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Anorexia Nervosa and Major Depression: Shared Genetic and Environmental Risk Factors

Wade, Tracey D., Bulik, Cynthia M., Neale, Michael, Kendler, Kenneth S.·2000·American Journal of Psychiatry

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Abstract

OBJECTIVE: The authors sought to derive heritability estimates for anorexia nervosa and to explore the etiology of the comorbid relationship between anorexia nervosa and major depression. METHOD: They applied bivariate structural equation modeling to a broad definition of anorexia nervosa and lifetime major depression as assessed in a population-based sample of 2,163 female twins. RESULTS: Anorexia nervosa was estimated to have a heritability of 58% (95% confidence interval=33%-84%). The authors were unable to completely rule out a contribution of shared environment. The comorbidity between anorexia nervosa and major depression is likely due to genetic factors that influence the risk for both disorders. CONCLUSIONS: Although the study was limited by the small number of affected twins, the results suggest that genetic factors significantly influence the risk for anorexia nervosa and substantially contribute to the observed comorbidity between anorexia nervosa and major depression.

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Authors: Wade, T. D., Bulik, C. M., Neale, M., & Kendler, K. S.
Affiliations: Virginia Commonwealth University (US)
ORCID: Wade, Tracey D.
Bulik, Cynthia M.
Neale, Michael
Kendler, Kenneth S.
Venue: American Journal of Psychiatry
Publisher: American Psychiatric Association Publishing
Published: 2000-03-01
Volume: 157
Issue: 3
Pages: 469-471
ISSN: 0002-953X (ISSN-L)
1535-7228
DOI: 10.1176/appi.ajp.157.3.469
OpenAlex: W2134453207
Cited by: 375
References: 9
Citations by year: 2026: 4 · 2025: 12 · 2024: 12 · 2023: 7 · 2022: 6 · 2021: 12 · 2020: 6 · 2019: 13 · 2018: 14 · 2017: 11 · 2016: 20 · 2015: 24 · 2014: 16 · 2013: 14 · 2012: 14
FWCI: 17.91
Type: journal article
Language: en
Open access: closed
Locations: American Journal of Psychiatry (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute on Alcohol Abuse and Alcoholism (R01AA009095, AA-09095)
National Institute of Mental Health (R01MH040828, MH 40828, MH-42953)
Topics: Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
Health Sciences › Nursing › Nutrition and Dietetics › Nutrition, Health and Food Behavior
Keywords: anorexia nervosa, major depressive disorder, comorbidities, heritability, genetic risk factors, shared environment, twin studies, female twins, psychiatric genetics
MeSH terms: Adult, Anorexia Nervosa, Depressive Disorder, Diseases in Twins, Female, Humans, Models, Genetic, Phenotype, Risk Factors, Twins, Dizygotic, Twins, Monozygotic, Genetic Variation, Comorbidity, Genetic Predisposition to Disease

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Anorexia Nervosa and Major Depression: Shared Genetic and Environmental Risk Factors

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