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Cited by 375Eating Disorders and BehaviorsGenetic Associations and EpidemiologyNutrition, Health and Food Behavior

The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.

Anorexia Nervosa and Major Depression: Shared Genetic and Environmental Risk Factors

Wade, Tracey D., Bulik, Cynthia M., Neale, Michael, Kendler, Kenneth S.·2000·American Journal of Psychiatry
DOI 10.1176/appi.ajp.157.3.469
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Abstract

OBJECTIVE: The authors sought to derive heritability estimates for anorexia nervosa and to explore the etiology of the comorbid relationship between anorexia nervosa and major depression. METHOD: They applied bivariate structural equation modeling to a broad definition of anorexia nervosa and lifetime major depression as assessed in a population-based sample of 2,163 female twins. RESULTS: Anorexia nervosa was estimated to have a heritability of 58% (95% confidence interval=33%-84%). The authors were unable to completely rule out a contribution of shared environment. The comorbidity between anorexia nervosa and major depression is likely due to genetic factors that influence the risk for both disorders. CONCLUSIONS: Although the study was limited by the small number of affected twins, the results suggest that genetic factors significantly influence the risk for anorexia nervosa and substantially contribute to the observed comorbidity between anorexia nervosa and major depression.

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Crossref · 10.1176/appi.ajp.157.3.469

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Metadata

Authors
Wade, T. D., Bulik, C. M., Neale, M., & Kendler, K. S.
Affiliations
Virginia Commonwealth University (US)
ORCID
Venue
American Journal of Psychiatry
Publisher
American Psychiatric Association Publishing
Published
2000-03-01
Volume
157
Issue
3
Pages
469-471
ISSN
  • 0002-953X (ISSN-L)
  • 1535-7228
DOI
10.1176/appi.ajp.157.3.469
OpenAlex
W2134453207
Cited by
375
References
9
Citations by year
2026: 4 · 2025: 12 · 2024: 12 · 2023: 7 · 2022: 6 · 2021: 12 · 2020: 6 · 2019: 13 · 2018: 14 · 2017: 11 · 2016: 20 · 2015: 24 · 2014: 16 · 2013: 14 · 2012: 14
FWCI
17.91
Type
journal article
Language
en
Open access
closed
Locations
  • American Journal of Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institute on Alcohol Abuse and Alcoholism (R01AA009095, AA-09095)
  • National Institute of Mental Health (R01MH040828, MH 40828, MH-42953)
Topics
  • Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
  • Health Sciences › Nursing › Nutrition and Dietetics › Nutrition, Health and Food Behavior
Keywords
anorexia nervosa, major depressive disorder, comorbidities, heritability, genetic risk factors, shared environment, twin studies, female twins, psychiatric genetics
MeSH terms
Adult, Anorexia Nervosa, Depressive Disorder, Diseases in Twins, Female, Humans, Models, Genetic, Phenotype, Risk Factors, Twins, Dizygotic, Twins, Monozygotic, Genetic Variation, Comorbidity, Genetic Predisposition to Disease

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