Association of the Serotonin Transporter Gene With Smoking Behavior
Abstract
OBJECTIVE: In an ongoing molecular genetic study of temperament, participants were genotyped to examine the association of smoking with two polymorphisms of the serotonin transporter gene (SERT): the promoter region, 5-HTTLPR, and an intronic variable-number-of-tandem-repeats region (VNTR). METHOD: Full information was available for 330 families, and 244 "ever smokers" were identified (54 past smokers, 190 current smokers). The average number of cigarettes smoked per day was 13.12, and the mean Fagerstrom Tolerance Questionnaire score was 4.79. Associations of genotype, Tridimensional Personality Questionnaire scores, and smoking phenotype were tested by using a robust family design with a variance-components framework and by case-control analysis. RESULTS: There was a significant excess of the 5-HTTLPR long allele with the 12-repeat VNTR in current smokers, past smokers, and ever smokers, compared to participants who had never smoked. The results from the population design were confirmed in the family-based analysis. No association was observed between two quantitative measures of smoking and the polymorphisms. A weak association was observed between novelty seeking and the VNTR polymorphism and between reward and 5-HTTLPR. Smokers, regardless of gender, scored significantly higher on novelty seeking and did not differ on harm avoidance or reward. CONCLUSIONS: There was a highly significant association between SERT and the categorical definition of smoking, irrespective of d…
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There is a highly significant association between a polymorphism of the SERT promoter region and the initiation of smoking.
“Such findings are consistent with a clinical study that revealed a highly significant association between a polymorphism of the SERT promoter region and the initiation of smoking, using both case-control analysis and family-based designs (Kremer et al. 2005).”
From <scp>N</scp> icotine and the adolescent brain (2015) · cites this paper as Kremer et al. 2005
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- Authors
- Kremer, I., Bachner-Melman, R., Reshef, A., Broude, L., Nemanov, L., Gritsenko, I., Heresco-Levy, U., Elizur, Y., & Ebstein, R. P.
- Affiliations
- Emek Medical Center (IL)
- Venue
- American Journal of Psychiatry
- Published
- 2005-05-01
- Volume
- 162
- Issue
- 5
- Pages
- 924-930
- ISSN
- 0002-953X (ISSN-L)
- 1535-7228
- OpenAlex
- W2129632411
- Cited by
- 101
- References
- 3
- Citations by year
- 2023: 4 · 2021: 1 · 2020: 2 · 2019: 1 · 2018: 2 · 2017: 1 · 2016: 7 · 2015: 8 · 2014: 8 · 2013: 3 · 2012: 9
- FWCI
- 6.55
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Keywords
- serotonin transporter gene, serotonin transporter, smoking behavior, 5-HTTLPR, variable number tandem repeats, promoter polymorphism, novelty seeking, temperament, smoking initiation, gene-environment association, mediation analysis, family-based association
- MeSH terms
- Adolescent, Adult, Age Factors, Aged, Exploratory Behavior, Female, Genotype, Humans, Introns, Male, Membrane Glycoproteins, Middle Aged, Nerve Tissue Proteins, Pedigree, Phenotype, Polymorphism, Genetic, Promoter Regions, Genetic, Serotonin, Sex Factors, Smoking, Temperament, Minisatellite Repeats, Membrane Transport Proteins, Serotonin Plasma Membrane Transport Proteins
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