited by 78 · see citing works
Type 1 and Type 2 Diabetes Mellitus: Commonalities, Differences and the Importance of Exercise and Nutrition
Krause, M. D. S., & VITO, G. D. (2023) · Nutrients · doi:10.3390/nu15194279 · Cited by 76 · see citing works
IL-1 mediates amyloid-associated islet dysfunction and inflammation in human islet amyloid polypeptide transgenic mice
Westwell-Roper, C. Y., Chehroudi, C., Denroche, H. C., Courtade, J. A., Ehses, J. A., & Verchere, C. B. (2014) · Diabetologia · doi:10.1007/s00125-014-3447-x · Cited by 75 · see citing works
Expression of the kynurenine pathway enzymes in the pancreatic islet cells. Activation by cytokines and glucolipotoxicity
Liu, J., Raynal, S., Bailbé, D., Gausserès, B., Carbonne, C., Autier, V., Movassat, J., Kergoat, M., & Portha, B. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2015.02.001 · Cited by 74 · see citing works
Glucose-Dependent Insulinotropic Peptide Stimulates Glucagon-Like Peptide 1 Production by Pancreatic Islets via Interleukin 6, Produced by α Cells
Timper, K., Dalmas, É., Dror, E., Rütti, S., Thienel, C., Sauter, N. S., Bouzakri, K., Bédat, B., Pattou, F. N., Kerr-Conte, J. A., et al. (2016) · Gastroenterology · doi:10.1053/j.gastro.2016.03.003 · Cited by 73 · see citing works
Differences in Biomarkers of Inflammation Between Novel Subgroups of Recent-Onset Diabetes
Herder, C., Maalmi, H., Straßburger, K., Zaharia, O., Ratter, J. M., Karusheva, Y., Elhadad, M. A., Bódis, K. B., Bongaerts, B. W. C., Rathmann, W., et al. (2021) · Diabetes · doi:10.2337/db20-1054 · Cited by 73 · see citing works
Toll‐like receptors and NLRP3 as central regulators of pancreatic islet inflammation in type 2 diabetes
Westwell-Roper, C. Y., Nąckiewicz, D., Dan, M., & Ehses, J. A. (2014) · Immunology and Cell Biology · doi:10.1038/icb.2014.4 · Cited by 73 · see citing works
Metformin selectively dampens the acute inflammatory response through an AMPK-dependent mechanism
Postler, T. S., Peng, V., Bhatt, D. M., & Ghosh, S. (2021) · Scientific Reports · doi:10.1038/s41598-021-97441-x · Cited by 72 · see citing works
β Cell-Specific Deletion of the IL-1 Receptor Antagonist Impairs β Cell Proliferation and Insulin Secretion
Böni‐Schnetzler, M., Häuselmann, S. P., Dalmas, É., Meier, D. T., Thienel, C., Traub, S., Schulze, F., Steiger, L., Dror, E., Martin, P., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.01.063 · Cited by 70 · see citing works
The protective effects of Chinese yam polysaccharide against obesity-induced insulin resistance
Cheng, Z., Hu, M., Tao, J., Yang, H., Yan, P., An, G., & Wang, H. (2019) · Journal of Functional Foods · doi:10.1016/j.jff.2019.02.023 · Cited by 68 · see citing works
An Overview of Glycosylation and its Impact on Cardiovascular Health and Disease
Loaeza-Reyes, K. J., Zenteno, E., Rodríguez, A. M., Rosas, R. T., Argueta‐Figueroa, L., Salinas-Marín, R., Castillo-Real, L. M., Pina-Canseco, M. D. S., & Pérez-Cervera, Y. (2021) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2021.751637 · Cited by 67 · see citing works
Pancreas Volume and Fat Deposition in Diabetes and Normal Physiology: Consideration of the Interplay Between Endocrine and Exocrine Pancreas
Saisho, Y. (2016) · The Review of Diabetic Studies · doi:10.1900/rds.2016.13.132 · Cited by 64 · see citing works
Irisin Ameliorates Glucolipotoxicity-Associated β-Cell Dysfunction and Apoptosis via AMPK Signaling and Anti-Inflammatory Actions
Zhang, D., Xie, T., & Leung, P. S. (2018) · Cellular Physiology and Biochemistry · doi:10.1159/000495395 · Cited by 65 · see citing works
Glucose-dependent partitioning of arginine to the urea cycle protects β-cells from inflammation
Fu, A., Álvarez-Pérez, J. C., Avizonis, D. Z., Kin, T., Ficarro, S. B., Choi, D. W., Karaköse, E., Badur, M. G., Evans, L., Rosselot, C., et al. (2020) · Nature Metabolism · doi:10.1038/s42255-020-0199-4 · Cited by 65 · see citing works
EGCG Attenuates Uric Acid-Induced Inflammatory and Oxidative Stress Responses by Medicating the NOTCH Pathway
Xie, H., Sun, J., Chen, Y., Zong, M., Li, S., & Wang, Y. (2015) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2015/214836 · Cited by 63 · see citing works
Improving glycaemic control in type 2 diabetes: S timulate insulin secretion or provide beta‐cell rest?
van Raalte, D. H., & Verchere, C. B. (2017) · Diabetes Obesity and Metabolism · doi:10.1111/dom.12935 · Cited by 61 · see citing works
Reduction of blood glucose by plant extracts and their use in the treatment of diabetes mellitus; discrepancies in effectiveness between animal and human studies
Furman, B. L., Candasamy, M., Bhattamisra, S. K., & Veettil, S. K. (2019) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2019.112264 · Cited by 62 · see citing works
Crosstalk between Macrophages and Pancreatic β-Cells in Islet Development, Homeostasis and Disease
Cosentino, C., & Regazzi, R. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22041765 · Cited by 60 · see citing works
Activation of NLRP3 Inflammasome by Advanced Glycation End Products Promotes Pancreatic Islet Damage
Kong, X., Lu, A., Yao, X.-M., Hua, Q., Li, X.-Y., Li, Q., Zhang, H., Meng, G., & Su, Q. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/9692546 · Cited by 59 · see citing works
β-cell neogenesis: A rising star to rescue diabetes mellitus
Niu, F., Liu, W., Ren, Y., Tian, Y., Shi, W., Li, M., Li, Y., Xiong, Y., & Lü, Q. (2023) · Journal of Advanced Research · doi:10.1016/j.jare.2023.10.008 · Cited by 65 · see citing works
Creating the amylin story
Lutz, T. A. (2022) · Appetite · doi:10.1016/j.appet.2022.105965 · Cited by 59 · see citing works
Death and Dysfunction of Transplanted β-Cells: Lessons Learned From Type 2 Diabetes?
Potter, K. J., Westwell-Roper, C. Y., Klimek-Abercrombie, A. M., Warnock, G. L., & Verchere, C. B. (2013) · Diabetes · doi:10.2337/db12-0364 · Cited by 56 · see citing works
Antidiabetic drug glyburide modulates depressive-like behavior comorbid with insulin resistance
Su, W., Wei, P., Gong, H., Liu, Y., Zhang, Y., Lian, Y., Cao, Z., Wu, R., Liu, L., Wang, B., et al. (2017) · Journal of Neuroinflammation · doi:10.1186/s12974-017-0985-4 · Cited by 56 · see citing works
Emerging role for kynurenines in metabolic pathologies
Liu, J., Movassat, J., & Portha, B. (2018) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0000000000000529 · Cited by 60 · see citing works
Beta Cell Physiological Dynamics and Dysfunctional Transitions in Response to Islet Inflammation in Obesity and Diabetes
Cerf, M. E. (2020) · Metabolites · doi:10.3390/metabo10110452 · Cited by 55 · see citing works
Differential Activation of Innate Immune Pathways by Distinct Islet Amyloid Polypeptide (IAPP) Aggregates
Westwell-Roper, C. Y., Denroche, H. C., Ehses, J. A., & Verchere, C. B. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.712455 · Cited by 54 · see citing works
Obesity and morbid obesity associated with higher odds of hypoalbuminemia in adults without liver disease or renal failure
Mosli, R. H., & Mosli, H. H. (2017) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s149832 · Cited by 53 · see citing works
The Hippo Signaling Pathway in Pancreatic β-Cells: Functions and Regulations
Ardestani, A. D., & Maedler, K. (2017) · Endocrine Reviews · doi:10.1210/er.2017-00167 · Cited by 54 · see citing works
Physiopathological mechanisms related to inflammation in obesity and type 2 diabetes mellitus
Lempesis, I. G., & GEORGAKOPOULOU, V. E. (2023) · World Journal of Experimental Medicine · doi:10.5493/wjem.v13.i3.7 · Cited by 52 · see citing works
Interleukin-37 treatment of mice with metabolic syndrome improves insulin sensitivity and reduces pro-inflammatory cytokine production in adipose tissue
Ballak, D. B., Li, S., Cavalli, G., Stahl, J. L., Tengesdal, I. W., van Diepen, J. A., Klück, V., Swartzwelter, B. J., Azam, T., Tack, C. J., et al. (2018) · Journal of Biological Chemistry · doi:10.1074/jbc.ra118.003698 · Cited by 52 · see citing works
Insulin Resistance in Osteoarthritis: Similar Mechanisms to Type 2 Diabetes Mellitus
Tchetina, E. V., Markova, G. A., & Sharapova, E. P. (2020) · Journal of Nutrition and Metabolism · doi:10.1155/2020/4143802 · Cited by 53 · see citing works
Dynamic pathology of islet endocrine cells in type 2 diabetes: β‐Cell growth, death, regeneration and their clinical implications
Yagihashi, S., Inaba, W., & Mizukami, H. (2015) · Journal of Diabetes Investigation · doi:10.1111/jdi.12424 · Cited by 50 · see citing works
Activation of NF-κB-Inducing Kinase in Islet β Cells Causes β Cell Failure and Diabetes
Li, X., Wu, Y., Song, Y., Ding, N., Lu, M. M., Jia, L., Zhao, Y., Liu, M. R., & Chen, Z. (2020) · Molecular Therapy · doi:10.1016/j.ymthe.2020.07.016 · Cited by 50 · see citing works
Approaches to Peripheral Artery Disease in Diabetes: Are There Any Differences?
Achim, A., Stanek, A., Homorodean, C., Spînu, M., Onea, H., Lazăr, F.-L., Marc, M., Ruzsa, Z., & Olinic, D.-M. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph19169801 · Cited by 53 · see citing works

Authors: Donath, M. Y., Dalmas, É., Sauter, N. S., & Böni-Schnetzler, M.
Affiliations: University Hospital of Basel (CH)
Corresponding author: Donath, Marc Y.
ORCID: Donath, Marc Y.
Dalmas, Élise
Venue: Cell Metabolism
Publisher: Elsevier BV
Published: 2013-06
Volume: 17
Issue: 6
Pages: 860-872
ISSN: 1550-4131 (ISSN-L)
DOI: 10.1016/j.cmet.2013.05.001
OpenAlex: W2053963810
Cited by: 338
References: 147
Citations by year: 2026: 16 · 2025: 18 · 2024: 9 · 2023: 25 · 2022: 28 · 2021: 39 · 2020: 33 · 2019: 29 · 2018: 24 · 2017: 30 · 2016: 20 · 2015: 33 · 2014: 29 · 2013: 5
FWCI: 5.14
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 368 d)
Locations: Cell Metabolism (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
Keywords: obesity, diabetes mellitus, insulitis, islet dysfunction, immune system, overnutrition, immunomodulatory therapy
MeSH terms: Insulin Secretion, Diabetes Mellitus, Type 2, Humans, Immunity, Innate, Inflammation, Insulin, Islets of Langerhans, Macrophages, Obesity, Interleukin-1beta

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Inflammation in obesity and diabetes: islet dysfunction and therapeutic opportunity

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cites

Cited by

Related

Record

About these checks