Dorsolateral Prefrontal Cortex and Anterior Cingulate Cortex White Matter Alterations in Late-Life Depression
Abstract
Background The dorsolateral prefrontal cortex (DLPFC) and anterior cingulate cortex (ACC) are critical for mood regulation. Alterations in the white matter connections of these regions may impair their role in mood regulation and increase the risk of developing depression. This study used diffusion tensor imaging to examine for white matter microstructural abnormalities of these regions and of central white matter structures in late-life depression.Methods One hundred six elderly depressed subjects and eighty-four elderly nondepressed subjects underwent clinical assessment and diffusion tensor imaging. The apparent diffusion coefficient (ADC) and fractional anisotropy (FA) were measured in regions of interest placed in the white matter of the DLPFC, ACC, corpus callosum, and internal capsule. Differences between groups were assessed, controlling for age, sex, and total cerebral volume.Results After controlling for covariates, depressed subjects had significantly lower FA values in white matter of the right ACC, bilateral superior frontal gyri, and left middle frontal gyrus. There were no significant differences in ADC values.Conclusions Lower FA, representing lower tissue organization, is observed in depressed elders in the DLPFC and right ACC. These findings support the hypothesis that altered connectivity between brain regions contributes to the risk of depression.
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Previous studies using diffusion imaging have demonstrated reduced fractional anisotropy in ACC and prefrontal white matter generally in depressed subjects.
“Previous studies using diffusion imaging have demonstrated reduced fractional anisotropy in ACC and prefrontal white matter generally in depressed subjects (Taylor et al. 2004; Bae et al. 2006; Nobuhara et al. 2006); future studies using diffusion tractography should test the integrity of the specific tracts identified here in patients with mood disorders.”
From Anatomical connectivity of the subgenual cingulate region targeted with deep brain stimulation for treatment-resistant depression (2008) · cites this paper as Bae et al. 2006
Cites
Folstein, M. F., Folstein, S. E., & McHugh, P. R. (1975) · Journal of Psychiatric Research · doi:10.1016/0022-3956(75)90026-6 · Cited by 88,282 · see citing works
The CES-D Scale: A Self-Report Depression Scale for Research in the General Population
Radloff, L. S. (1977) · Applied Psychological Measurement · doi:10.1177/014662167700100306 · Cited by 53,267 · see citing works
A new depression scale designed to be sensitive to change
Montgomery, S. A., & Åsberg, M. (1979) · British Journal of Psychiatry · doi:10.1192/bjp.134.4.382 · Cited by 13,962 · see citing works
Basser, P. J., & Pierpaoli, C. (1996) · Journal of Magnetic Resonance, Series B · doi:10.1006/jmrb.1996.0086 · Cited by 4,306 · see citing works
J Neuropsychiatry Clin Neurosci
Yudofsky, S. C., & Hales, R. E. (1992) · The Journal of Neuropsychiatry and Clinical Neurosciences · doi:10.1176/jnp.4.4.359 · Cited by 3,818 · see citing works
Establishment of Diagnostic Validity in Psychiatric Illness: Its Application to Schizophrenia
ROBINS, E., & GUZE, S. B. (1970) · American Journal of Psychiatry · doi:10.1176/ajp.126.7.983 · Cited by 2,243 · see citing works
Pezawas, L., Meyer-Lindenberg, A., Drabant, E. M., Verchinski, B. A., Munoz, K. E., Kolachana, B. S., Egan, M. F., Mattay, V. S., Hariri, A. R., & Weinberger, D. R. (2005) · Nature Neuroscience · doi:10.1038/nn1463 · Cited by 1,980 · see citing works
'Vascular Depression' Hypothesis
Alexopoulos, G. S. (1997) · Archives of General Psychiatry · doi:10.1001/archpsyc.1997.01830220033006 · Cited by 1,843 · see citing works
The developmental role of serotonin: news from mouse molecular genetics
Gaspar, P., Cases, O., & Maroteaux, L. (2003) · Nature Reviews Neuroscience · doi:10.1038/nrn1256 · Cited by 1,297 · see citing works
Frontal–subcortical neuronal circuits and clinical neuropsychiatry
Tekin, S., & Cummings, J. L. (2002) · Journal of Psychosomatic Research · doi:10.1016/s0022-3999(02)00428-2 · Cited by 1,240 · see citing works
Age-related alterations in white matter microstructure measured by diffusion tensor imaging
Salat, D. H., Tuch, D. S., Greve, D. N., van der Kouwe, A. J. W., Hevelone, N. D., Zaleta, A. K., Rosen, B. R., Fischl, B. R., Corkin, S., Rosas, H. D., et al. (2004) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2004.09.017 · Cited by 832 · see citing works
MRI-defined vascular depression
(1997) · American Journal of Psychiatry · doi:10.1176/ajp.154.4.497 · Cited by 770 · see citing works
Diffusion tensor imaging and aging
Sullivan, E. V., & Pfefferbaum, A. (2006) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2006.06.002 · Cited by 649 · see citing works
Head, D. (2004) · Cerebral Cortex · doi:10.1093/cercor/bhh003 · Cited by 645 · see citing works
A simplified method to measure the diffusion tensor from seven MR images
Basser, P. J., & Pierpaoli, C. M. (1998) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910390610 · Cited by 584 · see citing works
Uncinate Fasciculus Findings in Schizophrenia: A Magnetic Resonance Diffusion Tensor Imaging Study
Kubicki, M. R., Westin, C., Maier, S. E., Frumin, M., Nestor, P. G., Salisbury, D. F., Kikinis, R., Jolesz, F. A., McCarley, R. W., & Shenton, M. E. (2002) · American Journal of Psychiatry · doi:10.1176/appi.ajp.159.5.813 · Cited by 454 · see citing works
Compromised White Matter Tract Integrity in Schizophrenia Inferred From Diffusion Tensor Imaging
Lim, K. O., Hedehus, M., Moseley, M. E., de Crespigny, A. J., Sullivan, E. V., & Pfefferbaum, A. (1999) · Archives of General Psychiatry · doi:10.1001/archpsyc.56.4.367 · Cited by 447 · see citing works
DTI and MTR abnormalities in schizophrenia: Analysis of white matter integrity
Kubicki, M. R., Park, H., Westin, C., Nestor, P. G., Mulkern, R. V., Maier, S. E., Niznikiewicz, M. A., Connor, E. E., Levitt, J. J., Frumin, M., et al. (2005) · NeuroImage · doi:10.1016/j.neuroimage.2005.03.026 · Cited by 433 · see citing works
O'Brien, J. T. (2004) · American Journal of Psychiatry · doi:10.1176/appi.ajp.161.11.2081 · Cited by 409 · see citing works
Hickie, I., Scott, E., Mitchell, P., Wilhelm, K., Austin, M.-P., & Bennett, B. (1995) · Biological Psychiatry · doi:10.1016/0006-3223(94)00174-2 · Cited by 398 · see citing works
Executive Dysfunction in Geriatric Depression
Lockwood, K. A., Alexopoulos, G. S., & van Gorp, W. G. (2002) · American Journal of Psychiatry · doi:10.1176/appi.ajp.159.7.1119 · Cited by 378 · see citing works
Kubicki, M., Westin, C.-F., Nestor, P. G., Wible, C. G., Frumin, M., Maier, S. E., Kikinis, R., Jolesz, F. A., McCarley, R. W., & Shenton, M. E. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00419-0 · Cited by 376 · see citing works
MRI white matter diffusion anisotropy and PET metabolic rate in schizophrenia
Buchsbaum, M., Tang, C. Y., Peled, S., Gudbjartsson, H., Lu, D.-F., Hazlett, E., Downhill, J., Haznedar, M., Fallon, J., & Atlas, S. (1998) · NeuroReport · doi:10.1097/00001756-199802160-00013 · Cited by 369 · see citing works
Frontal circuitry degradation marks healthy adult aging: Evidence from diffusion tensor imaging
Pfefferbaum, A., Elfar Adalsteinsson, A., & Sullivan, E. V. (2005) · NeuroImage · doi:10.1016/j.neuroimage.2005.02.034 · Cited by 350 · see citing works
Executive dysfunction and the course of geriatric depression
Alexopoulos, G. S., Kiosses, D. N., Heo, M., Murphy, C. F., Shanmugham, B., & Gunning-Dixon, F. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.04.024 · Cited by 317 · see citing works
Alexopoulos, G. S., Kiosses, D. N., Choi, S. J., Murphy, C. F., & Lim, K. O. (2002) · American Journal of Psychiatry · doi:10.1176/appi.ajp.159.11.1929 · Cited by 307 · see citing works
Diffusion tensor imaging and aging—A review.
Moseley, M. (2002) · NMR in Biomedicine · doi:10.1002/nbm.785 · Cited by 302 · see citing works
Conturo, T. E., McKinstry, R. C., Akbudak, E., & Robinson, B. H. (1996) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910350319 · Cited by 293 · see citing works
Cognition and white matter hyperintensities in older depressed patients
Lesser, I. M., Boone, K. B., Mehringer, C. M., Wohl, M. A., Miller, B. L., & Berman, N. (1996) · American Journal of Psychiatry · doi:10.1176/ajp.153.10.1280 · Cited by 284 · see citing works
Sullivan, E. V., Adalsteinsson, E., & Pfefferbaum, A. (2006) · Cerebral Cortex · doi:10.1093/cercor/bhj045 · Cited by 280 · see citing works
White Matter Hyperintensity Progression and Late-Life Depression Outcomes
Taylor, W. D., Steffens, D. C., MacFall, J. R., McQuoid, D. R., Payne, M. E., Provenzale, J. M., & Krishnan, K. (2003) · Archives of General Psychiatry · doi:10.1001/archpsyc.60.11.1090 · Cited by 235 · see citing works
Self-citationClinical characteristics of magnetic resonance imaging-defined subcortical ischemic depression
Krishnan, K., Taylor, W. D., McQuoid, D. R., MacFall, J. R., Payne, M. E., Provenzale, J. M., & Steffens, D. C. (2003) · Biological Psychiatry · doi:10.1016/j.biopsych.2003.08.014 · Cited by 232 · see citing works
Self-citationTaylor, W. D., MacFall, J. R., Payne, M. E., McQuoid, D. R., Provenzale, J. M., Steffens, D. C., & Krishnan, K. R. R. (2004) · American Journal of Psychiatry · doi:10.1176/appi.ajp.161.7.1293 · Cited by 230 · see citing works
Self-citationMicrostructural but Not Macrostructural Disruption of White Matter in Women with Chronic Alcoholism
Pfefferbaum, A., & Sullivan, E. V. (2002) · NeuroImage · doi:10.1006/nimg.2001.1018 · Cited by 220 · see citing works
Abnormal frontal white matter tracts in bipolar disorder: a diffusion tensor imaging study
Adler, C. M., Holland, S. K., Schmithorst, V. J., Wilke, M., Weiss, K. L., Pan, H., & Strakowski, S. M. (2004) · Bipolar Disorders · doi:10.1111/j.1399-5618.2004.00108.x · Cited by 211 · see citing works
Bhagat, Y. A., & Beaulieu, C. (2004) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.20102 · Cited by 208 · see citing works
Magnetic Resonance Imaging Correlates of Depression After Ischemic Stroke
Vataja, R., Pohjasvaara, T., Leppävuori, A., Mäntylä, R., Aronen, H. J., Salonen, O. L. M., Kaste, M., & Erkinjuntti, T. (2001) · Archives of General Psychiatry · doi:10.1001/archpsyc.58.10.925 · Cited by 205 · see citing works
Haznedar, M. M., Roversi, F., Pallanti, S., Rossi, N. B., Schnur, D. B., LiCalzi, E. M., Tang, C. Y., Hof, P. R., Hollander, E., & Buchsbaum, M. S. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.01.002 · Cited by 204 · see citing works
Diffusion tensor imaging: background, potential, and utility in psychiatric research.
Taylor, W. D., Hsu, E., Krishnan, K. R., & MacFall, J. (2003) · Biological Psychiatry · doi:10.1016/j.biopsych.2003.07.001 · Cited by 197 · see citing works
Self-citationHickie, I. B., Scott, E. M., Wilhelm, K. A., & Brodaty, H. (1997) · Biological Psychiatry · doi:10.1016/s0006-3223(96)00363-0 · Cited by 191 · see citing works
Lim, K. O., Choi, S. J., Pomara, N., Wolkin, A., & Rotrosen, J. (2002) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01355-5 · Cited by 191 · see citing works
Nobuhara, K. (2006) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.2004.055129 · Cited by 191 · see citing works
Clinical and phenomenological comparisons of late-onset and early-onset depression
Krishnan, K., Hays, J. C., Tupler, L. A., George, L. K., & Blazer, D. G. (1995) · American Journal of Psychiatry · doi:10.1176/ajp.152.5.785 · Cited by 178 · see citing works
Self-citationThe regional prefrontal syndromes: a theoretical and clinical overview
Duffy, J. D., & Campbell, J. J. (1994) · Journal of Neuropsychiatry · doi:10.1176/jnp.6.4.379 · Cited by 173 · see citing works
White matter hyperintensities are related to physical disability and poor motor function
Sachdev, P. S. (2005) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.2004.042945 · Cited by 163 · see citing works
Cortical White Matter Microstructural Abnormalities in Bipolar Disorder
Beyer, J. L., Taylor, W. D., MacFall, J. R., Kuchibhatla, M. N., Payne, M. E., Provenzale, J. M., Cassidy, F., & Krishnan, K. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300802 · Cited by 155 · see citing works
Self-citationSex differences in the human corpus callosum: diffusion tensor imaging study
Shin, Y., Kim, D. J., Ha, T. H., Park, H., Moon, W., Chung, E. C., Lee, J. M., Kim, I. Y., Kim, S. I., & Kwon, J. S. (2005) · Neuroreport · doi:10.1097/00001756-200505310-00003 · Cited by 147 · see citing works
Westerhausen, R., Walter, C., Kreuder, F., Wittling, R. A., Schweiger, E., & Wittling, W. (2003) · Neuroscience Letters · doi:10.1016/j.neulet.2003.07.011 · Cited by 146 · see citing works
Evidence of white matter tract disruption in MRI hyperintensities
Taylor, W. D., Payne, M. E., Krishnan, K. R. R., Wagner, H. R., Provenzale, J. M., Steffens, D. C., & MacFall, J. R. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01160-x · Cited by 134 · see citing works
Self-citationCorpus callosum signal intensity in patients with bipolar and unipolar disorder.
(2004) · PubMed Central · Cited by 131 · see citing works
Magnetic-resonance morphometry in patients with major depression
Parashos, I. A., Tupler, L. A., Blitchington, T. F., & Krishnan, K. (1998) · Psychiatry Research Neuroimaging · doi:10.1016/s0925-4927(98)00042-0 · Cited by 130 · see citing works
Self-citationKrishnan, K., & McDonald, W. M. (1995) · Medical Hypotheses · doi:10.1016/0306-9877(95)90081-0 · Cited by 126 · see citing works
Self-citationThe Effect of Aging on the Apparent Diffusion Coefficient of Normal-Appearing White Matter
Engelter, S. T., Provenzale, J. M., Petrella, J. R., DeLong, D. M., & MacFall, J. R. (2000) · American Journal of Roentgenology · doi:10.2214/ajr.175.2.1750425 · Cited by 121 · see citing works
Self-citationGreater MRI lesion volumes in elderly depressed subjects than in control subjects
Taylor, W. D., MacFall, J. R., Payne, M. E., McQuoid, D. R., Steffens, D. C., Provenzale, J. M., & Krishnan, R. R. (2005) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2004.08.004 · Cited by 119 · see citing works
Self-citation1997 IPA/Bayer Research Awards in Psychogeriatrics
Simpson, S. W., Baldwin, R. C., Jackson, A., & Burns, A. (1997) · International Psychogeriatrics · doi:10.1017/s1041610297004432 · Cited by 115 · see citing works
Anatomical MRI study of corpus callosum in unipolar depression
Lacerda, A. L. T., Brambilla, P., Sassi, R. B., Nicoletti, M., Mallinger, A. G., Frank, E., Kupfer, D. J., Keshavan, M. S., & Soares, J. C. (2004) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2004.10.004 · Cited by 102 · see citing works
Sex differences in frontal lobe white matter microstructure: a DTI study
Szeszko, P. R., Vogel, J., Ashtari, M., Malhotra, A. K., Bates, J., Kane, J. M., Bilder, R. M., Frevert, T. A., & Lim, K. O. (2003) · Neuroreport · doi:10.1097/00001756-200312190-00035 · Cited by 96 · see citing works
Nobuhara, K., Okugawa, G., Minami, T., Takase, K., Yoshida, T., Yagyu, T., Tajika, A., Sugimoto, T., Tamagaki, C., Ikeda, K., et al. (2004) · Neuropsychobiology · doi:10.1159/000077941 · Cited by 94 · see citing works
The Duke Somatic Treatment Algorithm for Geriatric Depression (STAGED) Approach
Steffens, D. C., McQuoid, D. R., MHS, McQuoid, D. R., Bartolomé Iglesias, S., Krishnan, A. K. R. R., & Rush, A. J. (2025) · Psychopharmacology Bulletin · doi:10.64719/pb.4224 · Cited by 84 · see citing works
Self-citationSeverity of Subcortical Gray Matter Hyperintensity Predicts ECT Response in Geriatric Depression
Steffens, D. C., Conway, C. R., Dombeck, C., Wagner, H. R., Tupler, L. A., & Weiner, R. D. (2001) · Journal of Ect · doi:10.1097/00124509-200103000-00009 · Cited by 77 · see citing works
Self-citationWu, J. C., Buchsbaum, M. S., Johnson, J. C., Hershey, T. G., Wagner, E. A., Tung, C., & Lottenberg, S. (1993) · Journal of Affective Disorders · doi:10.1016/0165-0327(93)90073-s · Cited by 65 · see citing works
White matter hyperintensities and chronicity of depression
Heiden, A. M., Kettenbach, J., Fischer, P. A., Schein, B., Ba‐Ssalamah, A., Frey, R., Naderi, M. M., Gulesserian, T., Schmid, D., Trattnig, S., et al. (2004) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2004.07.004 · Cited by 62 · see citing works
Hippocampal volume and cell proliferation after acute and chronic clozapine or haloperidol treatment
Schmitt, A., Weber, S., Jatzko, A., Braus, D. F., & Henn, F. A. (2004) · Journal of Neural Transmission · doi:10.1007/s00702-003-0070-2 · Cited by 60 · see citing works
The 3-year course and outcome of patients with major depression and silent cerebral infarction
Yanai, I., Fujikawa, T., Horiguchi, J., Yamawaki, S., & Touhouda, Y. (1998) · Journal of Affective Disorders · doi:10.1016/s0165-0327(97)00148-1 · Cited by 49 · see citing works
MRI Lesion Severity and Mortality in Geriatric Depression
Levy, R. M., Steffens, D. C., McQuoid, D. R., Provenzale, J. M., MacFall, J. R., & Krishnan, K. R. R. (2003) · American Journal of Geriatric Psychiatry · doi:10.1176/appi.ajgp.11.6.678 · Cited by 38 · see citing works
Self-citationMRI of corpus callosum and septum pellucidum in depression
Lammers, C.-H., Doraiswamy, P. M., Husain, M. M., Fi, G. S., Lurie, S. N., Boyko, O. B., Ellinwood, E. H., Nemeroff, C. B., & Krishnan, K. R. (1991) · Biological Psychiatry · doi:10.1016/0006-3223(91)91297-5 · Cited by 33 · see citing works
Self-citationYamashita, H., Fujikawa, T., Yanai, I., Morinobu, S., & Yamawaki, S. (2001) · Neuropsychobiology · doi:10.1159/000054939 · Cited by 23 · see citing works
The effect of corticosteroid medication on quantitative MR parameters of the brain.
Steens, S. C. A., Steup‐Beekman, G. M., Bosma, G. P. T., et al. (2006) · PubMed · Cited by 15 · see citing works
Chronic Antidopaminergic Medication Might Affect Amygdala Structure in Patients with Schizophrenia
van Elst, L. T., Bäumer, D., Ebert, D., et al. (2004) · Pharmacopsychiatry · doi:10.1055/s-2004-832595 · Cited by 15 · see citing works
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Frontocingulate Dysfunction in Depression: Toward Biomarkers of Treatment Response
Pizzagalli, D. A. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2010.166 · Cited by 945 · see citing works
Koolschijn, P. C. M. P., van Haren, N. E. M., Lensvelt‐Mulders, G. J. L. M., Hulshoff Pol, H. E., & Kahn, R. S. (2009) · Human Brain Mapping · doi:10.1002/hbm.20801 · Cited by 902 · see citing works
Mechanisms and treatment of late-life depression
Alexopoulos, G. S. (2019) · Translational Psychiatry · doi:10.1038/s41398-019-0514-6 · Cited by 592 · see citing works
Johansen-Berg, H., Gutman, D. A., Behrens, T. E. J., Matthews, P. M., Rushworth, M. F. S., Katz, E., Lozano, A. M., & Mayberg, H. S. (2008) · Cerebral Cortex · doi:10.1093/cercor/bhm167 · Cited by 561 · see citing works
Bipolar and major depressive disorder: Neuroimaging the developmental-degenerative divide
Savitz, J., & Drevets, W. C. (2009) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2009.01.004 · Cited by 494 · see citing works
White matter hyperintensities in late life depression: a systematic review
Herrmann, L. L., Le Masurier, M., & Ebmeier, K. P. (2007) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.2007.124651 · Cited by 456 · see citing works
Alexopoulos, G. S., Hoptman, M. J., Kanellopoulos, D., Murphy, C. F., Lim, K. O., & Gunning, F. M. (2012) · Journal of Affective Disorders · doi:10.1016/j.jad.2011.12.002 · Cited by 437 · see citing works
Korgaonkar, M. S., Grieve, S. M., Koslow, S. H., Gabrieli, J. D. E., Gordon, E., & Williams, L. M. (2011) · Human Brain Mapping · doi:10.1002/hbm.21178 · Cited by 205 · see citing works
Murphy, M. L., & Frodl, T. (2011) · Biology of Mood & Anxiety Disorders · doi:10.1186/2045-5380-1-3 · Cited by 195 · see citing works
Depressive symptoms and white matter dysfunction in retired NFL players with concussion history
Strain, J., Didehbani, N., Cullum, C. M., Mansinghani, S., Conover, H., Kraut, M. A., Hart, J., & Womack, K. B. (2013) · Neurology · doi:10.1212/wnl.0b013e318299ccf8 · Cited by 155 · see citing works
Zhang, A., Leow, A., Ajilore, O., Lamar, M., Yang, S., Joseph, J., Medina, J., Zhan, L., & Kumar, A. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2011.279 · Cited by 121 · see citing works
Blood, A. J., Iosifescu, D. V., Makris, N., Perlis, R. H., Kennedy, D. N., Dougherty, D. D., Kim, B. W., Lee, M. J., Wu, S., Lee, S., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0013945 · Cited by 126 · see citing works
Romero, M. J., Asensio, S., Palau, C., Sanchez, A., & Romero, F. J. (2010) · Psychiatry Research: Neuroimaging · doi:10.1016/j.pscychresns.2009.07.004 · Cited by 103 · see citing works
Michelsen, K. A., van den Hove, D. L., Schmitz, C., Segers, O., Prickaerts, J., & Steinbusch, H. W. (2007) · BMC Neuroscience · doi:10.1186/1471-2202-8-107 · Cited by 100 · see citing works
Dalby, R. B., Frandsen, J., Chakravarty, M. M., Ahdidan, J., Sørensen, L., Rosenberg, R., Videbech, P., & Østergaard, L. (2010) · Psychiatry Research: Neuroimaging · doi:10.1016/j.pscychresns.2010.06.008 · Cited by 96 · see citing works
Carballedo, A., Amico, F., Ugwu, I., Fagan, A. J., Fahey, C., Morris, D., Meaney, J. F., Leemans, A., & Frodl, T. (2012) · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32060 · Cited by 95 · see citing works
Smith, R., Chen, K., Baxter, L., Fort, C., & Lane, R. D. (2013) · Journal of Affective Disorders · doi:10.1016/j.jad.2012.07.029 · Cited by 95 · see citing works
Rüsch, N., Weber, M., Il’yasov, K. A., Lieb, K., Ebert, D., Hennig, J., & van Elst, L. T. (2007) · NeuroImage · doi:10.1016/j.neuroimage.2006.12.007 · Cited by 93 · see citing works
Schermuly, I., Fellgiebel, A., Wagner, S., Yakushev, I., Stoeter, P., Schmitt, R., Knickenberg, R. J., Bleichner, F., & Beutel, M. E. (2010) · European Psychiatry · doi:10.1016/j.eurpsy.2010.05.001 · Cited by 67 · see citing works
Sen, Z. D., Danyeli, L. V., Woelfer, M., Lamers, F., Wagner, G., Sobanski, T., & Walter, M. (2021) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2020.12.020 · Cited by 65 · see citing works
Taylor, W. D., Zhao, Z., Ashley‐Koch, A., Payne, M. E., Steffens, D. C., Krishnan, R. R., Hauser, E., & MacFall, J. R. (2013) · Human Brain Mapping · doi:10.1002/hbm.21445 · Cited by 50 · see citing works
Self-citationWhite-matter tract integrity in late-life depression: associations with severity and cognition
Charlton, R. A., Lamar, M., Zhang, A., Yang, S., Ajilore, O., & Kumar, A. (2014) · Psychological Medicine · doi:10.1017/s0033291713001980 · Cited by 49 · see citing works
Tateishi, H., Nishihara, M., Kawaguchi, A., Matsushima, J., Murakawa, T., Haraguchi, Y., Kunitake, Y., Maekawa, T., Kato, T. A., Asami, T., et al. (2019) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s228501 · Cited by 26 · see citing works
Mechanisms and treatment of late-life depression
Alexopoulos, G. S. (2021) · Focus · doi:10.1176/appi.focus.19304 · Cited by 22 · see citing works
- Authors
- Bae, J. N., MacFall, J. R., Krishnan, K. R. R., Payne, M. E., Steffens, D. C., & Taylor, W. D.
- Affiliations
- Duke Medical Center (US)
- Corresponding author
- Taylor, Warren D.
- Venue
- Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2006-12
- Volume
- 60
- Issue
- 12
- Pages
- 1356-1363
- ISSN
- 0006-3223 (ISSN-L)
- OpenAlex
- W1994414964
- Cited by
- 288
- References
- 69
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 7 · 2023: 14 · 2022: 12 · 2021: 15 · 2020: 12 · 2019: 14 · 2018: 9 · 2017: 18 · 2016: 10 · 2015: 16 · 2014: 20 · 2013: 19 · 2012: 29
- FWCI
- 12.40
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (K23 MH 65939, R01 MH-54846, R01MH054846, K23MH065939, P50MH60451, P50MH060451)
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Keywords
- geriatric depression, dorsolateral prefrontal cortex, anterior cingulate cortex, white matter microstructure, fractional anisotropy, apparent diffusion coefficient, corpus callosum, internal capsule, white matter connectivity, mood regulation
- MeSH terms
- Aged, Aged, 80 and over, Brain, Corpus Callosum, Cross-Sectional Studies, Data Interpretation, Statistical, Depressive Disorder, Female, Gyrus Cinguli, Humans, Image Processing, Computer-Assisted, Male, Middle Aged, Psychiatric Status Rating Scales, Reproducibility of Results, Anisotropy, Prefrontal Cortex, Diffusion Magnetic Resonance Imaging
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