Cited by 412Treatment of Major DepressionStress Responses and CortisolTryptophan and brain disorders

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Double-blind treatment of major depression with dehydroepiandrosterone.

Wolkowitz, Owen M., Reus, Victor I., Keebler, Audrey, Nelson, Nicola, Friedland, Mirit, Brizendine, Louann, Roberts, Eugene·1999·American Journal of Psychiatry

DOI 10.1176/ajp.156.4.646

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Abstract

OBJECTIVE: This study was designed to assess possible antidepressant effects of dehydroepiandrosterone (DHEA), an abundant adrenocortical hormone in humans. METHOD: Twenty-two patients with major depression, either medication-free or on stabilized antidepressant regimens, received either DHEA (maximum dose = 90 mg/day) or placebo for 6 weeks in a double-blind manner and were rated at baseline and at the end of the 6 weeks with the Hamilton Depression Rating Scale. Patients previously stabilized with antidepressants had the study medication added to that regimen; others received DHEA or placebo alone. RESULTS: DHEA was associated with a significantly greater decrease in Hamilton depression scale ratings than was placebo. Five of the 11 patients treated with DHEA, compared with none of the 11 given placebo, showed a 50% decrease or greater in depressive symptoms. CONCLUSIONS: These results suggest that DHEA treatment may have significant antidepressant effects in some patients with major depression. Further, larger-scale trials are warranted.

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Authors: Wolkowitz, O. M., Reus, V. I., Keebler, A., Nelson, N., Friedland, M., Brizendine, L., & Roberts, E.
Affiliations: University of California, San Francisco (US)
ORCID: Wolkowitz, Owen M.
Reus, Victor I.
Venue: American Journal of Psychiatry
Publisher: American Psychiatric Association Publishing
Published: 1999-04-01
Volume: 156
Issue: 4
Pages: 646-649
ISSN: 0002-953X (ISSN-L)
1535-7228
DOI: 10.1176/ajp.156.4.646
OpenAlex: W1922088893
Cited by: 411
References: 46
Citations by year: 2026: 2 · 2025: 1 · 2024: 2 · 2023: 5 · 2022: 2 · 2021: 4 · 2020: 9 · 2019: 7 · 2018: 12 · 2017: 8 · 2016: 10 · 2015: 9 · 2014: 17 · 2013: 20 · 2012: 17
FWCI: 13.69
Type: journal article
Language: en
Open access: closed
Locations: American Journal of Psychiatry (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Keywords: dehydroepiandrosterone, major depressive disorder, antidepressant effects, adrenal cortex hormones, Hamilton Depression Rating Scale, adjunctive therapy
MeSH terms: Adult, Antidepressive Agents, Dehydroepiandrosterone, Depressive Disorder, Double-Blind Method, Drug Administration Schedule, Drug Therapy, Combination, Female, Humans, Male, Middle Aged, Placebos, Psychiatric Status Rating Scales, Treatment Outcome

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Double-blind treatment of major depression with dehydroepiandrosterone.

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