Childhood adversity, serotonin transporter (5-HTTLPR) genotype, and risk for cigarette smoking and nicotine dependence in alcohol dependent adults
Open accessAbstract
Background This study examined the extent to which cigarette smoking and nicotine dependence in adults with alcohol dependence (AD) are associated with adverse childhood experiences. Gender, social support, and an allelic variant in the gene encoding the serotonin transporter (5-HTTLPR) were examined as moderators of this relationship.Methods The Semi-Structured Assessment for the Genetics of Alcoholism - Version II (SSAGA-II) was used to assess DSM-IV diagnoses and cigarette smoking characteristics as well as traumatic life events and social support during childhood in 256 AD men (n=149) and women (n=107).Results An increase in number of adverse childhood events was associated with heightened risk of cigarette use and nicotine dependence. 5-HTTLPR genotype, gender, and social support did not significantly moderate the relationships among childhood adversity and ever-smoking or nicotine dependence.Conclusions Results extend previous findings to suggest that childhood adversity is strongly related to risk for ever-smoking and nicotine dependence in AD individuals. Additional research is needed to examine other potential genetic and environmental moderators and mediators of the relationships among smoking, alcohol use, and childhood trauma.
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- Authors
- Mingione, C. J., Heffner, J. L., Blom, T. J., & Anthenelli, R. M.
- Affiliations
- University of Cincinnati (US)
- Cincinnati VA Medical Center (US)
- Corresponding author
- Heffner, Jaimee L.
- Venue
- Drug and Alcohol Dependence
- Publisher
- Elsevier BV
- Published
- 2012-06
- Volume
- 123
- Issue
- 1-3
- Pages
- 201-206
- ISSN
- 0376-8716 (ISSN-L)
- PMC
- PMC3315603
- OpenAlex
- W2042037495
- Cited by
- 29
- References
- 52
- Citations by year
- 2024: 1 · 2023: 2 · 2022: 2 · 2021: 4 · 2020: 2 · 2019: 3 · 2018: 3 · 2017: 1 · 2016: 1 · 2015: 6 · 2014: 2 · 2013: 2
- FWCI
- 0.87
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Drug and Alcohol Dependence (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Alcohol Abuse and Alcoholism (AA013307, R01AA013307, R01AA013957, AA013957)
- National Institute on Drug Abuse (DA026517, K23DA026517)
- Topics
- Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
- Keywords
- childhood adversity, adverse childhood experiences, serotonin transporter gene, 5-HTTLPR, cigarette smoking, nicotine dependence, alcoholism, gender differences, social support, childhood trauma, genetic moderators
- MeSH terms
- Adolescent, Adult, Alcoholism, Anxiety Disorders, Child, Child Abuse, Child Abuse, Sexual, Female, Genotype, Humans, Male, Middle Aged, Poverty, Risk, Sex Factors, Smoking, Social Support, Socioeconomic Factors, Stress, Psychological, Tobacco Use Disorder, Violence, Logistic Models, Mood Disorders, Serotonin Plasma Membrane Transport Proteins, Gene-Environment Interaction
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