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Nonpharmacological interventions for insomnia: a meta-analysis of treatment efficacy
Abstract
OBJECTIVE: Because of the role of psychological factors in insomnia, the shortcomings of hypnotic medications, and patients' greater acceptance of nonpharmacological treatments for insomnia, the authors conducted a meta-analysis to examine the efficacy and durability of psychological treatments for the clinical management of chronic insomnia. METHOD: A total of 59 treatment outcome studies, involving 2,102 patients, were selected for review on the basis of the following criteria: 1) the primary target problem was sleep-onset, maintenance, or mixed insomnia, 2) the treatment was nonpharmacological, 3) the study used a group design, and 4) the outcome measures included sleep-onset latency, time awake after sleep onset, number of nighttime awakenings, or total sleep time. RESULTS: Psychological interventions, averaging 5.0 hours of therapy time, produced reliable changes in two of the four sleep measures examined. The average effect sizes (i.e., z scores) were 0.88 for sleep latency and 0.65 for time awake after sleep onset. These results indicate that patients with insomnia were better off after treatment than 81% and 74% of untreated control subjects in terms of sleep induction and sleep maintenance, respectively. Stimulus control and sleep restriction were the most effective single therapy procedures, whereas sleep hygiene education was not effective when used alone. Clinical improvements seen at treatment completion were well maintained at follow-ups averaging 6 months in duration. CONCLUSIONS: The findings indicate that nonpharmacological interventions produce reliable and durable changes in the sleep patterns of patients with chronic insomnia.
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“The recommended first-line treatment, Cognitive Behavioral Therapy for Insomnia (CBTI) does not carry these risks and is therefore preferable for reasons beyond demonstrated efficacy(244-248), efficacy relative to medications(249-253), and effectiveness(254).”
From Sleep: important considerations for the prevention of cardiovascular disease (2016) · cites this paper as [247]
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“Research suggests that relaxation is especially effective in helping with sleep initiation [29].”
From Non-Pharmacological Treatment of Insomnia (2012) · cites this paper as [29]
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“org includes: (1) video introductions to the technique provided by internationally recognized experts in that topic; (2) an overview of the module’s learning objectives; (3) a description of each intervention technique and step-by-step instructions for how to implement them, including sample scripts and handouts that…”
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BackgroundInfluentialPharmacological and non-pharmacological treatments for insomnia
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“Sleep hygiene education, while typically insufficient as a stand-alone sleep intervention, is a common element of effective multicomponent sleep programs for treating insomnia.(45) Examples of traditionally accepted sleep hygiene practices for the general population include limiting activities in bed to sleep and sex,…”
BackgroundBrief behavioral treatment for insomnia decreases trauma-related nightmare frequency in veterans
Ranney, R. M., Gloria, R., Metzler, T. J., Huggins, J., Neylan, T. C., & Maguen, S. (2022) · Journal of Clinical Sleep Medicine · doi:10.5664/jcsm.10002 · Cited by 14
“13,33 A manualized 4-session version of PMRT was developed that matched the BBTI treatment for session duration and type (ie, in-person vs by telephone).”
Youngstedt, S. D., Jean‐Louis, G., Bootzin, R. R., Kripke, D. F., Cooper, J., Dean, L. R., Catao, F., James, S., Vining, C., Williams, N. J., et al. (2013) · Contemporary Clinical Trials · doi:10.1016/j.cct.2013.06.014 · Cited by 13
“It is noteworthy that sleep restriction therapy is one of themost effective treatments for primary insomnia [80], which is often associated with excessive time in bed in an attempt to compensate for insomnia.”
Leerssen, J., Foster‐Dingley, J. C., Lakbila‐Kamal, O., Dekkers, L. M. S., Albers, A. C. W., Ikelaar, S. L. C., Maksimovic, T., Wassing, R., Houtman, S. J., Bresser, T., et al. (2020) · BMC Psychiatry · doi:10.1186/s12888-020-02554-8 · Cited by 14
Sleep hygiene use in a psychiatry outpatient setting.
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Sleep-medication for symptomatic insomnia in the general population of Japan
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“A meta-analysis of 59 studies found that psychological interventions led to durable and reliable changes in sleep latency and time awake after sleep onset (Morin et al. 1994).”
BackgroundAdvances in the management of insomnia
Pigeon, W. R., Bishop, T. M., & Marcus, J. A. (2014) · F1000Prime Reports · doi:10.12703/p6-48 · Cited by 13
“The most efficacious non-pharmacologic insomnia treatment, however, is a multi-component intervention referred to as cognitive behavioral therapy for insomnia (CBT-I), which typically combines sleep psychoeducation, stimulus control, sleep restriction therapy, sleep hygiene, cognitive therapy and relaxation training […”
BackgroundInsomnia Treatment Options for Women
Davidson, J. R. (2009) · Obstetrics and Gynecology Clinics of North America · doi:10.1016/j.ogc.2009.10.004 · Cited by 13
Sweetman, A., Reynolds, C. M., Lack, L. C., Vakulin, A., Chai‐Coetzer, C. L., Wallace, D. M., Crawford, M., & Richardson, C. E. (2024) · Frontiers in Sleep · doi:10.3389/frsle.2024.1355468 · Cited by 12
Nonpharmacologic Management of Excessive Daytime Sleepiness
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PREVALENCE OF SEDATIVE DRUG USE IN GERIATRIC IN-PATIENTS: A MULTI-CENTRE STUDY
Petrović, M., Spatharakis, G., Conroy, S., Maele, G. V., & Moulias, S. (2006) · Acta Clinica Belgica · doi:10.1179/acb.2006.019 · Cited by 12
Sequential Treatment for Chronic Insomnia: A Pilot Study
Vallières, A., Morin, C. M., Guay, B., Bastien, C., & LeBlanc, M. (2004) · Behavioral Sleep Medicine · doi:10.1207/s15402010bsm0202_2 · Cited by 12
Self-citationSelf-help therapy for sleep problems in hospital nurses in Japan: a controlled pilot study
Morimoto, H., Tanaka, H., Ohkubo, R., Mimura, M., Ooe, N., 市川, あ., & Yukitoshi, H. (2015) · Sleep and Biological Rhythms · doi:10.1007/s41105-015-0037-3 · Cited by 12
“Non-pharmacological treatments, especially cognitive behavioral therapy for insomnia (CBT-I), can overcome the shortcomings of pharmacological treatments, and the efficacy of CBT-I has been confirmed by metaanalyses [8, 9].”
BackgroundGAYLOR, E. E., & Manber, R. (2004) · CRC Press eBooks · doi:10.3109/9780203998007-9 · Cited by 12
Schlarb, A. A., Faber, J., & Hautzinger, M. (2018) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s164899 · Cited by 13
“31 On the one hand, components like stimulus control and sleep deprivation appeared to be more effective, whereas sleep hygiene alone showed no effect on sleep.”
Impact of Pharmacist-Led Cognitive Behavioural Therapy for Chronic Insomnia
Nurkowski, J., Elshorbagy, H., Halpape, K., Jensen, K., Lamb, D. A., Landry, E., Rémillard, A. J., & Jorgenson, D. J. (2020) · INNOVATIONS in pharmacy · doi:10.24926/iip.v11i3.3378 · Cited by 12
Deak, M. C., & Winkelman, J. W. (2012) · Neurologic Clinics · doi:10.1016/j.ncl.2012.08.012 · Cited by 13
Role of Lormetazepam in the Treatment of Insomnia in the Elderly
Vanna, M. D., Rubiera, M., Onor, M. L., & Aguglia, E. (2007) · Clinical Drug Investigation · doi:10.2165/00044011-200727050-00003 · Cited by 12
Morin, C. M., Daley, M., & Ouellet, M. (2001) · Current Treatment Options in Neurology · doi:10.1007/s11940-001-0020-y · Cited by 12
Self-citationThe condition of insomnia: Etiopathogenetic considerations and their impact on treatment practices
Dikeos, D., & Soldatos, C. (2005) · International Review of Psychiatry · doi:10.1080/09540260500104466 · Cited by 13
“…and so forth; it usually involves relaxation being practiced during the day, and only when the patient has mastered the technique is he/she allowed to implement it around sleeping time (Kales & Kales, 1984; Kales et al., 1987; Morin, 2002; Morin et al., 1994, 1999b; Soldatos & Dikeos, 2003).”
BackgroundClinical assessment and treatment of insomnia.
Pallesen, S., Nordhus, I. H., Havik, O. E., & Nielsen, G. H. (2001) · Professional Psychology Research and Practice · doi:10.1037//0735-7028.32.2.115 · Cited by 12
Metadata
- Authors
- Morin, C. M., Culbert, J. P., & Schwartz, S. M.
- Affiliations
- Virginia Commonwealth University (US)
- ORCID
- Charles M. Morin
- Venue
- American Journal of Psychiatry
- Published
- 1994-08-01
- Volume
- 151
- Issue
- 8
- Pages
- 1172-1180
- ISSN
- 0002-953X (ISSN-L)
- 1535-7228
- OpenAlex
- W1926957827
- Cited by
- 1,098
- References
- 32
- Citations by year
- 2026: 7 · 2025: 19 · 2024: 20 · 2023: 20 · 2022: 19 · 2021: 31 · 2020: 40 · 2019: 28 · 2018: 28 · 2017: 31 · 2016: 40 · 2015: 51 · 2014: 52 · 2013: 48 · 2012: 49
- FWCI
- 6.49
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r29mh047020-05)
- National Institute of Mental Health (NIMH MH-47020)
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Social Sciences › Psychology › Clinical Psychology › Psychotherapy Techniques and Applications
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Keywords
- insomnia, non-pharmacological treatment, psychological intervention, sleep onset insomnia, sleep maintenance insomnia, stimulus control, sleep restriction, sleep hygiene education, sleep latency, treatment efficacy, treatment durability
- MeSH terms
- Adult, Behavior Therapy, Biofeedback, Psychology, Chronic Disease, Circadian Rhythm, Female, Follow-Up Studies, Health Education, Humans, Sleep Initiation and Maintenance Disorders, Male, Medical Records, Psychotherapy, Relaxation Therapy, Sleep, Wakefulness, Cognitive Behavioral Therapy, Treatment Outcome
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