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Cited by 87Bipolar Disorder and TreatmentTreatment of Major DepressionSchizophrenia research and treatment

Reduced hedonic capacity in euthymic bipolar subjects: a trait-like feature

Di Nicola, Marco, De Risio, Luisa, Battaglia, Claudia, Camardese, Giovanni, Tedeschi, Daniela, Mazza, Marianna, Martinotti, Giovanni, Pozzi, Gino +4 more·2013·Journal of Affective Disorders
DOI 10.1016/j.jad.2012.10.004
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Abstract

Background The aim of our study was to assess hedonic capacity in euthymic bipolar subjects, identifying possible differences compared to remitted unipolar depressed patients and healthy controls.Methods 107 subjects with bipolar disorders, 86 with major depressive disorder and 106 healthy controls, homogeneous with respect to demographic characteristics, were enrolled. The following scales were administered: the Snaith-Hamilton pleasure scale (SHAPS), the subscale for 'anhedonia/asociality' of the scale for the assessment of negative symptoms (SANS) and the visual analogue scale (VAS) for hedonic capacity.Results Scores on SHAPS total, interests and social interactions, SANS 'anhedonia/asociality' and VAS were all significantly higher in affective disorder patients compared to healthy controls. No difference was found between clinical groups. 20.5% (n=22) of bipolar disorder subjects and 24.5% (n=21) of major depressed subjects showed a significant reduction in hedonic capacity (SHAPS total score ≥ 3), compared to 7.5% (n=8) of healthy controls (χ(2)=12.03; p=.002).Limitations Limitations include heterogeneity with respect to pharmacological status and longitudinal course (i.e., 'single' vs. 'recurrent' affective episodes).Conclusions The major finding of our study is that euthymic bipolar patients and remitted major depressed patients display residual anhedonic symptoms. This suggests that, in affective disorder patients, altered hedonic capacity could represent an enduring trait and that, possibly, dysfunctions in the neurobiological mechanisms underlying hedonic response and reward processing persist, irrespective of mood state.

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Crossref · 10.1016/j.jad.2012.10.004

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  • Current standard treatment of MDD, particularly SSRIs, fails to sufficiently treat reward-related symptoms of depression.

    “It was proposed that current standard treatment of MDD, particularly selective serotonin reuptake inhibitors (SSRIs), fail to sufficiently treat reward-related symptoms of depression (Dunlop and Nemeroff, 2007; Price et al., 2009; Di Nicola et al., 2013).”

    From Circuit Mechanisms of Reward, Anhedonia, and Depression (2019) · cites this paper as Di Nicola et al., 2013

  • In remitted bipolar patients, only some aspects of hedonic capacity (interests and social interactions) are impaired.

    “In remitted bipolar patients, for example, who display increased levels of anhedonia compared to healthy volunteers, only some aspects of hedonic capacity, namely interests and social interactions, seem to be impaired (Di Nicola et al., 2013).”

    From Circuit Mechanisms of Reward, Anhedonia, and Depression (2019) · cites this paper as Di Nicola et al., 2013

  • Anhedonia might be a trait marker rather than an expression of a disease state, with persistence of reduced hedonic capacity in euthymic remitted patients.

    “It was also suggested that anhedonia might be a trait marker rather than an expression of a disease state, with persistence of reduced hedonic capacity in euthymic remitted patients (Di Nicola et al., 2013).”

    From Circuit Mechanisms of Reward, Anhedonia, and Depression (2019) · cites this paper as Di Nicola et al., 2013

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Authors
Di Nicola, M., De Risio, L., Battaglia, C., Camardese, G., Tedeschi, D., Mazza, M., Martinotti, G., Pozzi, G., Niolu, C., Di Giannantonio, M., Siracusano, A., & Janiri, L.
Affiliations
  • Università Cattolica del Sacro Cuore (IT)
  • University of Chieti-Pescara (IT)
  • University of Rome Tor Vergata (IT)
ORCID
Venue
Journal of Affective Disorders
Publisher
Elsevier BV
Published
2013-05
Volume
147
Issue
1-3
Pages
446-450
ISSN
0165-0327 (ISSN-L)
DOI
10.1016/j.jad.2012.10.004
OpenAlex
W2027534854
Cited by
87
References
44
Citations by year
2026: 2 · 2025: 6 · 2024: 7 · 2023: 6 · 2022: 4 · 2021: 25 · 2020: 6 · 2019: 8 · 2018: 2 · 2016: 4 · 2015: 8 · 2014: 7 · 2013: 2
FWCI
3.87
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Journal of Affective Disorders (publishedVersion)
  • PubMed (publishedVersion)
  • Cineca Institutional Research Information System (Tor Vergata University) (submittedVersion)
  • IRIS Research product catalog (Sapienza University of Rome) (submittedVersion)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
  • Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Keywords
hedonic capacity, bipolar disorder, euthymia, major depressive disorder, anhedonia, reward processing, Snaith-Hamilton Pleasure Scale, Scale for the Assessment of Negative Symptoms, remitted depression
MeSH terms
Adult, Bipolar Disorder, Major Depressive Disorder, Depressive Disorder, Female, Humans, Male, Middle Aged, Pleasure

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