Pretreatment Attrition in a Comparative Treatment Outcome Study on Panic Disorder

Hofmann, Stefan G.; Barlow, David H.; Papp, Laszlo A.; Detweiler, Michael F.; Ray, Susan E.; Shear, M. Katherine; Woods, Scott W.; Gorman, Jack M.

doi:10.1176/ajp.155.1.43

Cited by 93Anxiety, Depression, Psychometrics, Treatment, Cognitive ProcessesPsychotherapy Techniques and ApplicationsEthics in Clinical Research

Pretreatment Attrition in a Comparative Treatment Outcome Study on Panic Disorder

Hofmann, Stefan G., Barlow, David H., Papp, Laszlo A., Detweiler, Michael F., Ray, Susan E., Shear, M. Katherine, Woods, Scott W., Gorman, Jack M.·1998·American Journal of Psychiatry

DOI 10.1176/ajp.155.1.43

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Abstract

OBJECTIVE: Whereas the fact of attrition during the course of treatment is well documented, little is known about the factors that affect sample selection before the beginning of a study ("pretreatment attrition"). The present study reports on the degree and sources of pretreatment attrition at two sites of a multicenter study on panic disorder that compared treatment outcomes for imipramine and cognitive behavior therapy. METHOD: Data were collected at two clinical research sites, one with a pharmacological treatment orientation (N = 420) and one with a psychosocial treatment orientation (N = 208). RESULTS: The main source of pretreatment attrition was participant refusal. At both research sites, eligible patients most often refused participation because they were either unwilling to start treatment with imipramine (30.6% and 47.4%, respectively) or discontinue their current medication (22.6% and 35.1%, respectively). CONCLUSIONS: Results from comparative treatment outcome studies are limited not only to people who meet the study criteria but also to those who are willing to begin a medication treatment and discontinue their current medication.

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Authors: Hofmann, S. G., Barlow, D. H., Papp, L. A., Detweiler, M. F., Ray, S. E., Shear, M. K., Woods, S. W., & Gorman, J. M.
Affiliations: Long Island Jewish Medical Center (US)
ORCID: Hofmann, Stefan G.
Barlow, David H.
Papp, Laszlo A.
Shear, M. Katherine
Woods, Scott W.
Gorman, Jack M.
Venue: American Journal of Psychiatry
Publisher: American Psychiatric Association Publishing
Published: 1998-01-01
Volume: 155
Issue: 1
Pages: 43-47
ISSN: 0002-953X (ISSN-L)
1535-7228
DOI: 10.1176/ajp.155.1.43
OpenAlex: W2114837010
Cited by: 93
References: 13
Citations by year: 2022: 2 · 2021: 4 · 2020: 3 · 2018: 2 · 2016: 1 · 2015: 4 · 2014: 4 · 2013: 4
FWCI: 6.58
Type: journal article
Language: en
Open access: closed
Locations: American Journal of Psychiatry (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Mental Health (MH 45965)
Topics: Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Social Sciences › Psychology › Clinical Psychology › Psychotherapy Techniques and Applications
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Ethics in Clinical Research
Keywords: panic disorder, imipramine, cognitive behavioral therapy, treatment outcome studies, drug discontinuation, sample selection
MeSH terms: Adolescent, Adult, Clinical Protocols, Combined Modality Therapy, Female, Humans, Imipramine, Male, Middle Aged, Patient Compliance, Patient Dropouts, Cognitive Behavioral Therapy, Treatment Refusal, Panic Disorder, Treatment Outcome, Patient Selection

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Pretreatment Attrition in a Comparative Treatment Outcome Study on Panic Disorder

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