Cited by 14Bipolar Disorder and TreatmentSmoking Behavior and CessationSchizophrenia research and treatment

The adverse effects of smoking on health outcomes in bipolar disorder: a review and synthesis of biological mechanisms

Slyepchenko, A., Brunoni, A.R., McIntyre, R.S., Quevedo, J., Carvalho, A.F.·2016·Current Molecular Medicine

Abstract

Several biological systems are implicated in the neuroprogression of bipolar disorder including but not limited to cytokine levels, oxidative stress markers, monoamine levels, tryptophan catabolite and glutamate-mediated excitotoxicity, microglial activation as well as structural and functional changes. The high rate of smoking behaviour in individuals with bipolar disorder provides the impetus for exploring shared and discrete pathogenetic mechanisms. In addition to contributing to increased mortality, smoking activates several neurobiological effector systems implicated in the progression of bipolar disorder. Here, a narrative review provides evidence and putative mechanisms of comorbid effects of BD, cigarette use, and nicotine dependence, and discusses the clinical implications of these interactions.

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Registry

Crossref · 10.2174/1566524016666160126144601

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180 of 180 references verified0 citation errors · 0 not checkable

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  • Tobacco smoke promotes neuroprogression in bipolar disorder via oxidative and nitrosative stress pathways, increasing oxidative burden, triggering reactive nitrogen species and reactive oxygen species, excitotoxicity and mitochondrial dysfunction.

    “In addition, tobacco smoke promotes neuroprogression in BD via several possible pathways leading to cumulative effects; particularly oxidative and nitrosative stress pathways where it increases the oxidative burden, further triggers reactive nitrogen species (RNS, e.g., nitric oxide) and reactive oxygen species (ROS) effects of excitotoxicity and mitochondrial dysfunction.”
  • Nicotine and the free radicals contained in cigarette smoke activate several neurobiological effector systems implicated in the neuroprogression of bipolar disorder.

    “Nicotine and the free radicals contained in cigarette smoke activate several neurobiological effector systems implicated in the neuroprogression of BD (22).”

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Authors
Slyepchenko, A., Brunoni, A. R., McIntyre, R. S., Quevedo, J., & Carvalho, A. F.
Affiliations
Universidade Federal do Ceará (BR)
Venue
Current Molecular Medicine
Published
2016-02-04
Volume
16
Issue
2
Pages
187-205
ISSN
1566-5240 (ISSN-L)
OpenAlex
W2252384097
Cited by
14
References
180
Citations by year
2025: 2 · 2023: 2 · 2022: 2 · 2021: 1 · 2020: 2 · 2019: 1 · 2017: 3 · 2016: 1
FWCI
1.48
Type
journal article
Language
en
Open access
closed
Locations
  • Current Molecular Medicine (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
  • Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Keywords
bipolar disorder, smoking, nicotine dependence, neuroprogression, cytokines, oxidative stress, monoamines, tryptophan metabolism, glutamate excitotoxicity, microglial activation, neuroinflammation, mortality, comorbidities
MeSH terms
Bipolar Disorder, Humans, Smoking, Biomarkers, Treatment Outcome, Oxidative Stress, Epigenesis, Genetic

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