The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.
Treatment outcomes for primary care patients with major depression and lifetime anxiety disorders.
Abstract
OBJECTIVE: Major depression occurs with generalized anxiety disorder and panic disorder in up to 60% of psychiatric and primary care patients. This comorbidity has been associated with greater severity of depression, poorer psychosocial functioning, and poorer treatment outcomes in psychiatric samples. This study examined the clinical outcomes for depressed primary care patients with and without a lifetime anxiety disorder. METHOD: A total of 157 primary care patients who met criteria for major depression were randomly assigned to standardized interpersonal psychotherapy or pharmacotherapy with nortriptyline and were assessed at baseline and at 4 and 8 months on severity of depression, psychosocial functioning, and health-related functioning. RESULTS: Depressed patients with a comorbid anxiety disorder presented with significantly more psychopathology and tended to prematurely terminate treatment more frequently than patients with major depression alone. Both standardized depression-specific treatments were effective for depressed patients with and without a comorbid generalized anxiety disorder, although time to recovery was longer for the former. Patients with lifetime panic disorder showed poor recovery in response to psychotherapy or pharmacotherapy. CONCLUSIONS: Standardized psychotherapy and pharmacotherapy are effective for patients with major depression with and without a generalized anxiety disorder. However, the longer time to recovery for the former group and lack of response to these treatments by patients with lifetime panic disorder suggest that primary care physicians should carefully assess history of anxiety disorder among depressed patients so as to select a proper intervention.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“in patients with a lifetime panic disorder, the response rates drop drastically to about 13% for each of the aforementioned therapeutic modalities (7)”
From Decreases in State and Trait Anxiety Post-psilocybin: A Naturalistic, Observational Study Among Retreat Attendees (2022) · cites this paper as [7]
Citations
Cites
Statistical Power Analysis for the Behavioral Sciences
Muller, K. E., & Cohen, J. (1989) · Technometrics · doi:10.2307/1270020 · Cited by 99,603
Statistical power analysis for the behavioral sciences
Cohen, J. (1990) · Computers Environment and Urban Systems · doi:10.1016/0198-9715(90)90050-4 · Cited by 65,417
The CES-D Scale: A Self-Report Depression Scale for Research in the General Population
Radloff, L. S. (1977) · Applied Psychological Measurement · doi:10.1177/014662167700100306 · Cited by 53,267
(1992) · PubMed · Cited by 33,716
Hamilton, M. (1960) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.23.1.56 · Cited by 32,817
The MOS 36-ltem Short-Form Health Survey (SF-36): I. Conceptual Framework and Item Selection
Ware, J. E., & Sherbourne, C. D. (1992) · Medical Care · doi:10.1097/00005650-199206000-00002 · Cited by 30,033
Random-Effects Models for Longitudinal Data
Laird, N. M., & Ware, J. H. (1982) · Biometrics · doi:10.2307/2529876 · Cited by 8,923
Robins, L. N. (1981) · Archives of General Psychiatry · doi:10.1001/archpsyc.1981.01780290015001 · Cited by 5,219
Frank, E. (1991) · Archives of General Psychiatry · doi:10.1001/archpsyc.1991.01810330075011 · Cited by 1,959
Utility of a New Procedure for Diagnosing Mental Disorders in Primary Care: The PRIME-MD 1000 Study
Spitzer, R. L. (1994) · JAMA · doi:10.1001/jama.1994.03520220043029 · Cited by 1,873
Flagged first, then by citations
Research works printed but not linked: 9
- Clayton P, 1990, J Clin Psychiatry, 1, 35
- Zung W, 1990, J Clin Psychiatry, 51, 77
- Lydiard B, 1991, J Clin Psychiatry, 52, 48
- Fawcett J, 1990, J Clin Psychiatry, 1, 40
- Coplan J, 1990, J Clin Psychiatry, 1, 9
- Tollefson G, 1994, J Clin Psychiatry, 55, 50
- Fawcett J, 1987, Elkin I
- Spitzer RL, 1990, Gibbon M
- Schulberg HC, Madonia MJ. Scott CP. Rodriquez E. Imber SD. PerelJ. Lave J. Houck PR
Cited by
Sorted by citations
Items 101–200 of 311
Citalopram treatment of social anxiety disorder with comorbid major depression
Schneier, F. R., Blanco, C., Campeas, R. B., Lewis‐Fernández, R., Lin, S., Marshall, R. D., Schmidt, A. B., Sanchez-Lacay, J. A., Simpson, H. B., & Liebowitz, M. R. (2003) · Depression and Anxiety · doi:10.1002/da.10112 · Cited by 56
“, 1997] and more likely to drop out of treatment [Brown et al., 1996].”
BackgroundResultKennedy, S. H., & Lam, R. W. M. (2003) · Bipolar Disorders · doi:10.1111/j.1399-2406.2003.00058.x · Cited by 54
Cognitive therapy for anxious depression in STAR(*) D: what have we learned?
Farabaugh, A., Alpert, J., Wisniewski, S. R., Otto, M. W., Fava, M., Baer, L., Perlis, R., Friedman, E., Nyer, M., Bitran, S., et al. (2012) · Journal of Affective Disorders · doi:10.1016/j.jad.2012.04.029 · Cited by 52
“In a study of interpersonal psychotherapy (IPT), Brown et al. (1996) found that depressed individuals with a lifetime history of anxiety disorders, though showing improvement during treatment, were nevertheless less likely to complete treatment, showed overall less improvement, and took longer to recover than those wi…”
BackgroundCyranowski, J. M., Schott, L. L., Kravitz, H. M., Brown, C., Thurston, R. C., Joffe, H., Matthews, K. A., & Bromberger, J. T. (2012) · Depression and Anxiety · doi:10.1002/da.21990 · Cited by 60
“[5–9] Moreover, as compared with patients with MDD alone, patients with comorbid MDD and anxiety display greater psychiatric symptom severity,[7,10–12] earlier age of onset,[7,13,14] greater MDD recurrence,[11,15,16] poorer psychosocial function,[11,17] and elevations in general distress and suicide risk.”
MethodSullivan, M. D., Katon, W. J., Russo, J. E., Frank, E., Barrett, J. E., Oxman, T. E., & Williams, J. W. (2003) · The Journal of the American Board of Family Medicine · doi:10.3122/jabfm.16.1.22 · Cited by 55
“sive episode.(8) Minor depression is less well characterized.”
BackgroundIncomplete remission in depression: role of psychiatric and somatic comorbidity
Otte, C. (2008) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2008.10.4/cotte · Cited by 57
“Patients with lifetime panic disorder showed poor recovery in response to psychotherapy or pharmacotherapy.(18) This was corroborated by another primary care study, in which depressed patients with comorbid anxiety disorder had a 44% increased risk of persistent depression after 12 months.”
Prevalence of Major Depressive Episodes in Rural Women Using Primary Care
Hauenstein, E., & Peddada, S. D. (2007) · Journal of health care for the poor and underserved · doi:10.1353/hpu.2007.0010 · Cited by 47
Race, Genetic Ancestry and Response to Antidepressant Treatment for Major Depression
Murphy, E. J., Hou, L., Maher, B. S., Woldehawariat, G., Kassem, L., Akula, N., Laje, G., & McMahon, F. J. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2013.166 · Cited by 56
“For example, comorbid anxiety in depressed patients is associated with lower remission and response rates (Brown et al, 1996; Trivedi et al, 2006; Baldwin and Lopes, 2009).”
BackgroundKosnes, L., Whelan, R., O’Donovan, A., & McHugh, L. (2013) · Consciousness and Cognition · doi:10.1016/j.concog.2013.06.001 · Cited by 55
A Review of the Diagnosis, Pharmacologic Treatment, and Economic Aspects of Anxiety Disorders
Arikian, S. R., & Gorman, J. M. (2001) · The Primary Care Companion For CNS Disorders · doi:10.4088/pcc.v03n0302 · Cited by 53
Enns, M. W., & Cox, B. J. (2005) · The Canadian Journal of Psychiatry · doi:10.1177/070674370505001206 · Cited by 48
Anxious depression: Clinical features and treatment
Rao, S. D. (2009) · Current Psychiatry Reports · doi:10.1007/s11920-009-0065-2 · Cited by 51
Persistence of abnormal cortisol levels in elderly persons after recovery from major depression
Beluche, I., Chaudieu, I., Norton, J., Carrière, I., Boulenger, J.-P., Ritchie, K., & Ancelin, M. L. (2009) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2008.10.011 · Cited by 49
Markowitz, J. C., Skodol, A. E., Petkova, E., Cheng, J., Sanislow, C. A., Grilo, C. M., Gunderson, J. G., & McGlashan, T. H. (2007) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v68n0202 · Cited by 48
Anxiety and Quality of Life in ESRD
Cukor, D., Halen, N. V., & Fruchter, Y. (2013) · Seminars in Dialysis · doi:10.1111/sdi.12065 · Cited by 48
Treatment of anxiety disorders in the elderly: issues and strategies.
Sheikh, J., & Cassidy, E. (2000) · Journal of Anxiety Disorders · doi:10.1016/s0887-6185(99)00047-x · Cited by 47
Walia, V., Chaudhary, S. K., & Kumar Sethiya, N. (2021) · Neurochemistry International · doi:10.1016/j.neuint.2020.104939 · Cited by 51
History of affective disorder and the temporal trajectory of fatigue in rheumatoid arthritis
Fifield, J., McQuillan, J., Tennen, H. A., Sheehan, T. J., Reisine, S., HESSELBROCK, V. M., & Rothfield, N. F. (2001) · Annals of Behavioral Medicine · doi:10.1207/s15324796abm2301_6 · Cited by 47
Predictors of nonresponse to treatment in primary care patients with dysthymia
Katon, W. J., Russo, J. E., Frank, E., Barrett, J., Williams, J. W., Oxman, T. E., Sullivan, M., & Cornell, J. E. (2002) · General Hospital Psychiatry · doi:10.1016/s0163-8343(01)00171-2 · Cited by 47
“When major depression is associated with a comorbid anxiety or an Axis II disorder, studies have shown less response to pharmacologic treatment or specific psychotherapies in both psychiatry and primary care patients [1,37–38].”
BackgroundSymptomatic and syndromal anxiety and depression
Ninan, P. T., & Berger, J. (2001) · Depression and Anxiety · doi:10.1002/da.1049 · Cited by 47
Interpersonal psychotherapy for depression? The need to define its ecological niche
Parker, G. B., Parker, I., Brotchie, H., & Stuart, S. P. (2006) · Journal of Affective Disorders · doi:10.1016/j.jad.2006.03.019 · Cited by 44
“Brown et al. (2000) found that lifetime anxiety or personality disorder predicted poorer outcome among dysthymic patients.”
BackgroundOn-site mental health workers in primary care: effects on professional practice
Bower, P., & Sibbald, B. (1999) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd000532 · Cited by 45
Zhang, L., Shao, H., Huo, M., Chen, J., Tao, M., & Liu, Z. (2022) · BMC Psychiatry · doi:10.1186/s12888-022-04256-9 · Cited by 45
“Compared with either disorder alone, comorbid depression and anxiety could increase impairment [26, 27].”
BackgroundLeyfer, O. T., Gallo, K. P., Cooper‐Vince, C. E., & Pincus, D. B. (2013) · Journal of Anxiety Disorders · doi:10.1016/j.janxdis.2013.01.010 · Cited by 45
Reliability and validity of the DSM-5 anxious distress specifier interview
Zimmerman, M., Clark, H., McGonigal, P., Harris, L., Holst, C. G., & Martin, J. (2017) · Comprehensive Psychiatry · doi:10.1016/j.comppsych.2017.02.010 · Cited by 45
Comorbidity and the Treatment of Principal Anxiety Disorders in a Naturalistic Sample
Davis, L., Barlow, D. H., & Smith, L. M. (2010) · Behavior Therapy · doi:10.1016/j.beth.2009.09.002 · Cited by 44
Cognitive Behavior Therapy in Panic Disorder and Comorbid Major Depression
Rief, W., Trenkamp, S., Auer, C., & Fichter, M. (2000) · Psychotherapy and Psychosomatics · doi:10.1159/000012369 · Cited by 51
“However, comorbidity is a negative predictor also in pharmacological trials [3, 34].”
An Open-Label Trial of Interpersonal Psychotherapy in Depressed Patients With Coronary Disease
Koszycki, D., Lafontaine, S., Frasure‐Smith, N., Swenson, R., & Lespérance, F. (2004) · Psychosomatics · doi:10.1176/appi.psy.45.4.319 · Cited by 46
Bitsika, V., & Sharpley, C. F. (2012) · British Journal of Guidance and Counselling · doi:10.1080/03069885.2012.701271 · Cited by 40
“…since comorbidity of anxiety and depression has been shown to predict impaired improvement following treatment (Brown, Schulberg, Madonia, Shear, & Houck, 1996; Gaynes et al., 1999), delayed recovery, poorer quality of life and increased suicide risk (Brown et al., 1996; Volirath & Angst, 1989).”
BackgroundCape, J. D., Barker, C., Buszewicz, M., & Pistrang, N. (2000) · Europe PMC (PubMed Central) · Cited by 40
El-Khayat, R., & Baldwin, D. (1998) · Journal of Psychopharmacology · doi:10.1177/026988119801200401 · Cited by 21
Escitalopram in the treatment of anxiety symptoms associated with depression
Bandelow, B., Andersen, H. F., & Dolberg, O. T. (2006) · Depression and Anxiety · doi:10.1002/da.20141 · Cited by 40
“It has been shown that the presence of comorbid symptoms confers a less favorable prognosis and poorer outcomes, and that these patients express higher levels of social distress, have higher suicide rates, have increased incidence of alcohol and drug abuse, and use health care services to a greater extent [Belzer and…”
The systematic assessment of depressed elderly primary care patients
Raue, P. J., Alexopoulos, G. S., BRUCE, M. L., Klimstra, S., Mulsant, B. H., Gallo, J. J., & the PROSPECT Study Group (2001) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.469 · Cited by 39
Pharmacologic treatment of generalized anxiety disorder.
Brawman-Mintzer, O. (2001) · Psychiatric Clinics of North America · doi:10.1016/s0193-953x(05)70209-4 · Cited by 38
Forand, N. R., & DeRubeis, R. J. (2013) · Journal of Consulting and Clinical Psychology · doi:10.1037/a0032985 · Cited by 41
Are Sexual Problems a Form of Internalizing Psychopathology? A Structural Equation Modeling Analysis
Forbes, M. K., & Schniering, C. A. (2012) · Archives of Sexual Behavior · doi:10.1007/s10508-012-9948-0 · Cited by 40
Depression, Sociocultural Factors, and African American Women
Hunn, V., & Craig, C. D. (2009) · Journal of Multicultural Counseling and Development · doi:10.1002/j.2161-1912.2009.tb00093.x · Cited by 36
A systematic review of the effectiveness of brief psychological therapies in primary health care.
Hemmings, A. (2000) · Families Systems & Health · doi:10.1037/h0091857 · Cited by 36
Interpersonal psychotherapy for depression and other disorders
Blanco, C., Markowitz, J. C., & Weissman, M. M. (2012) · doi:10.1093/med/9780199696758.003.0169 · Cited by 35
Amital, D., Fostick, L., Silberman, A., Calati, R., Spindelegger, C., Serretti, A., Juven‐Wetzler, A., Souery, D., Mendlewicz, J., Montgomery, S., et al. (2012) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2012.09.002 · Cited by 36
Negative affectivity moderated by BDNF and stress response
Perea, C. S., Paternina, A. C., Gómez, Y., & Lattig, M. C. (2011) · Journal of Affective Disorders · doi:10.1016/j.jad.2011.09.043 · Cited by 37
“Comorbidity between these disorders has been a more recent concern with a more severe chronic and severe clinical outcome observedwith the presence of comorbid anxiety and depression mood disorders (Brown et al., 1996); therefore,we though to explore negative affectivity derived from depression, anxiety and comorbidit…”
BackgroundHigh-end specificity of the children's depression inventory in a sample of anxiety-disordered youth
Comer, J. S., & Kendall, P. C. (2005) · Depression and Anxiety · doi:10.1002/da.20059 · Cited by 35
“Such patients present with greater levels of dysfunction, hypersomnia, agitation, weight disturbance, premature treatment termination, and suicidality [e.g., Brady and Kendall, 1992; Brown et al., 1996; Dunner, 2001; Kendall and Brady, 1995; Kessler et al., 1999; Mitchell et al., 1988].”
BackgroundAnxiety disorders comorbidity in mood disorder subgroups: data from a mood disorders clinic
Yerevanian, B. I., Koek, R. J., & Ramdev, S. (2001) · Journal of Affective Disorders · doi:10.1016/s0165-0327(01)00448-7 · Cited by 34
Interpersonal psychotherapy for depression with panic spectrum symptoms: a pilot study
Cyranowski, J. M., Frank, E., Shear, M. K., Swartz, H. A., Fagiolini, A. M., Scott, J., & Kupfer, D. J. (2005) · Depression and Anxiety · doi:10.1002/da.20069 · Cited by 33
“…depression is complicated by panic features display a more severe form of psychopathology [Grunhaus et al., 1994], poorer psychosocial function [VanValkenberg et al., 1984], greater risk of suicide [Fawcett et al., 1990], and poorer response to treatment [Brown et al., 1996; Frank et al., 2000].”
BackgroundCognitive therapy for depressed adults with comorbid social phobia
Smits, J. A. J., Minhajuddin, A., & Jarrett, R. B. (2009) · Journal of Affective Disorders · doi:10.1016/j.jad.2008.08.008 · Cited by 33
“This relationship was not observed for generalized anxiety disorder (Brown et al., 1996); the potential impact of other anxiety disorders was not examined.”
BackgroundWright, A. G. C., Hallquist, M. N., Swartz, H. A., Frank, E., & Cyranowski, J. M. (2013) · Journal of Consulting and Clinical Psychology · doi:10.1037/a0034430 · Cited by 32
“…response/remission to both psychotherapeutic (Brown et al., 1996; Feske, Frank, Kupfer, Shear, & Weaver, 1998; Frank et al., 2000; Smits, Minhajuddin, Thase, & Jarrett, 2012; but see also Fournier et al., 2009) and pharmacologic depression interventions (Brown et al., 1996; M. Fava et al., 2008).”
InfluentialRausch, J. L., Hobby, H. M., Shendarkar, N., Johnson, M. E., & Li, J. (2001) · Journal of Clinical Psychopharmacology · doi:10.1097/00004714-200104000-00004 · Cited by 33
Katzman, M. A. (2011) · Journal of Affective Disorders · doi:10.1016/s0165-0327(11)70004-0 · Cited by 33
“Many anxiety patients – indeed more than half – fail to adequately respond to antidepressant therapy (Brown et al., 1996; Yonkers et al., 1996; Thase, 2003; Adson et al., 2005; Worthington et al., 2005; Bystritsky, 2006; Hoge et al., 2008).”
BackgroundResultDepressed mood enhances anxiety to unpredictable threat
Robinson, O. J., Overstreet, C. M., Letkiewicz, A. M., & Grillon, C. (2011) · Psychological Medicine · doi:10.1017/s0033291711002583 · Cited by 35
“1998), worse treatment outcomes (Brown et al. 1996) and increased likelihood of suicide (Angst et al.”
BackgroundPredictors of antidepressant response: A selective review
Dodd, S., & Berk, M. (2004) · International Journal of Psychiatry in Clinical Practice · doi:10.1080/13651500410005423 · Cited by 32
Depression and anxiety in supportive oncology
Li, M., Boquiren, V., Lo, C., & Rodin, G. (2011) · Supportive Oncology · doi:10.1016/b978-1-4377-1015-1.00052-7 · Cited by 32
Mohamed, S., Osatuke, K., Aslam, M., & Kasckow, J. (2006) · The American Journal of Geriatric Pharmacotherapy · doi:10.1016/j.amjopharm.2006.08.001 · Cited by 31
Anxiety Symptom Focus in Sessions of Cognitive Therapy for Depression
Gibbons, C. J., & DeRubeis, R. J. (2007) · Behavior Therapy · doi:10.1016/j.beth.2007.05.006 · Cited by 31
Treatment Considerations for Anxiety in the Elderly
Lenze, E. J., Pollock, B. G., Shear, M. K., Mulsant, B. H., Bharucha, A. J., & Reynolds, C. F. (2003) · CNS Spectrums · doi:10.1017/s1092852900008221 · Cited by 31
A randomized trial of a brief mental health intervention for primary care patients.
Lang, A. J., Norman, G. J., & Casmar, P. V. (2006) · Journal of Consulting and Clinical Psychology · doi:10.1037/0022-006x.74.6.1173 · Cited by 31
The panic-agoraphobic spectrum: development, description, and clinical significance
Shear, M. K., Cassano, G. B., Frank, E., Rucci, P., Rotondo, A., & Fagiolini, A. M. (2002) · Psychiatric Clinics of North America · doi:10.1016/s0193-953x(02)00032-1 · Cited by 30
Rector, N. A., Man, V., & Lerman, B. (2014) · The Canadian Journal of Psychiatry · doi:10.1177/070674371405900603 · Cited by 28
IsHak, W. W., Mirocha, J., Christensen, S., Wu, F., Kwock, R., Behjat, J., Pi, S., Akopyan, A., Peselow, E. D., Cohen, R. M., et al. (2013) · Depression and Anxiety · doi:10.1002/da.22152 · Cited by 30
“[34] The literature clearly shows that patients experiencing comorbid depression and anxiety have more severe symptoms,[3] more chronic course,[35] increased rate of psychiatric admissions,[36] increased rate of suicide and suicide attempts,[37] serious impairment in social and occupational functioning,[32] and poor q…”
Shim, I. H., Woo, Y. S., & Bahk, W. (2016) · General Hospital Psychiatry · doi:10.1016/j.genhosppsych.2016.07.003 · Cited by 31
Labbate, L. A., Sonne, S. C., Randal, C. L., Anton, R. F., & Brady, K. T. (2004) · Comprehensive Psychiatry · doi:10.1016/j.comppsych.2004.03.015 · Cited by 28
DEPICS Study Group, Menchetti, M., Bortolotti, B., Rucci, P., Scocco, P., Bombi, A., & Berardi, D. (2010) · BMC Psychiatry · doi:10.1186/1471-244x-10-97 · Cited by 27
“However, methodological issues limit the findings of these trials: first,, they had very small sample sizes, thereby increasing the likelihood of Type II error; moreover the three older ones used tricyclic antidepressants that are now rarely prescribed [21-23]; finally, two studies recruited only patients suffering fr…”
BackgroundLawrence, A. E., Liverant, G. I., Rosellini, A. J., & Brown, T. A. (2009) · Depression and Anxiety · doi:10.1002/da.20607 · Cited by 28
“The absence of the group differences on most follow-up measures in this study is consistent with treatment studies finding similar outcomes in both ‘‘pure’’ depression and comorbid depression and anxiety.([42,43]) Furthermore, several studies of other emotional disorders have indicated that disorderspecific treatment…”
ResultCastillo, M. I. A., Cooke, M. L., Macfarlane, B., & Aitken, L. M. (2015) · Critical Care Medicine · doi:10.1097/ccm.0000000000001356 · Cited by 28
“While no study testing this relationship in the ICU population was located, anxiety and depression disorders are often comorbid with each other (42, 43).”
BackgroundCommon mental health disorders.
Bessant, M., & Ekers, D. (2011) · PubMed · Cited by 28
Comorbid anxiety disorders and treatment of depression in people with multiple sclerosis.
Burns, M. N., Siddique, J., Fokuo, J. K., & Mohr, D. C. (2010) · Rehabilitation Psychology · doi:10.1037/a0020492 · Cited by 29
“Favorable response during treatment in participants with comorbid anxiety disorders is in contrast with some studies on pharmacotherapy suggesting people with comorbid anxiety have slower treatment response and are less likely to remit (e.g., Fava, 2008; Brown et al., 1996).”
ResultKiraga, M. K., Kuypers, K. P. C., Uthaug, M. V., Ramaekers, J. G., & Mason, N. L. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.883869 · Cited by 26
“For instance, in patients with a lifetime panic disorder, the response rates drop drastically to about 13% for each of the aforementioned therapeutic modalities (7), whereas patients with comorbid anxiety and depression tend to prematurely terminate treatment more frequently than patients with a single diagnosis (8).”
Backgroundvan Bronswijk, S. C., Lemmens, L. H. J. M., Huibers, M. J. H., Arntz, A. R., & Peeters, F. P. M. L. (2018) · Journal of Affective Disorders · doi:10.1016/j.jad.2018.02.003 · Cited by 29
“…symptoms (Brown et al., 1996; Fava et al., 2004; Penninx et al., 2011; Smits et al., 2009), more functional impairment (Fava et al., 2004; Smits et al., 2009) and intensi fi ed suicidal thoughts and behavior (Brown et al., 1996; Fava et al., 2004; Fawcett et al., 1990; Pfei ff er et al., 2009).”
InfluentialLeibbrand, R., Hiller, W., & Fichter, M. M. (1999) · Comprehensive Psychiatry · doi:10.1016/s0010-440x(99)90004-4 · Cited by 26
Antidepressants and psychotherapy: a clinical research review
Frank, E., Novick, D. M., & Kupfer, D. J. (2005) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2005.7.3/efrank · Cited by 26
Brown, L. A., Gaudiano, B. A., & Miller, I. W. (2010) · Depression and Anxiety · doi:10.1002/da.20609 · Cited by 25
“[1–3] Overall depression severity has also been found to be more severe in comorbid depression and panic/agoraphobia.”
Schulz, A., Deuter, C. E., Breden, I.-H., Vögele, C., Wingenfeld, K., Otte, C., & Kuehl, L. K. (2021) · Development and Psychopathology · doi:10.1017/s0954579420001613 · Cited by 26
“…addition to the SCID-I interview, current depressive symptoms were assessed using a clinical rating scale and a questionnaire (Montgomery Asberg Depression Rating Scale [MADRS] (Montgomery & Asberg, 1979; Williams & Kobak, 2008) and the Beck Depression Inventory (BDI) (Beck, Steer, & Brown, 1996).”
Shahar, G., & Davidson, L. (2009) · Psychiatry · doi:10.1521/psyc.2009.72.2.154 · Cited by 25
Treatment of major depression in the context of panic disorder
Woody, S. R., McLean, P. D., Taylor, S. J., & Koch, W. J. (1999) · Journal of Affective Disorders · doi:10.1016/s0165-0327(98)00117-7 · Cited by 24
Batten, L. A., Hernández, M., Pilowsky, D. J., Stewart, J. W., Blier, P., Flament, M. F., Poh, E., WICKRAMARATNE, P. J., & Weissman, M. M. (2012) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2012.08.020 · Cited by 23
Variability in Anxiety and Depression Over Time Following Diagnosis in Patients with Prostate Cancer
Sharpley, C. F., Christie, D., & Bitsika, V. (2010) · Journal of Psychosocial Oncology · doi:10.1080/07347332.2010.516810 · Cited by 24
“Among general patient samples, anxiety–depression comorbidity has been shown to significantly predict delayed recovery, poorer quality of life, and increased suicide risk (Brown et al., 1996; Vollrag & Angst, 1989), and less improvement after treatment (Coryell et al.”
BackgroundMixed Anxiety and Depression in Older Adults: Clinical Characteristics and Management
Cassidy‐Eagle, E. L., Lauderdale, S. A., & Sheikh, J. I. (2005) · Journal of Geriatric Psychiatry and Neurology · doi:10.1177/0891988705276060 · Cited by 25
“Given these findings, it is not surprising that outpatient psychiatric and primary care samples also report substantial prevalence rates of comorbid MDD and anxiety disorders.(11,12) Less commonly reported are findings regarding the comorbid prevalence rate of anxiety and mood disorders in older adults.”
BackgroundFluoxetine treatment of depressed patients with comorbid anxiety disorders
Sonawalla, S. B., Farabaugh, A. H., Johnson, M. W., Morray, M., Delgado, M. L., Pingol, M. G., Rosenbaum, J. F., & D, M. F. M. (2002) · Journal of Psychopharmacology · doi:10.1177/026988110201600304 · Cited by 22
“Introduction Major depressive disorder (MDD) accompanied by comorbid anxiety disorders is characterized by distinct pathophysiology, course and treatment response (Hiller et al., 1989; Brown et al., 1996; Fava et al., 1997).”
BackgroundInfluentialEthical Considerations in Psychotherapy Effectiveness Research: Choosing the Comparison Group
Areán, P. A., & Alvidrez, J. (2002) · Ethics & Behavior · doi:10.1207/s15327019eb1201_4 · Cited by 23
Tsai, J., Thase, M. E., Mao, Y., Ng-Mak, D., Pikalov, A., & Loebel, A. (2017) · CNS Spectrums · doi:10.1017/s1092852917000074 · Cited by 22
The Prospective Role of Depression, Anxiety, and Worry in Stress Generation
Judah, M. R., Grant, D. M., Mills, A. C., Lechner, W. V., Slish, M. L., Davidson, C. L., & Wingate, L. R. (2013) · Journal of Social and Clinical Psychology · doi:10.1521/jscp.2013.32.4.381 · Cited by 23
Do hormone treatments for prostate cancer cause anxiety and depression?
Sharpley, C. F., Christie, D., & Bitsika, V. (2013) · International Journal of Clinical Oncology · doi:10.1007/s10147-013-0569-y · Cited by 22
“In addition, depression is often comorbid with anxiety, and that comorbidity predicts resistance to treatment [13–15], delayed recovery, poorer quality of life, and increased suicide risk [16, 17], and has been reported in 10.”
BackgroundPetersen, T., Andreotti, C., Chelminski, I., Young, D., & Zimmerman, M. A. (2009) · Psychiatry Research · doi:10.1016/j.psychres.2008.10.036 · Cited by 23
“2005), and lower psychosocial functioning (Brown et al., 1996).”
BackgroundKashdan, T., & Roberts, J. E. (2011) · Behaviour Research and Therapy · doi:10.1016/j.brat.2011.10.002 · Cited by 22
Cassano, P., Soares, C. N., Cohen, L. S., Lyster, A. K., & D, M. F. M. (2004) · Archives of Women s Mental Health · doi:10.1007/s00737-004-0051-y · Cited by 19
“…on treatment response in subjects with MDD, to our knowledge no studies have addressed sex- and age-related differences in response in the anxious and non-anxious subtype of depression (Brown et al., 1996) (Russell et al., 2001) (Frank et al., 2000) (Grunhaus et al., 1988) (Dew et al., 1997).”
BackgroundCoussement, C., Longueville, X. D., & Heeren, A. (2021) · Comprehensive Psychiatry · doi:10.1016/j.comppsych.2021.152294 · Cited by 21
The Roles of Exercise and Yoga in Ameliorating Depression as a Risk Factor for Cognitive Decline
Mathersul, D. C., & Rosenbaum, S. (2016) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2016/4612953 · Cited by 20
“…physiologists with tertiary training in exercise prescription are associated with reduced dropout and increased motivation to exercise among people with an affective disorder [111], highlighting the importance ofmultidisciplinarymental health teams to ensure the translation of findings into real…”
BackgroundBlay, S. L., Fillenbaum, G. G., Mello, M. F., Quintana, M. I., Mari, J. D. J., Bressan, R. A., & Andreoli, S. B. (2018) · Journal of Affective Disorders · doi:10.1016/j.jad.2018.02.023 · Cited by 22
Symptoms of Major Depression and Tricyclic Side Effects in Primary Care Patients
Rollman, B. L., Block, M. R., & Schulberg, H. C. (1997) · Journal of General Internal Medicine · doi:10.1046/j.1525-1497.1997.012005284.x · Cited by 19
Bandelow, B., Bauer, M., Vieta, E., El-Khalili, N., Gustafsson, U., Earley, W. R., & Eriksson, H. (2014) · The World Journal of Biological Psychiatry · doi:10.3109/15622975.2013.842654 · Cited by 18
“…and poorer outcomes and these patients may have higher levels of social distress, suicide rates, incidence of alcohol and drug abuse, and use of healthcare services than patients without comorbid conditions (Brown et al. 1996; Kessler et al. 1996; Roy-Byrne et al. 2000; Belzer and Schneier 2004).”
BackgroundOutcomes Focused Service Delivery: Developing an Academic-Management Partnership
Tobin, M. J., & Hickie, I. B. (1998) · Australian & New Zealand Journal of Psychiatry · doi:10.3109/00048679809065524 · Cited by 18
The impact of psychiatric comorbidities associated with depression: a literature review
Platona, R. I., Căiță, G. A., Voiţă-Mekereş, F., Peia, A. O., & ENĂTESCU, V. R. (2024) · Medicine and Pharmacy Reports · doi:10.15386/mpr-2700 · Cited by 20
“Brown et al. (1996) found that depressed patients who have panic disorder during their lifetime, show a greater severity of depressive symptoms, a more important impairment of physical and psychosocial functioning.”
BackgroundSharpley, C. F., Bitsika, V., Wootten, A. C., & Christie, D. (2014) · Psycho-Oncology · doi:10.1002/pon.3566 · Cited by 17
“suicide risk [21,22] and has been reported in 10.”
BackgroundEmotion Regulation Among Adolescents With Pediatric Depression As a Function of Anxiety Comorbidity
Dochnal, R., Vetró, Á., Kiss, E., Baji, I., Lefkovics, E., Bylsma, L. M., Yaroslavsky, I., Rottenberg, J. A., Kovács, M., & Kapornai, K. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.00722 · Cited by 18
“It has been reported that the treatment of depression is more difficult in the presence of anxiety: comorbidity lengthens the duration of treatment and decreases the response to interventions (49, 50).”
Background[Depressive disorder burden: global epidemiological issues and information needs in Portugal].
Gusmão, R., Xavier, M., Heitor, M. J., Bento, A., & Caldas‐de‐Almeida, J. M. (2005) · PubMed · doi:10.20344/amp.1012 · Cited by 32
Screening for anxiety disorders in depressed patients
Zimmerman, M. A., & Chelminski, I. (2006) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2005.03.001 · Cited by 16
Incidence and nature of anxiety–depression comorbidity in prostate cancer patients
Sharpley, C. F., Bitsika, V., & Christie, D. (2010) · Journal of Men s Health · doi:10.1016/j.jomh.2010.03.003 · Cited by 16
“This is surprising since comorbidity of anxiety and depression among other patient groups has been shown to predict impaired improvement following treatment [20–22], delayed recovery, poorer quality of life, and increased suicide risk [23,24].”
Achieving Long-Term Optimal Outcomes in Geriatric Depression and Anxiety
Mulsant, B. H., Whyte, E. M., Lenze, E. J., Lotrich, F. E., Karp, J. F., Pollock, B. G., & Reynolds, C. F. (2003) · CNS Spectrums · doi:10.1017/s1092852900008257 · Cited by 16
Bjelland, I. (2004) · NORA - Norwegian Open Research Archives · Cited by 16
Guaiana, G., Andretta, M., Griez, E. J. L., Biancosino, B., & Grassi, L. G. (2011) · Annals of General Psychiatry · doi:10.1186/1744-859x-10-24 · Cited by 15
“However, since anxiety and depression are closely intermingled, the former often being an indicator of the severity of the latter and vice versa [30], this limitation does not necessarily invalidate our main conclusions.”
ResultShankman, S. A., & Klein, D. N. (2002) · Journal of Affective Disorders · doi:10.1016/s0165-0327(01)00302-0 · Cited by 15
Metadata
- Authors
- Brown, C., Schulberg, H. C., Madonia, M. J., Shear, M. K., & Houck, P. R.
- Affiliations
- University of Pittsburgh (US)
- ORCID
- M. Katherine Shear
- Venue
- American Journal of Psychiatry
- Published
- 1996-10-01
- Volume
- 153
- Issue
- 10
- Pages
- 1293-1300
- ISSN
- 0002-953X (ISSN-L)
- 1535-7228
- OpenAlex
- W1563799145
- Cited by
- 312
- References
- 42
- Citations by year
- 2026: 2 · 2024: 3 · 2023: 5 · 2022: 4 · 2021: 11 · 2020: 10 · 2019: 8 · 2018: 9 · 2017: 8 · 2016: 6 · 2015: 7 · 2014: 11 · 2013: 16 · 2012: 19
- FWCI
- 15.75
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (2r01mh045815-05, 5r24mh053817-05)
- National Institute of Mental Health (MH-45815, MH53817, MH-18269, T32MH018269)
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Health Sciences › Medicine › Psychiatry and Mental health › Mental Health Treatment and Access
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Keywords
- major depressive disorder, anxiety disorders, comorbidities, generalized anxiety disorder, panic disorder, primary care, interpersonal psychotherapy, nortriptyline, antidepressant treatment, treatment outcomes, treatment discontinuation, time to recovery, psychosocial functioning, health-related functioning
- MeSH terms
- Adolescent, Adult, Antidepressive Agents, Anxiety Disorders, Combined Modality Therapy, Depressive Disorder, Female, Humans, Male, Middle Aged, Nortriptyline, Primary Health Care, Psychiatric Status Rating Scales, Psychotherapy, Severity of Illness Index, Comorbidity, Panic Disorder, Treatment Outcome
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
