Cited by 629Neural dynamics and brain functionSchizophrenia research and treatmentNeuroscience and Neuropharmacology Research

The Role of Oscillations and Synchrony in Cortical Networks and Their Putative Relevance for the Pathophysiology of Schizophrenia

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Uhlhaas, P. J., Haenschel, C., Nikolic, D., Singer, W.·2008·Schizophrenia Bulletin

Abstract

Neural oscillations and their synchronization may represent a versatile signal to realize flexible communication within and between cortical areas. By now, there is extensive evidence to suggest that cognitive functions depending on coordination of distributed neural responses, such as perceptual grouping, attention-dependent stimulus selection, subsystem integration, working memory, and consciousness, are associated with synchronized oscillatory activity in the theta-, alpha-, beta-, and gamma-band, suggesting a functional mechanism of neural oscillations in cortical networks. In addition to their role in normal brain functioning, there is increasing evidence that altered oscillatory activity may be associated with certain neuropsychiatric disorders, such as schizophrenia, that involve dysfunctional cognition and behavior. In the following article, we aim to summarize the evidence on the role of neural oscillations during normal brain functioning and their relationship to cognitive processes. In the second part, we review research that has examined oscillatory activity during cognitive and behavioral tasks in schizophrenia. These studies suggest that schizophrenia involves abnormal oscillations and synchrony that are related to cognitive dysfunctions and some of the symptoms of the disorder. Perspectives for future research will be discussed in relationship to methodological issues, the utility of neural oscillations as a biomarker, and the neurodevelopmental hypothesis of schizophrenia.

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  • Alpha activity increases during relaxation and decreases during active stimulus processing.

    “The α activity increases during a relaxed state and decreases during active stimulus processing.”
  • Firing properties of parvalbumin interneurons participate in establishing normal gamma oscillations and cortical synchrony, a physiological correlate of higher-order information processing.

    “The firing properties of parvalbumin interneurons participate in establishing the normal gamma oscillations and synchrony of cortical neuronal populations, thought to be a physiological correlate of higher-order information processing in brain”

    From Perineuronal nets and schizophrenia: The importance of neuronal coatings (2014) · cites this paper as Uhlhaas et al., 2008

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Research works printed but not linked: 2

  1. Berger H. Ueber das Electrocephalogramm des Menschen. Arch Psychiatr Nervenkr. 1929;87:527-570.
  2. Traub RD, Bibbig A, LeBeau FE, Buhl EH, Whittington MA. Cellular mechanisms of neuronal population oscilla- tions in the hippocampus in vitro. Annu Rev Neurosci. 2004;27:247-278.

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Authors
Uhlhaas, P. J., Haenschel, C., Nikolic, D., & Singer, W.
Affiliations
Goethe University Frankfurt (DE)
Corresponding author
Uhlhaas, P. J.
Venue
Schizophrenia Bulletin
Published
2008-07-21
Volume
34
Issue
5
Pages
927-943
ISSN
  • 0586-7614 (ISSN-L)
  • 1745-1701
OpenAlex
W2105966205
Cited by
629
References
167
Citations by year
2026: 13 · 2025: 25 · 2024: 18 · 2023: 17 · 2022: 26 · 2021: 53 · 2020: 29 · 2019: 25 · 2018: 32 · 2017: 37 · 2016: 35 · 2015: 47 · 2014: 36 · 2013: 45 · 2012: 39
FWCI
3.83
Type
journal article
Language
en
Open access
Locations
  • Schizophrenia Bulletin (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam) (submittedVersion)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
neural oscillations, neuronal synchronization
MeSH terms
Cerebral Cortex, Cognition Disorders, Electroencephalography, Humans, Nerve Net, Schizophrenia, Magnetoencephalography

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