Neuroimaging genetic approaches to Posttraumatic Stress Disorder

Lebois, Lauren A.M.; Wolff, Jonathan D.; Ressler, Kerry J.

doi:10.1016/j.expneurol.2016.04.019

Cited by 31Posttraumatic Stress Disorder ResearchNeurotransmitter Receptor Influence on BehaviorTraumatic Brain Injury Research

Neuroimaging genetic approaches to Posttraumatic Stress Disorder

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Lebois, Lauren A.M., Wolff, Jonathan D., Ressler, Kerry J.·2016·Experimental Neurology

DOI 10.1016/j.expneurol.2016.04.019PMC PMC5056798

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Abstract

Neuroimaging genetic studies that associate genetic and epigenetic variation with neural activity or structure provide an opportunity to link genes to psychiatric disorders, often before psychopathology is discernable in behavior. Here we review neuroimaging genetics studies with participants who have Posttraumatic Stress Disorder (PTSD). Results show that genes related to the physiological stress response (e.g., glucocorticoid receptor and activity, neuroendocrine release), learning and memory (e.g., plasticity), mood, and pain perception are tied to neural intermediate phenotypes associated with PTSD. These genes are associated with and sometimes predict neural structure and function in areas involved in attention, executive function, memory, decision-making, emotion regulation, salience of potential threats, and pain perception. Evidence suggests these risk polymorphisms and neural intermediate phenotypes are vulnerabilities toward developing PTSD in the aftermath of trauma, or vulnerabilities toward particular symptoms once PTSD has developed. Work distinguishing between the re-experiencing and dissociative sub-types of PTSD, and examining other PTSD symptom clusters in addition to the re-experiencing and hyperarousal symptoms, will further clarify neurobiological mechanisms and inconsistent findings. Furthermore, an exciting possibility is that genetic associations with PTSD may eventually be understood through differential intermediate phenotypes of neural circuit structure and function, possibly underlying the different symptom clusters seen within PTSD.

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Authors: Lebois, L. A. M., Wolff, J. D., & Ressler, K. J.
Affiliations: Harvard University (US)
Corresponding author: Ressler, Kerry J.
ORCID: Lebois, Lauren A.M.
Wolff, Jonathan D.
Ressler, Kerry J.
Venue: Experimental Neurology
Publisher: Elsevier BV
Published: 2016-10
Volume: 284
Issue: Pt B
Pages: 141-152
ISSN: 0014-4886 (ISSN-L)
DOI: 10.1016/j.expneurol.2016.04.019
PMC: PMC5056798
OpenAlex: W2343652181
Cited by: 31
References: 164
Citations by year: 2026: 1 · 2025: 2 · 2024: 4 · 2023: 3 · 2022: 2 · 2020: 2 · 2019: 3 · 2018: 7 · 2017: 6 · 2016: 1
FWCI: 0.84
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Experimental Neurology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Mental Health (MH096764, MH071537)
Topics: Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Health Sciences › Medicine › Epidemiology › Traumatic Brain Injury Research
Keywords: post-traumatic stress disorder, neuroimaging genetics, epigenetics, endophenotypes, glucocorticoid receptor, stress response, learning and memory, pain perception, emotion regulation, re-experiencing symptoms, dissociative symptoms, hyperarousal
MeSH terms: Brain, Emotions, Humans, Memory, Receptors, Glucocorticoid, Stress Disorders, Post-Traumatic, Executive Function, Neuroimaging

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