The DOI matches its Crossref record; 47 of the 47 references it cites were found in a registry or an index.
Double-blind treatment of major depression with dehydroepiandrosterone.
Abstract
OBJECTIVE: This study was designed to assess possible antidepressant effects of dehydroepiandrosterone (DHEA), an abundant adrenocortical hormone in humans. METHOD: Twenty-two patients with major depression, either medication-free or on stabilized antidepressant regimens, received either DHEA (maximum dose = 90 mg/day) or placebo for 6 weeks in a double-blind manner and were rated at baseline and at the end of the 6 weeks with the Hamilton Depression Rating Scale. Patients previously stabilized with antidepressants had the study medication added to that regimen; others received DHEA or placebo alone. RESULTS: DHEA was associated with a significantly greater decrease in Hamilton depression scale ratings than was placebo. Five of the 11 patients treated with DHEA, compared with none of the 11 given placebo, showed a 50% decrease or greater in depressive symptoms. CONCLUSIONS: These results suggest that DHEA treatment may have significant antidepressant effects in some patients with major depression. Further, larger-scale trials are warranted.
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“A significant improvement in mood and well-being was observed in patients with major depression (331) and midlife asthenia (332), whereas no effect was detected in perimenopausal women (333).”
From Endocrine and intracrine sources of androgens in women: inhibition of breast cancer and other roles of androgens and their precursor dehydroepiandrosterone (2003) · cites this paper as [331]
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Cites
Hamilton, M. (1960) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.23.1.56 · Cited by 32,817
Majewska, M. D. (1992) · Progress in Neurobiology · doi:10.1016/0301-0082(92)90025-a · Cited by 1,089
Effects of replacement dose of dehydroepiandrosterone in men and women of advancing age.
Morales, A. J., Nolan, J. J., Nelson, J. C., & Yen, S. S. (1994) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.78.6.7515387 · Cited by 841
Morales, A. J. (1994) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.78.6.1360 · Cited by 458
Monnet, F. P., Mahé, V, Robel, P., & Baulieu, E. E. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.9.3774 · Cited by 429
Anti-glucocorticoid effects of dehydroepiandrosterone (DHEA).
Kalimi, M., Shafagoj, Y., Loria, R., Padgett, D., & Regelson, W. (1994) · Molecular and Cellular Biochemistry · doi:10.1007/bf00925945 · Cited by 328
Dehydroepiandrosterone (DHEA) treatment of depression
Wolkowitz, O. M., Reus, V. I., Roberts, E., Manfredi, F., Chan, T., Raum, W. J., Ormiston, S., Johnson, R. C., Canick, J., Brizendine, L., et al. (1997) · Biological Psychiatry · doi:10.1016/s0006-3223(96)00043-1 · Cited by 314
Bergeron, R., de Montigny, C., & Debonnel, G. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-03-01193.1996 · Cited by 299
Berr, C., Lafont, S., Debuire, B., Dartigues, J., & Baulieu, É.-É. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.23.13410 · Cited by 292
Morley, J. E., Kaiser, F. E., Raum, W. J., Perry, H. M., Flood, J. F., Jensen, J., Silver, A. J., & Roberts, E. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.14.7537 · Cited by 289
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Research works printed but not linked: 2
- Scali G, Nonis E, Petronio G, Casa B: Impiego del dinistile e dell’astenile nelle forme neurastheiche e depressive in geriatria. G Ital Richerche Clin Ter 1980; 85:85–87
- Pelliccioni E, Nonis E, Ronchini P, Rizzi C, Scali M: Impiego del deidroandrosterone nelle forme neuroasteniche e depressive in geriatria. G Gerontol 1981; 29:602–603
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Chapter 8. Perimenopause and Menopause
(2005) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9781615377480.lg08
Chapter 1. Integrative Psychopharmacology: A Practical Approach to Herbs and Nutrients in Psychiatry
Brown, R. P., & Gerbarg, P. L. (2000) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9798894550091.lg01
Chapter 4. Psychobiology of Resilience to Stress
New, A. S., Keegan, K. A., & Charney, D. S. (2007) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9781585627080.lg04
Hartkamp, A. (2014) · Utrecht University Repository (Utrecht University)
Dehydroepiandrosterone (DHEA) and Glucocorticoids‐to‐DHEA(S) Ratio
Whitham, J. C., & Miller, L. J. (2026) · Wiley eBooks · doi:10.1002/9781394182237.ch10
BindingDB (2014) · UC San Diego · doi:10.7270/q22z1705
WEIGHT MANAGEMENT IN THE POST-EPHEDRA ERA
Chufo, B. M. (2004)
Sripada, R. K. (2013) · Deep Blue (University of Michigan)
Synergistic effects of physical and psychological distress on immunesenescence
Duggal, N. A. (2014) · University of Birmingham Institutional Research Archive (University of Birmingham)
Metadata
- Authors
- Wolkowitz, O. M., Reus, V. I., Keebler, A., Nelson, N., Friedland, M., Brizendine, L., & Roberts, E.
- Affiliations
- University of California, San Francisco (US)
- Venue
- American Journal of Psychiatry
- Published
- 1999-04-01
- Volume
- 156
- Issue
- 4
- Pages
- 646-649
- ISSN
- 0002-953X (ISSN-L)
- 1535-7228
- OpenAlex
- W1922088893
- Cited by
- 411
- References
- 46
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 2 · 2023: 5 · 2022: 2 · 2021: 4 · 2020: 9 · 2019: 7 · 2018: 12 · 2017: 8 · 2016: 10 · 2015: 9 · 2014: 17 · 2013: 20 · 2012: 17
- FWCI
- 13.69
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Keywords
- dehydroepiandrosterone, major depressive disorder, antidepressant effects, adrenal cortex hormones, Hamilton Depression Rating Scale, adjunctive therapy
- MeSH terms
- Adult, Antidepressive Agents, Dehydroepiandrosterone, Depressive Disorder, Double-Blind Method, Drug Administration Schedule, Drug Therapy, Combination, Female, Humans, Male, Middle Aged, Placebos, Psychiatric Status Rating Scales, Treatment Outcome
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