Cited by 107Anxiety, Depression, Psychometrics, Treatment, Cognitive ProcessesPsychosomatic Disorders and Their TreatmentsPain Management and Placebo Effect

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Reduction of CO2-induced anxiety in patients with panic attacks after repeated CO2 exposure

Marcel van den Hout, G.M. van der Molen, Eric J.L. Griez, H. Lousberg, A Nansen·1987·American Journal of Psychiatry

DOI 10.1176/ajp.144.6.788

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Abstract

The authors compared the subjective reaction of 13 panic patients and eight control subjects to a 35% CO2 challenge, a treatment known to produce physical symptoms comparable to those of natural or lactate-induced panic, and to placebo treatment (inhalation of air). They found that patients had higher placebo scores than control subjects, patients tended to get highly anxious on CO2 and control subjects did not, and CO2-induced subjective anxiety in patients decreased as the number of CO2-induced exposures to interoceptive anxiety symptoms increased. The data support a behavioral account of the effects of anxiogenics.

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Authors: van den Hout, M., van der Molen, G. M., Griez, E. J. L., Lousberg, H., & Nansen, A.
Venue: American Journal of Psychiatry
Publisher: American Psychiatric Association Publishing
Published: 1987-06-01
Volume: 144
Issue: 6
Pages: 788-791
ISSN: 0002-953X (ISSN-L)
1535-7228
DOI: 10.1176/ajp.144.6.788
OpenAlex: W2409959974
Cited by: 107
References: 16
Citations by year: 2026: 2 · 2021: 2 · 2020: 2 · 2019: 2 · 2018: 1 · 2017: 1 · 2016: 2 · 2015: 4 · 2014: 2 · 2013: 3 · 2012: 2
FWCI: 10.54
Type: journal article
Language: en
Open access: closed
Locations: American Journal of Psychiatry (publishedVersion)
PubMed (publishedVersion)
Topics: Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
Life Sciences › Neuroscience › Cognitive Neuroscience › Pain Management and Placebo Effect
Keywords: panic disorder, CO2 challenge, anxiety, placebo effect, anxiogenic effects, panic attacks
MeSH terms: Adolescent, Adult, Anxiety Disorders, Carbon Dioxide, Fear, Female, Habituation, Psychophysiologic, Humans, Lactates, Male, Models, Psychological, Panic, Sensation, Lactic Acid

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Reduction of CO2-induced anxiety in patients with panic attacks after repeated CO2 exposure

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