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Deficits on a Probabilistic Response-Reversal Task in Patients With Pediatric Bipolar Disorder
Abstract
OBJECTIVE: Patients with bipolar disorder become hyperhedonic when manic and anhedonic when depressed; therefore, it is important to test whether patients with bipolar disorder show deficits on behavioral paradigms exploring reward/punishment mechanisms. METHOD: A probabilistic response-reversal task was administered to 24 bipolar children and 25 comparison subjects. RESULTS: Patients made more errors during probabilistic reversal, took longer to learn the new reward object, and were less likely to meet the learning criterion. CONCLUSIONS: Children with bipolar disorder may have a reversal learning deficit.
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“Behavioral studies of response to rewards in bipolar disorder indicate deficits in behavioral adaptation to changing reward contingencies [267] and prolonged elevation of mood in response to monetary reward in euthymic patients with bipolar disorder [268].”
From Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings (2012) · cites this paper as [267]
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Metadata
- Authors
- Gorrindo, T., Blair, R. J. R., Budhani, S., Dickstein, D. P., Pine, D. S., & Leibenluft, E.
- Affiliations
- National Institute of Mental Health (US)
- Venue
- American Journal of Psychiatry
- Published
- 2005-10-01
- Volume
- 162
- Issue
- 10
- Pages
- 1975-1977
- ISSN
- 0002-953X (ISSN-L)
- 1535-7228
- OpenAlex
- W2110855184
- Cited by
- 111
- References
- 11
- Citations by year
- 2025: 1 · 2023: 1 · 2022: 1 · 2021: 6 · 2020: 2 · 2019: 2 · 2018: 2 · 2017: 6 · 2016: 7 · 2015: 12 · 2014: 6 · 2013: 7 · 2012: 9
- FWCI
- 6.01
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Keywords
- pediatric bipolar disorder, probabilistic reversal learning, reward learning, punishment learning, anhedonia, learning deficits
- MeSH terms
- Adolescent, Affective Symptoms, Age Factors, Bipolar Disorder, Child, Female, Frontal Lobe, Humans, Learning Disabilities, Male, Psychomotor Performance, Reversal Learning, Prefrontal Cortex
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