Cited by 230Advanced Neuroimaging Techniques and ApplicationsNeural and Behavioral Psychology StudiesTreatment of Major Depression

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Late-Life Depression and Microstructural Abnormalities in Dorsolateral Prefrontal Cortex White Matter

Taylor, Warren D., MacFall, James R., Payne, Martha E., McQuoid, Douglas R., Provenzale, James M., Steffens, David C., Krishnan, K. Ranga Rama·2004·American Journal of Psychiatry

DOI 10.1176/appi.ajp.161.7.1293

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Abstract

OBJECTIVE: The purpose of this study was to determine whether microstructural abnormalities in the white matter of the dorsolateral prefrontal cortex are associated with late-life depression. METHOD: Seventeen elderly depressed subjects were compared with 16 elderly subjects who were not depressed. Diffusion tensor imaging was used to measure the fractional anisotropy of the white matter in the dorsolateral prefrontal cortex's superior and middle frontal gyri bilaterally and in the left occipital lobe as a control region. The authors compared results between groups while controlling for age, sex, and comorbid medical disorders. RESULTS: Even after controlling for age, sex, hypertension, and heart disease, the authors found significantly lower fractional anisotropy values in the right superior frontal gyrus white matter of depressed patients than comparison subjects. CONCLUSIONS: Microstructural changes in the white matter of the right superior frontal gyrus are associated with late-life depression. Further work is needed to determine how these changes contribute to depression outcomes.

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Authors: Taylor, W. D., MacFall, J. R., Payne, M. E., McQuoid, D. R., Provenzale, J. M., Steffens, D. C., & Krishnan, K. R. R.
Affiliations: Duke Medical Center (US)
ORCID: Taylor, Warren D.
MacFall, James R.
Steffens, David C.
Krishnan, K. Ranga Rama
Venue: American Journal of Psychiatry
Publisher: American Psychiatric Association Publishing
Published: 2004-07-01
Volume: 161
Issue: 7
Pages: 1293-1296
ISSN: 0002-953X (ISSN-L)
1535-7228
DOI: 10.1176/appi.ajp.161.7.1293
OpenAlex: W2142902799
Cited by: 230
References: 35
Citations by year: 2026: 1 · 2025: 6 · 2024: 1 · 2023: 4 · 2022: 4 · 2021: 3 · 2020: 5 · 2019: 5 · 2018: 7 · 2017: 7 · 2016: 6 · 2015: 7 · 2014: 15 · 2013: 19 · 2012: 26
FWCI: 11.17
Type: journal article
Language: en
Open access: closed
Locations: American Journal of Psychiatry (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Mental Health (K234 MH 65939, R01 MH-54846, R01MH054846, K23MH065939, P50MH60451, P50MH060451)
Topics: Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
Keywords: geriatric depression, dorsolateral prefrontal cortex, white matter microstructure, fractional anisotropy, superior frontal gyrus, middle frontal gyrus
MeSH terms: Aged, Major Depressive Disorder, Depressive Disorder, Major, Female, Frontal Lobe, Heart Diseases, Humans, Hypertension, Image Processing, Computer-Assisted, Functional Laterality, Male, Middle Aged, Neural Pathways, Occipital Lobe, Psychiatric Status Rating Scales, Comorbidity, Anisotropy, Echo-Planar Imaging, Prefrontal Cortex, Diffusion Magnetic Resonance Imaging

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Late-Life Depression and Microstructural Abnormalities in Dorsolateral Prefrontal Cortex White Matter

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