Cited by 412Treatment of Major DepressionStress Responses and CortisolTryptophan and brain disorders

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Double-blind treatment of major depression with dehydroepiandrosterone.

Wolkowitz, Owen M., Reus, Victor I., Keebler, Audrey, Nelson, Nicola, Friedland, Mirit, Brizendine, Louann, Roberts, Eugene·1999·American Journal of Psychiatry

DOI 10.1176/ajp.156.4.646

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Abstract

OBJECTIVE: This study was designed to assess possible antidepressant effects of dehydroepiandrosterone (DHEA), an abundant adrenocortical hormone in humans. METHOD: Twenty-two patients with major depression, either medication-free or on stabilized antidepressant regimens, received either DHEA (maximum dose = 90 mg/day) or placebo for 6 weeks in a double-blind manner and were rated at baseline and at the end of the 6 weeks with the Hamilton Depression Rating Scale. Patients previously stabilized with antidepressants had the study medication added to that regimen; others received DHEA or placebo alone. RESULTS: DHEA was associated with a significantly greater decrease in Hamilton depression scale ratings than was placebo. Five of the 11 patients treated with DHEA, compared with none of the 11 given placebo, showed a 50% decrease or greater in depressive symptoms. CONCLUSIONS: These results suggest that DHEA treatment may have significant antidepressant effects in some patients with major depression. Further, larger-scale trials are warranted.

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A rating scale for depression
Hamilton, M. (1960) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.23.1.56 · Cited by 32,817
Neurosteroids: Endogenous bimodal modulators of the GABAA receptor mechanism of action and physiological significance
Majewska, M. D. (1992) · Progress in Neurobiology · doi:10.1016/0301-0082(92)90025-a · Cited by 1,089
Effects of replacement dose of dehydroepiandrosterone in men and women of advancing age.
Morales, A. J., Nolan, J. J., Nelson, J. C., & Yen, S. S. (1994) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.78.6.7515387 · Cited by 841
Effects of replacement dose of dehydroepiandrosterone in men and women of advancing age [published erratum appears in J Clin Endocrinol Metab 1995 Sep;80(9):2799]
Morales, A. J. (1994) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.78.6.1360 · Cited by 458
Neurosteroids, via sigma receptors, modulate the [3H]norepinephrine release evoked by N-methyl-D-aspartate in the rat hippocampus.
Monnet, F. P., Mahé, V, Robel, P., & Baulieu, E. E. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.9.3774 · Cited by 429
Anti-glucocorticoid effects of dehydroepiandrosterone (DHEA).
Kalimi, M., Shafagoj, Y., Loria, R., Padgett, D., & Regelson, W. (1994) · Molecular and Cellular Biochemistry · doi:10.1007/bf00925945 · Cited by 328
Dehydroepiandrosterone (DHEA) treatment of depression
Wolkowitz, O. M., Reus, V. I., Roberts, E., Manfredi, F., Chan, T., Raum, W. J., Ormiston, S., Johnson, R. C., Canick, J., Brizendine, L., et al. (1997) · Biological Psychiatry · doi:10.1016/s0006-3223(96)00043-1 · Cited by 314
Potentiation of neuronal NMDA response induced by dehydroepiandrosterone and its suppression by progesterone: effects mediated via sigma receptors
Bergeron, R., de Montigny, C., & Debonnel, G. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-03-01193.1996 · Cited by 299
Relationships of dehydroepiandrosterone sulfate in the elderly with functional, psychological, and mental status, and short-term mortality: A French community-based study
Berr, C., Lafont, S., Debuire, B., Dartigues, J., & Baulieu, É.-É. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.23.13410 · Cited by 292
Potentially predictive and manipulable blood serum correlates of aging in the healthy human male: Progressive decreases in bioavailable testosterone, dehydroepiandrosterone sulfate, and the ratio of insulin-like growth factor 1 to growth hormone
Morley, J. E., Kaiser, F. E., Raum, W. J., Perry, H. M., Flood, J. F., Jensen, J., Silver, A. J., & Roberts, E. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.14.7537 · Cited by 289

Show all 46 references

Research works printed but not linked: 2

Scali G, Nonis E, Petronio G, Casa B: Impiego del dinistile e dell’astenile nelle forme neurastheiche e depressive in geriatria. G Ital Richerche Clin Ter 1980; 85:85–87
Pelliccioni E, Nonis E, Ronchini P, Rizzi C, Scali M: Impiego del deidroandrosterone nelle forme neuroasteniche e depressive in geriatria. G Gerontol 1981; 29:602–603

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Tichomirowa, M. A., Keck, M. E., Schneider, H. J., Páez-Pereda, M., Renner, U., Holsboer, F., & Stalla, G. K. (2005) · Journal of Endocrinological Investigation · doi:10.1007/bf03345535 · Cited by 111
Psychobiological Mechanisms of Resilience and Vulnerability
Charney, D. S. (2004) · FOCUS The Journal of Lifelong Learning in Psychiatry · doi:10.1176/foc.2.3.368 · Cited by 127
Dehydroepiandrosterone and ageing
Arlt, W. (2004) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2004.02.006 · Cited by 108
Effect of dehydroepiandrosterone administration on fatigue, well-being, and functioning in women with primary Sjögren syndrome: a randomised controlled trial
Hartkamp, A., Geenen, R., Godaert, G. L. R., Bootsma, H., Kruize, A. A., Bijlsma, J. W. J., & Derksen, R. H. W. M. (2007) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2007.071563 · Cited by 104
Placebo-controlled trial of dehydroepiandrosterone (DHEA) for treatment of nonmajor depression in patients with HIV/AIDS.
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Anti-TNF-α Compounds as a Treatment for Depression
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Strous, R. D., Maayan, R., & Weizman, A. (2005) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2005.09.005 · Cited by 103
DHEA treatment of Alzheimer’s disease
Wolkowitz, O. M., Kramer, J. H., Reus, V. I., Costa, M. L., Yaffe, K. S., Walton, P., Raskind, M. A., Peskind, E. R., NEWHOUSE, P. A., Sack, D. A., et al. (2003) · Neurology · doi:10.1212/01.wnl.0000052994.54660.58 · Cited by 101
The Antidepressant-Like Effect Induced by ς1-Receptor Agonists and Neuroactive Steroids in Mice Submitted to the Forced Swimming Test
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Antidepressant medications and other treatments of depressive disorders: a CINP Task Force report based on a review of evidence
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Alhaj, H. A., Massey, A. E., & McAllister-Williams, H. (2005) · Psychopharmacology · doi:10.1007/s00213-005-0136-y · Cited by 99
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Panjari, M., & Davis, S. R. (2007) · Human Reproduction Update · doi:10.1093/humupd/dml055 · Cited by 95
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Retracted
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Dubrovsky, B. O. (2006) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2006.06.016 · Cited by 88
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Pérez-Neri, I., Montes, S., Ojeda-López, C., Ramírez-Bermúdez, J., & Ríos, C. (2008) · Progress in Neuro-psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2007.12.001 · Cited by 87
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Androgen in postmenopausal women
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Neuroactive Steroids: Receptor Interactions and Responses
Tuem, K. B., & Atey, T. M. (2017) · Frontiers in Neurology · doi:10.3389/fneur.2017.00442 · Cited by 89
Childhood adversity and allostatic overload of the hypothalamic–pituitary–adrenal axis: A vulnerability model for depressive disorders
Wilkinson, P. O., & Goodyer, I. M. (2011) · Development and Psychopathology · doi:10.1017/s0954579411000472 · Cited by 95
Salivary cortisol and dehydroepiandrosterone (DHEA) levels, psychological factors in patients with oral lichen planus
Girardi, C., Luz, C., Cherubini, K., de Figueiredo, M. A. Z., Nunes, M. L. T., & Salum, F. G. (2011) · Archives of Oral Biology · doi:10.1016/j.archoralbio.2011.02.003 · Cited by 85

Authors: Wolkowitz, O. M., Reus, V. I., Keebler, A., Nelson, N., Friedland, M., Brizendine, L., & Roberts, E.
Affiliations: University of California, San Francisco (US)
ORCID: Wolkowitz, Owen M.
Reus, Victor I.
Venue: American Journal of Psychiatry
Publisher: American Psychiatric Association Publishing
Published: 1999-04-01
Volume: 156
Issue: 4
Pages: 646-649
ISSN: 0002-953X (ISSN-L)
1535-7228
DOI: 10.1176/ajp.156.4.646
OpenAlex: W1922088893
Cited by: 411
References: 46
Citations by year: 2026: 2 · 2025: 1 · 2024: 2 · 2023: 5 · 2022: 2 · 2021: 4 · 2020: 9 · 2019: 7 · 2018: 12 · 2017: 8 · 2016: 10 · 2015: 9 · 2014: 17 · 2013: 20 · 2012: 17
FWCI: 13.69
Type: journal article
Language: en
Open access: closed
Locations: American Journal of Psychiatry (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Keywords: dehydroepiandrosterone, major depressive disorder, antidepressant effects, adrenal cortex hormones, Hamilton Depression Rating Scale, adjunctive therapy
MeSH terms: Adult, Antidepressive Agents, Dehydroepiandrosterone, Depressive Disorder, Double-Blind Method, Drug Administration Schedule, Drug Therapy, Combination, Female, Humans, Male, Middle Aged, Placebos, Psychiatric Status Rating Scales, Treatment Outcome

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Double-blind treatment of major depression with dehydroepiandrosterone.

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