The Role of Oscillations and Synchrony in Cortical Networks and Their Putative Relevance for the Pathophysiology of Schizophrenia
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Neural oscillations and their synchronization may represent a versatile signal to realize flexible communication within and between cortical areas. By now, there is extensive evidence to suggest that cognitive functions depending on coordination of distributed neural responses, such as perceptual grouping, attention-dependent stimulus selection, subsystem integration, working memory, and consciousness, are associated with synchronized oscillatory activity in the theta-, alpha-, beta-, and gamma-band, suggesting a functional mechanism of neural oscillations in cortical networks. In addition to their role in normal brain functioning, there is increasing evidence that altered oscillatory activity may be associated with certain neuropsychiatric disorders, such as schizophrenia, that involve dysfunctional cognition and behavior. In the following article, we aim to summarize the evidence on the role of neural oscillations during normal brain functioning and their relationship to cognitive processes. In the second part, we review research that has examined oscillatory activity during cognitive and behavioral tasks in schizophrenia. These studies suggest that schizophrenia involves abnormal oscillations and synchrony that are related to cognitive dysfunctions and some of the symptoms of the disorder. Perspectives for future research will be discussed in relationship to methodological issues, the utility of neural oscillations as a biomarker, and the neurodevelopmental hypothesis of schizophrenia.
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Alpha activity increases during relaxation and decreases during active stimulus processing.
“The α activity increases during a relaxed state and decreases during active stimulus processing.”
From Early Behavioral Intervention Is Associated With Normalized Brain Activity in Young Children With Autism (2012) · cites this paper as [15]
Firing properties of parvalbumin interneurons participate in establishing normal gamma oscillations and cortical synchrony, a physiological correlate of higher-order information processing.
“The firing properties of parvalbumin interneurons participate in establishing the normal gamma oscillations and synchrony of cortical neuronal populations, thought to be a physiological correlate of higher-order information processing in brain”
From Perineuronal nets and schizophrenia: The importance of neuronal coatings (2014) · cites this paper as Uhlhaas et al., 2008
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“In principle, the pathophysiology of AVH thus predict impaired EEG synchronisation during sensory processing in patient s with AVH, as shown in a series of studies (Kwon et al., 1999; Gallinat et al., 2004; Uhlhaas et al., 2008; Uhlhaas and Singer, 2010; Engel et al., 2013).”
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- Authors
- Uhlhaas, P. J., Haenschel, C., Nikolic, D., & Singer, W.
- Affiliations
- Goethe University Frankfurt (DE)
- Corresponding author
- Uhlhaas, P. J.
- Venue
- Schizophrenia Bulletin
- Publisher
- Oxford University Press (OUP)
- Published
- 2008-07-21
- Volume
- 34
- Issue
- 5
- Pages
- 927-943
- ISSN
- 0586-7614 (ISSN-L)
- 1745-1701
- PMC
- PMC2632472
- OpenAlex
- W2105966205
- Cited by
- 629
- References
- 167
- Citations by year
- 2026: 13 · 2025: 25 · 2024: 18 · 2023: 17 · 2022: 26 · 2021: 53 · 2020: 29 · 2019: 25 · 2018: 32 · 2017: 37 · 2016: 35 · 2015: 47 · 2014: 36 · 2013: 45 · 2012: 39
- FWCI
- 3.83
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Schizophrenia Bulletin (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- neural oscillations, neuronal synchronization
- MeSH terms
- Cerebral Cortex, Cognition Disorders, Electroencephalography, Humans, Nerve Net, Schizophrenia, Magnetoencephalography
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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