The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Natural antibodies with the T15 idiotype may act in atherosclerosis, apoptotic clearance, and protective immunity
Open accessAbstract
The immune response to oxidized LDL (OxLDL) may play an important role in atherogenesis. Working with apoE-deficient mice, we isolated a panel of OxLDL-specific B-cell lines that secrete IgM Abs that specifically bind to oxidized phospholipids such as 1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine (POVPC). These Abs block uptake of OxLDL by macrophages, recognize similar oxidation-specific epitopes on apoptotic cells, and are deposited in atherosclerotic lesions. The Abs were found to be structurally and functionally identical to classic "natural" T15 anti-PC Abs that are of B-1 cell origin and are reported to provide optimal protection from virulent pneumococcal infection. These findings suggest that there has been natural selection for B-1 cells secreting oxidation-specific/T15 antibodies, both for their role in natural immune defense and for housekeeping roles against oxidation-dependent neodeterminants in health and disease.
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Cites
Napoli, C., D'Armiento, F. P., Mancini, F. P., Postiglione, A., Witztum, J. L., Palumbo, G., & Palinski, W. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119813 · Cited by 1,014
Self-citationOxidized Phosphatidylcholines That Modify Proteins
Itabe, H., Yamamoto, H., Suzuki, M., Kawai, Y., Nakagawa, Y., Suzuki, A., Imanaka, T., & Takano, T. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.52.33208 · Cited by 128
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The immunology of atherosclerosis
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Metadata
- Authors
- Shaw, P. X., Hörkkö, S., Chang, M.-K., Curtiss, L. K., Palinski, W., Silverman, G. J., & Witztum, J. L.
- Venue
- Journal of Clinical Investigation
- Published
- 2000-06-15
- Volume
- 105
- Issue
- 12
- Pages
- 1731-1740
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2116592902
- Cited by
- 676
- References
- 2
- FWCI
- 8.44
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Shaw, P. X., Hörkkö, S., Chang, M.-K., Curtiss, L. K., Palinski, W., Silverman, G. J., & Witztum, J. L. (2000). Natural antibodies with the T15 idiotype may act in atherosclerosis, apoptotic clearance, and protective immunity. Journal of Clinical Investigation. https://doi.org/10.1172/jci8472
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