Hippo signaling interactions with Wnt/β-catenin and Notch signaling repress liver tumorigenesis

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Role of YAP/TAZ in mechanotransduction

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Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control

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NDR1 increases NOTCH1 signaling activity by impairing Fbw7 mediated NICD degradation to enhance breast cancer stem cell properties

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SPTAN1/NUMB axis senses cell density to restrain cell growth and oncogenesis through Hippo signaling

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Molecular Mechanisms in Tumorigenesis of Hepatocellular Carcinoma and in Target Treatments—An Overview

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Hippo Signaling Pathway in Colorectal Cancer: Modulation by Various Signals and Therapeutic Potential

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A positive feedback loop involving the LINC00346/β-catenin/MYC axis promotes hepatocellular carcinoma development

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Downregulation of STK4 promotes colon cancer invasion/migration through blocking β‐catenin degradation

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LEF1 Enhances the Progression of Colonic Adenocarcinoma via Remodeling the Cell Motility Associated Structures

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Liver regeneration after partial hepatectomy: Triggers and mechanisms

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The role of YAP1 in liver cancer stem cells: proven and potential mechanisms

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Hepatocyte reprogramming in liver regeneration: Biological mechanisms and applications

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Knockdown of microRNA-103a-3p inhibits the malignancy of thyroid cancer cells through Hippo signaling pathway by upregulating LATS1

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YAP1 activation and Hippo pathway signaling in the pathogenesis and treatment of intrahepatic cholangiocarcinoma

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Role of the Hippo pathway in autoimmune diseases

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Oncofetal reprogramming in tumor development and progression: novel insights into cancer therapy

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Deregulation and Therapeutic Potential of the Hippo Pathway in Cancer

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Long Non-Coding RNA-PAICC Promotes the Tumorigenesis of Human Intrahepatic Cholangiocarcinoma by Increasing YAP1 Transcription

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Stem cell therapy: A paradigm shift in breast cancer treatment

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The activation of the Notch signaling pathway by UBE2C promotes the proliferation and metastasis of hepatocellular carcinoma

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YAP/TAZ: An epitome of tumorigenesis

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Chinese Propolis Suppressed Pancreatic Cancer Panc-1 Cells Proliferation and Migration via Hippo-YAP Pathway

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Effect of Diphtheria Toxin-Based Gene Therapy for Hepatocellular Carcinoma

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YAP/TAZ as master regulators in liver regeneration and disease: insights into mechanisms and therapeutic targets

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Cell differentiation-related signaling pathways in hepatocellular carcinoma metastasis

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Ginsenoside Rh2 attenuates the progression of non‐small cell lung cancer by sponging miR ‐28‐5p/ STK4 axis and inactivating Wnt/β‐catenin signaling

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Mechanisms of breast cancer metastasis: the role of extracellular matrix

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N-Myristoylation by NMT1 Is POTEE-Dependent to Stimulate Liver Tumorigenesis via Differentially Regulating Ubiquitination of Targets

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Nuclear PTEN and p53 suppress stress-induced liver cancer through distinct mechanisms

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Hepatocyte-Specific Deletion of Yes-Associated Protein Improves Recovery From Acetaminophen-Induced Acute Liver Injury

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Interplay between YAP/TAZ and metabolic dysfunction-associated steatotic liver disease progression

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Yap/Taz are required for establishing the cerebellar radial glia scaffold and proper foliation

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Increased CDCA2 Level Was Related to Poor Prognosis in Hepatocellular Carcinoma and Associated With Up-Regulation of Immune Checkpoints

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Current Perspectives on the Immunosuppressive Niche and Role of Fibrosis in Hepatocellular Carcinoma and the Development of Antitumor Immunity

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TGF-β/SMAD canonical pathway induces the expression of transcriptional cofactor TAZ in liver cancer cells

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TIPE2 attenuates liver fibrosis by reversing the activated hepatic stellate cells

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Differentiation-inducing therapeutic effect of Notch inhibition in reversing malignant transformation of liver normal stem cells via MET

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STK3 Suppresses Ovarian Cancer Progression by Activating NF‐ κ B Signaling to Recruit CD8 + T‐Cells

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SPRY4-AS1, A Novel Enhancer RNA, Is a Potential Novel Prognostic Biomarker and Therapeutic Target for Hepatocellular Carcinoma

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Introduction to Molecular Mechanisms in Notch Signal Transduction and Disease Pathogenesis

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Smoke-induced SAV1 Gene Promoter Hypermethylation Disrupts YAP Negative Feedback and Promotes Malignant Progression of Non-small Cell Lung Cancer

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Nuclear receptor E75/NR1D2 promotes tumor malignant transformation by integrating Hippo and Notch pathways

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Anti-Jagged-1 immunotherapy in cancer

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Mice Deficient in TAZ (Wwtr1) Demonstrate Clinical Features of Late-Onset Fuchs’ Endothelial Corneal Dystrophy

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Spatial gene regulatory networks driving cell state transitions during human liver disease

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A yes-associated protein 1- Notch1 receptor positive feedback loop promotes breast cancer lung metastasis by attenuating the bone morphogenetic protein 4-SMAD family member 1/5 signaling

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Machine learning and experiments identifies SPINK1 as a candidate diagnostic and prognostic biomarker for hepatocellular carcinoma

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The potential role of Hippo pathway regulates cellular metabolism via signaling crosstalk in disease-induced macrophage polarization

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Molecular mechanisms of Hippo pathway in tumorigenesis: therapeutic implications

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LIN28B gene polymorphisms modify hepatoblastoma susceptibility in Chinese children

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Endothelial Shp2 deficiency controls alternative activation of macrophage preventing radiation-induced lung injury through notch signaling

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Delta/Notch-like Epidermal Growth Factor-Related Receptor (DNER), a Potential Prognostic Marker of Gastric Cancer Regulates Cell Survival and Cell Cycle Progression

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The Role of Yes‐Associated Protein in Inflammatory Diseases and Cancer

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Dihydroartemisinin inhibited interleukin-18 expression by decreasing YAP1 in hepatocellular carcinoma cells

Gong, Y., Peng, Q., Gao, Y., Yang, J., Lu, J., Zhang, Y., Yang, Y., Liang, H. L., Yue, Y., & Shi, X. (2023) · Acta Histochemica · doi:10.1016/j.acthis.2023.152040 · Cited by 12

Mask, a component of the Hippo pathway, is required for Drosophila eye morphogenesis

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Livin promotes tumor progression through YAP activation in ovarian cancer.

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Machine learning algorithms based on proteomic data mining accurately predicting the recurrence of hepatitis B‐related hepatocellular carcinoma

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SNTB1 regulates colorectal cancer cell proliferation and metastasis through YAP1 and the WNT/β-catenin pathway

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Maladaptive regeneration and metabolic dysfunction associated steatotic liver disease: Common mechanisms and potential therapeutic targets

Wu, D., & van de Graaf, S. F. J. (2024) · Biochemical Pharmacology · doi:10.1016/j.bcp.2024.116437 · Cited by 12

A novel role of Hippo-Yap/TAZ signaling pathway in lymphatic vascular development

Cha, B., Moon, S., & Kim, W. (2021) · BMB Reports · doi:10.5483/bmbrep.2021.54.6.020 · Cited by 11

Dickkopf1: An Immunomodulator in Tissue Injury, Inflammation, and Repair

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Hepatogenesis and hepatocarcinogenesis: Alignment of the main signaling pathways

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Molecular Classification of Hepatocellular Carcinoma Using Wnt–Hippo Signaling Pathway-Related Genes

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Notch signaling in cancer: metabolic reprogramming and therapeutic implications

Wang, S., Lv, H.-L., Nie, R., Liu, Y., Hou, Y., Chen, C., Tao, X.-Y., Luo, H.-M., & Li, P.-F. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1656370 · Cited by 9

Circular RNA hsa_circ_0098181 inhibits metastasis in hepatocellular carcinoma by activating the Hippo signaling pathway via interaction with eEF2

Gao, P., Yang, Y., Li, X., Zhao, Q., Liu, Y., Dong, C., Zhang, Y., & Liu, D. (2023) · Annals of Hepatology · doi:10.1016/j.aohep.2023.101124 · Cited by 9

Harnessing developmental cues for cardiomyocyte production

Maas, R. G. C., van den Dolder, F. W., Yuan, Q., van der Velden, J., Wu, S. M., Sluijter, J. P. G., & Buikema, J. W. (2023) · Development · doi:10.1242/dev.201483 · Cited by 9

Research Progress on Regulating LncRNAs of Hepatocellular Carcinoma Stem Cells

Zhang, X., & Zhu, Y. (2021) · OncoTargets and Therapy · doi:10.2147/ott.s289064 · Cited by 9

O-GlcNAcylation: An Emerging Protein Modification Regulating the Hippo Pathway

Kim, E., Kang, J. G., Jho, E., Yang, W. H., & Cho, J. W. (2022) · Cancers · doi:10.3390/cancers14123013 · Cited by 9

Transcatheter arterial chemoembolization combined with Hippo/YAP inhibition significantly improve the survival of rats with transplanted hepatocellular carcinoma

Quan, Y., Li, Z., Zhu, K., & Liang, J. (2021) · Lipids in Health and Disease · doi:10.1186/s12944-021-01486-w · Cited by 8

Modulation of Hippo signaling by Mnat9 N-acetyltransferase for normal growth and tumorigenesis in Drosophila

Mok, J.-W., & Choi, K. (2022) · Cell Death and Disease · doi:10.1038/s41419-022-04532-2 · Cited by 8

The Orphan GPR50 Receptor Regulates the Aggressiveness of Breast Cancer Stem-like Cells via Targeting the NF-kB Signaling Pathway

Biswas, P. K., Park, S. R., An, J., Lim, K. M., Dayem, A. A., Song, K., Choi, H. Y., Choi, Y., Park, K. S., Shin, H. J., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24032804 · Cited by 8

Mechanical stimuli control liver homeostasis

Lemaigre, F. P. (2019) · Journal of Hepatology · doi:10.1016/j.jhep.2019.04.002 · Cited by 7

The regulation of proliferation and apoptosis in hepatocellular carcinoma via insulin-like growth factor 1 receptor

Guanjun, X., Jiesheng, C., Shi, Y., Huang, L., & Fu, J. (2022) · Growth Hormone & IGF Research · doi:10.1016/j.ghir.2022.101499 · Cited by 7

Role of Hepatocyte Nuclear Factor 4 Alpha in Liver Cancer

Kotulkar, M., Paine‐Cabrera, D., & Apte, U. M. (2024) · Seminars in Liver Disease · doi:10.1055/a-2349-7236 · Cited by 7

Reaping Wnt after calming Hippo: Wnt and Hippo signaling cross paths in lung cancer

Andl, T., & Zhang, Y. (2017) · Journal of Thoracic Disease · doi:10.21037/jtd.2017.10.29 · Cited by 7

Comprehensive Analysis of the Expression of Key Genes Related to Hippo Signaling and Their Prognosis Impact in Ovarian Cancer

Kubelac, P. M., Braicu, C., Ráduly, L., Chiroi, P. A., Nutu, A. M., Cojocneanu, R., Budişan, L., Berindan‐Neagoe, I., & Achimaș-Cădariu, P. (2021) · Diagnostics · doi:10.3390/diagnostics11020344 · Cited by 7

Identification of glycolysis related pathways in pancreatic adenocarcinoma and liver hepatocellular carcinoma based on TCGA and GEO datasets

Li, J., Zhu, C., Yue, P., Zheng, T., Li, Y., Wang, B., Meng, X., & Zhang, Y. (2021) · Cancer Cell International · doi:10.1186/s12935-021-01809-y · Cited by 7

Prevention and Treatment of Hepatocellular Carcinoma Using miRNAs

Farzaneh, Z., & Farzaneh, M. (2022) · Archives of Iranian Medicine · doi:10.34172/aim.2022.23 · Cited by 7

Upregulated YAP promotes oncogenic CTNNB1 expression contributing to molecular pathology of hepatoblastoma

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A positive feedback loop of the TAZ/β-catenin axis promotes Helicobacter pylori-associated gastric carcinogenesis

Xu, X., Shu, C., Wu, X., Ouyang, Y., Cheng, H., Zhou, Y., Wang, H., He, C., Xie, C., He, X., et al. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.1065462 · Cited by 7

Exploring the mechanism of resistance to sorafenib in two hepatocellular carcinoma cell lines

Zhang, Z., He, C.-Z., Qin, Y., Liao, J., Huang, S.-T., Mo, S., Li, H., & Lin, J. (2020) · Aging · doi:10.18632/aging.104195 · Cited by 7

Signalling pathways in hepatocellular carcinoma (HCC) metastasis and invasion: Molecular mechanisms and therapeutic implications

Das, J., Barman, B., Sarma, P., Das, B. K., Chetia, R., & Kalita, P. P. (2025) · Biochemistry and Biophysics Reports · doi:10.1016/j.bbrep.2025.102403 · Cited by 8

Single-Cell RNA Sequencing Reveals LEF1-Driven Wnt Pathway Activation as a Shared Oncogenic Program in Hepatoblastoma and Medulloblastoma

Desterke, C., Fu, Y., Bonifacio-Mundaca, J., Monge, C., Pineau, P., Mata-Garrido, J., & Francés, R. (2025) · Current Oncology · doi:10.3390/curroncol32010035 · Cited by 6

Ablation of high‐mobility group box‐1 in the liver reduces hepatocellular carcinoma but causes hyperbilirubinemia in Hippo signaling‐deficient mice

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The Conundrum of the Pericentral Hepatic Niche: WNT/-Catenin Signaling, Metabolic Zonation, and Many Open Questions

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Exosomes from liver progenitor cells carrying JAG1 activate notch signaling to promote liver regeneration in PVL rats

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Loss of Epidermal Homeostasis Underlies the Development of Squamous Cell Carcinoma

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Hippo signaling pathway in companion animal diseases, an under investigated signaling cascade

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A review on decoding the roles of YAP/TAZ signaling pathway in cardiovascular diseases: Bridging molecular mechanisms to therapeutic insights

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Serotonin-induced miR-221/222 contribute to the activation of hepatic stellate cells

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Recent advances on Hippo-YAP pathway in skin diseases

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Mechanism of MicroRNA-375 Promoter Methylation in Promoting Ovarian Cancer Cell Malignancy

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Breast cancer drug resistance: Decoding the roles of Hippo pathway crosstalk

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Characterization of a novel compound that promotes myogenesis via Akt and transcriptional co-activator with PDZ-binding motif (TAZ) in mouse C2C12 cells

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Control of tissue homeostasis, tumorigenesis, and degeneration by coupled bidirectional bistable switches

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Expression patterns of Yes-associated protein 1 in the developing mouse liver

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Pharmacological targeting of large tumor suppressor kinases (LATS) 1 and 2 augments tissue repair and regeneration

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Hepatocellular carcinoma-linked AXIN1 mutations drive low Wnt/β-catenin activity enabling niche-independent growth and YAP/TAZ signaling

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CD160+ intraepithelial lymphocytes and CCRL2+ macrophages drive differential repair in cardiac and liver injuries

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Celecoxib inhibits COX-2 and initiates YAP-dependent mitochondrial apoptosis via YBX1 shuttling in hepatocellular carcinoma

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Dihydroartemisinin promotes ABCG5/G8-mediated cholesterol efflux to potentiate anti-PD-1 therapy through YAP1-TEAD1 complex disruption in hepatocellular carcinoma

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Interacting network of Hippo, Wnt/β-catenin and Notch signaling represses liver tumor formation

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The transcriptional regulator YAP induces Notch-pathway activity in hepatocytes and hepatocellular carcinoma cells

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Hepatic Hippo signaling inhibits development of hepatocellular carcinoma

Liu, Y., Wang, X., & Yang, Y. (2020) · Clinical and Molecular Hepatology · doi:10.3350/cmh.2020.0178 · Cited by 72

The Hippo signaling pathway in liver regeneration and tumorigenesis

Hong, L., Cai, Y., Jiang, M., Zhou, D., & Chen, L. (2014) · Acta Biochimica et Biophysica Sinica · doi:10.1093/abbs/gmu106 · Cited by 68

Abstract 984: High-level expression of YAP induces protumorigenic Notch signalling in human hepatocarcinogenesis

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