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Nonpharmacological interventions for insomnia: a meta-analysis of treatment efficacy
Abstract
OBJECTIVE: Because of the role of psychological factors in insomnia, the shortcomings of hypnotic medications, and patients' greater acceptance of nonpharmacological treatments for insomnia, the authors conducted a meta-analysis to examine the efficacy and durability of psychological treatments for the clinical management of chronic insomnia. METHOD: A total of 59 treatment outcome studies, involving 2,102 patients, were selected for review on the basis of the following criteria: 1) the primary target problem was sleep-onset, maintenance, or mixed insomnia, 2) the treatment was nonpharmacological, 3) the study used a group design, and 4) the outcome measures included sleep-onset latency, time awake after sleep onset, number of nighttime awakenings, or total sleep time. RESULTS: Psychological interventions, averaging 5.0 hours of therapy time, produced reliable changes in two of the four sleep measures examined. The average effect sizes (i.e., z scores) were 0.88 for sleep latency and 0.65 for time awake after sleep onset. These results indicate that patients with insomnia were better off after treatment than 81% and 74% of untreated control subjects in terms of sleep induction and sleep maintenance, respectively. Stimulus control and sleep restriction were the most effective single therapy procedures, whereas sleep hygiene education was not effective when used alone. Clinical improvements seen at treatment completion were well maintained at follow-ups averaging 6 months in duration. CONCLUSIONS: The findings indicate that nonpharmacological interventions produce reliable and durable changes in the sleep patterns of patients with chronic insomnia.
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“The recommended first-line treatment, Cognitive Behavioral Therapy for Insomnia (CBTI) does not carry these risks and is therefore preferable for reasons beyond demonstrated efficacy(244-248), efficacy relative to medications(249-253), and effectiveness(254).”
From Sleep: important considerations for the prevention of cardiovascular disease (2016) · cites this paper as [247]
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“Research suggests that relaxation is especially effective in helping with sleep initiation [29].”
From Non-Pharmacological Treatment of Insomnia (2012) · cites this paper as [29]
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Suzuki, E., Tsuchiya, M., Hirokawa, K., Taniguchi, T., Mitsuhashi, T., & Kawakami, N. (2008) · Journal of Occupational Health · doi:10.1539/joh.l7154 · Cited by 74
Kohn, L., & Espie, C. A. (2005) · SLEEP · doi:10.1093/sleep/28.1.104 · Cited by 72
CONSENSUS FOR THE PHARMACOLOGICAL MANAGEMENT OF INSOMNIA IN THE NEW MILLENNIUM
Roth, T. G., Hajak, G., & Üstün, T. (2001) · International Journal of Clinical Practice · doi:10.1111/j.1742-1241.2001.tb10973.x · Cited by 74
Sidani, S., Epstein, D. R., & Miranda, J. (2006) · Worldviews on Evidence-Based Nursing · doi:10.1111/j.1741-6787.2006.00060.x · Cited by 69
Sleep Disorders in the Elderly
Asplund, R. (1999) · Drugs & Aging · doi:10.2165/00002512-199914020-00002 · Cited by 73
Riedel, B. W., Winfield, C. F., & Lichstein, K. L. (2001) · Sleep Medicine · doi:10.1016/s1389-9457(00)00054-x · Cited by 72
Jansson‐Fröjmark, M., & Linton, S. J. (2005) · Journal of Occupational Rehabilitation · doi:10.1007/s10926-005-1217-9 · Cited by 72
“Further, this problem may not be too problematic given that there is evidence that CBT is effective in treating both chronic forms of primary and secondary insomnia (5,17).”
BackgroundResultInfluentialMorin, C. M., & Wooten, V. D. (1996) · Clinical Psychology Review · doi:10.1016/0272-7358(96)00027-x · Cited by 72
“Although behavioral interventions require more time to improve sleep patterns, these changes are fairly durable over follow-up periods averaging six to eight months in duration (Morin et al., 1994; Murtagh & Greenwood, 1995).”
BackgroundSelf-citationShallcross, A. J., Visvanathan, P. D., Sperber, S. H., & Duberstein, Z. T. (2019) · Current Opinion in Psychology · doi:10.1016/j.copsyc.2018.10.005 · Cited by 71
“However, additional treatment approaches are needed for the up to 25% of individuals who do not respond to CBT-I or who experience only partial symptomatic relief [19].”
BackgroundSleep Hygiene and Sleep-Onset Insomnia
Harvey, A. G. (2000) · The Journal of Nervous and Mental Disease · doi:10.1097/00005053-200001000-00011 · Cited by 71
Bothelius, K., Kyhle, K., Espie, C. A., & Broman, J. (2013) · Journal of Sleep Research · doi:10.1111/jsr.12067 · Cited by 71
“According to the literature, at least for SOL, a high effect size was expected (Morin et al., 1994).”
BackgroundWho is a candidate for cognitive-behavioral therapy for insomnia?
Smith, M. T., & Perlis, M. L. (2006) · Health Psychology · doi:10.1037/0278-6133.25.1.15 · Cited by 73
Putting Evidence Into Practice: Evidence-Based Interventions for Sleep-Wake Disturbances
Page, M. S., Berger, A. M., & Johnson, L. B. (2006) · Clinical journal of oncology nursing · doi:10.1188/06.cjon.753-767 · Cited by 70
Germain, A., Richardson, R., Stocker, R., Mammen, O. K., Hall, M. H., Bramoweth, A. D., Begley, A. E., Rode, N., Frank, E., Haas, G. L., et al. (2014) · Behaviour Research and Therapy · doi:10.1016/j.brat.2014.07.016 · Cited by 70
“In other words, while the longer CBTI formats (5e8 sessions) are effective for a majority of participants who receive the treatment, bibliotherapy and BBTI-MV are likely to be complementary treatments and help to deliver and disseminate behavioral insomnia treatments more broadly, especially in contexts where availabl…”
InfluentialEvaluation of a “Nondieting” Stress Reduction Program for Overweight Women: A Randomized Trial
Katzer, L., Bradshaw, A. J., Horwath, C. C., Gray, A. R., O'Brien, S., & Joyce, J. (2008) · American Journal of Health Promotion · doi:10.4278/060728113r1.1 · Cited by 72
Association between oxygen consumption and nitric oxide production during the relaxation response.
Dusek, J. A., Chang, B., Zaki, J., Lazar, S. W., Deykin, A., Stefano, G. B., Wohlhueter, A. L., Hibberd, P. L., & Benson, H. (2006) · PubMed · Cited by 70
Metadata
- Authors
- Morin, C. M., Culbert, J. P., & Schwartz, S. M.
- Affiliations
- Virginia Commonwealth University (US)
- ORCID
- Charles M. Morin
- Venue
- American Journal of Psychiatry
- Published
- 1994-08-01
- Volume
- 151
- Issue
- 8
- Pages
- 1172-1180
- ISSN
- 0002-953X (ISSN-L)
- 1535-7228
- OpenAlex
- W1926957827
- Cited by
- 1,098
- References
- 32
- Citations by year
- 2026: 7 · 2025: 19 · 2024: 20 · 2023: 20 · 2022: 19 · 2021: 31 · 2020: 40 · 2019: 28 · 2018: 28 · 2017: 31 · 2016: 40 · 2015: 51 · 2014: 52 · 2013: 48 · 2012: 49
- FWCI
- 6.49
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r29mh047020-05)
- National Institute of Mental Health (NIMH MH-47020)
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Social Sciences › Psychology › Clinical Psychology › Psychotherapy Techniques and Applications
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Keywords
- insomnia, non-pharmacological treatment, psychological intervention, sleep onset insomnia, sleep maintenance insomnia, stimulus control, sleep restriction, sleep hygiene education, sleep latency, treatment efficacy, treatment durability
- MeSH terms
- Adult, Behavior Therapy, Biofeedback, Psychology, Chronic Disease, Circadian Rhythm, Female, Follow-Up Studies, Health Education, Humans, Sleep Initiation and Maintenance Disorders, Male, Medical Records, Psychotherapy, Relaxation Therapy, Sleep, Wakefulness, Cognitive Behavioral Therapy, Treatment Outcome
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