White-matter tract integrity in late-life depression: associations with severity and cognition
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Background: Although significant changes in both gray and white matter have been noted in late-life depression (LLD), the pathophysiology of implicated white-matter tracts has not been fully described. In this study we examined the integrity of specific white-matter tracts in LLD versus healthy controls (HC). Method: Participants aged ⩾60 years were recruited from the community. The sample included 23 clinically diagnosed individuals with LLD and 23 HC. White-matter integrity metrics [fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD) and radial diffusivity (RD)] were calculated in the bilateral cingulum and uncinate fasciculus. Depression severity was measured using the Center for Epidemiological Studies Depression Scale (CESD). Composite scores for learning and memory and executive function were created using standardized neuropsychological assessments. Results: White-matter integrity was lower in LLD versus HC in the bilateral cingulum and right uncinate fasciculus (p⩽0.05). In the whole sample, depression severity correlated with integrity in the bilateral cingulum and right uncinate fasciculus (p ⩽0.05). In patients, depression severity correlated with the integrity of the left uncinate fasciculus (p = 0.03); this tract also correlated with executive function (p = 0.02). Among HC, tract integrity did not correlate with depression scores; however, learning and memory correlated with integrity of the bilateral uncinate fasciculus and bilateral cingulum; executive function correlated with the right uncinate and left cingulum (p ⩽0.05). Conclusions: White-matter tract integrity was lower in LLD than in HC and was associated with depression severity across all participants. Tract integrity was associated with cognition in both groups but more robustly among HC.
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Late-life depression is associated with lower uncinate fasciculus structural integrity than in non-depressed age-matched peers, and lower integrity correlates with executive dysfunction and depressive symptoms.
“older adults with LLD exhibit decreased structural integrity of the uncinate fasciculus compared to non-depressed age-matched peers, and decreased integrity is correlated with executive dysfunction and depression symptoms54.”
From State of the Science of Neural Systems in Late‐Life Depression: Impact on Clinical Presentation and Treatment Outcome (2018) · cites this paper as [54]
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- Authors
- Charlton, R. A., Lamar, M., Zhang, A., Yang, S., Ajilore, O., & Kumar, A.
- Affiliations
- University of Illinois Chicago (US)
- Corresponding author
- Charlton, R. A.
- Venue
- Psychological Medicine
- Publisher
- Cambridge University Press (CUP)
- Published
- 2013-09-16
- Volume
- 44
- Issue
- 7
- Pages
- 1427-1437
- ISSN
- 0033-2917 (ISSN-L)
- 1469-8978
- PMC
- PMC4310501
- OpenAlex
- W2001367656
- Cited by
- 49
- References
- 62
- Citations by year
- 2025: 2 · 2024: 3 · 2023: 6 · 2022: 3 · 2021: 4 · 2020: 6 · 2019: 3 · 2018: 5 · 2017: 3 · 2016: 3 · 2015: 4 · 2014: 6 · 2013: 1
- FWCI
- 3.61
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Psychological Medicine (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Figshare (submittedVersion, cc-by)
- Funders
- National Institutes of Health (5r01mh073989-05)
- University of Illinois at Chicago
- National Institute of Mental Health (R01MH-073989, 7R01MH073989-04)
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Keywords
- geriatric depression, white matter tract integrity, cingulum, uncinate fasciculus, fractional anisotropy, mean diffusivity, axial and radial diffusivity, depression severity, executive function, learning and memory, cognitive function, older adults, white matter
- MeSH terms
- Aged, Aged, 80 and over, Cognition Disorders, Major Depressive Disorder, Female, Gyrus Cinguli, Humans, Male, Middle Aged, Neural Pathways, Severity of Illness Index, White Matter
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